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All Journal International Journal of Public Health Science (IJPHS) Universa Medicina Paediatrica Indonesiana Makara Journal of Science Jurnal Kedokteran Meditek
Taniawati Supali
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Buana, Ria; Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.206-212

Abstract

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.
Perbandingan Uji Diagnostik Mini FLOTAC dengan Kato-Katz Sebelum dan Sesudah Pengobatan Albendazol Dosis Tunggal pada Anak yang Terinfeksi Cacing Usus Monica Puspa Sari; Taniawati Supali; Heri Wibowo
Jurnal Kedokteran Meditek Vol. 21 No. 55 Januari - April 2015
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v21i55.1200

Abstract

AbstrakUntuk memantau pengobatan anthelmintik, diperlukan teknik pemeriksaan yang lebih akurat dan sensitif dibandingkan dengan  Kato-Katz yang merupakan teknik standar yang ada saat ini.  Penelitian ini merupakan uji diagnostik yang dilakukan terhadap anak sekolah dasar dilakukan pada bulan Maret 2013 di Kelurahan Kalibaru, Kecamatan Cilincing, Jakarta Utara. Sampel tinja diperiksa menggunakan metode Kato-Katz dan Mini FLOTAC sebelum dan sesudah  pemberian obat albendazol 400 mg dosis tunggal pada hari ke 7,14, dan 21. Dari 209 subyek penelitian, terjaring 197 subyek yang bersedia ikut serta.  Sebelum pengobatan, sensitivitas dan NPV (negative predictive value)   Kato-Katz     dan  Mini FLOTAC masing–masing 94%, 96%  dan 81%, 88% terhadap infeksi A. lumbricoides. Terhadap T. trichiura 88%, 92% dibandingkan Mini FLOTAC 100%. Nilai kappa agreement antara teknik Kato-Katz dan Mini FLOTAC adalah 0.773 untuk diagnosis infeksi A. lumbricoides dan 0.895 untuk  infeksi T. trichiura. Terhadap Ascaris,  19.79% tergolong infeksi ringan dengan Kato-Katz. Sedangkan 25.88% tergolong infeksi ringan dengan Mini FLOTAC. Terhadap Trichuris,  34.51% tergolong infeksi ringan dengan Kato-Katz dan 42.13% tergolong infeksi ringan dengan Mini FLOTAC. Setelah diberikan pengobatan, Kato-Katz lebih sensitif dibandingkan  Mini FLOTAC dalam mendeteksi infeksi A. lumbricoides, terutama pada hari  7 dan 14 dan sebaliknya Mini FLOTAC lebih sensitif terhadap infeksi T. trichiura.Teknik Mini FLOTAC dapat dipakai sebagai alternatif dari teknik Kato-Katz dalam mendeteksi infeksi cacing usus dan lebih sensitif mendeteksi T. trichiura dibanding Kato-Katz.  Kata Kunci : Kato-Katz, Mini FLOTAC, Albendazol, Infeksi cacing usus  Abstract            To monitor anthelmintic treatment, will require examination techniques that are more accurate and sensitive than the Kato-Katz technique which is the current standard. This study is a diagnostic examination performed on primary school children. It was conducted in March 2013 in   Kalibaru village, Cilincing Sub-District, North Jakarta. Stool samples were examined using the Kato-Katz  and Mini FLOTAC methods on day 7,14, and 21 after the administration of a single dose of 400 mg albendazole. Of the 209 study subjects, 197 subjects were willing to participate. Before treatment, the sensitivity and the NPV (negative predictive value) against A. lumbricoides infection were 94%,96%, respectively for Kato-Katz and 81%, 88%, respectively for Mini FLOTAC. For T. trichiura, sensitivity and the NPV of Kato-Katz were 88%, 92%, respectively,while for Mini FLOTAC both values were 100%. Kappa value of agreement between Kato-Katz and Mini FLOTAC techniques was 0.773 for the diagnosis of A. lumbricoides infection and 0.895 for T. trichiura. For Ascaris, 19.79% versus 25.88% of infected children have light infection by Kato-Katz and Mini FLOTAC, respectively. For Trichuris, 34.51% versus 42.13% of infected children have light infection with Kato-Katz and Mini FLOTAC, respectively. After the treatment was given,  Kato-Katz  was more sensitive compared to Mini FLOTAC in detecting A. lumbricoides infection, especially at day 7 and day 14. On the contrary, Mini FLOTAC was more sensitive in detecting T. trichiura infection. The Mini FLOTAC technique can be used as an alternative for Kato-Katz in detecting  helminth infections. Mini FLOTAC was more sensitive to detect T. trichiura compared to Kato-Katz.  Keywords  :  Kato-Katz, Mini FLOTAC, Albendazole, Soil transmitted helminthes  
Detection of Submicroscopic Soil-Transmitted Helminth Infections from Fecal Samples in Nangapanda, Ende, Using Real-Time Polymerase Chain Reaction Maylasari, Roospita; Wulandhary, Sendy; Supali, Taniawati; Abinawanto, Abinawanto
Makara Journal of Science Vol. 18, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Soil-transmitted helminth (STH) infections (Necator americanus (hookworm), Ancylostoma duodenale (hookworm), and Ascaris lumbricoides) can lead to anemia, malnutrition, and iron deficiency. Traditionally, STH infections have been diagnosed using microscopy to detect eggs in human fecal samples. However, there are several limitations of this method. The aim of this research was to detect the percentage of submicroscopic STH infections from human fecal samples (children, 5–18 years old) in Nangapanda, Ende, using the real-time polymerase chain reaction (PCR) method. The fecal samples were collected in two time periods, which were before and after treatment, using 400 mg of Albendazole. There were 242 samples in total, but only 45 negative samples from microscopic detection were tested with real-time PCR. The DNA samples were isolated and amplified wih primers of internal transcribed spacer (ITS-1 and ITS-2) region of rDNA. The detection of samples with real-time PCR generated an amplification curve in VIC, FAM, and Texas Red fluorophore. Three samples (6.7%) in pre-treatment were low load of DNA (N. americanus and A. lumbricoides) (Ct > 35). Four samples (9.1%) were low load of DNA (N. americanus) (Ct > 35) in post-treatment. Five samples (11.4%) were moderate load of DNA (A. lumbricoides) (30 < Ct < 35) in post-treatment. This study showed that real-time PCR could detect submicroscopic infections from specific species of hookworm and A. lumbricoides
Spatial study of the implementation of ivermectin, diethylcarbamazine citrate, and albendazole in an urban area Nafilata, Ikrimah; Supali, Taniawati; Wahyono, Tri Yunis Miko; Prihartono, Nurhayati Adnan; Hikmah, Kholisotul; Devi, Yuli Puspita
International Journal of Public Health Science (IJPHS) Vol 14, No 1: March 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i1.24822

Abstract

Studies on lymphatic filariasis (LF) in Indonesia have mostly focused on the disease determinants with limited focus on spatial-based and the determinants of implementing ivermectin, diethylcarbamazine citrate, and albendazole (IDA). This study aimed to identify the causes of program failure. A cross-sectional survey was conducted from November to December 2022 in nine urban villages with high endemic records and one sentinel village in Pekalongan City, Central Java, Indonesia. The analysis using Quantum Geographical Information System (QGIS) and Pearson correlation. Slum settlements were linked to the presence of open sewers (p=0.000; r=0.974) and overcrowding (p=0.033; r=0.672), while the first round of IDA medication adherence correlated with knowledge of medication (p=0.054; r=-0.623) and willingness to take the medication in the second round (p=0.051, r=0.603). Adverse effects of the treatment are strongly correlated with drug boredom from taking medication (p=0.003; r=0.828) and assistance from health workers (p=0.027; r=0.791). We identified gaps in slum settlements, open sewers, overcrowding and medication adherence, including low knowledge of medication, unwillingness to take second-round medication, adverse effects, and boredom with taking medication. We recommend effective strategies by engaging health education between health workers, local leaders, and private sectors as key to ensuring elimination program.
Soil-transmitted helminth infection, intestinal permeability, and intestinal inflammation in preschool-age children Aulia, Gina; Djuardi, Yenny; Supali, Taniawati
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.232-8

Abstract

Background Soil-transmitted helminth (STH) infection is a major health problem in low-and middle-income countries (LMIC). The presence and activity of STH can cause changes in the intestinal mucosa, including cell damage that can affect intestinal permeability and stimulate immune responses such as inflammation. Objective To assess the inflammatory and permeability status of the intestinal mucosa in various STH infections in preschool-age children residing in Nangapanda District, Ende Regency, East Nusa Tenggara. Methods In this cross-sectional study, stool samples were obtained from children aged 12-59 months and examined for worm eggs using the Kato Katz method. Concentrations of biomarkers for intestinal permeability and inflammation were measured by enzyme-linked immunosorbent assay (ELISA). We measured fecal alpha-1-antitrypsin (AAT) as an intestinal permeability biomarker and fecal calprotectin (FC) as an intestinal inflammation biomarker and evaluated the association between these biomarkers with STH infection. Results The prevalence of STH infection in 111 evaluated preschool-age children was 17.1%. Ascaris lumbricoides was the predominant species, followed by Trichuris trichiura. Most subjects (64.7%) had AAT levels >0.27 mg/g, while only 35.1% had FC >50 mg/kg. STH infection status was not significantly associated with AAT concentration status, even when analyzed by STH species. A significant association was found only between T. trichiura infection and FC concentration. In this study, which included infected and uninfected groups, children infected with T. trichiura had higher concentrations of FC than those uninfected. Conclusion STH infection was not significantly correlated with fecal biomarkers except between T. trichiura infection status and increased gut inflammatory biomarker. AAT levels were generally elevated in the evaluated preschool-aged population regardless of STH infection, indicating that other factors may have contributed to increased gut permeability.
Co-Authors A.A. Ketut Agung Cahyawan W Abinawanto Abinawanto Abinawanto Abinawanto Agnes Kurniawan Aulia, Gina Bintari Rukmono Dante S. Harbuwono Endang S. Wardhani Felix Partono Heri Wibowo Hikmah, Kholisotul I Ketut Suada Jane Florida Kalumpiu, Jane Florida Laurentius A. Pramono Lisawati Susanto Lisawati Susanto Maylasari, Roospita Monica Puspa Sari Nafilata, Ikrimah Pradana Soewondo Prihartono, Nurhayati Adnan Purnomo Purnomo Ria Buana, Ria Rita Ekarina Roospita Maylasari Sari, Monica Puspa Sarwono Waspadji Sendy Wulandhary Srisasi Gandahusada Srisasi Gandahusada Suharko Soebardi Tjahaya Haerani Tri Yunis Miko Wahyono Wulandhary, Sendy Yenny Djuardi Yuli Puspita Devi Yuliana Yuliana