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Effect of Submaximal Exercise on Trained and Untrained Intensity on Estrogen Levels in Female White Rats (Rattus Norvegicus) Wistar Strains Cinthya Fitri Paramitha; Mita Herdiyantini; Eric Mayo Dagradi; Annisa Ulya Rasyida
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 1 (2024): March 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i1.2893

Background: Trained and continuous physical activity can increase estrogen levels in women, while irregular activity can increase excessive Estrogen levels. Submaximal exercise is a recommended exercise to improve a woman's physiological function The purpose of this experiment was to determine the effect of submaximal exercise on trained and untrained intensity on Estrogen levels in female white rats (Rattus norvegicus) Wistar strains. Methods: This research was an experimental study using a post-test-only control group design using 30 female Wistar rats which were divided into 5 groups: control group not treated (K1), experimental group of animals with exercise intensity without intervention (K2), group of experimental animals with untrained intensity without intervention (K3), group of experimental animals with exercise intensity with intervention (K4), and experimental group of animals with exercise intensity with intervention (K4). experimental animals with untrained intensity treatment with intervention (K5). The intervention was swimming at moderate intensity with a duration of 85% of the maximum time to swim and a load of 8% of the rat's body weight. After the treatment period, all groups were terminated to take intracardiac blood measured using ELISA. Results: The data results were analyzed using statistical tests. The results of this study found that the trained group had lower Estrogen levels compared to the untrained group, but higher than the control group. The Kruskal-Wallis test show a significance value (p = 0.157), p> 0.05. Conclusion: In this study, there was no effect of submaximal exercise between trained and untrained intensity on Estrogen levels in Wistar strain female white rat.

Pengaruh Pemberian Oksigen Hiperbarik Terhadap Diameter Calluspada Tikus Model Fraktur Diafisis Tulang Femur SATRIOAJI, ABDILLAH MAULANA; ROFIQ, AKHMAD; MAYO DAGRADI, ERIC
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.307

Background : Fracture is a condition where the bone is cut off due to significant pressure which can be in the form of bending, twisting, or pulling due to trauma, work accidents, traffic accidents, as well as degeneration and pathological processes. Fractures can result in loss of productivity and individual disability. One of the adjuvant therapies to accelerate the bone healing process in patients with fractures is hyperbaric oxygen therapy. Objective : The purpose of this study was to determine the effect of HBO therapy on the diameter of the callus formed in a rat model of fracture of the diaphysis of the femur. Methods : This research is an experimental study using a post test only control group design. The object of this study is a rat fracture model with HBO therapy as the independent variable and a fracture model without HBO therapy as a control variable. Results : The results of this study showed the effect of HBO therapy on increasing the diameter of the callus formed in the fracture of the rat model Conclusion : There was a significant difference in the diameter of the callus formed in fracture model mice treated with HBO compared to those not treated with HBO. From Winsgoal adalah slot mahjong gacor dengan fitur scatter hitam winrate kemenangan tinggi. Daftar dan nikmati fitur situs jackpot terbesar hari ini! Keywords : HBO therapy, Fracture, Callus, Wistar Rat

Pengaruh Latihan Submaksimal pada Intensitas Terlatih dan Tidak Terlatih Terhadap Kadar Eritrosit Darah Tikus Putih (Rattus norvegicus) Betina Galur Wistar HUSODO, STEFANUS DJONI; ERIC MAYO DAGRADI; AMIRIL MU’MININ
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.474

Penurunan aktivitas fisik serta perubahan gaya hidup dan pola makan yang tidak sehat di masa kini mengakibatkan semakin berkembangnya penyakit degeneratif dan penyakit infeksi. Eritrosit tubuh terutama eritrosit sangat berhubungan dengan terjadinya penyakit degeneratif. Untuk mendapatkan eritrosit yang baik dengan kadar eritrosit yang memadai dapat dilakukan dengan beberapa hal, salah satunya adalah olahraga dengan intensitas cukup dan teratur. Olahraga yang sesuai dengan kemampuan tubuh dapat mengaktifkan kerja eritrosit sehingga dapat meningkatkan eritrosit dan mencegah terjadinya penyakit degeneratif dan penyakit infeksi. Penelitian ini bertujuan untuk mengetahui pengaruh latihan submaksimal dengan intensitas terlatih dan tidak terlatih terhadap kadar eritrosit darah pada tikus putih betina galur wistar. Penelitian ini adalah penelitian eksperimen dengan menggunakan post test only control group design. Objek dalam penelitian ini adalah 25 tikus putih betina (Rattus norvegicus) galur wistar yang dibagi menjadi 5 kelompok. Hasil analisis statistik dengan uji One Way Anova yaitu p=0.034 Dari hasil uji didapatkan perbedaan yang bermakna antar kelompok perlakuan. hasil uji antar kelompok pada tabel 5.6 pada penelitian ini menunjukkan kelompok K1 dan K2 signifikan dengan nilai 0,46, kelompok K2 dan kelompok K3 signifikan dengan nilai 0,33, kelompok K2 dan kelompok K4 signifikan dengan nilai 0,19. Dapat disimpulkan terdapat perbedaan bermakna pada kadar eritosit antara latihan submaksimal intensitas terlatih dan tidak terlatih. Kata kunci : latihan submaksimal, terlatih, tidak terlatih, eritrosit

The Effect Of Dawood's Fasting In Removing Total Blood Cholesterol Levels In Surabaya Hidayatullah Islamic Boarding School’s Student Rahayu, Indri Ngesti; Wijayanti, Ni Luh Putu Ratih; Purwaningsari, Diah; Komalasari, Intan; Dagradi, Eric Mayo
Jurnal Medis Islam Internasional Vol 3 No 1 (2021): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v3i1.2445

Background: Hypercholesterolemia is a risk factor for causing death at a young age. The World Health Organization reported in 2002 that 4.4 million deaths were caused by hypercholesterolemia, or 7.9% of the total number of deaths at a young age. Hypercholesterolemia is a condition in which cholesterol levels in the body exceed normal levels. One way that can be done to prevent hypercholesterolemia is to control diet, namely by fasting. Dawood’s fasting is one of the obligatory fasts of Islamwhich is done with one-day fasting and one-day not. Objective: This study aims to determine the effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Methods: This study was designed with a quasi-experimental study research method using a comparative pre-test post-test non-equivalent control group design. The sample in this study was divided into two groups, namely one control group and one treatment group from the sample selected by purposive sampling. The population studied were students of the Hidayatullah Islamic Boarding School in Surabaya. Result: The results of statistical analysis using the Wilcoxon signed-rank test showed an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Conclusion: From research result that has been done, it can be concluded that there is an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya. Keywords: Dawood’s fasting, total blood cholesterol.

PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Dagradi, Eric Mayo; Sukmana, Judya; Rahayu, Indri Ngesti
Surabaya Biomedical Journal Vol 2 No 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol

Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Rahayu, Indri N.; Kumala, Asami Rietta; Taruna, Dody; Husodo, Stefanus Djoni; Dagradi, Eric Mayo; Sukmana, Judya
Surabaya Biomedical Journal Vol 3 No 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.

PENGARUH LATIHAN RENANG INTENSITAS SUBMAKSIMAL TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH BETINA KELOMPOK TERLATIH DAN TIDAK TERLATIH Alexander, Michael; Dagradi, Eric Mayo; Andisari, Hendrata Erry
Surabaya Biomedical Journal Vol 4 No 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.118

Olahraga adalah kegiatan fisik yang dilakukan untuk meningkatkan kesehatan tubuh. Dengan meningkatnya jumlah masyarakat yang berolahraga, penting untuk memahami batasan intensitas olahraga yang dilakukan. Intensitas olahraga yang melampaui kemampuan tubuh akan menyebabkan munculnya stres oksidatif. Stres oksidatif akan menimbulkan berbagai masalah fisiologis tubuh, termasuk metabolisme glukosa. Jenis penelitian adalah eksperimental laboratoris. Tikus putih (Rattus norvegicus) betina galur Wistar usia 2 bulan dengan berat badan 180-200 gram dikelompokkan ke dalam 5 kelompok melalui teknik random sampling. K1 merupakan kontrol, K2 diberi latihan setiap hari selama 2 minggu, K3 diberi latihan sekali seminggu selama 2 minggu, K4 diberi latihan setiap hari selama 2 minggu, dan K5 diberi latihan sekali seminggu selama 2 minggu. Semua kelompok setelahnya diistirahatkan selama 1 minggu. K1, K2, dan K3 tidak diberi intervensi. K4 dan K5 diberi intervensi latihan submaksimal 85% rerata waktu tenggelam pertama. Penelitian diterminasi dan dilakukan pengambilan sampel untuk pengujian kadar glukosa darah acak. Hasil kadar glukosa darah acak diolah statistik dengan uji parametrik one-way Anova dan uji post hoc LSD. Hasil kadar glukosa darah (K1) 127,8 mg/dL, (K2) 133,4 mg/dL, (K3) 186,4 mg/dL, (K4) 160,6 mg/dL, dan (K5) 140,6 mg/dL. Uji one-way Anova menunjukkan perbedaan signifikan (p<0,05). Uji post hoc LSD menunjukkan tidak ada perbedaan bermakna antara kelompok terlatih dengan intervensi dan tidak terlatih dengan intervensi (p>0,05). Intervensi latihan submaksimal setelah istirahat satu minggu pada kelompok terlatih dan tidak terlatih dengan latihan submaksimal tidak memiliki pengaruh terhadap kadar glukosa darah tikus putih (Rattus norvegicus) betina galur Wistar.

Perbandingan Tekanan Darah pada Masyarakat Dataran Tinggi dan Dataran Rendah serta Korelasinya dengan Indeks Massa Tubuh dan Konsumsi Makanan Asin Nexiary, Azzahra Banafsaj Altima; Dagradi, Eric Mayo; hisnindarsyah, Hisnindarsyah
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 16 No 3 (2024): JIKM Vol. 16, Edisi 3, Agustus 2024
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v16i3.649

Hipertensi merupakan masalah kesehatan masyarakat yang signifikan karena prevalensinya yang tinggi di seluruh dunia. Beberapa faktor telah ditemukan terkait dengan hipertensi, termasuk demografi sosial ekonomi (usia lanjut, wanita, jenjang pendidikan yang lebih rendah, rumah tangga yang memiliki pendapatan rendah), lokasi geografis, dan faktor risiko lainnya, termasuk stroke, diabetes, indeks massa tubuh (IMT) yang tinggi, konsumsi sodium berlebih, jarang melakukan aktivitas fisik, merokok, minum alkohol, jarang mengontrol kesehatan di puskesmas/posbindu serta kurangnya konsumsi buah dan sayur. Indonesia adalah negara kepualauan dengan kondisi geografis yang sangat beragam. Adanya dataran rendah dan dataran tinggi menyebabkan perbedaan cuaca, iklim, suhu, dan konsentrasi O2 di setiap wilayah yang dapat mempengaruhi kondisi kesehatan. Penelitian ini dilakukan untuk mengetahui perbandingan tekanan darah dan insiden hipertensi pada masyarakat dataran tinggi dan dataran rendah. Desain penelitian ini adalah kuantitatif dengan jenis penelitian analitik observasional yang menggunakan studi cross sectional dengan consecutive sampling sebagai teknik pengambilan sampel agar dapat melihat perbandingan tekanan darah dan insiden hipertensi pada masyarakat dataran tinggi dan dataran rendah. Penelitian ini dilaksanakan di Desa Ngadisari sebagai kelompok dataran tinggi dan Desa Ketapang sebagai kelompok dataran rendah pada tanggal 26 Agustus 2023. Hasil uji Mann Whitney U dari uji komparasi tekanan darah masyarakat dataran tinggi dan dataran rendah adalah p = 0,00. Uji korelasi spearman antara IMT dengan tekanan darah pada masyarakat dataran tinggi dan dataran rendah adalah p = 0,000 dan r = 0,597. Uji Kendall Tau b dari uji korelasi antara kebiasaan konsumsi makanan asin dengan tekanan darah pada masyarakat dataran tinggi dan dataran rendah adalah p < 0,001 dan r = 0,646. Berdasarkan hasil penelitian ini, didapatkan kesimpulan bahwa terdapat perbedaan yang signifikan pada tekanan darah masyarakat dataran tinggi dan dataran rendah

Analysis Of Maternal Hygiene Practices And Sanitation Knowledge On Stunting Incidence In Children Under Five At Sepatan Health Center, Tangerang Regency Muhamarudin; Anindya, Pramita; Budipramana , Vicky Sumarki; Dagradi, Eric Mayo
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 1 (2025): June
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Stunting remains a significant global health challenge, profoundly impacting child growth and development, defined by a height-for-age z-score below -2 standard deviations of the WHO growth standards. Substandard sanitation and poor hygiene practices substantially elevate the risk of stunting, potentially by up to five-fold. Parental involvement, especially maternal knowledge and understanding of stunting, is crucial for its prevention. This study aimed to analyze the association between maternal hygiene practices, maternal sanitation knowledge, and stunting prevalence in toddlers. We conducted a cross-sectional, observational analytic study among mothers of stunted children aged 0-5 years within the working area of Puskesmas Sepatan, Tangerang Regency, Indonesia. A total of 63 respondents completed questionnaires assessing their hygiene behaviors and sanitation knowledge. Our findings indicate that most stunted toddlers had mothers with suboptimal hygiene practices, despite their sanitation knowledge generally being in the 'good' category. Spearman's correlation analysis revealed a significant association between maternal hygiene practices and stunting incidence (p=0.044), as well as between maternal sanitation knowledge and stunting incidence (p=0.000). This study concludes that both maternal hygiene practices and sanitation knowledge are significantly associated with stunting among toddlers in this Indonesian community, underscoring the critical need for targeted interventions focusing on behavioral change alongside educational initiatives to combat this pervasive public health issue.

PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Dagradi, Eric Mayo; Sukmana, Judya; Rahayu, Indri Ngesti
Surabaya Biomedical Journal Vol. 2 No. 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol

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