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All Journal Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Indian Journal of Forensic Medicine & Toxicology Hang Tuah Medical Journal JPMP
Tamam Jauhar
Hang Tuah University
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Engineering Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats Tamam Jauhar; Bilqis Inayatillah; Maftuchah Rochmanti; Achmad Basori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14461

Abstract

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which canlead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterizedby decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti-hyperglycemia and antioxidant effects because of its large amount of polyphenoliccomponents . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascenaby measuring the lipid profile using various doses. Methods: This research is experimental study withrandomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groupswere Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2(500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL(11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBWafter 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemicdrugs.
Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets Bilqis Inayatillah; Tamam Jauhar; Gondo Mastutik; Alphania Rahniayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14679

Abstract

Background: Diabetes mellitus is a chronic disorder caused by elevated levels of high blood glucose(hyperglycemia). This chronic hyperglycemia causes ROS to accumulate and oxidative stress to increase.Rosa damascena is a plant that contains high levels of antioxidants and polyphenols, but this is not widelyknown to the public. Purpose: The aim of this study is to understand the hypoglycemic effects from Rosadamascena on blood glucose levels and diameter of Langerhans pancreatic islets. Method: Thirty Wistaralbino rats (200-225gr) were divided into 6 groups. Group 1 was a normal control (KN), group 2 washyperglycemic (KD), group 3 was metformin 250 mg/kg BW (KM), group 4 was treatment extract 250 mg/kg BW (P1), group 5 was treatment extract 500 mg/kg BW (P2) group 6 was treatment extract 1000 mg/kg BW (P3). All animals in the group were injected with STZ 50 mg/kg BW, except for group 1. Result:Data were analyzed statistically using SPSS- 22 software with the Kruskall-Wallis test (p<0.05). The resultshowed that ethanolic extract of Rosa damascena has decreased blood glucose levels in days-14 (382±21,97) with 250 mg/kg BW (P1) compare with another treatment group. In histological observed there areno significant different between group (p>0.05). This is showing that ethanolic extract of Rosa damascenahas inability to repaired the diameter of Langerhans pancreatic islets. Conclusion: Ethanolic extract of Rosadamascena decreased blood glucose levels but did not repaired the diameter of Langerhans pancreatic islets.
DETEKSI DINI FAKTOR RISIKO DAN EDUKASI KESEHATAN PENYAKIT TIDAK MENULAR PADA MASYARAKAT DUSUN TLOCOR DESA KEDUNGPANDAN KECAMATAN JABON KABUPATEN SIDOARJO Ronald Pratama A.; Riami; Tamam Jauhar; Pramudita Riwanti; Sylvia Rizki; Ersanda Nurma; Astrid Kusuma
Jurnal Pengabdian Masyarakat Pesisir VOLUME 1 NO 2
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v1i2.82

Abstract

Penyakit Tidak Menular (PTM) masih merupakan masalah kesehatan yang menjadi penyebab tingginya angka kesakitan dan kematian di dunia pada umumnya dan di Indonesia pada khususnya. PTM khususnya hipertensi dan diabetes mellitus seringkali berujung pada komplikasi antara lain penyakit jantung, gagal ginjal dan menjadi penyumbang yang signifikan beban pembiayaan kesehatan di Indonesia sehingga merupakan suatu hal yang penting untuk mengendalikan faktor-faktor risiko yang memicu terjangkitnya PTM. Pengetahuan akan faktor risiko penyebab timbulnya PTM, dan kesadaran untuk melakukan upaya-upaya pencegahan PTM dengan mengendalikan faktor-faktor risiko tersebut serta rutin memeriksakan kesehatan secara berkala adalah hal yang penting dalam keberhasilan mengendalikan PTM. Masyarakat di Dusun Tlocor, Desa Kedungpandan, Kecamatan Jabon, Kabupaten Sidoarjo merupakan kelompok masyarakat yang terdampak akibat dari semburan lumpur Lapindo menyebabkan tempat pemukimannya direlokasikan. Fasilitas pelayanan kesehatan yang relatif jauh dari tempat tinggal, ditambah dengan kurangnya kesadaran dan pengetahuan masyarakat tersebut akan PTM dan upaya pengendaliannya ditunjukkan dengan tingginya kasus hipertensi dan diabetes mellitus sehingga dilaksanakan kegiatan pengabdian masyarakat berupa deteksi dini faktor risiko dan edukasi kesehatan pencegahan PTM.
The Hygiene Hypothesis And Covid-19: A Look At The Evidence And New Perspectives Peppy Nawangsasi; Ronald Pratama Adiwinoto; Verna Biutifasari; Tamam Jauhar; Wahyu Prasasti Mutiadesi
ANATOMICA MEDICAL JOURNAL | AMJ Vol 6, No 3 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v6i3.15787

Abstract

The hygiene hypothesis postulates that early-life exposure to infectious agents and microbes has a significant impact on the maturation of the immune system, providing protection against allergies and autoimmune diseases.Recent studies have challenged the hypothesis's universality, suggesting that it might only be relevant in developed countries. New perspectives on the hygiene hypothesis propose a multifaceted theory that considers not only microbial exposure but also factors such as diet, stress, and the environment. The role of specific immune cells in the development of allergies and autoimmune diseases has been emphasized, and innovative therapies based on manipulation of immune cells have been proposed. The importance of reconciling the hygiene hypothesis with recent insights into the human microbiome and the importance of maintaining a balance between hygiene and microbial exposure is also emphasized. Lastly, the article delves into the hygiene hypothesis, investigates the connection between gut microbiota dysbiosis and the development of allergies and autoimmune diseases, and examines the influence of COVID-19 on both gut microbiota and immune function.Keywords: allergies and autoimmune diseases, gut microbiome dysbiosis
Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Abstract

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin
Co-Authors Achmad Basori, Achmad Alphania Rahniayu Astrid Kusuma Bilqis Inayatillah Biutifasari, Verna Eric Mayo Dagradi Ersanda Nurma Gondo Mastutik JULIA ANGELINA SAFITRI Peppy Nawangsasi Peter Gunawan Tandean Pramudita Riwanti Riami Rochmanti, Maftuchah Rochmanti Ronald Pratama Adiwinoto Sylvia Rizki Wahyu Prasasti Mutiadesi