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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Health Sains International Journal of Advanced Health Science and Technology Gemakes: Jurnal Pengabdian Kepada Masyarakat
Siti Sakdiah
Department Of Medical Laboratory Technology, Politeknik Kesehatan Kemenkes Jambi, Jambi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Investigation Activities of Vitamin D, Interleukin-17A, and Alkaline Phosphatase as Biological Markers in Asthma James Perdinan Simanjuntak; Siti Sakdiah; Fardiah Tilawati Sitanggang; Eva Ayu Maharani
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 02 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol24-iss02/359

Abstract

Inflammation in asthma occurs due to the activation of various cells that produce proinflammatory cytokines. Corticosteroid treatment can affect bone formation, impacting vitamin D levels and alkaline phosphatase (ALP) enzyme activity. This study aimed to evaluate the decrease in vitamin D and increase in ALP due to inflammatory events characterized by an increase in interleukin-17A (IL-17A). The research design is a case-control design. Thirty-four adults with asthma and 34 healthy controls were monitored for blood through laboratory testing. Comparative and correlation statistics were analyzed using Medcalc ver. 19.0.7. All three laboratory parameters showed significant differences between the asthmatic and control groups (P < 0.05). Each vitamin D and ALP gave a good correlated wellults of the IL-17A examination (r = -0.2950; P = 0.015 and r = 0.2590; P = 0.033). There is no significant correlation between Vitamin D and ALP (r = -0.0483; P = 0.696). Moreover, ALP showed a low sensitivity (32%) in identifying vitamin D deficiency in asthmatic patients.
Aktivitas Enzim Metabolik Dalam Saliva Sebagai Penanda Biologis Penyakit Paru Obstruktif Kronik (PPOK) Siti Sakdiah; James Perdinan Simanjuntak; Fardiah Tilawati Sitanggang; Ahmad Syarthibi; Tamrin Tamrin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.293 KB) | DOI: 10.36418/syntax-literate.v7i12.11483

Abstract

PPOK menjadi permasalahan kesehatan yang semakin mengkhawatirkan pada masyarakat di seluruh dunia. Usaha deteksi dini PPOK terus dikembangkan untuk mencegah perkembangan penyakit. Penggunaan parameter pemeriksaan laboratorium rutin dan sederhana dinilai berpotensi sebagai penanda perkembangan PPOK. Pengujian aktivitas enzim terhadap spesimen darah adalah parameter yang biasa diterapkan untuk diagnosis berbagai penyakit akut dan kronik. Pengujian tersebut belum dilakukan terhadap spesimen saliva dalam analisis rutin. Pengujian terhadap spesimen saliva masih sedikit dipelajari dan belum mendapat pengakuan sebagai parameter uji laboratorium. Sementara itu saliva diketahui memiliki kandungan enzim-enzim yang cukup tinggi dan telah dibuktikan keterkaitannya dengan perubahan kondisi pada penyakit-penyakit lainnya. Pengujian dilakukan untuk menganalisis profil enzim LDH, ALT, AST, GGT dan ALP sebagai penanda biologis untuk deteksi dini PPOK. Penelitian menggunakan desain case control dengan 20 responden PPOK dan 40 kontrol, terdiri dari 20 orang perokok aktif dan 20 orang bukan perokok. Saliva diperiksa aktivitas enzim menggunakan spektrofotometer di laboratorium kimia klinik jurusan TLM Poltekkes Kemenkes Jambi. Data dianalisis menggunakan Anova dan Benferonni. Hasil penelitian mendapatkan bahwa rata rata aktivitas ALT dan GGT signifikan lebih tinggi dibanding kontrol non PPOK perokok dan bukan perokok (p<0.05). Rata rata aktivitas LDH signifikan lebih rendah dibanding kontrol non PPOK perokok dan bukan perokok (p<0.05). Hasil analisis lebih lanjut membuktikan bahwa kelompok yang berbeda signifikan adalah aktivitas GGT dengan PPOK dan non PPOK bukan perokok. Rata-rata aktivitas AST dan ALP tidak berbeda signifikan antara ke 3 kelompok. Kesimpulan aktivitas LDH, ALT terutama GGT dalam saliva berpotensi sebagai penanda biologis untuk deteksi dini diagnosa PPOK.
SOSIALISASI VITAMIN D PADA PENDERITA TUBERKULOSIS PARU DAN KELUARGA PENDERITA TUBERKULOSIS PARU DI WILAYAH PUSKESMAS PAKUAN BARU KOTA JAMBI: SOCIALIZATION OF VITAMIN D IN PULMONARY TUBERCULOSIS PATIENTS AND FAMILY OF PULMONARY TUBERCULOSIS PATIENTS IN PAKUAN BARU HEALTH CENTERS JAMBI CITY Fardiah Tilawati Sitanggang; Siti Sakdiah; James P. Simanjuntak
GEMAKES: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2022): GEMAKES: Jurnal Pengabdian Kepada Masyarakat
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.005 KB) | DOI: 10.36082/gemakes.v2i2.794

Abstract

Tuberkulosis(TB) adalah penyakit infeksi akibat Mycobacterium tuberculosis yang menimbulkan komplikasi hingga kematian. Permasalahan TB di Indonesia semakin kompleks dengan meningkatnya kejadian TB resistensi OAT termasuk di Kota Jambi. Proses penyembuhan TB memerlukan respon imun yang efektif. Kurangnya nutrisi mempengaruhi respon imun dalam tubuh. Salah satu nutrisi yang berperan di respon imun pada TB paru adalah vitamin D. Tingginya kasus TB paru di PKM Pakuan Baru menjadi salah satu masalah pada pemberantasan TB paru. Permasalahan lainnya, hasil penelitian Simanjuntak dkk 2020 menunjukkan kadar vitamin D pada penderita TB resistensi OAT lebih rendah dibanding penderita TB Paru. Hasil Observasi awal  menunjukkan penderita TB  belum memiliki pengetahuan tentang manfaat pemberian vitamin D pada penderita TB paru..Metode pelaksanaan pengabmas kepada 50 sasaran (penderita TB paru dan keluarga penderita TB paru )dilakukan dengan pretest dengan kuesioner pertanyaan pilihan ganda mengenai vitamin D, dilanjutkan pemberian vitamin D dan sosialisasi dengan metode pemberian buku saku , ceramah diskusi dengan media video dan ppt, dilanjutkan dengan post test melihat perbedaan pengetahuan sebelum dan setelah sosialisasi yang diukur dengan uji T. Hasil pengabmas menunjukkan pada pretest  pengetahuan peserta mengenai vitamin D pada TB paru  masih rendah,hal ini disebabkan berbagai faktor seperti kurangnya partisipasi  warga dalam pencegahan TB paru, rendahnya tingkat pendidikan serta rendahnya kemampuan ekonomi.Setelah dilakukan sosialisasi terjadi peningkatan pengetahuan mengenai vitamin D yang terlihat dari hasil pretest dan post test dengan  perubahan yang signifikan. Keterlibatan aparat pemerintah seperti petugas Puskesmas,perangkat RT juga kader juga berperan signifikan dalam memotivasi penderita TB paru dan keluarganya untuk hadir dan bergabung dalam kegiatan sosialisasi vitamin D
Survey of Inflammatory Biomarkers in Blood and Sputum in Pulmonary Tuberculosis Patients James Perdinan Simanjuntak; Siti Sakdiah; Fardiah Tilawati Sitanggang; Eva Ayu Maharani
Jurnal Health Sains Vol. 4 No. 10 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i10.1092

Abstract

Tuberculosis (TB) is still a global health problem that exists today. Various efforts to reduce the number of TB patients have been carried out ranging from detection efforts to treatment and prevention efforts. Many studies have been conducted previously to look at the detection potential of laboratory diagnoses in finding new cases of tuberculosis. Likewise, efforts to detect prognosis in the laboratory to monitor the development of the condition of TB patients. The development of inflammatory conditions in TB patients is important to accelerate the healing process of these patients. Inflammatory marker tests have been widely performed on several types of laboratory test parameters. CRP and LDH are types of testing that have potential as markers of inflammatory development in TB patients. However, proven tests generally use blood specimens, which are commonly used in laboratory analysis for these parameters. Meanwhile, the current research theme has also been directed at the use of other types of specimens that can show inflammatory conditions experienced by a person. Saliva is known to have potential as another alternative specimen that can be used for such purposes. Saliva is easily obtained and does not require invasive techniques such as needle invocation, so it is considered to have more advantages if it can be proven as a laboratory test specimen that can provide information that is as good and accurate as blood or serum. This study aimed to assess the potential of saliva as an alternative specimen for laboratory analysis with the aim of markers in the assessment of prognosis of TB patients. CRP examination and LDH enzyme activity were chosen in this study of serum and saliva specimens of TB subjects and controls. From this study, it is expected to be shown that saliva can be used as an alternative specimen in laboratory analysis for inflammatory marker tests on both parameters. The results obtained showed that the measurement of LDH activity and and CRP levels in saliva observed in this study proved to have good potential in predicting the presence of inflammation and cell damage experienced by TB subjects. LDH test results have a strong relationship between serum and saliva as laboratory test materials, even salivary LDH levels are higher than serum. While CRP, although saliva showed low levels, the correlation test carried out still showed a strong relationship between the results of the two types of specimens.
Study on the relationship between Vitamin D deficiency and Leukocyte Ratio in Multidrug Resistant Tuberculosis patients Fardiah Tilawati Sitanggang; James Perdinan Simanjuntak; Siti Sakdiah
International Journal of Advanced Health Science and Technology Vol. 3 No. 6 (2023): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v3i6.300

Abstract

Tuberculosis (TB) remains an important health problem in Indonesia,the problems more complex with phenomenon of multi-drug resistance Tuberculosis (MDR) which cause worse prognosis, long treatment,high risk of transmission to other and side effect of treatment. Vitamin D plays a role in non specific and specific immune responses in Mycobacterium tuberculosis (M.tb) infection. Vitamin D have a role in hematopoiesis and affects the early development of monocytes and granulocytes. M.tb infection causes changer in the ratio of neutrophil cells, lymphocytes and monocytes. Changes in the ratio reflect an increase or decrease of effective immune response. Using a case control design, this study will evaluate the correlation between vitamin D, leukocyte ratio and MDR-TB patients among MDR-TB patient cases and TB patient controls. Independent variable in this study were vitamin D levels, leukocyte ratios consisting of NLR, MLR, NMLR, and clinical status of respondents were the dependent variable. The result of this study found that vitamin D levels of TB patients all showed values ​​that were within range of in the insufficiency and deficiency categories. From this result TB patients must coverIn addition, the NLR and NMLR parameters were able to show that immune status problems were mainly found in the MDR-TB patients
Co-Authors Ahmad Syarthibi Eva Ayu Maharani Eva Ayu Maharani Fardiah Tilawati Sitanggang Fardiah Tilawati Sitanggang James Perdinan Simanjuntak James Perdinan Simanjuntak James Perdinan Simanjuntak Tamrin Tamrin