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Review Analisis Efektivitas dan Risiko Toksisitas Aminofilin pada Pengobatan Penyakit Asma Nurma Dwi Rahmawati; Indah Laily Hilmi; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.35 KB) | DOI: 10.36490/journal-jps.com.v6i1.14

Abstract

Asthma is a chronic inflammatory disease of the airways that involves many cells and factors. Physiologically, asthma is characterized by narrowing of the airways that causes increased hypersensitivity which is characterized by repeated episodic symptoms of wheezing, shortness of breath, chest tightness, and coughing, especially at night and or in the morning. The World Health Organization (WHO) estimates that the number of asthmatic diseases in 2019 is around 235 million. Asthma is a worldwide health problem, affecting approximately 1-18% of the population in various countries around the world. Aminophylline is the most common asthma drug used to treat asthma in Indonesia and is a drug with a narrow therapeutic range with a high risk of adverse drug reaction (ADR). Improper use of aminophylline will cause many side effects that can potentially be fatal and can actually make a person experience medical problems due to side effects that are more severe than the main medical problem. The purpose of this review article is to analyze the effectiveness and risk of aminophylline in the treatment of asthma using a literature study method taken from various international and national journals. Based on the results of the literature study, it was found that aminophylline in its use produces a toxic effect that is greater than its effectiveness.
Metode Analisis Natrium Benzoat pada Makanan dan Minuman: Literatur Review Erlangga Muhamad Prayuda; Febi Febriani Hasanah; Rika Valensia; Nurma Dwi Rahmawati; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.504 KB) | DOI: 10.36490/journal-jps.com.v6i2.38

Abstract

Preservatives are food additives that can inhibit the growth of microorganisms so that food does not get stale easily. Sodium benzoate is one of the preservatives that is allowed to be used in food but within a predetermined limit of <1 g / kg according to BPOM RI. The purpose of this review is to find out an overview and provide information about the method of analyzing sodium benzoate levels in food and comparing the results with the provisions. The method used is literature review from various journals with a span of 10 years. The results of this study, the method of analyzing sodium benzoate in food can be carried out qualitatively and quantitatively. Qualitative tests can use the addition of FeCl3, test kits, and KLT, while quantitative tests can use KCKT, spectrophotometry UV-Vis and titration. The samples studied from 11 journals obtained were syrup, sauce (tomato and chili), soy sauce, beverage and strawberry jam products produced industrially and/or home-produced. The conclusion of the various methods tested is that there are still many food producers who use sodium benzoate as a preservative, but not all samples studied are in accordance with the provisions