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Potensi antibakteri teripang Timba Kolong (Holothuria sp.) Kepulauan Mentawai Sumatera Barat Arma, Utmi; Prestya, Pebrian Diki; Busman, Busman
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 3 (2017): Desember
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Sumber senyawa bioaktif yang diyakini memiliki aktivitas antikanker yang kuat salah satunya adalah teripang. Teripang Timba Kolong (Holothuria sp.) merupakan spesies yang dominan di Kepulauan Mentawai Sumatera Barat Indonesia. Tujuan penelitian ini adalah untuk menentukan aktivitas antibakteri Holothuria sp. Kepulauan Mentawai Sumatera Barat. Metode: Penelitian ini adalah penelitian laboratorium eksperimental. Pengukuran aktivitas antibakteri teripang Holothuria sp. digunakan metode Kirby-Bauer dengan mengukur zona hambat terhadap Streptococcus viridans pada karies gigi. Absorbsi tiap sumuran diukur dengan spectrophotometer microplate reader pada panjang gelombang 570 nm. Penelitian aktivitas antibakteri dengan post-test only control group design dan metode disk difusion. Bakteri Streptococcus viridans dibuat suspensi dengan konsentrasi 0,625%; 1,25%; 2,5%; 5%; 10% dan 20% disiapkan dengan pelarut dimethil sulfoksida (DMSO). Hasil: Hampir semua sampel menunjukkan aktivitas antibakteri terhadap Streptococcus viridans dengan konsentrasi yang paling tinggi 0,625% yaitu 7,598 Â± 0,8427 mm. Simpulan: Ekstrak Holothuria sp. memiliki aktivitas antibakteri terhadap pertumbuhan Streptococcus viridans, maka berpotensi untuk dikembangkan sebagai sumber baru antibiotik.Introduction: For a long time, sea cucumber was believed of having powerful antibacterial potency. Timba kolong sea cucumber (Holothuria sp.) is a dominant species in Mentawai Islands, West Sumatra. The objective of this study was to determine the antibacterial activity of Holothuria sp. of Mentawai Islands West Sumatra. Methods: The methods used in this study was experimental laboratory. Antibacterial activity of Holothuria sp. was determined by using Kirby-Bauer methods by measuring the inhibitory zone of Holothuria sp. extract against Streptococcus viridans on caries. The absorption of each well was measured with a spectrophotometer microplate reader at a wavelength of 570 nm. Antibacterial activity was tested with post-test only control group design and disk difusion methods. Streptococcus viridans bacteria were made into suspension with concentration of 0.625%; 1.25%; 2.5%; 5%; 10% and 20%, prepared with dimethyl sulphoxide (DMSO) solvent. Results: Almost all samples of Holothuria sp. extracts were showed antibacterial activity against Streptococcus viridans, with the highest inhibitory zone was found in concentration of 0.625%, which was 7,598 Â± 0.8427 mm. Conclusion: Extract of Holothuria sp. has powerful antibacterial activity against the growth of Streptococcus viridans, therefore, the extract of Holothuria sp. potentially developed as new source of antibiotics.

Characteristics of Fibrous Dysplasia at Oral and Maxillofacial Surgery Department RSUP Dr. Hasan Sadikin: A 6-year Retrospective Study Prestya, Pebrian Diki; Hadikrishna, Indra; Sylvyana, Melita; Adiantoro, Seto; Rizki, Kiki Achmad
Odonto : Dental Journal Vol 11, No 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.188-193

Introduction: Oral and Maxillofacial surgeon encounter challenges diagnose fibrous dysplasia due to wide variety of investigations required, such as radiographic, histological, and clinical examinations. Fibrous dysplasia typically manifests at first or second decade of life; these lesions tend to form at young age and cease when somatic growth completed. Aim: The aim of this study understanding the characteristics of fibrous dysplasia in patients treated from 2017 to 2023 at Department of Oral and Maxillofacial Surgery Hasan Sadikin Hospital. Research Method: Design of this study is a qualitative descriptive study with retrospective using medical record data of patients diagnosed as fibrous dysplasia at Department of Oral and Maxillofacial Surgery of Hasan Sadikin General Hospital in January 2017 — March 2023. Variables in this study include age, gender, anatomical location at craniofacial area, histopathological diagnosis, and treatment provided. Results: This study showed Characteristics of fibrous dysplasia patients results by sex being highest in Women as many as 6 patients (54.54%), by age indicating the most age at 17-25 years old as 5 patients (45.45%). In addition, the highest prevalence based on histopathological diagnosis is monostotic type, which is 8 patients (72.72%) and three patients (27.27%) with polyostotic type. Based on the anatomical location the most at maxilla region, which is 7 patients, which is 5 (45,45%) patients at left maxilla region and 2 (18,18%) patients at right maxilla region. In addition, based on treatment the most was reshaping with 7 patients (63.63%).Conclusion: The most prevalent characteristic of patients with fibrous dysplasia is woman and by age indicating the most age at 17-25 years old. According to anatomical location the most is maxilla region. Monostotic fibrous dysplasia the most diagnose and the most prevalent treatmet is reshaping, which is the best therapy for of fibrous dysplasia.

Characteristics of Fibrous Dysplasia at Oral and Maxillofacial Surgery Department RSUP Dr. Hasan Sadikin: A 6-year Retrospective Study Prestya, Pebrian Diki; Hadikrishna, Indra; Sylvyana, Melita; Adiantoro, Seto; Rizki, Kiki Achmad
Odonto : Dental Journal Vol 11, No 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.188-193

Introduction: Oral and Maxillofacial surgeon encounter challenges diagnose fibrous dysplasia due to wide variety of investigations required, such as radiographic, histological, and clinical examinations. Fibrous dysplasia typically manifests at first or second decade of life; these lesions tend to form at young age and cease when somatic growth completed. Aim: The aim of this study understanding the characteristics of fibrous dysplasia in patients treated from 2017 to 2023 at Department of Oral and Maxillofacial Surgery Hasan Sadikin Hospital. Research Method: Design of this study is a qualitative descriptive study with retrospective using medical record data of patients diagnosed as fibrous dysplasia at Department of Oral and Maxillofacial Surgery of Hasan Sadikin General Hospital in January 2017 — March 2023. Variables in this study include age, gender, anatomical location at craniofacial area, histopathological diagnosis, and treatment provided. Results: This study showed Characteristics of fibrous dysplasia patients results by sex being highest in Women as many as 6 patients (54.54%), by age indicating the most age at 17-25 years old as 5 patients (45.45%). In addition, the highest prevalence based on histopathological diagnosis is monostotic type, which is 8 patients (72.72%) and three patients (27.27%) with polyostotic type. Based on the anatomical location the most at maxilla region, which is 7 patients, which is 5 (45,45%) patients at left maxilla region and 2 (18,18%) patients at right maxilla region. In addition, based on treatment the most was reshaping with 7 patients (63.63%).Conclusion: The most prevalent characteristic of patients with fibrous dysplasia is woman and by age indicating the most age at 17-25 years old. According to anatomical location the most is maxilla region. Monostotic fibrous dysplasia the most diagnose and the most prevalent treatmet is reshaping, which is the best therapy for of fibrous dysplasia.

INFEKSI CANDIDA ALBICANS PADA NECROTIZING FASCIITIS: LAPORAN KASUS Prestya, Pebrian Diki; Putri, Farah Asnely; Arumsari, Asri
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 11, No 2 (2024): Vol. 11,No 2 (Desember 2024)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v11i2.1719

Introduction: Necrotizing fasciitis is an infection with very rapid progress affected subcutaneous tissue, spread to the fascia lead to subcutaneous blood vessels thrombosis. Hence, caused necrosis of skin. Frequently polymicrobial, caused by β-haemolytic bacteria such as Streptococcus, Staphylococcus spp. and obligate anaerobes. Necrotizing fasciitis due to fungal infection is a rare case, only five cases were recently reported where Candida albicans was identified as necrotizing fasciitis microorganism Case Report: A 51 years old male patient was referred to Emergency Room at Hasan Sadikin General Hospital, Bandung complaints of swelling accompanied by pain in the left cheek extended to eye and neck, with clinical features shown necrosis of the skin, fluctuations and crepitations. The patient was diagnosed as necrotizing fasciitis. The patient has a history of systemic disease which is diabetes mellitus type 2 with hyponatremia and chronic kidney disease. The patient performed necrotomy debridement and incision drainage at submental, temporal and bukal region in general anaesthesia, then followed by wound care with modern dressings. Bacteria culture shown the growth of C.albicans Conclusion: Necrotizing fasciitis caused by C. albicans is a rare case. Several factors that can increase Candida virulence lead to invasive soft tissue infections, the importance was anti-fungal therapy in necrotizing fasciitis beside broad-spectrum antibiotic therapy of this case. Additionally, postoperative wound care was necessary for encourage wound healing

PEDERSEN DIFFICULTY INDEX ACCURATELY PREDICTS OPERATIVE DURATION IN MANDIBULAR THIRD MOLAR REMOVAL: A CROSS-SECTIONAL CLINICAL STUDY Prestya, Pebrian Diki; Yuza, Abel Tasman; Zam, Syarifah Nova Amiza
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 10 No. 3 (2026): Volume 10, Nomor 3, June 2026
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v10i3.56795

Mandibular third molar removal is one of the most performed procedures in oral surgery. Surgical intervention is indicated for both preventive and therapeutic purposes. Preoperative evaluation of surgical difficulty is a critical determinant in the management of impacted mandibular third molars. There are methods for predicting extraction complexity, including the widely recognized Pedersen Difficulty Index, which provides a systematic approach to assessing surgical risk and procedural. The aim of this study understanding the correlation between Pedersen Difficulty Index as a predictor of operative duration in Mandibular Third Molar Removal at Department of OMFS Unimus Dental Teaching Hospital. Design of this study is analytics observational with a cross-sectional study at Department of Oral and Maxillofacial Surgery in January 2026 — March 2026. Minimum sample size was estimated for correlation analysis using a 95% confidence level. Data obtained from 29 patients undergo third molar removal. Variables in this study was Pedersen Difficulty Index and duration in Mandibular third molar removal. Sampling was conducted using consecutive sampling. Data analysis using Spearman rank correlation test. Results: Statistically highly significant difference in duration was observed among three levels of difficulty index (p=0.000; p<0.05). A Spearman’s Rank correlation coefficient of 0.733 indicates a strong positive correlation between the Pedersen difficulty score and operative duration. There is a strong and statistically significant positive correlation between the Pedersen difficulty index and duration in impacted mandibular third molar removal. Higher difficulty scores associated with longer surgical times, indicating that the Pedersen Difficulty Index is a reliable predictor of complexity.

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