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Optimasi Formula Tablet Ekstrak Kering Daun Jati Belanda Menggunakan Kombinasi Starch 1500 sebagai Pengikat dan Crospovidone sebagai Penghancur Gunawan, Indra; Darsono, Farida Lanawati; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Bastard cedar leaves (Guazuma ulmifolia L.) can lower cholesterol level on blood. Tannins and musilago are the components in bastar cedar leaves that play a role in lowering cholesterol. The purpose of this study was to determine the effect of starch 1500, crospovidone and its interaction on the physical quality of tablets. Tablets were made using wet granulation method. Optimization of tablet formulation consists of two factors. The first factor is the Starch 1500 which is used as a binder with the level (+1) that is 3% and the level (-1) that is 1.5%, and the second factor is the crospovidone used as disintegrant with the level (+1) that is 5% (-1) that is 2%. The response used is tablet hardness, fragility, and time of disintegration. The results of this study indicate that starch 1500 can increase the hardness, but can prolong the disintegration time of the tablet and can decrease the tablet fragility, while crospovidone can decrease the hardness, increase the fragility, and accelerated tablet disintegration time. The interaction of these two factors has a significant effect on tablet hardness, fragility and time of disintegration. The optimum formula was obtained with the combination of Starch 1500 2.22% and crospovidone 3.54% with estimated result of physical hardness test quality of 5.2Kgf; Fragility 0.643%; and disintegration time 11.54 minutes.

Formulasi Sediaan Masker Wajah Ekstrak Labu Kuning (Cucurbita moschata) Bentuk Clay Menggunakan Bentonit dan Kaolin Sebagai Clay Mineral Santoso, Cynthia C.; Darsono, Farida L.; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Free radicals can cause oxidative damage that plays a role in the aging process and cause degenerative diseases that appear on the skin, so that antioxidants are needed to reduce the cumulative effects of oxidative damage in the form of clay mask. One of the natural materials that can be used as a clay mask is pumpkin fruit. Beta carotene in the yellow pumpkin can be used as an antioxidant that has a mechanism of electron transfer process so that free radical can be deactivated, and the saponin content in yellow pumpkin was function as cleanser effect. The aims of this study were to determine the effect of the combination of bentonite and kaolin as clay minerals, and to get the optimum composition of the formula. Clay mask formulation was optimized using factorial design with design expert software ver 10.0. Responses used were the viscosity, spreadability, and drying time. The results showed that bentonite give a significant effect to increase the viscosity, decrease spreadability and drying time. Kaolin gives a significant effect to increase the viscosity, decrease spreadability and drying time. The interaction between kaolin and bentonite give significant effect to increase the viscosity, spreadability, and drying time. The optimum formulation of clay mask was obtained with the combination of bentonite 23.95% and kaolin 18.60%, which estimates viscosity 236222 cps; spreadability 4.20 cm; and drying time 14.65 minute.

Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538 Uthari, Ni Made; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of Â½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).

Potensi Antibakteri dan Antibiofilm Ekstrak Etanol Bunga Bintaro (Cerbera odollam) terhadap Staphylococcus aureus ATCC 6538 Lestari, Dwi Rahma Suci; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Cerbera odollam was one of the plants that can inhibit the growth of bacteria that cause infectious diseases. The misuse of antibiotic in the treatment of infection frequent caused bacterial resistance. One of the forms of antibiotic resistance was the capability of microorganism forming biofilm. This study was conducted to determine the antibacterial and anti-biofilm activity of ethanolic extract from Cerbera odollam flower against Staphylococcus aureus. The ethanolic extract obtained by maceration method using 96% ethanol as a solvent. The ethanol extract of Suicide tree (10, 20 and 30%) were tested for antibacterial activity against Staphylococcus aureus using well diffusion method and anti-biofilm activity using microdilution method. Based on the results, ethanol extract of flowers Cerbera odollam inhibit the growth of Staphylococcus aureus with inhibition zone of 21.66Â±0.73 mm (10%), 25.66Â±1.50 mm (20%) and 27.10Â±1.06 mm (30%). The ethanol extract of Suicide tree flower inhibit biofilm formation 98.29% at the concentration of 3.75%. The bio autography results showed that alkaloid and tannin responsible as bioactive compounds from the ethanol extract Suicide tree flower.

Formulasi Ekstrak Kering Kulit Buah Delima (Punica granatum L.) Sebagai Masker Wajah dalam Bentuk Peel-Off Gel Wattimena, Jeane Hobertina; Darsono, Farida L.; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 7, No 2 (2020): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2792

Kulit wajah memerlukan pemeliharaan yang khusus karena kulit wajah merupakan organ yang sensitif terhadap perlakuan dan rangsangan. Berbagai faktor lingkungan seperti cuaca, kosmetik, makanan obat-obatan, serta faktor stres dan kelelahan dapat menjadi penyebab gangguan kesehatan kulit wajah. Salah satu cara untuk mengatasi masalah kesehatan kulit adalah dengan menggunakan sediaan kosmetik perawatan wajah (skin care) yaitu masker wajah. Bahan alam yang dapat digunakan adalah delima (Punica granatum L.). Kandungan tanin pada kulit buah delima berfungsi sebagai adstrigensia yang banyak digunakan sebagai pengencang kulit dalam kosmetik. Penelitian ini bertujuan untuk melihat pengaruh peningkatan konsentrasi ekstrak kering kulit buah delima terhadap mutu fisik, efektivitas dan keamanan sediaan masker wajah dalam bentuk gel peel-off. Konsentrasi yang digunakan adalah 10%, 15% dan 20%. Hasil penelitian menunjukan bahwa peningkatan konsentrasi ekstrak kering kulit buah delima (Punica granatum L.) mempengaruhi hasil uji secara signifikan, terhadap hasil uji mutu fisik sediaan yaitu pH, viskositas dan daya sebar; efektivitas sediaan yaitu waktu kering, kekencangan masker, elastisitas lapisan film dan kemudahan dibersihkan serta stabilitas sediaan yaitu stabilitas pH dan viskositas dari sediaan masker wajah bentuk gel peel-off. Sediaan yang terbaik adalah sediaan dengan konsentrasi ekstrak 10%.

Formulasi Sediaan Masker Wajah Ekstrak Labu Kuning (Cucurbita moschata) Bentuk Clay Menggunakan Bentonit dan Kaolin Sebagai Clay Mineral Santoso, Cynthia C.; Darsono, Farida L.; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 2 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i2.2138

Free radicals can cause oxidative damage that plays a role in the aging process and cause degenerative diseases that appear on the skin, so that antioxidants are needed to reduce the cumulative effects of oxidative damage in the form of clay mask. One of the natural materials that can be used as a clay mask is pumpkin fruit. Beta carotene in the yellow pumpkin can be used as an antioxidant that has a mechanism of electron transfer process so that free radical can be deactivated, and the saponin content in yellow pumpkin was function as cleanser effect. The aims of this study were to determine the effect of the combination of bentonite and kaolin as clay minerals, and to get the optimum composition of the formula. Clay mask formulation was optimized using factorial design with design expert software ver 10.0. Responses used were the viscosity, spreadability, and drying time. The results showed that bentonite give a significant effect to increase the viscosity, decrease spreadability and drying time. Kaolin gives a significant effect to increase the viscosity, decrease spreadability and drying time. The interaction between kaolin and bentonite give significant effect to increase the viscosity, spreadability, and drying time. The optimum formulation of clay mask was obtained with the combination of bentonite 23.95% and kaolin 18.60%, which estimates viscosity 236222 cps; spreadability 4.20 cm; and drying time 14.65 minute.

Potensi Antibakteri dan Antibiofilm Ekstrak Etanol Bunga Bintaro (Cerbera odollam) terhadap Staphylococcus aureus ATCC 6538 Lestari, Dwi Rahma Suci; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2176

Cerbera odollam was one of the plants that can inhibit the growth of bacteria that cause infectious diseases. The misuse of antibiotic in the treatment of infection frequent caused bacterial resistance. One of the forms of antibiotic resistance was the capability of microorganism forming biofilm. This study was conducted to determine the antibacterial and anti-biofilm activity of ethanolic extract from Cerbera odollam flower against Staphylococcus aureus. The ethanolic extract obtained by maceration method using 96% ethanol as a solvent. The ethanol extract of Suicide tree (10, 20 and 30%) were tested for antibacterial activity against Staphylococcus aureus using well diffusion method and anti-biofilm activity using microdilution method. Based on the results, ethanol extract of flowers Cerbera odollam inhibit the growth of Staphylococcus aureus with inhibition zone of 21.66±0.73 mm (10%), 25.66±1.50 mm (20%) and 27.10±1.06 mm (30%). The ethanol extract of Suicide tree flower inhibit biofilm formation 98.29% at the concentration of 3.75%. The bio autography results showed that alkaloid and tannin responsible as bioactive compounds from the ethanol extract Suicide tree flower.

Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538 Uthari, Ni Made; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2183

Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of ½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).

Optimasi Formula Tablet Ekstrak Kering Daun Jati Belanda Menggunakan Kombinasi Starch 1500 sebagai Pengikat dan Crospovidone sebagai Penghancur Gunawan, Indra; Darsono, Farida Lanawati; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2186

Bastard cedar leaves (Guazuma ulmifolia L.) can lower cholesterol level on blood. Tannins and musilago are the components in bastar cedar leaves that play a role in lowering cholesterol. The purpose of this study was to determine the effect of starch 1500, crospovidone and its interaction on the physical quality of tablets. Tablets were made using wet granulation method. Optimization of tablet formulation consists of two factors. The first factor is the Starch 1500 which is used as a binder with the level (+1) that is 3% and the level (-1) that is 1.5%, and the second factor is the crospovidone used as disintegrant with the level (+1) that is 5% (-1) that is 2%. The response used is tablet hardness, fragility, and time of disintegration. The results of this study indicate that starch 1500 can increase the hardness, but can prolong the disintegration time of the tablet and can decrease the tablet fragility, while crospovidone can decrease the hardness, increase the fragility, and accelerated tablet disintegration time. The interaction of these two factors has a significant effect on tablet hardness, fragility and time of disintegration. The optimum formula was obtained with the combination of Starch 1500 2.22% and crospovidone 3.54% with estimated result of physical hardness test quality of 5.2Kgf; Fragility 0.643%; and disintegration time 11.54 minutes.

Standarisasi Simplisia Daun Ekor Kucing (Acalypha hispida Burm.f.) dari Tiga Daerah Berbeda Bay, Wilhelmina Walu; Hermanu, Liliek S.; Sinansari, Restry
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2394

The fox tail (Acalypha hispida) is known for its many benefits and has been used in traditional medicine. This aim of this research was determining the profile of specific and non specific standardization of fox tail leaves from three different areas (Batu, Bogor and West Sumba). The specific parameters consist of identity, organoleptic, microscopic, water soluble extract, ethanol soluble extract, phytochemical screening, chromatogram profile determination by thin layer chromatography (TLC), determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of secondary metabolite content (phenol and flavonoid). Non spesific parameters include shrinkage drying, ash content, acid insoluble ash, water soluble ash, percent foreign material and pH measurement. The result of standardization of dried powder fox tail leaves, have value of soluble ethanol extract ˃ 14%, water soluble extract ˃ 23%, contain flavonoids compounds, polyphenols, tannins, quinones and triterpenoids, total flavonoid levels > 0.2% and phenol > 0.7%, pectrophotometry IR result showed the presence of O-H, C-H, C = C and C-C groups, total ash content < 15.5%, acid insoluble ash < 2.5%, water soluble ash < 5.5%, drying shrinkage level < 10% and pH 4.5-5.

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