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MIKROPENIS PADA ANAK DENGAN BERAT BADAN NORMAL Peter Gunawan Tandean
Denta Journal Kedokteran Gigi Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

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Latar Belakang: Mikropenis adalah diagnosis medis yang seringkali salah untuk ditegakkan. Mikropenis dapat terjadi sebagai kelainan tunggal dengan sendirinya maupun sebagai salah satu gejala dari suatu penyakit. Tujuan: Laporan kasus ini diperlukan untuk menegakkan diagnosis penyebab mikropenis pada anak laki-laki dengan berat badan normal. Metode: Metode yang digunakan adalah dengan melakukan penegakkan diagnosis secara lege artists berdasarkan referensi ilmiah mutakhir. Hasil: Laporan kasus ini memberikan hasil mengenai penegakkan diagnosis penyebab mikropenis pada anak laki-laki dengan berat badan normal. Kesimpulan: Kesimpulan dari laporan kasus ini adalah didapatkannya penyebab dari mikropenis dari anak laki-laki dengan berat badan normal.

MIKROPENIS PADA ANAK DENGAN BERAT BADAN NORMAL Peter Gunawan Tandean
Oceana Biomedicina Journal Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i2.16

Latar Belakang: Mikropenis adalah diagnosis medis yang seringkali salah untuk ditegakkan. Mikropenis dapat terjadi sebagai kelainan tunggal dengan sendirinya maupun sebagai salah satu gejala dari suatu penyakit. Tujuan: Laporan kasus ini diperlukan untuk menegakkan diagnosis penyebab mikropenis pada anak laki-laki dengan berat badan normal. Metode: Metode yang digunakan adalah dengan melakukan penegakkan diagnosis secara lege artists berdasarkan referensi ilmiah mutakhir. Hasil: Laporan kasus ini memberikan hasil mengenai penegakkan diagnosis penyebab mikropenis pada anak laki-laki dengan berat badan normal. Kesimpulan: Kesimpulan dari laporan kasus ini adalah didapatkannya penyebab dari mikropenis dari anak laki-laki dengan berat badan normal.

Pengaruh Pemberian Ekstrak Kencur (Kaempferia galanga L.) terhadap Peningkatan Zona Hambat Pertumbuhan Bakteri Staphylococcus aureus Linda Putri Utami; Peter Gunawan Tandean; Liliawanti Liliawanti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 2 (2020): SEPTEMBER 2020
Publisher : Universitas Wijaya Kusuma Surabaya

The prevalence of infectious diseases in Indonesia is still relatively high, for example Infection caused by Staphylococcus aureus. Indonesia has many traditional plants that can be used for herbal treatments containing tannins, flavonoids, and essential oils which have relatively high antibacterial activity by forming inhibitory zones in the Staphylococcus aureus bacteria which are the cause of skin infections food poisoning to systemic infections. Thereforekencur can be used as an alternative medicine. This study was intented to determine the effect of giving kencur extract (Kaempferia galanga L.) In inhibiting the growth of Staphylococcus aureus bacteria. This study was experimental laboratory used plate diffusion method of “Postest Ony Control Group Design” design. There were 7 groups, 5 treatment groups and 2 control groups. The concentration of treatment group was 100%, 50%, 25%, 12,5%, 6,25% while for positive control using amoxicillin 25μg and aquadest as negative control. The bacterial used were Staphylococcus aureus. The results showed that kencur extract (Kaempferia galanga L.) had an antibacterial effect in inhibiting the growth of Staphylococcus aureus bacteria.With a value of p = 0.001 or p <α. kencur extract (Kaempferia galanga L.) has an antibacterial effect in inhibiting the growth of Staphylococcus aureus bacteria.

Effectiveness of Dexamethasone as a Preventive for PONV (Post Operative Nausea and Vomiting) Rachma Pramita, Andhina; Pandu Harijono; Peter Gunawan Tandean
Majalah Anestesia & Critical Care Vol 41 No 2 (2023): Juni
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v41i2.311

Postoperative nausea and vomiting (PONV) is the second most common side effect on general anesthesia. This can be classified as a complex problem that caused by patient factors, anesthesia technique and surgery factors. PONV is a physiological event that associated with various neurophysological in both central and peripheral nervous system. Dexamethasone reported can decreased PONV and with the combination of antiemetic. The instrument used in this study are data taken from journal / articles indexed at least 10 internationally, such as Scimago, Scopus, Thompson Reuters. The journals that were used related to the effectivness of dexamethasone in preventing PONV published from 2017 to 2022. This research is a descriptive study using the literature review method. Dexamethasone has shown to be effective in preventing PONV at the dose of 4 mg IV, 5 mg IV and 8 mg IV.Dexamethasone combined with other drugs especially antagonist 5 HT3 is known more effective rather than single dose of dexamethasone. The common side effect that usually occurs are dizzy, headache, and low urine output. Although dexamethasone were proven to decrease the incident of PONV, but there are other drugs option that can be more effective than dexamethasone such as group of drugs from antagonist 5 HT3.

HUBUNGAN KEPATUHAN MENGONSUMSI TABLET FE DENGAN ANEMIA DALAM KEHAMILAN DI RS NINDHITA, KABUPATEN SAMPANG, PERIODE AGUSTUS-OKTOBER 2022 Brilliandinda Ichsasqia Sidqi Auliayahya; Ronald Pratama Adiwinoto; Peter Gunawan Tandean; Liliawanti
Surabaya Biomedical Journal Vol 2 No 3 (2023): Mei
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i3.110

Anemia pada ibu hamil merupakan suatu keadaan ketika jumlah kadar atau konsentrasi hemoglobin (Hb) pada ibu menurun yaitu menempati nilai kurang dari 11 gr/dl. Anemia pada ibu hamil sampai saat ini masih menjadi masalah kesehatan di Indonesia karena berkaitan erat dengan nilai-nilai kesejahteraan sosial dan ekonomi masyarakat di Indonesia. Menurut WHO, angka kejadian anemia mencapai prosentase sebesar 20% hingga 89%. Di kabupaten Sampang, prevalensi anemia pada ibu hamil juga menduduki angka yang cukup tinggi yang dapat dilihat dari tingginya tingkat pemberian suplementasi Fe pada ibu hamil pada tahun 2019 yaitu sebesar 112%. Jenis penelitian adalah analitik observasional dengan memberikan kuisioner sebagai data primer kepada responden ibu hamil. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat pengetahuan dengan kategori baik yaitu berjumlah 52 responden (52%), berdasarkan tingkat kepatuhan didapatkan sebagian besar responden memiliki kategori kurang patuh yaitu berjumlah 78 responden (78%), dan berdasarkan kadar hemoglobin didapatkan sebagian besar responden dikategorikan sebagai anemia derajat 1 yaitu 49 responden (49%). Jadi, dapat disimpulkan bahwa hubungan antara tingkat pengetahuan dengan kadar hemoglobin didapatkan p=0,169, artinya tidak ada hubungan. Hubungan antara tingkat kepatuhan dengan kadar hemoglobin didapatkan p=0,155, artinya tidak ada hubungan. Hubungan antara tingkat pengetahuan dengan tingkat kepatuhan didapatkan p=0,393, artinya tidak ada hubungan.

Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin

Pengaruh Pandemi COVID-19 Terhadap Nilai Biologi Mahasiswa Semester Satu Fakultas Kedokteran Universitas Hang Tuah LILIAWANTI, LILIAWANTI; GUNAWAN TANDEAN, PETER; ARUNDNI, PRIMA
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.813

The COVID-19 pandemic has also had a significant impact on the education sector. The policy requires all activities carried out outside the home, including teaching and learning activities, to be stopped until the COVID-19 pandemic subsides. The change from face-to-face to online learning systems brings a number of problems that are challenges for the world of education. To determine the effect of the COVID-19 pandemic on the biology grades of first semester students of the UHT Faculty of Medicine in the 2017/2018, 2018/2019 and 2020/2021, 2021/2022 academic years. This study will use the cross-sectional group design method. This study used all first semester students of the Faculty of Medicine, Hang Tuah University, batch 2017/2018, 2018/2019 and 2020/2021, 2021/2022. RESULTS: In CBT, the results of the T test were obtained with insignificant results for the Biology scores of first semester students of the UHT Medical Faculty during the non-pandemic period of 2017/2018 with the pandemic period of 2020/2021 with p = 0.0085 (p ˂ 0.05). In SOOCA with the T test, the results were obtained with insignificant results for the Biology scores of first semester students of the UHT Medical Faculty during the non-pandemic period of 2017/2018 with the pandemic period of 2020/2021 with p = 0.078 (p ˂ 0.05). and Final Value with T-test obtained insignificant results of the Biology value of first semester FK UHT students during the non-pandemic period 2017/2018 with the pandemic period 2020/2021 with p = 0.054 (p ˂ 0.05). In CBT, the results of the T-test were obtained with significant results of the Biology value of first semester FK UHT students during the non-pandemic period 2017/2018 with the pandemic period 2021/2022 and 2021/2022 with p = 0.000 (p ˂ 0.05). ). In SOOCA and Final Value with T-test, significant results were obtained of the Biology value of first semester FK UHT students during the non-pandemic period 2018/2019 with the pandemic period 2021/2022 with p = 0.000 (p ˂ 0.05). In CBT, the results of the one-way ANOVA test were obtained with significant results for the Biology scores of first-semester FK UHT students during the 2018/2019 non-pandemic period with the 2020/2021 and 2021/2022 pandemic periods with p = 0.000 (p ˂ 0.05). In SOOCA and Final Scores with the T-test, significant results were obtained for the Biology scores of first-semester FK UHT students during the 2018/2019 non-pandemic period with the 2020/2021 and 2021/2022 pandemic periods with p = 0.000 (p ˂ 0.05). In the pre-pandemic academic year 2017/2018 and the pandemic academic year 2020/2021, there was a difference in the average CBT, SOOCA, and Final Scores for biology of first-semester FK UHT students. In the academic year before the pandemic 2017/2018 and the academic year during the pandemic 2021/2022, there was a difference in the average CBT, SOOCA, and Final Biology Scores of first-semester FK UHT students. In the academic year before the pandemic 2018/2019 and the academic years during the pandemic 2020/2021 and 2021/2022, there was a difference in the average CBT, SOOCA, and Final Biology Scores of first-semester FK UHT students. Keywords:

HUBUNGAN KEPATUHAN MENGONSUMSI TABLET FE DENGAN ANEMIA DALAM KEHAMILAN DI RS NINDHITA, KABUPATEN SAMPANG, PERIODE AGUSTUS-OKTOBER 2022 Brilliandinda Ichsasqia Sidqi Auliayahya; Ronald Pratama Adiwinoto; Peter Gunawan Tandean; Liliawanti
Surabaya Biomedical Journal Vol. 2 No. 3 (2023): May
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i3.110

Anemia pada ibu hamil merupakan suatu keadaan ketika jumlah kadar atau konsentrasi hemoglobin (Hb) pada ibu menurun yaitu menempati nilai kurang dari 11 gr/dl. Anemia pada ibu hamil sampai saat ini masih menjadi masalah kesehatan di Indonesia karena berkaitan erat dengan nilai-nilai kesejahteraan sosial dan ekonomi masyarakat di Indonesia. Menurut WHO, angka kejadian anemia mencapai prosentase sebesar 20% hingga 89%. Di kabupaten Sampang, prevalensi anemia pada ibu hamil juga menduduki angka yang cukup tinggi yang dapat dilihat dari tingginya tingkat pemberian suplementasi Fe pada ibu hamil pada tahun 2019 yaitu sebesar 112%. Jenis penelitian adalah analitik observasional dengan memberikan kuisioner sebagai data primer kepada responden ibu hamil. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat pengetahuan dengan kategori baik yaitu berjumlah 52 responden (52%), berdasarkan tingkat kepatuhan didapatkan sebagian besar responden memiliki kategori kurang patuh yaitu berjumlah 78 responden (78%), dan berdasarkan kadar hemoglobin didapatkan sebagian besar responden dikategorikan sebagai anemia derajat 1 yaitu 49 responden (49%). Jadi, dapat disimpulkan bahwa hubungan antara tingkat pengetahuan dengan kadar hemoglobin didapatkan p=0,169, artinya tidak ada hubungan. Hubungan antara tingkat kepatuhan dengan kadar hemoglobin didapatkan p=0,155, artinya tidak ada hubungan. Hubungan antara tingkat pengetahuan dengan tingkat kepatuhan didapatkan p=0,393, artinya tidak ada hubungan.

The Relationship Between HbA1c Levels and the Severity of Erectile Dysfunction in Type 2 Diabetes Mellitus Patients at the Andrology Clinic of Dr. Ramelan General Hospital, Surabaya Adinda Rifqi Faradila Tsany; Peter Gunawan Tandean; Prawesty Diah Utami; Jakaria Zansen
Indonesian Andrology and Biomedical Journal Vol. 7 No. 1 (2026): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v7i1.87049

Background: Type 2 diabetes mellitus (T2DM) can cause erectile dysfunction (ED) complications in the long term, the severity of which is considered important to correlate with blood glucose control, as measured by HbA1c levels.Objective: To determine the relationship between HbA1c levels and the severity of erectile dysfunction in T2DM patients at the Andrology Clinic of Dr. Ramelan General Hospital, Surabaya. Methods: Observational analysis using a cross-sectional approach, utilizing secondary medical record data from 25 patients during the period 2019–2024, in which the severity of ED was measured using the Erection Hardness Score (EHS) and analyzed using the Spearman's rank correlation test.Results: A total of 64% of patients were in the diagnostic range for diabetes, and there was a significant relationship between HbA1c levels and the severity of ED, as indicated by a p-value of 0.043 and a correlation coefficient of r=0.407 (moderate positive correlation).Conclusion: There is a relationship between HbA1c levels and the severity of erectile dysfunction, where a moderate positive correlation indicates that higher HbA1c levels are associated with lower severity or improvement of erectile dysfunction. The moderate strength of the correlation suggests that HbA1c is not the only factor influencing the occurrence of erectile dysfunction.

Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin

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