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Ani Agustina
Universitas Sari Mulia
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Studi Pharmacovigilance Obat Antihipertensi Sintetis pada Pasien Hipertensi di Kota Banjarmasin Iwan Yuwindry; Ani Agustina; Darini Kurniawati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 5 No 2 (2021): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v5i2.305

Abstract

Indonesia is a country with a fairly low level of health awareness, the number of patients who do not realize that they are suffering from hypertension and who do not use drugs rationally, causing side effects is quite high. Several publications show that antihypertensive drug therapy triggers a high incidence of ROTD in society. The purpose of this study was to determine the presence or absence of ADR in the treatment of hypertension with synthetic anti hypertension drugs using the WHO-UMC method. This study used a cross-sectional study method which is a form of observational study (non-experimental). The results obtained in this study were 15 people (50%) who reported the absence of ROTD and 15 people (50%) reported the absence of ROTD. In this study, it is known that there is ROTD with the use of the drugs amlodipine, captopril, spironolactone and a combination of amlodipine with candesartan. ROTD that occurred in 11 subjects was classified as possible, which means that there is a possibility that the drug causes ROTD in the form of an increase in the frequency of BAK. The conclusion of this study is that there is a synthetic antihypertensive drug therapy that found the incidence of ROTD in the form of an increase in the frequency of BAK in the use of captopril drugs and the incidence of dizziness, vomiting, and drowsiness on the use of the drug amlodipine.
ANALGESIC POWER TEST OF MAHOGANY LEAF EXTRACT (Swietenia mahagoni) ON MALE MICE (Mus musculus. L) Linda Sari; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.8

Abstract

Mahogany leaves (Swietenia mahagoni) have flavonoids in them that might help with pain by stopping the cyclooxygenase enzyme from working. The purpose of this study is to see if compounds from mahogany leaves (Swietenia mahagoni) can help relieve pain in mice that have been given acetic acid. This study used the chemical stimulation method (writhing). Twenty-five mice were divided into 5 treatment groups, namely group 1 was given Na-CMC as a negative control, group 2 was given paracetamol at a dose of 1.3 mg/20 gBW as a positive control, and groups 3, 4, and 5 were given mahogany leaf extract (Swietenia mahagoni) at a dose of 2.8 mg/20 gBW, 5.6 mg/20 gBW, and 11.2 mg/20 gBW. Each group was given treatment orally; 30 minutes later, the mice were injected with 1% acetic acid intraperitoneally. Additionally, researchers observed and counted the number of wriggles every 15 minutes for a duration of 90 minutes. This study shows that the ethanol extract of mahogany leaves (Swietenia mahagoni) at a dose of 11.2 mg/20 g BB with a 100% success rate can relieve pain.
Co-Authors Darini Kurniawati Iwan Yuwindry Linda Sari Nur Mahdi