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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Science and Technology Indonesia Biodiversitas Journal of Biological Diversity
Nadila Nur Khotimah
Doctoral Program In Environmental Science, Postgraduate Program, Universitas Sriwijaya. Jl. Padang Selasa No. 524 Bukit Besar, Palembang 30139, South Sumatra, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Physics

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Insecticidal Activity and Phytochemical Profiles of Avicennia marina and Excoecaria agallocha Leaves Extracts Rozirwan Rozirwan; Muhtadi Muhtadi; Tengku Zia Ulqodry; Redho Yoga Nugroho; Nadila Nur Khotimah; Fauziyah Fauziyah; Wike Ayu Eka Putri; Riris Aryawati; Che Abd Rahim Mohamed
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 28, No 2 (2023): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.28.2.148-160

Abstract

Toxic bioactive compounds can be obtained from various mangrove plants that have the potential to be developed in agriculture as bioinsecticides. The coast of South Sumatra has relatively abundant Avicennia marina and Excoecaria agallocha vegetation. This study was conducted to analyze the bioactivity of insecticides and the phytochemical profiles of mangrove leaves A. marina and E. agallocha was extracted with methanol, ethyl acetate, and n-hexane from the most toxic extract fraction. Samples were obtained from the Barong River in Sembilang National Park, Banyuasin Regency. The insecticidal activity of the samples was carried out on Gryllus bimaculatus and Tenebrio molitor. Furthermore, the phytochemical profile was analyzed using GC-MS. Based on the results of insecticidal activity on G. bimaculatus, the respective LC50 values of A. marina and E. agallocha extracts for the hexane fraction were 12,562 mg.L-1 and 15,464 mg.L-1, ethyl acetate 9,986 mg.L-1 and 10,292 mg.L-1, methanol 6,454 mg.L-1 and 6,969 mg.L-1. Whereas in T. molitor, the LC50 values for the hexane fraction were 10,682 mg.L-1 and 11,070 mg.L-1, ethyl acetate 9,065 mg.L-1 and 9,269 mg.L-1, methanol 4,799 mg.L-1, and 5,408 mg.L-1. The results of GC-MS analysis on the methanol extract of A. marina leaves which contained phytochemical compounds such as alcohol, lauric acid, myristic, linoleic, elaidate, stearate, endogenous, olead, phthalic ester, and siloxane. Based on the insecticide toxicity category, the insecticidal activity of both A. marina and E. agallocha leaves extracts were low and non-toxic. Further research is needed regarding variations in anti-insecticide of mangrove extract measurements in the future studies.
An Assessment of Pb and Cu in Waters, Sediments, and Mud Crabs (Scylla serrata) from Mangrove Ecosystem Near Tanjung Api-Api Port Area, South Sumatra, Indonesia Rozirwan; Aning Puji Saputri; Redho Yoga Nugroho; Nadila Nur Khotimah; Wike Ayu Eka Putri; Fauziyah; Anna Ida Sunaryo Purwiyanto
Science and Technology Indonesia Vol. 8 No. 4 (2023): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.4.675-683

Abstract

Heavy metal pollution from anthropogenic activities can harm aquatic ecosystems. This study aims to determine the concentration of heavy metals (Pb and Cu) in waters, sediments, and mud crabs (Scylla serrata), and to analyze the relationship between environmental parameters and S. serrata consumed by humans. Samples were taken in the mangrove ecosystem around the Tanjung Api-Api port area in South Sumatra, Indonesia. Pb and Cu analysis used the Atomic Absorption Spectrophotometer (AAS). Pb and Cu linkages in waters, sediments, and S. serrata analyzed by SigmaPlot V12.5 and Principal Component Analysis (PCA) analyzed by XLSTAT 2022. The limit consumption of S. serrata was calculated using MWI (Maximum Weekly Intake) and MIT (Maximum Intake Tolerance). Based on the results, the heavy metal Pb in water was 0.1055 – 0.1322 mg.L-1, and Cu was not detected. Furthermore, Pb in sediments ranged from 7.0104 - 11.8186 mg.kg-1, Cu 3.7127 - 4.5347 mg.kg-1, and Pb in S. serrata ranged from 0.0001 - 0.0021 mg.kg-1, and Cu ranged from 0.03 – 0.0791 mg.kg-1. The concentration of heavy metals in water, sediment, and S. serrata had not exceeded the specified quality standard, except for Pb in water. The principal component analysis obtained F1 (44.35%), F2 (27.53%) and F3 (17.83%) groups. Based on MWI and MIT value, it showed high quality which concluded S. serrata was still safe for human consumption.
Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery Rozirwan; Ade Siswanto; Nadila Nur Khotimah; Redho Yoga Nugroho; Wike Ayu Eka Putri; Fauziyah; Rezi Apri; Hartoni
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.502-516

Abstract

The increasing demand for effective and natural anti-inflammatory agents prompts an investigation into the properties of Sonneratia caseolaris (L.) Engl., a plant traditionally used in medicine. This study aimed to explore the ability of S. caseolaris leaves extract to inhibit inflammation and accelerate wound healing. S. caseolaris leaves were collected from Tanjung Api-Api area, Banyuasin, South Sumatra. The method involved carrageenan induction in rat paws as an inflammatory model. The results showed that the most effective dose was found in the group with a dose of 150 mg/kg BW measured using a digital caliper and plethysmometer. The qualitative phytochemical test contain alkaloids, steroids, flavonoids, and phenols. The results GC-MS analysis were thought to contain aldehydes, glucosinolates, coumarins, esters, terpenoids, alcohols, lipids, tocopherols, and steroids. Due to their diverse range of mechanisms of action, coumarins show significant promise in mitigating inflammation and hold potential for treating inflammatory conditions. This study provides new insights related to the potential of S. caseolaris as a source of natural anti-inflammatory agents, supporting public comprehension regarding the utilization of traditional herbal remedies.
Copper and Lead Contamination in Sediment and Benthic Ecosystems of Sembilang National Park’s Coastal Region, South Sumatra Rozirwan; Ananta, Dio Alif; Khotimah, Nadila Nur; Putri, Wike Ayu Eka; Fauziyah; Dianysah, Gusti; Siregar, Yusni Ikhwan; Ramses; Isnaini; Melki; Aryawati, Riris; Agustriani, Fitri; Nugroho, Redho Yoga
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.866-876

Abstract

Littoral zone often face environmental pressure due to anthropogenic activities, which can impact the quality of their ecosystem. This study analyzes the concentrations of copper (Cu) and lead (Pb) in sediments and benthic (Anadara granosa and Cerithidea cingulata). Sampling procedures were implemented during September 2022 across the aquatic habitats of Sembilang National Park, in South Sumatra Province, using the purposive sampling method. Sediment grain size and substrate type were analyzed using Shepard’s triangle. Metal detection using a spectrophotometric method based on atomic absorption. The results showed that the sediment fraction mostly consisted of clay, ranging from 92.03% to 94%. Cu concentrations in the sediment ranged from 5.01±0.017 to 5.71±0 mg/kg, while Pb concentrations ranged from 10.5±0.195 to 11.51±0.395 mg/kg. In the benthic, Cu concentrations ranged from 0.0037±0.00005773 to 0.0147±0.00000346 mg/kg, and Pb concentrations ranged from 0.0001±0.000227 to 0.005±0 mg/kg. According to the statistical evaluation testing via independent sample t-test showed that heavy metals differed significantly (p <0.05) between sediment and benthic compartments. These results show that the environmental quality in Sembilang National Park is still comparatively well maintained and within current quality requirements, despite certain activities that have the potential to pollute the environment. To guarantee the long-term viability of this area, it is advised that environmental quality be frequently monitored as a mitigation action.
Environmental risk assessment of Pb, Cu, Zn, and Cd concentrations accumulated in selected mangrove roots and surrounding their sediment ROZIRWAN ROZIRWAN; NADILA NUR KHOTIMAH; WIKE AYU EKA PUTRI; FAUZIYAH FAUZIYAH; RIRIS ARYAWATI; NURHAYATI DAMIRI; ISNAINI ISNAINI; REDHO YOGA NUGROHO
Biodiversitas Journal of Biological Diversity Vol. 24 No. 12 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d241236

Abstract

Abstract. Rozirwan, Khotimah NN, Putri WAE, Fauziyah, Aryawati R, Damiri N, Isnaini, Nugroho RY. 2023. Environmental risk assessment of Pb, Cu, Zn, and Cd concentrations accumulated in selected mangrove roots and surrounding their sediment. Biodiversitas 24: 6733-6742. Mangroves as the largest coastal ecosystem can accumulate heavy metals from their environment. This study aimed to evaluate the environmental risk associated with heavy metal pollution accumulated in the roots of mangroves and the surrounding sediments. The mangrove roots consisted of three species Sonneratia caseolaris, Rhizopora apiculata, and Xylocarpus granatum, collected from three observation stations within the Payung Island mangrove ecosystem in South Sumatra, Indonesia. The concentrations of heavy metals were determined using atomic absorption spectrometry. Statistical analysis employed one-way Analysis of Variance (ANOVA). At the same time, ecological risk assessment utilized the Bioconcentration Factor (BCF), Geoaccumulation Index (Igeo), Contamination factor (Cf), and Pollution Load Index (PLI). The highest sediment concentrations of heavy metals at station 3 were 12.786±0.26 mg/kg for Pb, 10.413±0.011 mg/kg for Cu, 42.752±0.053 mg/kg for Zn, and Cd was not detected. In mangrove roots, the highest concentrations were found in S. caseolaris, with 2.596±0.002 mg/kg for Pb and 11.881±0.015 mg/kg for Zn, while X. granatum exhibited 8.850±0.011 mg/kg for Cu and 0.160±0.020 mg/kg for Cd. BCF values &lt;1 were categorized as exclusion, Igeo&lt;0 indicated non-contamination, Cf&lt;1 signified low pollution, and PLI&lt;0 denoted an unpolluted status. Based on the results, the quality of the mangrove ecosystems affected by heavy metal pollution is currently considered safe regarding environmental risk assessment.
Enhancement of ovarian maturation in bronze featherback Notopterus notopterus through pregnant mare serum gonadotropin for sustainable aquaculture and conservation MUSLIM MUSLIM; ELIKA PITRIANI; SELLY OKTARINA; NADILA NUR KHOTIMAH
Biodiversitas Journal of Biological Diversity Vol. 27 No. 1 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270121

Abstract

Abstract. Muslim, Pitriani E, Oktarina S, Khotimah NN. 2026. Enhancement of ovarian maturation in bronze featherback Notopterus notopterus through pregnant mare serum gonadotropin for sustainable aquaculture and conservation. Biodiversitas 27 (1): d270121. https://doi.org/10.13057/biodiv/d270121. The bronze featherback Notopterus notopterus is a freshwater fish of high economic value whose population is declining due to overfishing and habitat destruction. This study evaluated the effectiveness of pregnant mare serum gonadotropin in inducing ovarian maturation in N. notopterus, addressing reproductive challenges that hinder its domestication and conservation. A total of 45 female fish (mean weight 50-55 g and total length 18-20 cm) at the second stage of ovarian maturity were injected intramuscularly with pregnant mare serum gonadotropin doses of 0, 1.0, 1.25, and 1.5 mL kg⁻¹ body weight. Observations were conducted for nine days with parameters including Ovi-Somatic Index (IOS), Hepato-Somatic Index (IHS), oocyte diameter, fecundity, cholesterol levels, and ovarian maturity level. The results indicated that pregnant mare serum gonadotropin significantly influenced IOS, oocyte diameter, fecundity, and ovarian maturity level (ANOVA, P&lt;0.05; post-hoc LSD test), whereas it showed no significant effect on IHS and cholesterol levels (p&gt;0.05). A dose of 1.5 mL kg⁻¹ produced the highest IOS, oocyte diameter, and fecundity values (378 eggs), as well as ovarian maturity levels up to stage V (mature). This study provides that hormonal induction using pregnant mare serum gonadotropin effectively stimulates ovarian development in N. notopterus, offering a biological solution to reproductive challenges that limit domestication success. By enhancing spawning success rates, reducing dependence on wild-caught broodstock, and enabling the establishment of captive breeding protocols, this hormonal induction technique offers practical tools for ex-situ conservation and directly contributes to biodiversity protection by supporting the long-term sustainability of N. notopterus populations. These findings show that aquaculture-based reproductive management supports SDG 14 by promoting sustainable use of aquatic resources. Hormonal induction serves as a bridge between reproductive biotechnology and conservation, helping restore freshwater biodiversity through domestication-based recovery strategies.
Co-Authors Ade Siswanto Ananta, Dio Alif Aning Puji Saputri Anna Ida Sunaryo Purwiyanto Che Abd Rahim Mohamed Dianysah, Gusti ELIKA PITRIANI FAUZIYAH Fauziyah FAUZIYAH FAUZIYAH Fauziyah Fauziyah Fitri Agustriani Hartoni Isnaini ISNAINI ISNAINI Melki Muhtadi Muhtadi MUSLIM MUSLIM NURHAYATI DAMIRI Ramses REDHO YOGA NUGROHO Redho Yoga Nugroho Rezi Apri RIRIS ARYAWATI Riris Aryawati Rozirwan . ROZIRWAN ROZIRWAN SELLY OKTARINA Tengku Zia Ulqodry WIKE AYU EKA PUTRI Wike Ayu Eka Putri Wike Ayu Eka Putri Yusni Ikhwan Siregar