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All Journal Althea Medical Journal Indonesian Journal of Cancer Chemoprevention Majalah Kesehatan FKUB PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Ramadhanti, Julia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Tinjauan Literatur: PERAN HESPERIDIN DAN DIOSMIN PADA TERAPI COVID-19 BERDASARKAN STUDI IN SILICO Bukit, Raihan Shaquille; Ramadhanti, Julia; Yunivita, Vycke
Majalah Kesehatan Vol. 10 No. 3 (2023): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2023.010.03.7

Abstract

Corona Virus Disease-19 (COVID-19) yang disebabkan oleh Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) menyebar dengan cepat di seluruh dunia. Para peneliti berupaya untuk menemukan terapi untuk penyakit ini. Strategi penemuan terapi ini salah satunya dengan menggunakan obat di luar indikasi asalnya (drug repurposing) yang lebih cepat diperoleh dan terjangkau dibandingkan penemuan obat baru. Hasil skrining terhadap obat yang sudah tersedia dan senyawa alami, menunjukkan hesperidin dan diosmin memiliki potensi untuk menginhibisi siklus hidup SARS-CoV-2. Hesperidin dan Diosmin dalam bentuk Micronized Purified Flavonoid Fraction (MPFF), sebelumnya digunakan sebagai pengobatan insufisiensi vena kronik. Tujuan penulisan kajian ini yaitu untuk mengkaji potensi hesperidin dan diosmin dalam menginhibisi jalur infeksi COVID-19. Metode yang digunakan pada kajian pustaka ini yaitu metode tinjauan pustaka naratif dengan pencarian literatur melalui database Google Scholar, Pubmed, dan ScienceDirect. Hasil kajian yang dilakukan menunjukkan dari 2012 jurnal didapatkan 16 jurnal in silico yang menunjukkan target pengobatan pada infeksi COVID-19 pada hesperidin dan diosmin diantaranya dapat menghambat reseptor Angiotensin Converting Enzyme 2 (ACE2) yang menjadi tempat SARS-CoV-2 berikatan dengan sel inang, menghambat aktivitas Transmembrane Serine Protease 2 (TMPRSS2), menghambat proses proteolitik dengan menghambat enzim 3Clpro, menghambat aktivitas RNA dependent RNA polymerase (RdRp) yang menghambat pembentukan protein struktural SARS-CoV-2. Selain itu, hesperidin dapat menghambat aktivitas protein virus nucleocapsid dan menghambat sitokin pro-inflammatory. Sebagai kesimpulan, hesperidin dan diosmin dapat menjadi kandidat yang potensial dalam menginhibisi COVID-19.
Family Support in Adherence to Oral Anti-Diabetic Medications among Patients with Type 2 Diabetes Mellitus Hilyah, Dini; Kuswinarti, Kuswinarti; Ramadhanti, Julia
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3454

Abstract

Background: Adherence to medication is an important aspect in type 2 diabetes mellitus management. One of the factors that determine medication adherence is family support. This study aimed to analyze the relationship between family support and adherence to oral anti-diabetic medications in patients with type 2 diabetes mellitus.Methods: This study was a quantitative, non-experimental correlational study with a cross-sectional method conducted in December 2022–January 2023 on patients with type 2 diabetes mellitus at the Pasirkaliki Public Health Center, Bandung City, Indonesia.  The study used a minimal sampling method. Data collection analysis was performed using the SPSS program with the Chi-square test.Results: In total, 50 respondents were included, of whom the majority (n30; 60%) had good family support, whereas 17 (34%) had sufficient family support, and only 3 (6%) had poor family support. A good level of medication adherence was indicated by 39 (78%). There was a significant relationship between family support and adherence to oral anti-diabetic medications in type 2 diabetes mellitus (p=0.003).Conclusions: A good relationship between family support and adherence to oral anti-diabetic medications is crucial in enhancing quality of life and wellness among patients with type 2 diabetes mellitus. Research related to other factors that affect adherence to oral anti-diabetic medications warrant further studies.
Edukasi Pencegahan Stroke pada Masyarakat Desa Cigugur Girang: Stroke Prevention Education in Cigugur Girang Village Goenawan, Hanna; Tarawan, Vita Murniati; Radhiyanti, Putri Teesa; Ramadhanti, Julia; Lesmana, Ronny
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7058

Abstract

Stroke patients could get sequelae, and it will decrease the patient’s quality of life. Stroke could be caused by comorbid diseases such as hypertension, diabetes mellitus, and dyslipidemia. Thus, stroke could be prevented by reducing the comorbid diseases. The prevention of stroke is necessary to be done in order to reduce stroke cases, especially in Bandung’s rural area. Villagers have limited access to health information and health services. In this community service, the methods we used were to screen the two risk factors of stroke (blood pressure and blood glucose ad random measurement) in Cigugur Girang Village, West Bandung area. The aim of this community service is to find comorbid factors of stroke and give education to people who have one or more stroke risk factors. The results of the blood pressure measurement screening showed that more than 40% of the residents of Cigugur Girang village had blood pressure above normal, and 5% of the population had blood sugar levels higher than normal. The risk factor for stroke in residents of Cigugur Girang Village mainly is high blood pressure. In this community service, people with high blood pressure were educated on how to maintain normal blood pressure and how to change their lifestyle. On the other hand, some participant has high blood glucose level. High blood glucose levels will develop into diabetes mellitus. In this education program, we gave information about the complications of high blood glucose, including stroke. Thus, this education program could increase community awareness to prevent stroke.
Distribution and Viability of Peripheral Blood Mononuclear Cells from Imatinib-resistant Chronic Myeloid Leukemia Patients: an In Vitro Study Ramadhanti, Julia; Utami, Kharima Dwi; Bashari, Muhammad Hasan; Wijaya, Indra
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp22-32

Abstract

The incidence of Chronic Myeloid Leukemia (CML) in the world is approximately 1.5 cases per 100,000 individuals. The level of resistance to CML treatment, imatinib in Indonesia is relatively high compared to Europe. Culturing CML cells can be used as a model for the determination of pathogenesis of CML, drug efficacy testing, and drug resistance testing. Studies using CML patients’ cells to be cultured in vitro and the methods used are rarely varied. This study aims to examine the distribution and viability of peripheral blood mononuclear cells from imatinib-resistant CML patients, expected to be a reference for mononuclear cell cultures from CML patients. This study was conducted in June-August 2019 using quantitative descriptive methods. The sample was mononuclear cells isolated from peripheral blood of three imatinib-resistant CML patients at the Hemato-Oncology Polyclinic of Hasan Sadikin Hospital, each of which was cultured in vitro using RPMI 1640 for 28 days. Distribution were seen using Giemsa staining, while viability was calculated using trypan blue. Data is processed using Microsoft Excel 2013 and Graphpad. Cell viability decreased during culture. Cell distribution had a different development pattern. Blast cells, eosinophils and basophils had presentation of between 0-5%. The percentage of lymphocyte changed between 11-31%. The percentage of neutrophil changed between 16-41%. The percentage of immature cells decreased, whereas the percentage of monocyte increased. In conclusion, cell viability decreases during the culture. Distribution of cells similar to the initial condition lasted until the 7th day and in the final phase it was only dominated by monocytes.Keywords: myeloid leukemia, chronic, cell culture, in vitro, peripheral blood mononuclear cell, cell viability.
Co-Authors Bashari, Muhammad Hasan Bukit, Raihan Shaquille Hanna Goenawan Hilyah, Dini Kuswinarti Kuswinarti, Kuswinarti Radhiyanti, Putri Teesa Ronny Lesmana Utami, Kharima Dwi Vita Murniati Tarawan Wijaya, Indra Yunivita, Vycke