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All Journal Universa Medicina Paediatrica Indonesiana Indonesian Journal of Advanced Research (IJAR)
Yenny Djuardi
Department Of Parasitology, Faculty Of Medicine, Universitas Indonesia, Jakarta
Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

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Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Buana, Ria; Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.206-212

Abstract

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.
Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol Jane Florida Kalumpiu; Yenny Djuardi; Taniawati Supali
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.121-128

Abstract

BackgroundSoil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.MethodsAn experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. ResultsOf the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). ConclusionsIn children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.
Evaluation of Intestinal Helminth Infection Among Stunting Children Under Five Years of Age in Bendung Village, Kasemen District, Banten: A Cross-Sectional Study Trasia, Reqgi First; Fitriani, Nabilla; Djuardi, Yenny
Indonesian Journal of Advanced Research Vol. 4 No. 3 (2025): March 2025
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v4i3.14085

Abstract

One of the risk factors for stunting is intestinal helminth infection. Soil-Transmitted Helminth (STH) is the most common worm that infects the human intestine. Evaluation of the relationship between intestinal helminth infection and stunting in children under five years will be carried out in Bendung Village, Kasemen District, Banten. This research is a cross-sectional study conducted in Bendung Village, Kasemen District, Banten. Intestinal helminth infections were examined using the Kato-Katz method. Socioeconomic status is measured based on the Kuppuswamy’s socioeconomic scale. Immunization status is obtained from the Mother & Child Card (KIA). The statistical analysis used was bivariate Chi-Square and Fisher’s Exact tests. The prevalence of stunting among 12-59 months children in Bendung Village, Kasemen District, Banten was 48.6%. The prevalence of intestinal helminth infection was 41.7% (each species A. lumbricoides 33.3%, T. Trichiura 1.4%, hookworm 1.4%, mixed infections of A. lumbricoides and T. Trichiura 1.4%, mixed infections of A. lumbricoides and hookworm 1.4%). Intestinal helminth infection were significantly associated with stunting in children under five years. The results of this study indicate a high rate of stunting and intestinal helminth infection in children under five years in Bendung Village. Intestinal helminth infection has a negative impact on the growth of children under five years.
Soil-transmitted helminth infection, intestinal permeability, and intestinal inflammation in preschool-age children Aulia, Gina; Djuardi, Yenny; Supali, Taniawati
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.232-8

Abstract

Background Soil-transmitted helminth (STH) infection is a major health problem in low-and middle-income countries (LMIC). The presence and activity of STH can cause changes in the intestinal mucosa, including cell damage that can affect intestinal permeability and stimulate immune responses such as inflammation. Objective To assess the inflammatory and permeability status of the intestinal mucosa in various STH infections in preschool-age children residing in Nangapanda District, Ende Regency, East Nusa Tenggara. Methods In this cross-sectional study, stool samples were obtained from children aged 12-59 months and examined for worm eggs using the Kato Katz method. Concentrations of biomarkers for intestinal permeability and inflammation were measured by enzyme-linked immunosorbent assay (ELISA). We measured fecal alpha-1-antitrypsin (AAT) as an intestinal permeability biomarker and fecal calprotectin (FC) as an intestinal inflammation biomarker and evaluated the association between these biomarkers with STH infection. Results The prevalence of STH infection in 111 evaluated preschool-age children was 17.1%. Ascaris lumbricoides was the predominant species, followed by Trichuris trichiura. Most subjects (64.7%) had AAT levels >0.27 mg/g, while only 35.1% had FC >50 mg/kg. STH infection status was not significantly associated with AAT concentration status, even when analyzed by STH species. A significant association was found only between T. trichiura infection and FC concentration. In this study, which included infected and uninfected groups, children infected with T. trichiura had higher concentrations of FC than those uninfected. Conclusion STH infection was not significantly correlated with fecal biomarkers except between T. trichiura infection status and increased gut inflammatory biomarker. AAT levels were generally elevated in the evaluated preschool-aged population regardless of STH infection, indicating that other factors may have contributed to increased gut permeability.
Co-Authors Aulia, Gina Fitriani, Nabilla Jane Florida Kalumpiu, Jane Florida Reqgi First Trasia Ria Buana, Ria Taniawati Supali Taniawati Supali Yuliana Yuliana