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All Journal Jurnal Kesehatan As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan Batoboh : Jurnal Pengabdian Pada Masyarakat Pharmaceutical Reports Celebes Journal of Community Services MPSJ
Harti Widiastuti
Laboratorium Kimia Farmasi, Universitas Muslim Indonesia, Makassar
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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IDENTIFIKASI AKTIVITAS IMUNOGLOBULIN M (IG.M) EKSTRAK ETANOLIK DAUN CEPLUKAN (Physalis Minima Linn.) PADA MENCIT Effendi, Nurmaya; Widiastuti, Harti
Jurnal Kesehatan Vol 7, No 2 (2014): Jurnal Kesehatan
Publisher : Kesehatan Masyarakat UIN Alauddin Makassar

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Abstract

Sistem imun adalah sistem yang sangat penting bagi tubuh untuk menghindari dan melawan berbagai penyakit (Abbas et al, 2007). Keseimbangan sistem imun dapat dipengaruhi oleh faktor internal dalam tubuh dan faktor eksternal yang perlu dipertahankan untuk menjaga tubuh agar tetap sehat (Ma’at, 2010). Sistem imun ini berkaitan erat dengan adanya antibodi. Antibodi merupakan protein immunoglobulin yang disekresi oleh sel B yang terfiksasi oleh antigen. Tanaman ceplukan (Physalis minima Linn.) termasuk famili Solanaceae merupakan tanaman yang tidak banyak diketahui orang bahwa dapat menyembuhkan berbagai penyakit. Tujuan penelitian ini adalah untuk mengetahui kemampuan ekstrak etanol daun ceplukan (Physalis minima Linn.) untuk meningkatkan aktivitas IgM.Daun ceplukan kering dimaserasi dengan etanol. Ekstrak etanolik cair yang diperoleh dikentalkan dengan rotavavor dan kemudian disuspensikan dengan Na-CMC sebagai pembawa. Ekstrak diberikan secara oral kekelompok mencit uji dengan menggunakan kontrol negatif Na-CMC dan selanjutnya diimunisasi dengan suspensi sel darah merah domba secara intraperitonial dan setelah lima hari selanjutnya darah mencit diambil secara intrakardial. Darah mencit selanjutnya digumpalkan, serumnya lalu diencerkan dengan PBS dan diuji lagi dengan sel darah merah domba, dan setelah diinkubasi selanjutnya diamati pengenceran tertinggi darah yang dapat mengaglutinasi sel darah domba.Hasil penelitian menunjukkan bahwa ekstrak etanolik daun Ceplukan (Physalis minima Linn.) konsentrasi 4%, 8% dan 12% b/v dapat meningkatkan aktivitas Ig.M dengan titer imunoglobulin rata-rata masing-masing sebesar 1/32, 1/128 dan 1/64 sedangkan kelompok perlakuan kontrol, rata-rata titer imunoglobulinnya hanya 1/8. Kata Kunci : sistem imun, antibiotik, ceplukan, IgM
Aktivitas Antioksidan Ekstrak Etanol Buah Merah (Pandanus conoideus Lam.) dengan Metode FRAP Wabula, Rheytno Asdin; Dali, Seniwati; Widiastuti, Harti
Window of Health : Jurnal Kesehatan Vol. 2 No. 4 (Oktober, 2019)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (901.39 KB) | DOI: 10.33368/woh.v0i0.203

Abstract

Red fruit (Pandanus conoideus Lam.) Is an endemic plant that grows in the Papua region. Based on previous research, red fruit contains several active compounds with a fairly high level, including carotenoids, tocopherol, beta-carotene, α tocopherol, and fatty acids such as oleic acid, linoleic acid, linolenic acid, and dexoic acid. The high tocopherol content in red fruit has antioxidant activity. This study aims to determine the antioxidant capacity of the ethanol extract of red fruit (Pandanus conoideus Lam.) Using the FRAP method. Three replications of red fruit ethanol extract were measured for antioxidant capacity using standard α-tocopherol solution in a UV-Vis spectrophotometer at a maximum wavelength of 757 nm. The results showed that the sample of red fruit ethanol extract (Pandanus conoideus Lam.) Had total antioxidant activity with an activity of 1,392 x 10-3 g ATE / g extract.
Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Gedi (Abelmoschus Manihot L. Medik) Secara In Vitro Ilyas, Andi Nurjayanti; Rahmawati, Rahmawati; Widiastuti, Harti
Window of Health : Jurnal Kesehatan Vol. 3 No. 1 (Januari, 2020)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.382 KB) | DOI: 10.33368/woh.v0i0.216

Abstract

Lifestyle changes, including eating patterns, have caused traditional diets to shift to western diets such as fast foods that contain lots of calories, fat, and cholesterol. One of the plants that are often used by the community as medicine is Gedi (Abelmoschus Manihot (L.) Medik). Gedi (Abelmoschus Manihot (L.) Medik) leaves are empirically used to treat kidney pain, reduce cholesterol, and ulcers. Gedi (Abelmoschus Manihot (L.) Medik) leaves contain compounds that have the efficacy of flavonoids that can be used as cholesterol-lowering agents. This study aims to determine the anti-cholesterol activity of Gedi leaf extract (Abelmoschus Manihot (L.) Medik) in vitro and determine the EC50 value. Samples were extracted by maceration method using 96% ethanol solvent with 9% extract extraction obtained. The extract obtained was analyzed anticolesterol activity by the Lieberman-Burchard method of anhydrous acetic acid and concentrated sulfuric acid using UV-Vis spectrophotometer measurements with a maximum wavelength of 666.97 nm. Ethanol extract of gedi leaves (Abelmoschus Manihot (L.) Medik) has anti-cholesterol activity in vitro. EC50 value of gedi leaf extract (Abelmoschus Manihot (L.) Medik) that is equal to 5007.5 ppm. Research conclusions that at a concentration of 5007.5 ppm can reduce 50% of initial cholesterol. It is recommended to use gedi leaf ethanol extract as medical therapy.
ANALISIS KADAR PROTEIN PADA ULAT SAGU (RHYNCHOPHORUS FERRUGINEUS) ASAL KABUPATEN HALMAHERA TIMUR MALUKU UTARA DENGAN METODE KJELDAHL Widiastuti, Harti; Kisan, Chakrawaty M.
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Analysis of Protein Levels In Sago Worm (Rhynchophorus ferrugineus) East Halmahera, North Maluku regency with Kjeldahl Method Has done research on the analysis of protein content in sago (Rhynchophorus ferrugineus) from East Halmahera in North Maluku kjeldahl method. This study aims to obtain scientific data about the protein content in sago (Rhynchophorus ferrugineus).This research includes testing levels  of total nitrogen and non protein nitrogen method kjeldahl on sago(Rhynchophorus ferrugineus). Research results showed that the protein content in sago (Rhynchophorus ferrugineus) Originof East Halmahera in North Maluku is 4.0575 %.Key words : Protein, Ulat Sagu.
PENGUJIAN AKTIVITAS EKSTRAK ETANOL KULIT BUAH KECOMBRANG (Etlingera elatior (Jack) R.M.Sm) SEBAGAI INHIBITOR TIROSINASE Widiastuti, Harti; Abidin, Zainal
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.766

Abstract

Healthy skin should have a flat surface, the texture is soft, elastic, and have the same skin color. Skin color is determined by the size, number and distribution of melanin pigment. Pigment brownish pigment melanin is to protect the skin from UV light scattering. An enzyme that plays a role in this browning reaction is tyrosinase. Browning reaction tyrosinase inhibitor can be inhibited by an enzymatic by an enzymatic reaction in the form of ions or molecules called tyrosinase. Inhibition of tyrosinase is one way to prevent skin hyperpigmentation. Tyrosinase enzyme catalyzes two main reactions in the biosynthesis of melanin, the hydroxylation of L-tyrosin into L-dopa and the oxidation of L-dopa becomes dopakuinon. Polyphenol compounds (Flavonoids) the group is basically have the effect cant inhibit melanogenesis as a tyrosinase inhibitor. Kecombrang a wild plant that has many benefits one of them as a source of natural antioxidants. Based on this research is conducted on the fruit skin kecombrang to see the activity of the enzyme tyrosinase barriers and whether rind kecombrang can inhibit tyrosinase enzyme and with the aim to utilize natural materials and waste that can inhibit the enzyme tyrosinase and can be used as a skin whitheter.Research iniated by the extraction of fruit skins kecombrang using etanol. Flavonid content test on the sample using Mg powder and HCl p, the results show a color change from dark brown to yellow. So positive it contains flavonoids. Measurements were contucted on a maximum wavelength of 478,003 nm, using the substrate L-tyrosine and the enzyme tyrosinase. Using comparators hidroquinon. Of the results of this study concluded that kecombrang fruit peel ectract at a concentration of 2 mg/mL could inhibit amounted to 55,92% and a concentration of 2,5 mg/mL could inhibit amounted to 56,58%.
SABUN ORGANIK : PENGENALAN, MANFAAT DAN PEMBUATAN PRODUK Widiastuti, Harti; Maryam, ST
Batoboh Vol 7, No 1 (2022): BATOBOH : JURNAL PENGABDIAN PADA MASYARAKAT
Publisher : Institut Seni Indonesia Padangpanjang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26887/bt.v7i1.1400

Abstract

Kegiatan pengabdian kepada masyarakat merupakan salah satu Tridharma Perguruan Tinggi dan sebagai upaya perguruan tinggi untuk menjalin kerjasama dengan masyarakat.  Pengabdian ini bertujuan untuk mengenalkan sabun organic. Sabun organic dibuat sendiri di rumah dan memiliki manfaat untuk kulit sensitif,. Sabun organic dapat menyehatkan kulit sehat tanpa efek samping karena tidak mengandung bahan kimia yang dapat menyebabkan kulit kering, gatal, iritasi, hingga bintik merah pada kulit. Adapun sabun organic, selain ramah lingkungan juga dapat menunda penuaan kulit dimana kulit akan lebih kencang dan tidak cepat keriput. Kegiatan pengabdian ini juga memberikan pelatihan kepada masyarakat mengenai cara pembuatan sabun organic dengan penambahan kopi yang nantinya dapat dibuat sendiri dir umah dan manfaatkan oleh masyarakat untuk mandi sehari-hariKata Kunci: sabun organik; kopi; sabun mandi
POTENSI ANTIDIABETES EKSTRAK ETANOL DAUN KOPASANDA (Chromolaena odorata L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis Rahmawati, Rahmawati; Widiastuti, Harti; Puspita, Della
As-Syifaa Jurnal Farmasi Vol 16, No 2 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i2.1095

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by an increase in glucose levels in the blood. There are many treatment efforts to control and reduce blood glucose levels with natural ingredients. One of the treatment efforts that is expected to treat diabetes comes from plants, namely kopasanda leaves which have many benefits and contain several main compounds such as tannins, phenols, flavonoids, saponins and steroids. Secondary metabolite compounds such as phenols, flavonoid alkaloids and steroids have the potential to act as antidiabetics. The aim of this research was to determine the antidiabetic potential of ethanol extract of kopasanda leaves (Chromolaena odorata L.) in vitro using the Nelson-Somogyi reagent with the UV-Vis spectrophotometric method. The test was carried out by making a series of concentrations of ethanol extract of kopasanda leaves (Chromolaena odorata L.), namely 5, 10, 15, 20, 25 and 30 ppm using a UV-Vis spectrophotometer measured at a maximum wavelength of 749 nm. From the results of testing the antidiabetic potential of kopasanda leaves (Chromolaena odorata L.) in vitro, it was found that the equation y = 1.5986x + 38.183 with a correlation coefficient (r) = 0.9775 and an EC50 value of 7.3920 µg/mL showed that the leaf sample Kopasanda has potential as an antidiabetic
Uji Aktivitas Antioksidan Minyak Nilam (Pogostemon cablin Benth.) Dengan Metode FRAP Niza, Nabila Ikhwanun; Ahmad, Aktsar Roskiana; Widiastuti, Harti
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.319

Abstract

ABSTRACT Patchouli oil (Pogostemon cablin Benth.) is an essential oil derived from the leaves of the patchouli plant. This oil is recognized for its primary component, patchouli alcohol, an antioxidant. The antioxidant properties of patchouli oil effectively inhibit free radical oxidation through the exchange of hydrogen atoms, forming more stable compounds. This study seeks to evaluate the antioxidant potential of patchouli oil through the FRAP method, utilizing a UV-Vis spectrophotometer for measurement at a wavelength of 692 nm. The findings indicate a regression equation of y = 0.0258x + 0.0256, with correlation coefficient of r = 0.9981 and an antioxidant activity measured at 1.7831 mgQE/g extract. Keywords: Antioxidant; Patchouli oil (Pogostemon cablin Benth.); FRAP method; UV-Vis spectrophotometer ABSTRAK Minyak nilam (Pogostemon cablin Benth.) merupakan minyak atsiri yang diperoleh dari daun tanaman nilam. Minyak ini dikenal memiliki kandungan utama patchouli alcohol, yang berfungsi sebagai antioksidan. Aktivitas antioksidan minyak nilam dapat menghambat oksidasi radikal bebas dengan cara menyumbangkan atom hidrogen, sehingga menghasilkan senyawa yang lebih stabil. Penelitian ini bertujuan untuk mengetahui potensi minyak nilam sebagai antioksidan menggunakan metode FRAP, kemudian diukur menggunakan spektrofotmeter UV-Vis pada panjang gelombang 692 nm. Dari penelitian ini diperoleh persamaan regresi y = 0,0258x + 0,0256, r = 0,9981 dan aktivitas antioksidan sebesar 1,7831 mgQE/g ekstrak. Kata kunci: Antioksidan; Minyak nilam (Pogostemon cablin Benth.); Metode FRAP; Spektrofotometer UV-Vis
Edukasi Pengolahan Minyak Jelantah Menjadi Sabun Kertas Bernilai Ekonomi Pada Kelompok PKK Tamalanrea Jaya Ahmad, Akstar Roskiana; Kamase, Jeni; Suhaenah, Asriani; Handayani, Virsa; Widiastuti, Harti; Razak, Rais; Abidin, Zainal; Abd. Malik
Celebes Journal of Community Services Vol. 4 No. 2 (2025): June - November
Publisher : STIE Amkop Makassar, Indonesia

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Abstract

Tamalanrea Jaya merupakan hasil pemekaran dari Kelurahan Tamalanrea memiliki luas sekitar 31,84 km², dan jumlah penduduk yang diperkirakan pada pertengahan 2023 mencapai 106.262 jiwa. Dengan jumlah penduduk yang tinggi, maka jumlah limbah Rumah Tangga (RT) akan dihasilkan salah satunya adalah minyak jelantah. Permasalahan yang diidentifikasi dalam program ini meliputi minimnya pengetahuan dan keterampilan masyarakat, khususnya ibu-ibu PKK, dalam mengolah limbah RT menjadi produk bermanfaat dan bahkan memiliki nilai ekonomi. Kegiatan ini kami harapkan memberikan kontribusi langsung dalam memperkuat kapasitas masyarakat desa dalam pengolahan limbah RT minyak jelantah dan menciptakan peluang usaha. Kegiatan berlangsung selama tiga bulan dan meliputi beberapa tahap utama, yaitu perencanaan, penyuluhan dan edukasi, pelatihan dan demonstrasi, serta pendampingan dan monitoring. Hasil kegiatan ini berupa sabun kertas dengan banyak keuntungan serperti Praktis dibawa saat bepergian, Mudah larut di air, Ramah lingkungan dan bisa menjadi produk UMKM atau suvenir eco-friendly. Kegiatan pelatihan pembuatan sabun kertas dari minyak jelantah memberikan banyak manfaat bagi ibu-ibu PKK (Pemberdayaan Kesejahteraan Keluarga), baik dari segi lingkungan, ekonomi, keterampilan, hingga kesehatan keluarga. Peningkatan Kesadaran Lingkungan ibu-ibu agar tidak membuang minyak jelantah sembarangan.
EFEK ANTI INFLAMASI IN VITRO EKSTRAK ETANOL DAUN KARET KEBO (Ficus elastica) DENGAN METODE STABILISASI MEMBRAN Red Blood Cell (RBCs) Suhaenah, Asriani; Widiastuti, Harti; Aprianti, Tiara
As-Syifaa Jurnal Farmasi Vol 17, No 1 (2025): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v17i1.1299

Abstract

The rubber kebo plant (Ficus elastica) is traditionally known to have various benefits, including as an anti-inflammatory agent. This study aimed to evaluate the anti-inflammatory effect of ethanol extract of rubber kebo leaves using the red blood cell (RBCs) membrane stabilisation method in vitro. Kebo rubber leaves were extracted by a maceration method using 96% ethanol, and anti-inflammatory activity was tested by measuring the stability of RBCs membrane against hypotonic solution-induced haemolysis. The results showed that ethanol extract of rubber kebo leaves had anti-inflammatory activity with a percentage of membrane stabilisation of 31.156% at a concentration of 40 ppm and reached 51.998% at a concentration of 200 ppm. This activity is caused by the content of secondary metabolites such as flavonoids and tannins that work by stabilising the red blood cell membrane. Compared to the positive control of diclofenate sodium, the extract showed competitive effectiveness, albeit lower
Co-Authors ABD. MALIK Abd. Malik Afifah, Aulia Nur Ahmad, Akstar Roskiana Ahmad, Aktsar Roskiana Aminah Aminah Aprianti, Tiara Ardin, Nisradhiyah Caesarika Asriani Suhaenah Ayu Andini Chakrawaty M. Kisan, Chakrawaty M. Fauzan, Muh. Alif Noor Hudayanti, Andi Isti Ilyas, Andi Nurjayanti Kamase, Jeni Mamat Pratama, Mamat Muammar Fawwaz Muflihunnah, Andi Mustafa, Diyan Nurkhalisah Muzakkir Baits, Muzakkir Nadya, Alifah Rifa Niza, Nabila Ikhwanun Nurmaya Effendi Puspita, Della Rahmawati, Rahmawati Rais Razak, Rais Seniwati Dali St Maryam, St Virsa Handayani Wabula, Rheytno Asdin Zainal Abidin