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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Diponegoro Medical Journal of Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan Medica Hospitalia Risenologi Psychiatry Nursing Journal (Jurnal Keperawatan Jiwa) Diponegoro International Medical Journal (DIMJ) Neurona
Amin Husni
Department Of Neurology, Faculty Of Medicine, Universitas Diponegoro Semarang, Indonesia
Chemistry Dentistry Education Engineering Health Professions Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Elementary knowledge about epilepsy among the patients, their family, and common people Husni, Amin
Medical Journal of Indonesia Vol 12, No 1 (2003): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.74 KB) | DOI: 10.13181/mji.v12i1.87

Abstract

It is assumed that health education has been done and health information has been given through health service institutions and mass media, but it seems that the patients as well as common people have insufficient knowledge about epilepsy. Interviews had been carried out upon 127 epilepsy patients in out patient clinic Dr. Kariadi Hospital Semarang, 95 patients’ family, and 95 common people to explore their knowledge on the main disturbed organ, etiology, symptoms and signs, and trigger factors of repeating seizure in epilepsy.  The respondents’ answers were recorded verbatim, and analyzed by matching to the right answers according to references. Bad and insufficient knowledge on the main organ disturbed in epilepsy, etiology, symptoms and signs, and trigger factors for repeated seizure was founded among the epilepsy patients, their family, and common people. There were no significant differences of the level of knowledge among the three groups of respondents. The patients’ knowledge was the worst, compared to the others. The level of education of the respondents did not influence their level of knowledge. In conclusion, this study reflects an insufficient communication between doctors and the patients in the health service institution, and an insufficient public health education about epilepsy received by the patients’ family and common people. (Med J Indones 2003; 12: 29-39) Keywords: epilepsy, knowledge, patients, common people
Pengaruh Latihan Fisik dan Intervensi Kognitif Anagrams Untuk Memperbaiki Fungsi Kognitif Lansia: Literature Review Antonius Ngadiran; Amin Husni; Dian Ratna Sawitri
Risenologi Vol. 6 No. 1a (2021): Seminar Nasional Keperawatan-STIKEP PPNI Jawa Barat
Publisher : Kelompok Peneliti Muda Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47028/j.risenologi.2021.61a.217

Abstract

This literature review study is motivated by psychological problems that often arise in the elderly, one of which is a decline in cognitive function.  Cognitive function declines with age, especially the elderly whose physical activity is limited. Cognitive functions include: executive function, visuospatial, naming, memory, attention, language, abstraction, remembering and orientation. This literature is intended to theoretically analyze the effect of physical exercise and cognitive intervention on improving cognitive function in the elderly. The literature review method was carried out on seven articles obtained from a number of Google Scholar and PubMed databases. The keywords for the article search were “Fysical Execution, Cognitive Training, Cognitive Function, Elderly”. The criteria articles used in English and Indonesian, published from 2010 to 2021. The results of this study showed a significant value, namely from the seven articles showing a value (p < 0.05), which means that there is an effect of physical exercise and cognitive intervention on improving cognitive function in elderly. Physical exercise and cognitive intervention are therapies that are believed to increase cognitive function scores in the elderly. The results of this study are expected to be applied by health workers to prevent cognitive decline in the elderly.
Pemberian Fenitoin Oral dan Timbulnya Hiperplasia Ginggiva pada Pasien Epilepsi Tranggono Yudo Utomo; Amin Husni; Farichah Hanum
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.222 KB)

Abstract

ABSTRACTPhenytoin oral treatment and the development of ginggival hyperplasia in epileptic patientsBackground: Phenytoin is commonly used as a first line drug therapy for epilepsy because of its potency and low cost. Dosage and duration of oral phenytoin administration have been considered as important factors in the development of ginggival hyperplasia.Objective: To investigate whether dosage and duration of oral phenytoin usage were risk factors of ginggival hyperplasia in epileptic patients.Method: Twenty epileptic patiens with phenytoin monotherapy who developed ginggival hyperplasia, and 20 epileptic patients with phenytoin monotherapy without ginggival hyperplasia as a control group were studied. The history of illness, physical examination, fasting and post prandial blood glucose level, funduscopy, oral hygiene, index of hyperplasia scoring from Saymor were taken. Blood sample 3-5 cc were also taken to examine the level of phenytoin. Oral dose, serum dose and duration of administration were noted. Odd ratio was calculated by multiple regression statistic (95% confidence interval).Result: High dose of oral phenytoin was a significant risk factor of ginggival hyperplasia, (p<0.05), while duration of administration >6 months was not a risk factor (p=0.522). Adjusted by duration of oral phenytoin usage, high dose of oral phenytoin usage was still a significant risk factor for gingival hyperplasia, OR=29.14 (95%CI 3.8-291.9).Conclusion: High dose of phenytoin was a significant risk factor for ginggival hyperplasia.Keywords: Dosage and duration of phenytoin administration, ginggival hyperplasiaABSTRAKLatar belakang: Fenitoin sering digunakan sebagai lini pertama pengobatan epilepsi karena potensial dan ekonomis. Dosis dan lama pemberian fenitoin, dianggap sebagai faktor yang berperan dalam timbulnya hiperplasia ginggiva. Tujuan penelitian ini mengetahui apakah dosis fenitoin yang tinggi dan durasi pemberian fenitoin yang panjang merupakan faktor risiko terhadap timbulnya hiperplasia ginggiva pada penderita epilepsi.Metode: Dua puluh pasien epilepsi dengan monoterapi fenitoin yang mengalami hiperplasia ginggiva dan dua puluh pasien epilepsi dengan monoterapi fenitoin yang tidak hiperplasia ginggiva diambil sebagai studi kasus kontrol. Dilakukan anamnesa, pemeriksaan fisik, gula darah puasa dan postprandial, funduskopi, higine mulut, skoring hiperplasia Indek Saymor, pengambilan sampel darah serum fenitoin 3-5cc. Selanjutnya mendata dosis oral, dosis serum dan lama pemberian. Rasio odds (95% interval kepercayaan) dihitung dengan statistik multiple regresi.Hasil: Dosis tinggi fenitoin merupakan faktor risiko yang signifikan terhadap risiko hiperplasia ginggiva (p<0,05), sementara lama pemberian obat >6 bulan tidak terbukti sebagai faktor risiko (p=0,522). Bila dikendalikan oleh faktor durasi, maka besar dosis fenitoin oral tetap merupakan faktor risiko hiperplasia ginggiva yang signifikan OR=29,14 (95%CI, 38-291,9) sedang lama pemberian fenitoin tetap bukan merupakan faktor risiko yang signifikan.Simpulan: Dosis tinggi fenitoin merupakan faktor risiko yang signifikan terhadap hiperplasia ginggiva.
OSTEOPENIA IN MALE AND FEMALE PATIENTS USING CARBAMAZEPIN AND VALPROIC ACID COMBINATION THERAPY: Analysis of Prevalence and Its Relationship with Epilepsy Characteristics Krisninda Anggonowati; Endang Kustiowati; M.I. Widiastuti; Amin Husni; Aris Catur Bintoro; Rahmi Ardhini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32744

Abstract

ABSTRACT Background : Epilepsy is a chronic condition with unprovoked seizures. One of the changes affected by anti-epileptic drugs is a decrease in bone density. Gender and sex hormones have implications on bone density.Objective : To determine the prevalence difference osteopenia between male and female, and relationship with clinical characteristics epilepsy patients taking a combination of carbamazepine and valproic acid.Methods: A cross-sectional study with 22 epileptic patients with age range of 18-60 years taking combination of carbamazepine and valproic acid at the Neurology Department Dr. Kariadi Semarang during June to October 2021 who met the inclusion and exclusion criteria. Patient data were obtained by filling out a questionnaire. The assessment of osteopenia was carried out by examination of Bone Mineral Densitometry. Data analysis was using Chi Square test and Spearman correlation test. The result was determined to be significant if the p value <0.05.Results : There were 11 male subjects and 11 female subjects. Chi Square resulted in significant difference between male and female (p<0.05). Spearman correlation test showed a relationship between osteopenia and duration before combination therapy, for men rho 0.734 (p<0.05), women rho 0.786 (p<0.001). There was a relationship between osteopenia and the onset of epilepsy, male rho 0.603 (p<0.05), female rho 0.757 (p<0.001). There was a relationship between osteopenia and age, male rho 0.487 (p=0.129), female rho 0.780 (p<0.001). There was also a relationship between osteopenia and seizure frequency, male rho 0.457 (p<0.05), female rho 0.467 (p=0.026).Conclusion: There was a significant osteopenia prevalence difference between male and female epilepsy patients taking combination of carbamazepine and valproic acid. Moderate and strong relationship were found between osteopenia and clinical characteristics epilepsy. Keywords : Epilepsy, osteopenia, carbamazepine, valproic acid
The Relationship Between Pre-Operative Clinical Characteristics With Changes In Post-Operative Memory Scores On Temporal Lobe Epilepsy Patient Bintoro, Aris Catur; Arifin, Muhammad Thohar; Harsono, Harsono; Muttaqin, Zainal; Hadisaputro, Soeharyo; Husni, Amin; Bakhtiar, Yuriz; Karlowe, Vega; Pratomo, Joko
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.844

Abstract

Background: Most temporal lobe epilepsy (TLE) will become seizure-free after anterior temporal lobectomy (ATL) surgery but often result in cognitive decline, specifically in verbal or visual memory. Objective: This study examined the relationship between several demographic characteristics and pre-operative clinical conditions with changes in pre-post surgical memory of TLE patients. Methods: This study used a retrospective cohort in which the subjects were TLE patients who had undergone ATL surgery at Kariadi Hospital or Telogorejo Hospital, Semarang. Demographic variables include the age of onset, duration of illness, level of education, and clinical variables include seizure frequency, EEG waveform, number of AED, lesion site, and IQ score. Results: Memory re-examination was conducted on TLE patients who had undergone surgery between 2018 and 2021, with 55 subjects who fulfilled the criteria. Characteristics of the subjects were male 31(56%) males, 38% Senior High School education, the mean age of onset was 13,87±6,899, age at surgery was 27,67±9,802, 21 (39%) normal pres-surgical EEG waveform, 31 (56%) lesion on the left and the most frequent seizures occurred in 36 subjects (65%). Statistical test results showed a significant relationship between age of onset and changes in verbal memory recognition scores (p 0.044), lesion side with changes in verbal memory task scores (p 0.018), recall (p 0.005), recognition (0.008), and IQ scores with changes in visual memory construction recall (p 0.041) Conclusion: Age of onset, lesion side, and IQ score characteristics were related to the changes in memory scores between pre- and post-operative anterior temporal lobectomy in TLE patients.
Pain Improvement Among Chronic Lumbar Disc Herniation Patients Underwent Epidural Triamcinolone With Or Without Hyaluronidase Injection Within 3 Months Of Follow-Up: A Prospective Study Budisulistyo, Trianggoro; Husni, Amin; Tugasworo, Dodik; Pudjonarko, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.850

Abstract

Background Chronic lumbar disc herniation (CLDH) will accompany by chronic inflammation, so the fibrosis tissues formed in the epidural space and adjacent nerve roots, and lead to mixed pain syndrome. Objectives To compare between triamcinolone only and hyaluronidase 1500 international unit (IU) administration epidural injection for treating bulged or protrusion CLDH.     Methods This prospective study involved CLDH patients visiting the outpatient department of Neurology at Dr. Kariadi Hospital Semarang Indonesia from November 2021 until August 2022. They divided: triamcinolone (Group 1) and hyaluronidase 1500 IU and triamcinolone epidural injection (Group 2) with 3 days of hospitalization. Neurotrophic was prescribed during 3 months of follow-up and ordered for personal physical treatment. They analyzed pain improvements (NRS and Pain DETECT), and the Oswestry Disability Index (ODI) scores. Results The 37 subjects were recruited but 1 female dropped out cause of re-injection, so 13 males and 23 females aged between 24 to 72 years old (mean 48+2) were followed. They significantly improved (Wilcoxon test p=.000), as the NRS score was 47.9% (Group 1) and 55.4% (Group 2). ODI scores without significance (Mann-Whitney p> .005), such at 2 weeks (group 1= 20.4%, group 2= 23.6%) and 3 months (group 1= 58.1%, group 2= 53.7%). They observed nociceptive and neuropathic improvement even though needed more time for the healing process. Conclussions This study proved hyaluronidase administration before triamcinolone epidural injection with better improvements for treating bulged or protrusion CLDH patients.
The Wistar Rat Parietal Lobe Cell And Pain Perception Changes After Frequent Of Mobile Phone Electromagnetic Wave Expose Tamad, Fatiha Sri Utami; Budisulistyo, Trianggoro; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Suryadi, Suryadi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.884

Abstract

Background: The increasing number of mobile phone users raises concerns about the effects. Mobile phone electromagnetic wave radiation harms pain perception due to granular cell changes in the cerebral parietal cortex. Objective: To determine the effect of exposure to electromagnetic waves mobile phone on pain perception due to changes in the granular cells of the cerebral parietal cortex Wistar rats. Methods: Experimental research using randomized posttest with control group design. Samples were 28 rats divided into 4 groups. The control group was not exposed, the treatment group was exposed to 2100 MHz electromagnetic waves for 2 hours/day with a distance of 3 cm for 15 days in treatment group 1, for 30 days in treatment group 2, and 45 days in treatment group 3. Measurement of pain onset using the hot method. Changes in pain threshold were taken from the difference in pain onset after exposure to before exposure. Granular cell changes in the cerebral parietal cortex were assessed from the total score with the provisions of normal cells (sumx0), hydropic degenerated cells (sumx1), and necrotic cells (sumx2). Results: The longer the exposure to mobile phones, the higher the pain threshold and the cerebral parietal cortex granular cell damage score. There was a significant difference in pain threshold and changes in cerebral parietal cortex granular cells between groups (p=0.000). There was a significant relationship between changes in the parietal cerebral cortex granular cells and pain threshold in Wistar rats exposed to electromagnetic waves (p=0.000). Conclusion: Exposure to mobile phone electromagnetic waves affects pain perception due to changes in the granular cells of the cerebral parietal cortex in wistar rats.
The Relationship Between Serum Folic Acid Levels With The Cognitive Function of The Elderly Hermanto, Hermanto; Muhartomo, Hexanto; Husni, Amin; Widiastuty, Maria Immaculata; Suryawati, Herlina; Wati, Arinta Puspita
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.891

Abstract

Background: Cognitive decline is a common condition that occurs in the elderly. One of the early indicators of senility is a decrease in cognitive function. Folic acid is thought to protect the arteries from damage because of homocysteine by converting homocysteine into cysteine and then excreted in the urine. Increased levels of homocysteine can interfere with vascular function and cause toxic effects on neurons thereby increasing the risk of cognitive decline. Objective: To determine the relationship between serum folic acid levels and cognitive function of the elderly. Method: Analytical descriptive research with a cross-sectional approach. The research subjects were the elderly who met the inclusion criteria and did not have exclusion criteria. The research was conducted from May to July 2022 at the Pucang Gading Nursing Home, Semarang. Serum folic acid levels were examined using the ELISA (Enzyme-linked immunosorbent assay) method. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA) simultaneously on the subject. Cognitive function is normal if the MoCA-INA value is ≥ 26 and it is said to be cognitive dysfunction if the MoCA-INA value is < 26. Data were analyzed using the Spearman test. Results are considered significant if the value of p <0.05.  Result: There is a strong positive correlation between serum folic acid levels and cognitive function in the elderly (r=0.914, p<0.001). There is a relationship between educational level and cognitive function (r=0.922, p<0.001) where higher education correlates with increased cognitive function in the elderly. Conclusion: There is a significant positive correlation between serum folic acid levels and cognitive function in the elderly
Effect Of Triamcinolone Trigger Point Injection On Changes In TNF-α Levels And Oswestry Disability Index (ODI) Scores Non-Specific Low Back Pain (LBP) Patients Fakih, Mohamad; Suryadi; Tugasworo, Dodik; Pudjanarko, Dwi; Husni, Amin; Budisulistyo, Trianggoro; Puspitawati, Arinta
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.976

Abstract

Background: Low back pain (LBP) is the most common musculoskeletal problem and a major cause of worldwide disability causing increased health costs and indirect costs associated with reduced or lost productivity. One of the therapeutic management of LBP is Triamcinolone trigger point injection. Until now, research on the effect of Triamcinolone trigger point injection on changes in TNF-α levels and Oswestry Disability Index (ODI) scores in Non-Specific LBP patients is still limited. Objective: To analyze the effect of Triamcinolone trigger point injection on changes in TNF-α levels and ODI scores before and after Triamcinolone trigger point injection in Non-Specific LBP patients. Methods: This is a quasi-experimental analytic observational study with a pre and post-test group design approach. Subjects were diagnosed with Non-Specific LBP who had met the inclusion criteria (acute pain less than 3 months, patient age 30-55 years, moderate-severe pain intensity, had never received a Triamcinolone trigger point injection) with the exclusion criteria patients experiencing severe pain. not only caused by NPB. The study subjects were checked for TNF-α levels and ODI scores before and after the Triamcinolone trigger point injection. Then a paired T-test was carried out. Results: During the study period September - November 2022 at the Neurology Outpatient Polyclinic, RSUP Dr. Kariadi Semarang obtained 32 subjects. There was a significant difference between changes in TNF-α levels before and after Triamcinolone trigger point injection (p=0.000). There was a significant difference in ODI scores before and after the Triamcinolone trigger point injection (p=0.000). There was no significant relationship between the risk factors for gender, occupation, BMI, physiotherapy, and changes in TNF-α levels with changes in the ODI score. Conclusion: There is a significant difference in changes in TNF-α levels and ODI scores before and after Triamcinolone trigger point injection.
Cognitive behavior therapy intervention on adolescents to decrease anxiety problem study: the role of serotonin Nancye, Pandeirot Marjory; Husni, Amin; Sawitri, Dian Ratna
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.23739

Abstract

The existence of demands that occur simultaneously causes some adolescents to be unable to adapt properly, especially the condition of adolescents who experience changeable emotions, are unstable, easily stressed, feel anxious, depressed, and feel helpless. Cognitive behavior therapy (CBT) is a form of psychotherapy that can be used for adolescent emotional problems. The purpose of this study is to prove that CBT interventions can increase serotonin levels and reduce adolescent anxiety levels. The research population is adolescents with anxiety problems in the city of Surabaya. The research sample is 32 respondents with techniques systematic sampling. Inclusion criteria include: i) adolescents aged 12–18 years, ii) experiencing mental emotional anxiety problems as measured by a score with self-reporting questionnaire (SRQ-29), and iii) being willing to participate in the research and get permission from parents. Data collection using an instrument in the form of a Taylor Manifest Anxiety Scale (TMAS). The data have been analyzed by the Wilcoxon test. The results show that there were significant differences in serotonin levels and anxiety levels before and after the intervention given CBT. The average value of serotonin levels in the posttest was higher than the pretest (p=0.001) and the average value of anxiety levels in the posttest was lower than the pretest (p=0.043) indicating that giving CBT interventions was able to significantly reduce anxiety levels. CBT interventions are proven to increase serotonin levels and reduce adolescent anxiety levels. By changing the form of thought and the resulting consequences, the intensity of the subject's anxiety decreases.
Co-Authors -, Retnaningsih Anjani, Gemala Arinta Puspita Wati, Arinta Puspita Aris Catur Bintoro Aris Catur Bintoro Bakhtiar, Yuriz Budisulistyo, Trianggoro Darmawan, Taufan Citra Dian Ratna Sawitri Dodik Tugasworo Dwi Pudjonarko Endang Kustiowati Fakih, Mohamad Farichah Hanum Hadi, Jason Reynald Harsono Harsono Hartono, Jimmy Eko Budi Hermanto Hermanto Hexanto Muhartomo, Hexanto Iva Puspitasari, Iva Jaeri, Santoso Joko Pratomo, Joko Karlowe, Vega Krisninda Anggonowati M Nancye, Pandeirot M.I. Widiastuti Muhammad Thohar Arifin Nancye, Pandeirot Marjory Nani Maharani Ngadiran, Antonius Novriansyah, Robin Pandeirot, Nancye Pudjanarko, Dwi Puspitawati, Arinta Rahmawati, Maria Belladonna Rahmi Ardhini Ratna Sawitri, Dian Retnaningsih Retnaningsih Rifky Ismail Soeharyo Hadisaputro Suryadi Suryadi Suryadi Suryawati, Herlina Tamad, Fatiha Sri Utami Tikalaka, Elisabeth Romana Tori, Marthin Tranggono Yudo Utomo Widiastuty, Maria Immaculata Zainal Muttaqin