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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. ARTERI : Jurnal Ilmu Kesehatan
Desy Andari
Universitas Muhammadiyah Malang
Electrical & Electronics Engineering Health Professions Medicine & Pharmacology Nursing Public Health

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Kajian Literatur: Analisis Pengaruh Suhu Dingin Ekstrem Terhadap Radang Dingin Pada Pekerja Tempat Penyimpanan Beku Andi Abdillah; Ainun Tungga Dewi; Rubayat Indradi; Desy Andari
ARTERI : Jurnal Ilmu Kesehatan Vol 4 No 3 (2023): Mei
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v4i3.251

Abstract

Frostbite is a disease caused by continuous exposure to extreme cold and is very susceptible to cold storage workers. This paper focuses on the study of Frostbite due to exposure to cold temperatures in the cold storage room. This study uses a literature study method using search results through the research results library and a review of 30 references that have been presented in reputable international journals indexed by Scopus Q1, Q2 and Q3. Besides that, national journals indexed by Sinta and book references are also used. The results of this study indicate a relationship between an increase of temperature in the cold room with an increase in intercellular fluid in human body tissue to freeze due to extreme cold temperatures. The first phase of frostbite treatment is to remove the sufferer from the environment with extreme cold temperatures as soon as possible. Increasing body temperature from the inside (with food / drink / medicine) and the outside (warm water) is a good option for the first phase. In the second phase, sufferers need professional help in the medical field. Avoid breaking the clear liquid layer. The third and fourth phases require first aid to avoid secondary infection.
Ethanol Extract of Tamarind Fruit Increased Glomerular Area in Lead-Induced Wistar Rats Desy Andari; Muhammad Naufal Alzaky; Isbandiyah
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 22 No. 1 (2026): June 2026
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol22.SMUMM1.43903

Abstract

Lead (Pb) exposure is associated with nephrotoxicity, particularly structural alterations of the glomerulus mediated by oxidative stress. Tamarind fruit (Tamarindus indica L.) contains antioxidant compounds and vitamin C that may help attenuate lead-induced renal alterations. This study aimed to investigate the effect of ethanol extract of tamarind fruit on the glomerular area of Wistar rat kidneys exposed to lead. This experimental study conducted a post-test only control group design using 20 male Wistar rats. All groups were induced with lead acetate at a dose of 10 mg/kg body weight/day for 14 days. Treatment groups received ethanol extract of tamarind fruit (TFE) at doses of 12.5, 25, and 50 mg/kg body weight/day. Glomerular area was assessed histologically, and data were analyzed using one-way ANOVA and PostHoc. The results showed a significant difference in glomerular area among groups (p < 0.05). Administration of TFE at a dose of 12.5 mg/kg body weight/day demonstrated a more favorable glomerular area compared to the lead-only group, whereas higher doses did not show additional improvement. These findings suggest that low-dose TFE may influence glomerular structural changes induced by lead exposure.
Co-Authors Ainun Tungga Dewi Andi Abdillah Isbandiyah Muhammad Naufal Alzaky rubayat indradi