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All Journal Indonesian Journal of Pharmaceutical Research Jurnal Medika Nusantara
Marisa Tamara Sari
Universitas 17 Agustus 1945 Jakarta
Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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Determination of % Caffeine Levels in Packed Black Haidar Dwi Putranto; Riong Seulina Panjaitan; Violetta Djohansah; Liany Carolina Rambulika; Marisa Tamara Sari
Indonesian Journal of Pharmaceutical Research Vol 2, No 1 (2022): Indo J Pharm Res 2022 2(1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v2i1.3479

Abstract

Kafein diketahui memiliki efek farmakologi yaitu sebagai stimulan sistem saraf pusat dan metabolisme selain itu dapat digunakan untuk pengobatan dalam mengurangi kelelahan fisik dan juga dapat meningkatkan tingkat kewaspadaan. Penelitian ini bertujuan untuk mengetahui kadar kafein dalam 25 gram (10 kantong teh celup) dari 3 kemasan yang berbeda. Teh hitam di ekstraksi dengan metode maserasi menggunakan pelarut air. Di gunakan 3 merek teh hitam celup antara lain Teh Hitam Merek A memiliki massa kafein 24 mg dengan % kadar kafein adalah 0,096%, Teh Hitam Merek B memiliki massa kafein 22,5 mg dengan % kadar kafein adalah 0,09% dan Teh Hitam Merek C memiliki massa kafein 24,6 mg dengan % kadar kafein adalah 0,0984%. Menurut SNI 01-7152-2006 batas maksimum mengkonsumsi kafein baik secara langsung maupun tercampur di dalam makanan atau minuman adalah 150 mg/hari atau 50 mg/sajian.
CAFFEIN LEVELS IN GREEN TEA BAGS Riong Seulina Panjaitan; Risty Setyati Ashari; Saiful Anwar; Nurul Asfia; Silvy Widya Rahmi; Marisa Tamara Sari
Indonesian Journal of Pharmaceutical Research Vol 2, No 1 (2022): Indo J Pharm Res 2022 2(1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v2i1.3513

Abstract

Caffeine is known to have a pharmacological effect, namely as a stimulant for the central nervous system and metabolism, besides that it can be used for treatment in reducing physical overload and can also increase alertness levels. This study aims to determine the caffeine content in 25 grams (10 bags of green tea bags) from 3 different packaging brands. Extraction of caffeine from green tea bags was carried out using the maceration method, and recrystallization of the caffeine content with hot acetone, then titration of ligroin(n-hexane) to obtain pure crystals. The caffeine obtained from 3 samples, namely sample A obtained 0.099% sample B obtained 0.088% sample C obtained 0.094 % and all samples in the safe category did not exceed SNI is 50 mg/serving.
Systematic Review of Cost-Effectiveness Of Sglt2 Inhibitors Compared With Other Glucose-Lowering Therapies in Type 2 Diabetes Mellitus Yelfi Anwar; Luqyana Salsabila; Alfian Nur Ilmi; Glori Destasya; Marisa Tamara Sari; Nur Chyntia A. M. T; Kratiwi Setiawan Lestari
Jurnal Medika Nusantara Vol. 4 No. 4 (2026): : Jurnal Medika Nusantara
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v4i4.2876

Abstract

Type 2 diabetes mellitus imposes substantial clinical and economic burdens, necessitating treatment strategies that balance clinical effectiveness and economic value. This study aimed to synthesize evidence regarding the cost-effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT2i) compared with other glucose-lowering therapies. A systematic literature review was conducted following the PRISMA 2020 guidelines, using Scopus as the primary database. Of the 243 records identified, 81 articles underwent further assessment, and 35 studies met the inclusion criteria. The findings indicated that SGLT2i were generally cost-effective, particularly compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, and standard or conventional care. However, comparisons with glucagon-like peptide-1 receptor agonists (GLP-1 RAs), metformin, and thiazolidinediones produced heterogeneous results, while direct comparative evidence against insulin remained limited. Differences in cost-effectiveness outcomes were influenced by economic modeling approaches, analytical time horizons, discount rates, evaluation perspectives, medication prices, willingness-to-pay thresholds, patient risk profiles, treatment pathways, and healthcare system characteristics. These findings suggest that SGLT2i offer substantial economic value in managing type 2 diabetes mellitus, although their relative cost-effectiveness varies across comparators and decision-making contexts. Future economic evaluations should incorporate locally relevant costs, long-term clinical outcomes, and healthcare system characteristics to support evidence-based treatment decisions and optimize resource allocation in diabetes care.
Co-Authors Alfian Nur Ilmi Anwar, Yelfi Glori Destasya Haidar Dwi Putranto Kratiwi Setiawan Lestari Liany Carolina Rambulika Luqyana Salsabila Nur Chyntia A. M. T Nurul Asfia Panjaitan, Riong Seulina Risty Setyati Ashari Saiful Anwar Silvy Widya Rahmi Violetta Djohansah