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Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats Tamam Jauhar; Bilqis Inayatillah; Maftuchah Rochmanti; Achmad Basori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14461

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which canlead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterizedby decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti-hyperglycemia and antioxidant effects because of its large amount of polyphenoliccomponents . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascenaby measuring the lipid profile using various doses. Methods: This research is experimental study withrandomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groupswere Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2(500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL(11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBWafter 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemicdrugs.

Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets Bilqis Inayatillah; Tamam Jauhar; Gondo Mastutik; Alphania Rahniayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14679

Background: Diabetes mellitus is a chronic disorder caused by elevated levels of high blood glucose(hyperglycemia). This chronic hyperglycemia causes ROS to accumulate and oxidative stress to increase.Rosa damascena is a plant that contains high levels of antioxidants and polyphenols, but this is not widelyknown to the public. Purpose: The aim of this study is to understand the hypoglycemic effects from Rosadamascena on blood glucose levels and diameter of Langerhans pancreatic islets. Method: Thirty Wistaralbino rats (200-225gr) were divided into 6 groups. Group 1 was a normal control (KN), group 2 washyperglycemic (KD), group 3 was metformin 250 mg/kg BW (KM), group 4 was treatment extract 250 mg/kg BW (P1), group 5 was treatment extract 500 mg/kg BW (P2) group 6 was treatment extract 1000 mg/kg BW (P3). All animals in the group were injected with STZ 50 mg/kg BW, except for group 1. Result:Data were analyzed statistically using SPSS- 22 software with the Kruskall-Wallis test (p<0.05). The resultshowed that ethanolic extract of Rosa damascena has decreased blood glucose levels in days-14 (382±21,97) with 250 mg/kg BW (P1) compare with another treatment group. In histological observed there areno significant different between group (p>0.05). This is showing that ethanolic extract of Rosa damascenahas inability to repaired the diameter of Langerhans pancreatic islets. Conclusion: Ethanolic extract of Rosadamascena decreased blood glucose levels but did not repaired the diameter of Langerhans pancreatic islets.

DETEKSI DINI FAKTOR RISIKO DAN EDUKASI KESEHATAN PENYAKIT TIDAK MENULAR PADA MASYARAKAT DUSUN TLOCOR DESA KEDUNGPANDAN KECAMATAN JABON KABUPATEN SIDOARJO Ronald Pratama A.; Riami; Tamam Jauhar; Pramudita Riwanti; Sylvia Rizki; Ersanda Nurma; Astrid Kusuma
Jurnal Pengabdian Masyarakat Pesisir VOLUME 1 NO 2
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v1i2.82

Penyakit Tidak Menular (PTM) masih merupakan masalah kesehatan yang menjadi penyebab tingginya angka kesakitan dan kematian di dunia pada umumnya dan di Indonesia pada khususnya. PTM khususnya hipertensi dan diabetes mellitus seringkali berujung pada komplikasi antara lain penyakit jantung, gagal ginjal dan menjadi penyumbang yang signifikan beban pembiayaan kesehatan di Indonesia sehingga merupakan suatu hal yang penting untuk mengendalikan faktor-faktor risiko yang memicu terjangkitnya PTM. Pengetahuan akan faktor risiko penyebab timbulnya PTM, dan kesadaran untuk melakukan upaya-upaya pencegahan PTM dengan mengendalikan faktor-faktor risiko tersebut serta rutin memeriksakan kesehatan secara berkala adalah hal yang penting dalam keberhasilan mengendalikan PTM. Masyarakat di Dusun Tlocor, Desa Kedungpandan, Kecamatan Jabon, Kabupaten Sidoarjo merupakan kelompok masyarakat yang terdampak akibat dari semburan lumpur Lapindo menyebabkan tempat pemukimannya direlokasikan. Fasilitas pelayanan kesehatan yang relatif jauh dari tempat tinggal, ditambah dengan kurangnya kesadaran dan pengetahuan masyarakat tersebut akan PTM dan upaya pengendaliannya ditunjukkan dengan tingginya kasus hipertensi dan diabetes mellitus sehingga dilaksanakan kegiatan pengabdian masyarakat berupa deteksi dini faktor risiko dan edukasi kesehatan pencegahan PTM.

The Hygiene Hypothesis And Covid-19: A Look At The Evidence And New Perspectives Peppy Nawangsasi; Ronald Pratama Adiwinoto; Verna Biutifasari; Tamam Jauhar; Wahyu Prasasti Mutiadesi
ANATOMICA MEDICAL JOURNAL | AMJ Vol 6, No 3 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v6i3.15787

The hygiene hypothesis postulates that early-life exposure to infectious agents and microbes has a significant impact on the maturation of the immune system, providing protection against allergies and autoimmune diseases.Recent studies have challenged the hypothesis's universality, suggesting that it might only be relevant in developed countries. New perspectives on the hygiene hypothesis propose a multifaceted theory that considers not only microbial exposure but also factors such as diet, stress, and the environment. The role of specific immune cells in the development of allergies and autoimmune diseases has been emphasized, and innovative therapies based on manipulation of immune cells have been proposed. The importance of reconciling the hygiene hypothesis with recent insights into the human microbiome and the importance of maintaining a balance between hygiene and microbial exposure is also emphasized. Lastly, the article delves into the hygiene hypothesis, investigates the connection between gut microbiota dysbiosis and the development of allergies and autoimmune diseases, and examines the influence of COVID-19 on both gut microbiota and immune function.Keywords: allergies and autoimmune diseases, gut microbiome dysbiosis

Karakteristik Pasien Stroke Di Klinik Rehabilitasi Medik Rspal Dr. Ramelan Surabaya Periode Januari – Juni 2024 Febrian, Amellia Ika; Jauhar, Tamam; Wijayaningrum, Lena; Tjahjono, Varidianto Yudo
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 3 (2025): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v5i3.271

Stroke adalah kelainan neurologi yang menjadi faktor penyebab kematian terbanyak kedua di dunia. Penderita stroke umumnya berusia diatas 50 tahun dan banyak yang berasal dari negara berkembang. Stroke bisa terjadi karena banyak faktor, seperti penyakit penyerta, pola hidup buruk, lingkungan yang kurang sehat, dan kurangnya aktivitas fisik. Meskipun stroke banyak terjadi di usia lanjut, namun faktor risiko tersebut banyak didapatkan ketika usia muda yang dapat meningkatkan risiko stroke di usia mendatang. Penelitian ini bertujuan untuk mengetahui karakteristik pasien stroke di klinik Rehabilitasi Medik RSPAL dr. Ramelan Surabaya periode Januari – Juni 2024. Metode penelitian yang digunakan adalah deskriptif dengan pengambilan sampel menggunakan metode total sampling. Populasi penelitian adalah seluruh pasien stroke yang memiliki rekam medis lengkap. Data yang dilihat antara lain usia, jenis kelamin, penyakit penyerta berupa hipertensi dan diabetes mellitus. Berdasarkan data yang diperoleh dari rekam medis didapatkan 70 sampel dengan variabel penelitian hipertensi, diabetes mellitus, usia, dan jenis kelamin. Distribusi pasien stroke dengan faktor risiko hipertensi berjumlah 53 orang. Distribusi pasien stroke dengan faktor risiko diabetes mellitus berjumlah 24 orang. Distribusi pasien stroke dengan faktor usia mayoritas termasuk dalam usia ≥45 tahun sebanyak 66 orang. Distribusi pasien stroke dengan faktor risiko jenis kelamin mayoritas pada laki-laki sebanyak 47 orang. Kesimpulan penelitian ini yaitu faktor risiko yang mendominasi kejadian stroke pada pasien stroke di Klinik Rehabilitasi Medik RSPAL dr. Ramelan Surabaya periode Januari – Juni 2024 adalah memiliki hipertensi, berjenis kelamin laki-laki, dan berusia ≥45 tahun

Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin

In Silico Bahan Aktif Epigallocatechin Gallate dari Sargassum cristaefolium untuk Menghambat Pembentukan Interleukin 1B pada Sindroma Mata Kering Faiq, Muhammad Nabil; Pasaribu, Irma A.; Jauhar, Tamam; Biutifasari, Verna
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 6 No 3 (2025): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v6i3.528

Dry eye syndrome is a multifactorial condition that disrupts the tear film and ocular surface, causing discomfort, visual disturbances, and damage to the ocular surface. Sargassum cristaefolium, a brown alga found in Indonesia, contains the active compound Epigallocatechin gallate (EGCG), which has anti-inflammatory potential. EGCG can inactivate interleukin-1B signaling, thereby triggering the activation of MMPs that play a role in epithelial barrier degradation and maintaining lubrication of the corneal surface. EGCG also exhibits functions comparable to Cyclosporin A, a drug used for dry eye syndrome. This study aims to determine the performance of EGCG in suppressing interleukin-1B to inhibit the production and activation of MMPs through an in-silico approach. The method involves several stages, namely molecular docking, ADME prediction, and toxicity prediction of the active compound EGCG. EGCG is predicted to have potential equivalent to Cyclosporin A in inhibiting interleukin-1B. EGCG shows advantages such as good distribution in blood plasma, no effect on CYP3A4 enzymes, and no influence on OCT2 substrates. In addition, EGCG has a slower excretion rate, is non-mutagenic, does not cause skin sensitization, and is non-hepatotoxic. Thus, EGCG found in Sargassum cristaefolium may serve as an anti-inflammatory agent and inhibit interleukin-1B protein in dry eye syndrome through in silico mechanisms.

HUBUNGAN POLA KUMAN DAN PEMILIHAN ANTIBIOTIKA DENGAN MORTALITAS PADA ANAK PNEUMONIA BERAT DI PICU RSPAL DR. RAMELAN SURABAYA Onisdia Maria Geslin; Sitti Radhiah; Tamam Jauhar; Angela Puspita
Surabaya Biomedical Journal Vol. 5 No. 3 (2026): May
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/v5i3.194

Latar Belakang: Di PICU anak, pneumonia adalah salah satu penyebab utama morbiditas dan mortalitas. Dalam pengobatan pneumonia berat, identifikasi pola kuman dan pemilihan antibitiotika yang tepat sangat penting, tetapi hubungan antara keduanya dengan mortalitas belum sepenuhnya jelas. Tujuan: Menentukan angka mortalitas, pola kuman, dan hubungan antara pola kuman dan pemilihan antibiotik dengan mortalitas pada pasien anak dengan pneumonia berat yang dirawat di PICU RSPAL dr. Ramelan Surabaya. Metode: Penelitian ini adalah studi observasional analitik dengan desain cross-sectional. dengan data rekam medis dari anak-anak berusia 1 bulan hingga 18 tahun yang dirawat dengan diagnosis pneumonia berat di PICU RSPAL dr. Ramelan Surabaya. Hasil: 20 pasien memenuhi kriteria inklusi. 14 dari mereka, yang merupakan 70% dari total, meninggal, dan 6 dari mereka, yang merupakan 30% dari total, dinyatakan hidup. Bakteri gram negatif adalah penyebar kuman yang paling sering. Sebagai isolat yang paling umum, Klebsiella pneumoniae berada di urutan kedua, diikuti oleh Acinetobacter baumannii, Burkholderia cepacia, Pseudomonas aeruginosa, dan Enterobacter cloacae complex. Menurut analisis statistik, tidak ada hubungan yang signifikan antara pola kuman (p = 0,329) dan pemilihan antibiotika dengan mortalitas (p = 0,792). Kesimpulan: Tidak ada hubungan pola kuman dan pemilihan antibiotika dengan mortalitas pada anak pneumonia berat di PICU RSPAL dr. Ramelan Surabaya.

In Silico Bahan Aktif Epigallocatechin Gallate dari Sargassum cristaefolium untuk Menghambat Pembentukan Interleukin 1B pada Sindroma Mata Kering Muhammad Nabil Faiq; Irma A. Pasaribu; Tamam Jauhar; Verna Biutifasari
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 6 No 3 (2025): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v6i3.528

Dry eye syndrome is a multifactorial condition that disrupts the tear film and ocular surface, causing discomfort, visual disturbances, and damage to the ocular surface. Sargassum cristaefolium, a brown alga found in Indonesia, contains the active compound Epigallocatechin gallate (EGCG), which has anti-inflammatory potential. EGCG can inactivate interleukin-1B signaling, thereby triggering the activation of MMPs that play a role in epithelial barrier degradation and maintaining lubrication of the corneal surface. EGCG also exhibits functions comparable to Cyclosporin A, a drug used for dry eye syndrome. This study aims to determine the performance of EGCG in suppressing interleukin-1B to inhibit the production and activation of MMPs through an in-silico approach. The method involves several stages, namely molecular docking, ADME prediction, and toxicity prediction of the active compound EGCG. EGCG is predicted to have potential equivalent to Cyclosporin A in inhibiting interleukin-1B. EGCG shows advantages such as good distribution in blood plasma, no effect on CYP3A4 enzymes, and no influence on OCT2 substrates. In addition, EGCG has a slower excretion rate, is non-mutagenic, does not cause skin sensitization, and is non-hepatotoxic. Thus, EGCG found in Sargassum cristaefolium may serve as an anti-inflammatory agent and inhibit interleukin-1B protein in dry eye syndrome through in silico mechanisms.

Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin

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