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Kuswinarti Kuswinarti, Kuswinarti
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Chemistry Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Althea Medical Journal

 1 
Anonna muricata Linn Leaf Effect in Inhibiting SGPT Elevation Tanaya, Galih; Kuswinarti, Kuswinarti; Dewi, R. Nina Susana
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

  Background: Hepatitis is an infection or inflammation disease of the liver which is caused by virus, toxic substance, and immunological abnormalities. Soursop plant as a medicinal plants is known to have an antioxidant effect and nowadays is used as an alternative drug for hepatitis. One of the methods to assess liver function is to measure the serum Glutamate Piruvate Transaminase (SGPT) level. The purpose of this study was to find the effect of Soursop Leaf  in inhibiting the SGPT elevation .Methods: An experimental study was conducted on 25 white male rats of wistar strain in the pharmacology laboratory of Faculty of Medicine, Universitas Padjadjaran during the period of September to October 2012. The rats were divided into 5 groups (group 1 and 2 as control; group 3, 4, and 5 as treatment groups treated by 200, 400, 600 mg/kgbw soursop extract, respectively). The soursop extract was administered to the treatment groups for 8 days. On the 8th day, group 2, 3, 4, and 5 received 1.6 ml CCl410% intraperitoneally. After 18 hours, the mean SGPT levels from all groups were measured. ANOVA test was used to analyze the result.Results : The mean SGPT levels were lower in the 3rd, 4th, and 5th group compared to group 2. There was a significant difference among treatment groups. Group 3 had the most significant result.Conclusion: Soursop leaf inhibits the elevation of SGPT level. Keywords: Hepatitis, SGPT, soursop leaf (Annona muricata) DOI: 10.15850/amj.v2n1.438 
Knowledge of Housewives Regarding Non Steroid Anti Inflammatory Drug Use on Joint Pain in Hegarmanah Village Jatinangor Gondopurwanto, Adi Mulyono; Kuswinarti, Kuswinarti; Wibisono, Yusuf
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

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Background: Joint pain is frequently found in daily life activities. The prevalence of joint pain increases within the age. One of the medicine used for joint pain is non-steroidal anti-inflammatory drug (NSAID). In connection with inappropriate usage and their side effects, this study aimed to seek the extent ofhousewives’ knowledge on the use of NSAID for joint pain in Hegarmanah village, Jatinangor subdistrict.Methods: This cross-sectional descriptive study was conducted in October 2013 to the housewives resided in Hegarmanah village, Jatinangor subdistrict, West Java. Questionaire sheet was distributed to each of 110 housewives that had been stratifiedly with randomized sample. The questionaire contained identity, age, education level, and knowledge of NSAID in related to joint pain.Results: Based on the data collected, 73 subjects had adequate level of the knowledge and 37 subjects were in a poor level of the knowledge. The proportion of respondents who knew that joint pain was the pain occurs in the joint was 99.1%, the proportion of respondents who knew that the pain relieving drugs are called NSAID group was 40.9%, the proportion of respondents who knew that NSAID had a side-effect was 73.6%, and the proportion of respondents who knew that the side-effect of NSAID is abdominal pain was 61.8%.Conclusions: Most of the housewives in Hegarmanah Subdistrict have adequate knowledge in the use ofNSAID for joint pain relief. [AMJ.2016;3(1):115–9]DOI: 10.15850/amj.v3n1.711
Treatment of Rheumatoid Arthritis with Methotrexate Alone or A Combination of Methotrexate and Hydroxychloroquine Nadarajah, Natharubini; Pramudyo, Riardi; Kuswinarti, Kuswinarti
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

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Background: Rheumatoid arthritis (RA) is an autoimmune disease that causes significant morbidity in most patients and also premature mortality in some. To prevent this, therapeutic approaches call for the early treatment of RA by using disease-modifying antirheumatic drugs (DMARDSs), either as single therapy or combination therapy. Although in the previous decade DMARDs were rarely used as combination, however now they are used widely to treat RA. The objective of this study was to compare the effectiveness of methotrexate (MTX) alone and the combination of MTX & hydroxychloroquine (HCQ) in RA patients.Methods: An analytic retrospective cohort study was conducted from May 2014 until October 2014, on 46 patients with RA in the rheumatology clinic of Dr. Hasan Sadikin General Hospital Bandung from January 2009−October 2014 who were taking MTX or MTX & HCQ for at least 1 year. The secondary data obtained from these patients’ medical record were then analyzed using the independent t-test and Mann-Whitney test.Results: The study showed that 93.48% of the patients were females. The mean change in disease activity measures were not significant for any of the parameter (p-value for SJC = 0.337; TJC = 0.676; ESR = 0.780). Also the comparisons of the disease activity score (DAS 28) before and after therapy was not significant (p-value = 0.584).Conclusion: There is no difference in the effectiveness of DMARD monotherapy with MTX and combination therapy with MTX & HCQ in RA patients.DOI: 10.15850/amj.v3n3.474
Relationship between Knowledge and Compliance Using Anti-dyslipidemic Drugs among Hypertensive Patients with Dyslipidemia in Bandung, West Java, Indonesia Batasalsabilla, Sitti Alifa; Kuswinarti, Kuswinarti; Andean, Rudolf
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3084

Abstract

Background: Dyslipidemia occurs in 60% of hypertensive patients. Effective treatment of hypertensive patients with dyslipidemia can reduce the risk of cardiovascular disease by more than 50%. However, compliance with dyslipidemia medication in dyslipidemia patients is still low. Low compliance can be attributed to poor knowledge. This study aimed to analyze the relationship between knowledge and compliance using antidyslipidemic drugs in hypertensive patients with dyslipidemia.Methods:  A cross-sectional analytical study was conducted from August to September 2022 at the Pasirkaliki Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas), Bandung, Indonesia. The consecutive sampling method was used to collect 64 hypertensive patients with dyslipidemia who were taking anti-dyslipidemic drugs. Primary data on knowledge and compliance were obtained through valid and reliable questionnaires. The Chi-square test was used to determine the relationship between the two variables.Results: The study results showed that 95.3% of respondents had good knowledge. Respondent compliance showed obedience of 78.1%. Respondents with good knowledge had an obedience rate of 78.1%. There was a relationship between knowledge and compliance to using anti-dyslipidemic drugs in hypertensive patients with dyslipidemia (p=0.001).Conclusions: There is a relationship between knowledge and compliance with the use of anti-dyslipidemia drugs in hypertensive patients with dyslipidemia. Almost all patients have good knowledge.  Continuous maintenance and improvement of patient knowledge is required, which can be achieved by conducting health education to better understand the relationship between diseases and the importance of taking medication.
Family Support in Adherence to Oral Anti-Diabetic Medications among Patients with Type 2 Diabetes Mellitus Hilyah, Dini; Kuswinarti, Kuswinarti; Ramadhanti, Julia
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3454

Abstract

Background: Adherence to medication is an important aspect in type 2 diabetes mellitus management. One of the factors that determine medication adherence is family support. This study aimed to analyze the relationship between family support and adherence to oral anti-diabetic medications in patients with type 2 diabetes mellitus.Methods: This study was a quantitative, non-experimental correlational study with a cross-sectional method conducted in December 2022–January 2023 on patients with type 2 diabetes mellitus at the Pasirkaliki Public Health Center, Bandung City, Indonesia.  The study used a minimal sampling method. Data collection analysis was performed using the SPSS program with the Chi-square test.Results: In total, 50 respondents were included, of whom the majority (n30; 60%) had good family support, whereas 17 (34%) had sufficient family support, and only 3 (6%) had poor family support. A good level of medication adherence was indicated by 39 (78%). There was a significant relationship between family support and adherence to oral anti-diabetic medications in type 2 diabetes mellitus (p=0.003).Conclusions: A good relationship between family support and adherence to oral anti-diabetic medications is crucial in enhancing quality of life and wellness among patients with type 2 diabetes mellitus. Research related to other factors that affect adherence to oral anti-diabetic medications warrant further studies.
Co-Authors A.A. Ketut Agung Cahyawan W Adi Mulyono Gondopurwanto, Adi Mulyono aditya nugraha nurtatinjo, aditya nugraha algiza gauthfa, algiza Anisah Dahlan Batasalsabilla, Sitti Alifa Deni Sunjaya, Deni Dini, Faiz Fajar Galih Tanaya, Galih Gusti, Eko Kuncoro Manunggaling Hilyah, Dini Nadarajah, Natharubini Nina Susana Dewi Nita Arisanti Pramudyo, Riardi Ramadhanti, Julia Rudolf Andean surya dwi sembada, surya dwi