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All Journal Indonesian Journal of Cancer Chemoprevention Pharmaceutical Sciences and Research (PSR) PubHealth Jurnal Kesehatan Masyarakat Pharmaceutical Journal
Khairunnisa Azani Meilinasary, Khairunnisa Azani
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Other

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Antibiotic Sensitivity in Pseudomonas aeruginosa of DiabeticPatient’s Foot Ulcer Apridamayanti, Pratiwi; Meilinasary, Khairunnisa Azani; Sari, Rafika
Pharmaceutical Sciences and Research Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Diabetes Mellitus (DM) patients are at risk to have the diabetic ulcer. The main reason for DM’s patient with ulcer complication to be treated and healed in hospital is bacterial infection. One of many bacteria that infects diabetic ulcer is Pseudomonas aeruginosa. The effort to treat this infection is by using antibiotic. The use of antibiotic unfortunately, is often found inaccurate causing the microbe resistance to occur. To choose the right antibiotic, it needs to test the antibiotic’s sensitivity towards Pseudomonas aeruginosa. The aim of this study is to determine the sensitivity of antibiotics against Pseudomonas aeruginosa. Sample used was taken from diabetic ulcers swab with grade III and IV Wagner. The identification of bacteria was managed using the biochemical test and Gram staining test. Antibiotic sensitivity was determined by Kirby Bauer method. Antibiotics that were found still sensitive towards Pseudomonas aeruginosa included ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime, whereas cefadroxil and amikacin were resistant. Antibiotics that can be used for Pseudomonas aeruginosa in diabetic foot ulcer patients are ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime.
Efektivitas Edukasi Gaya Hidup Sehat terhadap Pengelolaan Kadar Kolesterol pada Penderita Hiperkolesterolemia: Studi Literatur Agata, Cornelia; MEILINASARY, KHAIRUNNISA AZANI
Pharmaceutical Journal Vol. 1 No. 1 (2025): February Editions
Publisher : Program Studi Farmasi Sekolah Tinggi Ilmu Kesehatan Sambas

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Abstract

Hiperkolesterolemia merupakan salah satu faktor risiko utama penyakit kardiovaskular (CVD), yang memerlukan pengelolaan efektif untuk mengurangi risiko penyakit jantung dan meningkatkan kesehatan secara keseluruhan. Studi ini bertujuan untuk meninjau efektivitas edukasi gaya hidup sehat dalam pengelolaan kadar kolesterol melalui pendekatan studi literatur sistematis. Data diambil dari database ilmiah seperti PubMed dan ScienceDirect dalam rentang publikasi 10 tahun terakhir. Hasil tinjauan menunjukkan bahwa intervensi non-farmakologis, termasuk wawancara motivasional, diet, dan aktivitas fisik, secara signifikan berdampak positif pada penurunan kadar kolesterol lipoprotein densitas rendah (LDL-C) dan peningkatan kepatuhan terhadap pengobatan. Program edukasi yang terstruktur, baik oleh perawat maupun ahli diet, terbukti meningkatkan kebiasaan hidup sehat dan mengurangi faktor risiko kardiovaskular tanpa efek samping yang merugikan. Selain itu, modifikasi gaya hidup seperti penyesuaian diet, peningkatan aktivitas fisik, dan penghentian merokok direkomendasikan sebagai langkah lini pertama dalam manajemen hiperkolesterolemia. Temuan ini mendukung pentingnya pendekatan preventif dan pengelolaan jangka panjang melalui intervensi edukasi dan gaya hidup yang dipersonalisasi.
Dampak Peredaran Obat Ilegal Lintas Negara terhadap Kesehatan Masyarakat Global dan Strategi Penanggulangannya Meilinasary, Khairunnisa Azani; Malindea, Chinda; Athirah; Andriani, Yeni; Shofiaa, Lulu Dhiya
Pharmaceutical Journal Vol. 1 No. 2 (2025): August Editions
Publisher : Program Studi Farmasi Sekolah Tinggi Ilmu Kesehatan Sambas

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The World Health Organization (WHO) established an international organisation  known as the Member State Mechanism, aimed at combating the circulation of falsified  and substandard medicines to ensure that the global population has access to high-quality,  safe, and affordable medicines. Indonesia, as one of the member countries, has  consistently taken an active role in this forum. However, in reality, both Indonesia and  other countries around the world have not yet succeeded in overcoming this issue. The  widespread circulation of falsified and substandard medicines poses significant risks to  global public health. The objective of this study is to examine the impact of falsified and  substandard medicines on global public health and to analyze the efforts undertaken by  Indonesia and other countries to handle the proliferation of these medicines. This article  employs a qualitative research method with an explanatory approach. The concepts of  international cooperation and international regimes are used to explain the outcomes of  collaboration within the Member State Mechanism and the role of WHO as an  international organization in supporting efforts to combat counterfeit medicines. The  result of this study is to illustrate the negative impacts caused by the circulation of  falsified and substandard medicines, as well as the challenges faced by Indonesia and  other countries in addressing the issue. These challenges stem from two main sources:  external factors related to international cooperation, and internal factors stemming from  domestic conditions. 
Selectivity Index of Alpinia galanga Extract and 1’-Acetoxychavicol Acetate on Cancer Cell Lines Da'i, Muhammad; Meilinasary, Khairunnisa Azani; Suhendi, Andi; Haryanti, Sari
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp95-100

Abstract

Previous research stated that galangal (Alpinia galanga) extract has a potential as cytotoxic agent with active compound of 1’-Acetoxychavicol Acetate (ACA). The objective of this study was to determine the selectivity of ethanol extract, ethyl acetate fraction, and methanol fraction of of galangal, and ACA on cancer cell lines. Cytotoxic activity was carried out using the MTT method on T47D breast cancer, WiDr colon cancer, HeLa cervical cancer, and Vero normal cell lines. The results showed that galangal ethanol extract and its fractions had selectivity index equal to or less than 2 on cancer cells. Meanwhile, ACA had selectivity index more than 3 on T47D cell and HeLa cell. ACA showed a strong cytotoxic activity against cancer cells T47D, HeLa, and WiDr with IC50 values of 3.14, 7.26, and 12.49 μg/ml, respectively. Based on data, it could be concluded that ACA was the most selective to inhibit T47D cell with a selectivity index of 6.6.Keywords: 1’-Acetoxychavicol acetate, galangal (Alpinia galanga), selective index, cytotoxic
Gambaran Penggunaan Obat Nonsteroidal Anti-Inflamatory Drugs (NSAID) pada Pasien Osteoarthtritis (OA) Geriatri Anggi, Anggi; Aqsa, Kathina Deswi; Meilinasary, Khairunnisa Azani
PubHealth Jurnal Kesehatan Masyarakat Vol. 4 No. 2 (2025): Edisi Oktober
Publisher : Ilmu Bersama Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56211/pubhealth.v4i2.1199

Abstract

Nyeri kronis adalah gejala umum dari osteoartritis (OA), kondisi sendi degeneratif yang sebagian besar menyerang lansia.  Pengobatan lini pertama untuk pereda nyeri OA adalah NSAID.  Tujuan penelitian ini adalah untuk menilai efektivitas obat antiinflamasi nonsteroid (OAINS) dalam mengobati pasien OA lanjut usia di poliklinik RSUD Dr. Abdul Aziz Singkawang menggunakan Wong-Baker Faces Scale (WBFS).  Sembilan puluh dari 115 pasien di masyarakat menjadi subjek penelitian observasional retrospektif ini. Analisis data dilakukan menggunakan uji Wilcoxon. Hasil menunjukkan bahwa mayoritas pasien adalah perempuan (67%) dan NSAID yang paling banyak digunakan adalah Etoricoxib (67%). Namun, NSAID yang paling efektif dalam menurunkan nyeri adalah Meloxicam dengan rata-rata penurunan skor WBFS sebesar 2,18 (p<0.05) dan Etorixocib kurang efektif dalam menurunkan nyeri dengan rata-rata penurunan skor WBFS sebesar 1,83. Penelitian ini menyimpulkan bahwa Meloxicam lebih efektif dibandingkan NSAID lainnya seperti Etoricoxib dalam meredakan nyeri OA pada pasien geriatri.
Co-Authors Agata, Cornelia Andi Suhendi Anggi, Anggi Aqsa, Kathina Deswi Athirah Da'i, Muhammad Malindea, Chinda Pratiwi Apridamayanti, Pratiwi Rafika Sari Sari Haryanti Shofiaa, Lulu Dhiya Yeni Andriani, Yeni