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GAMBARAN HASIL UJI SARING HEPATITIS B PADA PENDONOR DARAH DI UNIT TRANSFUSI DARAH RSUD RADEN MATTAHER PROVINSI JAMBI Witi Karwiti; Sholeha Rezekiyah; Wuni Sri Lestari; Eka Fitriana; Fardiah Tilawati S.; Nasrazuhdy Nasrazuhdy; Budiyanto Budiyanto
Journal of Indonesian Medical Laboratory and Science Vol 3 No 2: Oktober 2022
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v3i2.105

Hepatitis B occurs in people throughout the world and is one of the world's major health problems. Hepatitis B virus infection can develop into chronic hepatitis, liver cirrhosis, liver cancer and even death. This disease is caused by the hepatitis B virus which is transmitted through exposure to blood, and does not cause specific symptoms so that an infected person can carry out blood donor activities. Blood donors are people who donate blood or components to patients for the purpose of healing diseases and restoring health. Donor blood needs to be screened for screening tests to avoid the risk of disease transmission through blood screening tests for infectious infections through blood transfusion (IMLTD). One of them is a screening test for hepatitis B to detect Hepatitis B surface antigens (HBsAg). Research method: This research is descriptive. The purpose of the study: to find out the description of the results of hepatitis B strain test on blood donors based on the type of donation in the Blood Transfusion Unit of Raden Mattaher Hospital Jambi Province in 2019. Data analysis using bivariate and univariate. Results: 335 blood donors were 6 (1.8%) people with reactive HBsAg results. Conclusion: Based on the type of donation from 83 voluntary donors, there were 2 (2.4%) reactive HBsAg people, while 252 donor replacements were found in 4 (1.6%) reactive HBsAg people. Suggestion: Donors with reactive test results should be notified, so counseling can be done and referred to a confirmation check.

Investigation Activities of Vitamin D, Interleukin-17A, and Alkaline Phosphatase as Biological Markers in Asthma James Perdinan Simanjuntak; Siti Sakdiah; Fardiah Tilawati Sitanggang; Eva Ayu Maharani
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 02 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol24-iss02/359

Inflammation in asthma occurs due to the activation of various cells that produce proinflammatory cytokines. Corticosteroid treatment can affect bone formation, impacting vitamin D levels and alkaline phosphatase (ALP) enzyme activity. This study aimed to evaluate the decrease in vitamin D and increase in ALP due to inflammatory events characterized by an increase in interleukin-17A (IL-17A). The research design is a case-control design. Thirty-four adults with asthma and 34 healthy controls were monitored for blood through laboratory testing. Comparative and correlation statistics were analyzed using Medcalc ver. 19.0.7. All three laboratory parameters showed significant differences between the asthmatic and control groups (P < 0.05). Each vitamin D and ALP gave a good correlated wellults of the IL-17A examination (r = -0.2950; P = 0.015 and r = 0.2590; P = 0.033). There is no significant correlation between Vitamin D and ALP (r = -0.0483; P = 0.696). Moreover, ALP showed a low sensitivity (32%) in identifying vitamin D deficiency in asthmatic patients.

Aktivitas Enzim Metabolik Dalam Saliva Sebagai Penanda Biologis Penyakit Paru Obstruktif Kronik (PPOK) Siti Sakdiah; James Perdinan Simanjuntak; Fardiah Tilawati Sitanggang; Ahmad Syarthibi; Tamrin Tamrin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

PPOK menjadi permasalahan kesehatan yang semakin mengkhawatirkan pada masyarakat di seluruh dunia. Usaha deteksi dini PPOK terus dikembangkan untuk mencegah perkembangan penyakit. Penggunaan parameter pemeriksaan laboratorium rutin dan sederhana dinilai berpotensi sebagai penanda perkembangan PPOK. Pengujian aktivitas enzim terhadap spesimen darah adalah parameter yang biasa diterapkan untuk diagnosis berbagai penyakit akut dan kronik. Pengujian tersebut belum dilakukan terhadap spesimen saliva dalam analisis rutin. Pengujian terhadap spesimen saliva masih sedikit dipelajari dan belum mendapat pengakuan sebagai parameter uji laboratorium. Sementara itu saliva diketahui memiliki kandungan enzim-enzim yang cukup tinggi dan telah dibuktikan keterkaitannya dengan perubahan kondisi pada penyakit-penyakit lainnya. Pengujian dilakukan untuk menganalisis profil enzim LDH, ALT, AST, GGT dan ALP sebagai penanda biologis untuk deteksi dini PPOK. Penelitian menggunakan desain case control dengan 20 responden PPOK dan 40 kontrol, terdiri dari 20 orang perokok aktif dan 20 orang bukan perokok. Saliva diperiksa aktivitas enzim menggunakan spektrofotometer di laboratorium kimia klinik jurusan TLM Poltekkes Kemenkes Jambi. Data dianalisis menggunakan Anova dan Benferonni. Hasil penelitian mendapatkan bahwa rata rata aktivitas ALT dan GGT signifikan lebih tinggi dibanding kontrol non PPOK perokok dan bukan perokok (p<0.05). Rata rata aktivitas LDH signifikan lebih rendah dibanding kontrol non PPOK perokok dan bukan perokok (p<0.05). Hasil analisis lebih lanjut membuktikan bahwa kelompok yang berbeda signifikan adalah aktivitas GGT dengan PPOK dan non PPOK bukan perokok. Rata-rata aktivitas AST dan ALP tidak berbeda signifikan antara ke 3 kelompok. Kesimpulan aktivitas LDH, ALT terutama GGT dalam saliva berpotensi sebagai penanda biologis untuk deteksi dini diagnosa PPOK.

SOSIALISASI VITAMIN D PADA PENDERITA TUBERKULOSIS PARU DAN KELUARGA PENDERITA TUBERKULOSIS PARU DI WILAYAH PUSKESMAS PAKUAN BARU KOTA JAMBI: SOCIALIZATION OF VITAMIN D IN PULMONARY TUBERCULOSIS PATIENTS AND FAMILY OF PULMONARY TUBERCULOSIS PATIENTS IN PAKUAN BARU HEALTH CENTERS JAMBI CITY Fardiah Tilawati Sitanggang; Siti Sakdiah; James P. Simanjuntak
GEMAKES: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2022): GEMAKES: Jurnal Pengabdian Kepada Masyarakat
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Tuberkulosis(TB) adalah penyakit infeksi akibat Mycobacterium tuberculosis yang menimbulkan komplikasi hingga kematian. Permasalahan TB di Indonesia semakin kompleks dengan meningkatnya kejadian TB resistensi OAT termasuk di Kota Jambi. Proses penyembuhan TB memerlukan respon imun yang efektif. Kurangnya nutrisi mempengaruhi respon imun dalam tubuh. Salah satu nutrisi yang berperan di respon imun pada TB paru adalah vitamin D. Tingginya kasus TB paru di PKM Pakuan Baru menjadi salah satu masalah pada pemberantasan TB paru. Permasalahan lainnya, hasil penelitian Simanjuntak dkk 2020 menunjukkan kadar vitamin D pada penderita TB resistensi OAT lebih rendah dibanding penderita TB Paru. Hasil Observasi awal menunjukkan penderita TB belum memiliki pengetahuan tentang manfaat pemberian vitamin D pada penderita TB paru..Metode pelaksanaan pengabmas kepada 50 sasaran (penderita TB paru dan keluarga penderita TB paru )dilakukan dengan pretest dengan kuesioner pertanyaan pilihan ganda mengenai vitamin D, dilanjutkan pemberian vitamin D dan sosialisasi dengan metode pemberian buku saku , ceramah diskusi dengan media video dan ppt, dilanjutkan dengan post test melihat perbedaan pengetahuan sebelum dan setelah sosialisasi yang diukur dengan uji T. Hasil pengabmas menunjukkan pada pretest pengetahuan peserta mengenai vitamin D pada TB paru masih rendah,hal ini disebabkan berbagai faktor seperti kurangnya partisipasi warga dalam pencegahan TB paru, rendahnya tingkat pendidikan serta rendahnya kemampuan ekonomi.Setelah dilakukan sosialisasi terjadi peningkatan pengetahuan mengenai vitamin D yang terlihat dari hasil pretest dan post test dengan perubahan yang signifikan. Keterlibatan aparat pemerintah seperti petugas Puskesmas,perangkat RT juga kader juga berperan signifikan dalam memotivasi penderita TB paru dan keluarganya untuk hadir dan bergabung dalam kegiatan sosialisasi vitamin D

Survey of Inflammatory Biomarkers in Blood and Sputum in Pulmonary Tuberculosis Patients James Perdinan Simanjuntak; Siti Sakdiah; Fardiah Tilawati Sitanggang; Eva Ayu Maharani
Jurnal Health Sains Vol. 4 No. 10 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i10.1092

Tuberculosis (TB) is still a global health problem that exists today. Various efforts to reduce the number of TB patients have been carried out ranging from detection efforts to treatment and prevention efforts. Many studies have been conducted previously to look at the detection potential of laboratory diagnoses in finding new cases of tuberculosis. Likewise, efforts to detect prognosis in the laboratory to monitor the development of the condition of TB patients. The development of inflammatory conditions in TB patients is important to accelerate the healing process of these patients. Inflammatory marker tests have been widely performed on several types of laboratory test parameters. CRP and LDH are types of testing that have potential as markers of inflammatory development in TB patients. However, proven tests generally use blood specimens, which are commonly used in laboratory analysis for these parameters. Meanwhile, the current research theme has also been directed at the use of other types of specimens that can show inflammatory conditions experienced by a person. Saliva is known to have potential as another alternative specimen that can be used for such purposes. Saliva is easily obtained and does not require invasive techniques such as needle invocation, so it is considered to have more advantages if it can be proven as a laboratory test specimen that can provide information that is as good and accurate as blood or serum. This study aimed to assess the potential of saliva as an alternative specimen for laboratory analysis with the aim of markers in the assessment of prognosis of TB patients. CRP examination and LDH enzyme activity were chosen in this study of serum and saliva specimens of TB subjects and controls. From this study, it is expected to be shown that saliva can be used as an alternative specimen in laboratory analysis for inflammatory marker tests on both parameters. The results obtained showed that the measurement of LDH activity and and CRP levels in saliva observed in this study proved to have good potential in predicting the presence of inflammation and cell damage experienced by TB subjects. LDH test results have a strong relationship between serum and saliva as laboratory test materials, even salivary LDH levels are higher than serum. While CRP, although saliva showed low levels, the correlation test carried out still showed a strong relationship between the results of the two types of specimens.

Study on the relationship between Vitamin D deficiency and Leukocyte Ratio in Multidrug Resistant Tuberculosis patients Sitanggang, Fardiah Tilawati; Simanjuntak, James Perdinan; Siti Sakdiah
International Journal of Advanced Health Science and Technology Vol. 3 No. 6 (2023): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v3i6.300

Tuberculosis (TB) remains an important health problem in Indonesia,the problems more complex with phenomenon of multi-drug resistance Tuberculosis (MDR) which cause worse prognosis, long treatment,high risk of transmission to other and side effect of treatment. Vitamin D plays a role in non specific and specific immune responses in Mycobacterium tuberculosis (M.tb) infection. Vitamin D have a role in hematopoiesis and affects the early development of monocytes and granulocytes. M.tb infection causes changer in the ratio of neutrophil cells, lymphocytes and monocytes. Changes in the ratio reflect an increase or decrease of effective immune response. Using a case control design, this study will evaluate the correlation between vitamin D, leukocyte ratio and MDR-TB patients among MDR-TB patient cases and TB patient controls. Independent variable in this study were vitamin D levels, leukocyte ratios consisting of NLR, MLR, NMLR, and clinical status of respondents were the dependent variable. The result of this study found that vitamin D levels of TB patients all showed values that were within range of in the insufficiency and deficiency categories. From this result TB patients must coverIn addition, the NLR and NMLR parameters were able to show that immune status problems were mainly found in the MDR-TB patients

Pemberdayaan Masyarakat dalam Optimalisasi Konsumsi Vitamin D untuk Pencegahan Defisiensi Vitamin D pada Penderita Tuberkulosis Paru di Puskesmas Sakdiah, Siti; Sitanggang, Fardiah Tilawati
Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS) Vol 6 No 2 (2024): Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS)
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Politeknik Kesehatatan Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/j.abdikemas.v6i2.2497

Permasalahan utama TB adalah malnutrisi yang menyebabkan perubahan keseimbangan respon immun, yang sangat meningkatkan kerentanan individu terhadap infeksi atau perkembangan infeksi menjadi penyakit. Salah satu nutrisi yang berperan penting pada respon immun terhadap Mycobacterium tuberculosis adalah vitamin D. Pemberdayaan masyarakat dalam optimalisasi konsumsi vitamin D untuk pencegahan defisiensi vitamin d pada penderita tuberkolosis paru ini sangat penting dengan sasaran penderita TB, keluarga dan kader.Tujuan Pengabdian kepada masyarakat adalah untuk memberdayakan masyarakat dalam optimalisasi konsumsi vitamin D untuk pencegahan defisiensi vitamin D pada penderita TB paru. Kegiatan yang dilakukan adalah pemberdayaan masyarakat yakni penderita TB paru dan kader kesehatan dalam optimalisasi vitamin D untuk pencegahan defisiensi vitamin D pada pasien TB paru. Dalam kegiatan ini juga terlihat partisipasi dari peserta sangat tinggi dengan dilihat dari jumlah peserta juga keaktifan pada saat diskusi. Dari hasil kegiatan pengabmas dan dari evaluasi didapatkan peningkatan pengetahuan signifikan dari pengetahuan para penderita TB paru, keluarga penderita TB paru dan juga kader kesehatan di wilayah Puskesmas Penyengat Olak, terlihat dari uji statistic terdapat perbedaan serta kenaikan signifikan dari pengetahuan mengenai Vitamin D. Dari kegiatan ini juga masyarakat sudah diberdayakan dalam optimalisasi Vitamin D terutama dalam pemanfaatan sumber daya lokal seperti ikan lambak sebagai sumber vitamin D bagi penderita TB paru sehingga kedepannya konsistensi dari pelaksanaan ini dapat mencegah terjadinya defisiensi Vitamin D bagi penderita TB paru.

Potensi Vitamin D3 pada Minyak Ikan Lambak Pipih untuk Penurunan Sitokin Pro Inflamasi Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Maharani, Eva Ayu; Widhyasih, Retno Martini
Journal of Telenursing (JOTING) Vol 6 No 2 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i2.13012

This study aims to analyze the differences in vitamin D3 levels in fish oil in the body parts of lamb fish. The method used is an experiment with a Factorial Randomized Design with three replications. The results showed that the Vitamin D3 content in lamb fish oil is quite high, ranging from 767.52 IU / g to 787.34 IU / g. The highest vitamin D3 content is in group one, namely the whole fish (scales, head, meat, bones, and innards). The conclusion is that there is a significant difference between the vitamin D3 content in fish oil and whole fish, meat, meat, and waste. Keywords: Inflammation, Fish Oil, Flat Lambak, Vitamin D

CRP/Lymphocyte Ratio and CRP/Albumin Ratio for Prognosis of Hyperglycemia in Patients Tuberculosis with Diabetes Mellitus Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Putra, Egy Sunanda
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): December 2024
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1593

The issue is complicated by the rise in Diabetes Mellitus (DM) cases, a known risk factor for pulmonary TB, with 15% of pulmonary TB patients having a history of DM. DM and chronic hyperglycemia impair immune function, leading to long-term inflammation and worsening TB prognosis. Diagnostic methods include blood culture, AFB examination, chest X-ray, and genotyping, but more accessible tests are needed. Inflammatory markers, particularly lymphocytes, play a crucial role in TB prognosis with DM. Lymphopenia indicates chronic inflammation and a shift to memory lymphocytes. CRP, an inflammatory marker, indicates chronic inflammation, and hypoalbuminemia in DM due to kidney damage further complicates TB prognosis. The ratios of CRP to lymphocytes (CLR) and CRP to albumin (CAR) are gaining attention to better illustrate TB prognosis with DM. This cross-sectional study analyzed CLR and CAR as prognostic indicators in 30 pulmonary TB patients with DM in Jambi City from May to June 2024. CRP was tested at Prodia Jambi Laboratory, while Albumin, Lymphocytes, and blood glucose levels were tested at Labkesda of Jambi Province. The results show a Comparison with each parameter based on treatment status. Both parameters show slightly higher average values in intensive (< 2 months), with an average of 5.55 for CLR and 1.82 for CAR, and there is a significant difference in CLR between intensive and follow-up treatment statuses, and ROC curve shows that CLR parameters have indicated high sensitivity and low false positive rate with AUC 0,692. A significant relationship is found between CLR and blood glucose levels with a p-value of 0.024 and an r-value of 0.411, indicating a moderately strong relationship where an increase in CRP-Lymphocyte ratio corresponds to an increase in blood glucose levels than each parameter.

CRP/Lymphocyte Ratio and CRP/Albumin Ratio for Prognosis of Hyperglycemia in Patients Tuberculosis with Diabetes Mellitus Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Putra, Egy Sunanda
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): Bahasa Inggris
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1593

The issue is complicated by the rise in Diabetes Mellitus (DM) cases, a known risk factor for pulmonary TB, with 15% of pulmonary TB patients having a history of DM. DM and chronic hyperglycemia impair immune function, leading to long-term inflammation and worsening TB prognosis. Diagnostic methods include blood culture, AFB examination, chest X-ray, and genotyping, but more accessible tests are needed. Inflammatory markers, particularly lymphocytes, play a crucial role in TB prognosis with DM. Lymphopenia indicates chronic inflammation and a shift to memory lymphocytes. CRP, an inflammatory marker, indicates chronic inflammation, and hypoalbuminemia in DM due to kidney damage further complicates TB prognosis. The ratios of CRP to lymphocytes (CLR) and CRP to albumin (CAR) are gaining attention to better illustrate TB prognosis with DM. This cross-sectional study analyzed CLR and CAR as prognostic indicators in 30 pulmonary TB patients with DM in Jambi City from May to June 2024. CRP was tested at Prodia Jambi Laboratory, while Albumin, Lymphocytes, and blood glucose levels were tested at Labkesda of Jambi Province. The results show a Comparison with each parameter based on treatment status. Both parameters show slightly higher average values in intensive (< 2 months), with an average of 5.55 for CLR and 1.82 for CAR, and there is a significant difference in CLR between intensive and follow-up treatment statuses, and ROC curve shows that CLR parameters have indicated high sensitivity and low false positive rate with AUC 0,692. A significant relationship is found between CLR and blood glucose levels with a p-value of 0.024 and an r-value of 0.411, indicating a moderately strong relationship where an increase in CRP-Lymphocyte ratio corresponds to an increase in blood glucose levels than each parameter.

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