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All Journal ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Indonesia Medicus Veterinus Althea Medical Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Global Medical and Health Communication Jurnal Sistem Kesehatan Indonesian Journal of Cardiology Jurnal Penyakit Dalam Indonesia
Adi Imam Cahyadi
Departemen Ilmu Kedokteran Dasar, Divisi Mikrobiologi, Fakultas Kedokteran, Universitas Padjadjaran
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Althea Medical Journal

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Destructive Effect of Calcium Hypochlorite against Pseudomonas aeruginosa Biofilm Arifani, Ilma; Pradini, Gita Widya; Desy Arya, Insi Farisa; Cahyadi, Adi Imam
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (681.179 KB) | DOI: 10.15850/amj.v4n3.1205

Abstract

Background: Pseudomonas aeruginosa is the most common bacteria contaminating the hemodialysis water and has high capability to form a biofilm. The presence of biofilm is hazardous because it becomes a constant source of bacterial and toxin release toward the hemodialysis patient’s blood. Calcium hypochlorite (Ca(OCl)2) is an easily obtained disinfectant. This study was aimed to detect the destructive effect of Ca(OCl)2 against P. aeruginosa biofilm and the optimal disinfectant concentration required to achieve significant effect.Methods: This experimental study was conducted in six replicates from September to October 2015 in Microbiology Laboratory of Faculty of Medicine Universitas Padjadjaran Bandung. A modified tissue culture plate method was performed to grow P. aeruginosa biofilms which were subsequently treated with Ca(OCl)2 in various chlorine concentrations, namely 20, 30, 40, and 500 parts per million (ppm). The data was analyzed using Welch Analysis of Variance (ANOVA) and Games-Howell post-hoc tests and presented in tables.Results: Data were obtained from 36 flat-bottomed polystyrene wells. There was a statistically significant mean difference between groups [F(4, 11.92)= 91.198, p<0.001)]. All of the tested chlorine concentrations caused significant decreases in biofilm optical densities (p = 0.027 for 20 ppm and p< 0.001 for 30, 40, and 500 ppm).Conclusions: Ca(OCl)2 with chlorine concentrations of 20, 30, 40, and 500 ppm have significant destructive effect against P. aeruginosa biofilm. The mean differences among treated groups were not significant. The most optimum concentration is 30 ppm.
Destructive Effect of Calcium Hypochlorite against Pseudomonas aeruginosa Biofilm Ilma Arifani; Gita Widya Pradini; Insi Farisa Desy Arya; Adi Imam Cahyadi
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (681.179 KB) | DOI: 10.15850/amj.v4n3.1205

Abstract

Background: Pseudomonas aeruginosa is the most common bacteria contaminating the hemodialysis water and has high capability to form a biofilm. The presence of biofilm is hazardous because it becomes a constant source of bacterial and toxin release toward the hemodialysis patient’s blood. Calcium hypochlorite (Ca(OCl)2) is an easily obtained disinfectant. This study was aimed to detect the destructive effect of Ca(OCl)2 against P. aeruginosa biofilm and the optimal disinfectant concentration required to achieve significant effect.Methods: This experimental study was conducted in six replicates from September to October 2015 in Microbiology Laboratory of Faculty of Medicine Universitas Padjadjaran Bandung. A modified tissue culture plate method was performed to grow P. aeruginosa biofilms which were subsequently treated with Ca(OCl)2 in various chlorine concentrations, namely 20, 30, 40, and 500 parts per million (ppm). The data was analyzed using Welch Analysis of Variance (ANOVA) and Games-Howell post-hoc tests and presented in tables.Results: Data were obtained from 36 flat-bottomed polystyrene wells. There was a statistically significant mean difference between groups [F(4, 11.92)= 91.198, p<0.001)]. All of the tested chlorine concentrations caused significant decreases in biofilm optical densities (p = 0.027 for 20 ppm and p< 0.001 for 30, 40, and 500 ppm).Conclusions: Ca(OCl)2 with chlorine concentrations of 20, 30, 40, and 500 ppm have significant destructive effect against P. aeruginosa biofilm. The mean differences among treated groups were not significant. The most optimum concentration is 30 ppm.
Co-Authors Alberta Claudia Undarsa Ardini Raksanagara Ardini Saptaningsih Raksanagara Arifani, Ilma Asmali, Adik Sandia Santosa Badai Bhatara Tiksnadi Gita Widya Pradini Iceu Dimas Kulsum Ilma Arifani Insi Farisa Desy Arya Jasmine Maulinda Utami Kusumawati, Maya Larasati, Savira Azhari Lelani Reniarti M. Ersyad Hamda Mauli Warma Dewi, Intan Maulida, Diva Harnum Mogenes Ravichandran Mohammad Ghozali Muhamad Iqbal Najwa Namira Nova Sylviana Nurjanah, Gina Siti Prayudi Santoso Ramdan Panigoro Reni Ghrahani Ridad Agoes Rovina Ruslami, Rovina Sarasati Windria Sri Yusnita Irda Sari Sri Yusnita Irda Sari Sumaryati Sudigdoadi Sumaryati Sudigdoadi, Sumaryati Titik Respati Tyagita Hartady