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All Journal Jurnal Surya Medika Indonesia Berdaya Borneo Journal Of Pharmascientech Prima Abdika: Jurnal Pengabdian Masyarakat Sains Medisina JPEPT
Ani Agustina
Universitas Sari Mulia
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Studi Pharmacovigilance Obat Antihipertensi Sintetis pada Pasien Hipertensi di Kota Banjarmasin Iwan Yuwindry; Ani Agustina; Darini Kurniawati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 5 No 2 (2021): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v5i2.305

Abstract

Indonesia is a country with a fairly low level of health awareness, the number of patients who do not realize that they are suffering from hypertension and who do not use drugs rationally, causing side effects is quite high. Several publications show that antihypertensive drug therapy triggers a high incidence of ROTD in society. The purpose of this study was to determine the presence or absence of ADR in the treatment of hypertension with synthetic anti hypertension drugs using the WHO-UMC method. This study used a cross-sectional study method which is a form of observational study (non-experimental). The results obtained in this study were 15 people (50%) who reported the absence of ROTD and 15 people (50%) reported the absence of ROTD. In this study, it is known that there is ROTD with the use of the drugs amlodipine, captopril, spironolactone and a combination of amlodipine with candesartan. ROTD that occurred in 11 subjects was classified as possible, which means that there is a possibility that the drug causes ROTD in the form of an increase in the frequency of BAK. The conclusion of this study is that there is a synthetic antihypertensive drug therapy that found the incidence of ROTD in the form of an increase in the frequency of BAK in the use of captopril drugs and the incidence of dizziness, vomiting, and drowsiness on the use of the drug amlodipine.
ANALGESIC POWER TEST OF MAHOGANY LEAF EXTRACT (Swietenia mahagoni) ON MALE MICE (Mus musculus. L) Linda Sari; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept(journalofpharmacologyexperimentandpharmaceuticaltechnology).v1i1.8

Abstract

Mahogany leaves (Swietenia mahagoni) have flavonoids in them that might help with pain by stopping the cyclooxygenase enzyme from working. The purpose of this study is to see if compounds from mahogany leaves (Swietenia mahagoni) can help relieve pain in mice that have been given acetic acid. This study used the chemical stimulation method (writhing). Twenty-five mice were divided into 5 treatment groups, namely group 1 was given Na-CMC as a negative control, group 2 was given paracetamol at a dose of 1.3 mg/20 gBW as a positive control, and groups 3, 4, and 5 were given mahogany leaf extract (Swietenia mahagoni) at a dose of 2.8 mg/20 gBW, 5.6 mg/20 gBW, and 11.2 mg/20 gBW. Each group was given treatment orally; 30 minutes later, the mice were injected with 1% acetic acid intraperitoneally. Additionally, researchers observed and counted the number of wriggles every 15 minutes for a duration of 90 minutes. This study shows that the ethanol extract of mahogany leaves (Swietenia mahagoni) at a dose of 11.2 mg/20 g BB with a 100% success rate can relieve pain.
The Edukasi Penggunaan Obat Herbal Alami Menggunakan Daun Salam, Serai, dan Jahe untuk Atasi Asam Urat di Desa Sungai Bakung RT.08: Educational Program on the Use of Natural Herbal Remedies Made from Bay Leaves, Lemongrass, and Ginger to Treat Gout in Sungai Bakung Village, RT 08 Ani Agustina; Chintya Amanie; Desy Mutia; Hafizatul Husna
Indonesia Berdaya Vol. 7 No. 3 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261563

Abstract

Gout (hyperuricemia) is a health problem characterized by elevated uric acid levels in the blood, which can lead to joint pain, inflammation, and decreased quality of life if not properly managed. In Sungai Bakung Village RT 08, community knowledge regarding non-pharmacological management of gout and the utilization of herbal plants remains limited. Objective: This community service activity aimed to improve community knowledge and skills in utilizing bay leaves (Syzygium polyanthum), lemongrass (Cymbopogon citratus), and ginger (Zingiber officinale) as herbal beverages to support gout management. Methods: The program was implemented through problem identification, pre-test and post-test evaluations, health education sessions, educational videos, discussions, and the distribution of booklets containing practical herbal preparation guidelines. Results: The intervention showed a significant improvement in participants' knowledge, with an average increase of approximately 80% based on pre-test and post-test scores. Participants also demonstrated more positive attitudes toward the safe and appropriate use of herbal remedies as supportive therapy for gout. Conclusion: Health education and training on herbal utilization effectively improved community knowledge and attitudes and provided a practical approach for promoting non-pharmacological management of gout through locally available medicinal plants.   Abstrak. Asam urat (hiperurisemia) merupakan salah satu masalah kesehatan yang ditandai dengan tingginya kadar asam urat dalam darah, yang dapat menyebabkan nyeri sendi, peradangan, serta penurunan kualitas hidup apabila tidak dikelola dengan baik. Di Desa Sungai Bakung RT 08, pengetahuan masyarakat mengenai penatalaksanaan nonfarmakologis asam urat dan pemanfaatan tanaman herbal masih terbatas. Tujuan: Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam memanfaatkan daun salam (Syzygium polyanthum), serai (Cymbopogon citratus), dan jahe (Zingiber officinale) sebagai minuman herbal pendukung pengelolaan asam urat. Metode: Kegiatan dilaksanakan melalui identifikasi masalah, evaluasi menggunakan pre-test dan post-test, penyuluhan kesehatan, pemutaran video edukasi, diskusi interaktif, serta pembagian booklet yang berisi panduan praktis pembuatan minuman herbal. Hasil: Intervensi menunjukkan peningkatan pengetahuan peserta yang signifikan, dengan rata-rata peningkatan sekitar 80% berdasarkan hasil pre-test dan post-test. Peserta juga menunjukkan sikap yang lebih positif terhadap penggunaan herbal secara aman dan tepat sebagai terapi pendukung dalam pengelolaan asam urat. Kesimpulan: Edukasi kesehatan dan pelatihan pemanfaatan tanaman herbal terbukti efektif dalam meningkatkan pengetahuan dan sikap masyarakat serta memberikan alternatif praktis dalam mendukung penatalaksanaan nonfarmakologis asam urat melalui pemanfaatan tanaman obat yang tersedia di lingkungan sekitar.
Edukasi Cara Pengolahan Sediaan Herbal Untuk Hipertensi di Kampung Ketupat RT. 07 Kota Banjarmasin Pebrianti Pebrianti; Zahra Desy Safitri; Michael Elisier; Nawwal Nawwal; Nur Syifa; Ani Agustina; Rohama Rohama
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 6 No. 2 (2026): Volume 6 Nomor 2 Tahun 2026 (Juni 2026)
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v6i2.6989

Abstract

The rapid advancement of science and technology in pharmaceutical preparations has not entirely shifted public preference toward modern medicine. This is evident from the fact that many community groups continue to use herbal plants as alternative therapeutic options, although their knowledge regarding appropriate use remains limited. This community engagement program aimed to improve residents' knowledge and skills in Kampung Ketupat RT. 07, Banjarmasin City, in the utilization of herbal plants as antihypertensive agents. The program consisted of three phases: the preparation phase (survey and material development), the implementation phase (education and a workshop on celery juice preparation), and the evaluation phase, which involved comparing pre-test and post-test results. Educational activities were conducted in person using leaflets as learning media. The results showed an improvement in participants’ knowledge, as indicated by an increase in the number of participants with good knowledge levels—from 4 (26.67%) before the intervention (pre-test) to 10 (66.67%) after the educational session (post-test).
Studi Farmakovigilans Efek Samping Obat Hipertensi pada Pasien Rawat Jalan di RSUD Ulin Banjarmasin: Pharmacovigilance Study of Hypertension Drug Side Effects in Outpatients at Ulin General Hospital Banjarmasin Viviana Viviana; Darini Kurniawati; Ani Agustina; Iwan Yuwindry
Jurnal Surya Medika (JSM) Vol. 11 No. 3 (2025): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v11i3.11951

Abstract

Hipertensi merupakan kondisi medis yang tidak menular, namun menjadi pemicu utama penyakit jantung dan stroke. Efek samping penggunaan obat hipertensi dipengaruhi oleh durasi pemakaian jangka panjang serta peningkatan dosis obat. Oleh karena itu, perlu dilakukan pengkajian terkait efek samping obat hipertensi menggunakan Algoritma Naranjo.Tujuan Penelitian mengetahui kejadian efek samping yang terjadi pada pengobatan hipertensi dan mengidentifikasi ketegori efek samping dengan Naranjo.Metode Observasional Analitik pendekatan Cross Sectional dan kuisioner Algoritma Naranjo untuk mengetahui kategori efek samping obat. Didapatkan hasil efek samping yang dirasakan 36 responden yaitu batuk kering 13 responden (36,11%), kaki bengkak11 responden (30,55%), pusing 8 responden (22,22%), sakit kepala dan kadang sulit tidur 2 responden (5,55%), sakit kepala 1 responden (2,77%) dan batuk kering disertai sakit kepala 1 responden (2,77%). Berdasarkan kuesioner Naranjo diperoleh 14 responden (38,88%) Possible, dan 22 responden (61,11%) Probable. Obat yang menimbulkan kejadian efek samping yaitu Captopril, Amlodipine, Candesartan, Bisoprolol, dan Propanolol. Dapat disimpulkan bahwa 36 responden mengalami efek samping dari obat hipertensi yaitu batuk kering, kaki bengkak, pusing, sakit kepala dan kadang sulit tidur, sakit kepala, dan batuk kering disertai sakit kepala. Berdasarkan Algoritma Naranjo 14 responden (Possible), dan 22 responden (Probable).
Review Artikel: Ekstrak Sebagai Antihiperlipidemia Siti Monica Anjani; Ani Agustina
Sains Medisina Vol 4 No 3 (2026): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i3.981

Abstract

Hiperlipidemia adalah gangguan metabolisme lipid yang meningkatkan kadar kolesterol total, trigliserida, dan LDL. Meskipun terapi farmakologi seperti statin efektif, penggunaan jangka panjang sering memicu efek samping, sehingga diperlukan alternatif dari bahan alam. Review ini bertujuan mengidentifikasi senyawa kimia dan penggunaan tradisional berbagai tumbuhan yang memiliki aktivitas antihiperlipidemia. Metode yang digunakan adalah studi pustaka melalui basis data Google Scholar dan PubMed dengan kata kunci spesifik seperti “Aktivitas antihiperlipidemia” dan “Antihyperlipidemic activity”. Pencarian dilakukan menggunakan operator Boolean dan filter lanjutan untuk memperoleh referensi yang akurat dan relevan. Berdasarkan sintesis terhadap 10 artikel penelitian in vivo, ditemukan bahwa ekstrak berbagai tanaman secara signifikan mampu menurunkan kadar kolesterol total pada tikus yang diinduksi pakan tinggi lemak dibandingkan dengan kontrol negatif. Senyawa metabolit sekunder seperti flavonoid, saponin, tanin, dan triterpenoid diidentifikasi sebagai komponen utama yang berperan dalam aktivitas tersebut. Mekanisme kerjanya meliputi penghambatan penyerapan lemak dan regulasi enzim metabolisme kolesterol. Hasil ini menegaskan potensi besar tanaman herbal sebagai agen antihiperlipidemia alami yang lebih aman untuk penggunaan jangka panjang.
Co-Authors Chintya Amanie Darini Kurniawati Desy Mutia Hafizatul Husna Iwan Yuwindry Linda Sari Michael Elisier Nawwal Nawwal Nur Mahdi Nur Syifa Pebrianti Pebrianti Rohama Rohama Siti Monica Anjani Viviana Viviana Zahra Desy Safitri