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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Farmasi Higea
Beti Pudyastuti, Beti
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Medicine & Pharmacology

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Efek Ukuran Partikel terhadap Disolusi Ibuprofen Yosephine, Samuella; Intan, Nur; Anjani, Sabrina; Rahma, Shesa; Pudyastuti, Beti; Wijaya, Triyadi Hendra; Kurniawan, Dhadhang Wahyu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.3409

Abstract

The dissolution rate is an important characteristic to consider when designing a pharmaceutical dosage form, particularly for oral medications. Ibuprofen is an oral medication with a low dissolution rate. The common solution to this problem is to increase the dose to improve drug absorption and effectiveness in order to achieve therapeutic concentration. Some methods to increase dissolution rates have been explored, such as salt formation, prodrug formation, particle size reduction, crystal modification, micellar solubilization, complex formation, solid dispersion, and self-emulsifying. This review focuses on a strategy for increasing ibuprofen dissolution rate by reducing the particle size of the drug. Reduced particle size could improve ibuprofen solubility, allowing it to be absorbed more easily and achieve the desired therapeutic effect.
Total phenolic content and in vitro photoprotective activity of ethanolic extract of torch ginger (Etlingera elatior) Fahmi, Fawnia Alma Arabella; Rehana, Rehana; Pudyastuti, Beti
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.11624

Abstract

Background: Previous research highlighted the photoprotective potential of various extracts from torch ginger leaves, but the efficacy of ethanolic extracts, particularly from leaves and other plant parts, remained unexplored. Objective: This study aimed to assess the total phenolic content and SPF value of ethanolic extracts from torch ginger leaves, flowers, and stems, comparing these with a known photoprotective agent, oxybenzone. Method: Ethanolic extraction was performed on approximately 200 grams of each plant part. The total phenolic content was determined using the Folin-Ciocalteu method, while SPF values were measured spectrophotometrically between 290 and 320 nm. Statistical analysis involved Kruskal-Wallis tests followed by post-hoc Fisher's LSD. Results: The leaf extract exhibited the highest phenolic content (483.788 ± 2.57 mg GAE/g) and SPF value at 1000 ppm, surpassing that of flowers, stems, and the positive control, oxybenzone. The correlation between phenolic content and SPF value across plant parts was statistically significant. Conclusion: The ethanolic extract of torch ginger leaves shows superior photoprotective potential, indicated by its high phenolic content and SPF value, suggesting its promising application in natural sunscreen formulations up to the permissible active substance limit of 6% set by BPOM.
FORMULASI DAN UJI STABILITAS SEDIAAN CLAY MASK EKSTRAK BUNGA TELANG (Clitoria ternatea L.) DENGAN VARIASI KONSENTRASI KAOLIN DAN BENTONIT Rahmawati, Dewi; Auli, Andira; Ambari, Yani; Ningsih, Arista Wahyu; Beti Pudyastuti, Beti; Erwiyani, Agitya Resti
Jurnal Farmasi Higea Vol 17, No 2 (2025)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v17i2.735

Abstract

Pemakaian bahan alami dalam produk perawatan kulit semakin populer karena dinilai lebih aman dan ramah lingkungan. Salah satu tanaman yang berpotensi sebagai bahan aktif adalah bunga telang (Clitoria ternatea L.), yang diketahui mengandung senyawa flavonoid, alkaloid, tanin, terpenoid, dan antosianin dengan aktivitas antioksidan yang tinggi. Senyawa-senyawa ini berperan penting dalam menangkal radikal bebas yang dapat merusak sel kulit. Tujuan dari penelitian ini adalah untuk mengetahui apakah ekstrak bunga telang dapat diformulasikan menjadi sediaan clay mask yang memenuhi standar mutu fisik serta stabil selama penyimpanan. Metode yang digunakan eksperimental laboratorium. Ekstrak bunga telang diperoleh melalui maserasi dengan etanol 70% dan kemudian di formulasi menjadi sediaan clay mask dengan berbagai konsentrasi F1 (kaolin 35% : bentonite 0,5%), F2 (kaolin 30% : bentonite 1%), dan F3 (kaolin 25% : bentonite 1,5%). Parameter uji stabilitas fisik meliputi uji organoleptik, homogenitas, daya sebar, daya lekat, waktu kering, viskositas dan pH. Hasil penelitian yang diperoleh bahwa ekstrak bunga telang dapat dibuat menjadi clay mask dengan perbedaan konsentrasi basis yang digunakan. Stabilitas fisik ketiga sediaan clay mask untuk pengujian organoleptik, homogenitas, daya sebar, daya lekat, waktu kering, viskositas dan pH sudah memenuhi pesyaratan formulasi yang baik. Perbedaan konsentrasi basis sediaan clay mask didapatkan formula terbaik pada F1 (kaolin 35% : bentonite 0,5%). Perbedaan konsentrasi basis pada F1, F2, dan F3 berdampak signifikan pada hasil uji mutu fisik.
Co-Authors Agitya Resti Erwiyani Ambari, Yani Anjani, Sabrina Arista Wahyu Ningsih Auli, Andira DEWI RAHMAWATI Dhadhang Wahyu Kurniawan Fahmi, Fawnia Alma Arabella Nur Intan, Nur Rahma, Shesa Rehana, Rehana Triyadi Hendra Wijaya Yosephine, Samuella