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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan Jurnal Mandala Pengabdian Masyarakat Indonesian Community Journal Pharmaceutical Reports MPSJ
Muzakkir Baits, Muzakkir
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Fitofarmaka Indonesia

 1 
In vitro, efek antidiabetes dan antikolestrol kopasanda (Chromolaena odorata L.) Rahmawati, Rahmawati; Baits, Muzakkir; Putri, Hemalia; Nurhikmah, Nurhikmah
Jurnal Fitofarmaka Indonesia Vol 12, No 1 (2025): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v12i1.1330

Abstract

The leaves of the kopasanda plant (Chromolaena odorata L.) contain alkaloids, flavonoids, saponins, terpenoids and tannins which have the potential to be anti-diabetic and anti-cholesterol. In vitro research has been carried out on the ethanol extract of kopasanda leaves (Chromolaena odorata L.) to determine the potential of α-glucosidase enzyme inhibitor compounds as antidiabetic by determining the IC50 value and the potential to reduce cholesterol levels as an anticholesterol by determining the EC50 value. Testing for the inhibitory activity of the α-glucosidase enzyme used the spectrophotometer method with a microplate reader at a wavelength of 405 nm, with acarbose as a comparison. The results showed that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) as an inhibitor of the α-glucosidase enzyme obtained an IC50 value of 444.019 µg/mL in the very weak category. In testing the anti-cholesterol potential using a UV-Vis spectrophotometer with measurements at a wavelength of 672 nm, the calculation results obtained an EC50 value of 1,017.118 µg/L. This shows that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) has the potential to inhibit cholesterol.
Antioxidant Activity Test for Button Mushroom (Agaricus bisporus) Ethanol Extract Using The FRAP Method (Ferric Reducing Antioxidant Power) Suhaenah, Asriani; Baits, Muzakkir; Ismail, Normawati
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1104

Abstract

Button mushrooms (Agaricus bisporus) are plants that contain phenols as antioxidants. Antioxidants are electron donor or reductant compounds. These compounds have a small molecular weight but are able to inhibit the development of oxidation reactions by preventing the formation of radicals. phenol is the main antioxidant component found in Agaricus bisporus extracts.  The aim of this research is to determine the antioxidant activity value of button mushroom ethanol extract (Agaricus bisporus) using the method of ferric reducing antioxidant power (FRAP). This research uses the maceration method as an extraction process using 96% ethanol. The resulting filtrate was concentrated with a vacuum rotary evaporator to produce a thick extract. Antioxidant testing was carried out using the FRAP method with a reagent solution of potassium feryricide, phosphate buffer pH 6.6 tricloroacetic acid (TCA), aquadest, and iron 3 chloride (FeCl3). Samples were analyzed using a UV-Vis spectrophotometer at a wavelength of 725 nm using quercetin as a standard solution. The results showed that the antioxidant activity value of the button mushroom ethanol extract (Agaricus bisporus) with the FRAP method was 3.847 mg QE /g extract.
Co-Authors Abdul Malik aenung, nurul Amalia, Alifya Ananda, Savitri Anggrayni, Anggi Aris, Arru'nnisa Ika Nur Ilmi arniati, arniati Asriani Suhaenah Ayu Andini Dahlia, Andi Faradiba Harti Widiastuti Herwin Herwin, Herwin Ismail, Normawati Mamat Pratama, Mamat Masdiana Tahir, Masdiana Mochammad Imron Awalludin Muammar Fawwaz Muflihunna, A Nur Fadillah, Nur Nurhikmah Nurhikmah Nurung, Ayyub Harly Praditha, Elyana putri, Hemalia Rachmat Kosman, Rachmat Rahmawati, Rahmawati Rezky M, Mega Ririn Ririn Sari, Wina Astri St Maryam, St St. Maryam, St. Syam, Nurizzah Aulia Syarif, Rezki Tadjuddin Naid Trihadi, Andi Yenni Triana, Yenni Yusuf, Rudy Zainal Abidin