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All Journal Journal of Molecular Docking Tribakti: Jurnal Pemikiran Keislaman
Muhammad Irfan
University of Sargodha
Religion Humanities Education Medicine & Pharmacology Social Sciences

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Alantolactone: A Potential Multitarget Drug candidate for Prevention of SARS-CoV-2 Cell Entry Erum Zafar; Zainab Ahsan; Muhammad Faisal Maqbool; Aqsa Zaman; Sameena Gul; Amara Maryam; Muhammad Khan; Hafiz Abdullah Shakir; Muhammad Irfan
Journal of Molecular Docking Vol. 2 No. 2 (2022): Journal of Molecular Docking
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jmd.v2i2.3679

Abstract

The novel strain of coronavirus, SARS-CoV-2, has spread adverse effects on human health with high mortality rates worldwide. SARS-CoV-2 is a severe respiratory disease expressed through positive single stranded RNA enveloped virus. SARS-CoV-2 had affected globally and is influencing the economy as well. The rapidly spreading coronavirus infection has discombobulated the researchers in perpetuate search for different or effective therapeutic drugs.  Most of the connatural products are proposed to have significant clinical outcomes but their pathways of action are not clear. This molecular docking study presents alantolactone, a bio-active member of sesquiterpene family as a successful inhibitor of SARS-Cov-2 and human receptor proteins. Alantolactone shows high binding affinity with the SARS-CoV-2 target proteins such as spike glycoprotein (S-protein), nucleocapsid protein (N-protein), main protease (MPro), and papain-like protease (PLPro) with a binding affinity of -7.3 kcal/mol, -7.9 kcal/mol, -6.8 kcal/mol, and -7.1 kcal/mol, respectively as well as human receptor  proteins associated with the recognition, binding and biogenesis of SARS-CoV-2 such as angiotensin-converting enzyme 2 (ACE-2), receptor binding domain (S1-RBD) and ACE2 interphase, furin, adaptor-associated protein kinase 1 (AAK1), cyclin G-associated kinase (GAK), and both closed and open configurations of the two-pore channel (TPC2) with binding energies of -6.7 kcal/mol, - 6.9 kcal/mol, -8.1 kcal/mol, -7.3 kcal/mol, and -7.9 kcal/mol, respectively. Molecular docking and ADMET properties and toxicity predictions suggest that alantolactone could effectively binds with various viral target protein and human target proteins and could be developed into a novel SARS-coV-2 inhibitor.
Strengthening Religious Moderation to Counter the Spread of Transnational Ideologies; a Case Study of Religious Activities in Indonesian Universities Andy Hadiyanto; Dewi Anggraeni; Ibnu Rusyd; Muhammad Irfan
Tribakti: Jurnal Pemikiran Keislaman Vol. 37 No. 2 (2026): Tribakti: Jurnal Pemikiran Keislaman
Publisher : Universitas Islam Tribakti (UIT) Lirboyo Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33367/tribakti.v37i2.7289

Abstract

The platform of religious moderatism continues to be widely used in the university context as a means to spread wasathiyah religious ideas. This study explores the role of religious institutional activities in fostering religious moderation as a strategic response to the growing influence of transnational Islamic ideologies within Indonesian higher education. Focusing on three prominent public universities Universitas Pendidikan Indonesia (UPI), Universitas Negeri Jakarta (UNJ), and Universitas Negeri Malang (UM). This qualitative research employs a multiple case study approach supported by document analysis, Focus Group Discussion, and observation. The findings reveal that while each institution adopts distinct approaches shaped by their unique socio-cultural and ideological contexts, all three share a commitment to embedding the principles of religious moderation into religious activities. UPI institutionalizes religious programs within the academic structure, UNJ emphasizes inclusivity and diversity, whereas UM integrates values of tolerance and contextual learning. The study affirms that structured mentoring programs rooted in the university’s religious and cultural frameworks are instrumental in shaping students’ moderate religious outlooks. The implications suggest that religious moderation must be mainstreamed into curricular and extracurricular domains through policies that respect institutional contexts.
Co-Authors Amara Maryam Andy Hadiyanto Aqsa Zaman Dewi Anggraeni Erum Zafar Hafiz Abdullah Shakir Ibnu Rusyd Muhammad Faisal Maqbool Muhammad Khan Sameena Gul Zainab Ahsan