Articles
<![CDATA[Prevalence of antiâC-reactive protein autoantibody and its correlation with disease activity in systemic lupus erythematosus patients at Cipto Mangunkusumo General Hospital ]]>
<![CDATA[Lusiani, Lusiani]]>;
<![CDATA[Setiyohadi, Bambang]]>;
<![CDATA[Sukmana, N]]>;
<![CDATA[Abdullah, M]]>
<![CDATA[ Indonesian Journal of Rheumatology Vol 2, No 3 (2010) ]]>
Publisher : <![CDATA[Indonesian Rheumatology Association ]]>
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<![CDATA[Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various underlying mechanisms characterized by autoantibody overproduction. It has been known that mortality and morbidity of SLE was higher in Asian patients compared with white patients. Several studies had showed that C-reactive protein (CRP) has the ability to suspend the progression of SLE through regulatory and clearance pathway, and low level of CRP and high level of anti-CRP antibody has been detected in SLE patients. A question raise whether mortality and morbidity in Asian SLE patients are associated with anti-CRP antibody.Objective: To study the prevalence of anti-CRP antibody and its relationship with disease activity in SLE patients at Cipto Mangunkusumo General Hospital,Jakarta.Methods: This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from December 2009 until May 2010. Subjects were SLE patients whowere diagnosed based on the 1982 American College of Rheumatology criteria. Disease activity was measured using the Mexican SLE Disease Activity Index scoringsystem. Anti-CRP antibody assay was performed using the Western blot analysis. Correlation between the presence of anti-CRP antibody and disease activitywas evaluated using the T-test and multivariate logistic regression analysis.Result: Forty SLE patients with a mean age of 31.65 (SD 8.84) were enrolled in the study, 33 of which (82.5%) had positive autoantibody to CRP pentamer. The anti-CRP antibody was signifi cantly correlated (p = 0.024) with disease activity. Conclusions: There was a relatively large proportion of patients with positive anti-CRP antibody among SLE patients in Cipto Mangunkusumo General Hospital. Therewas also a signifi cant correlation between anti-CRP antibody and the disease activity.]]>
<![CDATA[MISKONSEPSI TENTANG PEMAHAMAN KONSEP SISWA SMP PADA MATERI SEGIEMPAT ]]>
<![CDATA[Lusiani, Lusiani]]>
<![CDATA[ EKUIVALEN - Pendidikan Matematika Vol 20, No 1 (2016): EKUIVALEN ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purworejo ]]>
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<![CDATA[Penelitian ini bertujuan untuk mengetahui dimana letak miskonsepsi tentang pemahaman konsep siswa SMP pada materi segiempat. Metode yang digunakan adalah metode kualitatif dengan teknik analisis data triangulasi. Subjek penelitian adalah siswa yang mengalami miskonsepsi. Teknik pengambilan subjek menggunakan teknik purposive sampling dan snowball sampling. Berdasarkan penelitian diperoleh bahwa letak miskonsepsi terletak pada saat: (1) menyatakan ulang sebuah konsep, (2) mengklasifikasi setiap objek menurut sifat-sifat tertentu, dan (3) mengaplikasikan konsep atau algoritma pada pemecahan masalah. Untuk miskonsepsi saat menyatakan ulang sebuah konsep dan mengklasifikasi setiap objek menurut sifat-sifat tertentu adalah saat siswa memilih gambar persegi sebagai gambar belah ketupat. Siswa memilih gambar persegi yang sebenarnya hanya diputar bentuknya. Selanjutnya saat mengaplikasikan konsep atau algoritma pada pemecahan masalah, miskonsepsi terjadi ketika siswa memberikan pernyataan. Selain itu, alasan yang diberikan siswa juga menguatkan bahwa siswa mengalami miskonsepsi. Siswa juga mengalami miskonsepsi saat siswa tidak menggunakan rumus sesuai konsep yang seharusnya.]]>
<![CDATA[Analisis Kesiapan Belajar Taruna Teknika pada Materi Mekanika Terapan dalam Sistem Pembelajaran Online ]]>
<![CDATA[Lusiani, Lusiani]]>
<![CDATA[ Jurnal Penelitian Pendidikan Fisika Vol 6, No 3 (2021): Jurnal Penelitian Pendidikan Fisika, Vol. 6, No. 3, Juli 2021 ]]>
Publisher : <![CDATA[Universitas Halu Oleo ]]>
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DOI: 10.36709/jipfi.v6i3.19406
<![CDATA[Permasalahan kajian ini yakni bagaimana analisis kesiapan belajar taruna teknika pada materi mekanika terapan dalam sistem pembelajaran online. Tujuan yang akan dicapai dalam kajian ini yaitu menganalisis kesiapan belajar taruna teknika pada materi mekanika terapan dalam sistem pembelajaran daring. Metode dalam kajian ini berupa survey dan kajian literatur. Obyek dalam penelitian ini yakni taruna teknika Akademi Maritim Nusantara. Waktu Pelaksanaan penelitian pada bulan April-Agustus Tahun 2020. Prosentase kesiapan belajar tertinggi terdapat pada pertanyaan nomor 6 yaitu memiliki nilai 78.6%; peringkat kedua senilai 69% pada pertanyaan nomor 3; peringkat ketiga senilai 57.1% pada pertanyaan nomor 2; peringkat keempat senilai 45.2% pada pertanyaan nomor 4; peringkat kelima senilai 33.3% pada pertanyaan nomor 5; peringkat keenam senilai 26.2% pada pertanyaan nomor 6. Hasil tersebut menunjukkan bahwa kesiapan belajar taruna tertinggi yaitu bahwa taruna menyiapkan perlengkapan belajar. Hal ini berkaitan dengan beberapa perangkat pembelajaran yang harus dipersiapkan taruna saat mengikuti pembelajaran melalui sistem online saat pandemi covid-19. Berdasarkan pembahasan yang telah dilakukan disimpulkan bahwa kesiapan belajar berada pada nilai 78.6% berada pada kategori baik, yaitu taruna menyiapkan perlengkapan belajar dengan baik, sehingga rasa aman yang merupakan kebutuhan siswa mengenai keadaan sekitar tempat siswa belajar yang meliputi ketersediaan alat belajar lengkap serta aman yang dapat berpengaruh terhadap kesiapan belajar dikarenakan siswa yang memiliki rasa aman belajar maka dapat jauh lebih termotivasi untuk terus belajar dan mempersiapkan keperluan yang dibutuhkan. ]]>
<![CDATA[Prevalence of anti–C-reactive protein autoantibody and its correlation with disease activity in systemic lupus erythematosus patients at Cipto Mangunkusumo General Hospital ]]>
<![CDATA[Lusiani Lusiani]]>;
<![CDATA[Bambang Setiyohadi]]>;
<![CDATA[N Sukmana]]>;
<![CDATA[M Abdullah]]>
<![CDATA[ Indonesian Journal of Rheumatology Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology ]]>
Publisher : <![CDATA[Indonesian Rheumatology Association ]]>
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DOI: 10.37275/ijr.v2i3.81
<![CDATA[Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various underlying mechanisms characterized by autoantibody overproduction. It has been known that mortality and morbidity of SLE was higher in Asian patients compared with white patients. Several studies had showed that C-reactive protein (CRP) has the ability to suspend the progression of SLE through regulatory and clearance pathway, and low level of CRP and high level of anti-CRP antibody has been detected in SLE patients. A question raise whether mortality and morbidity in Asian SLE patients are associated with anti-CRP antibody.Objective: To study the prevalence of anti-CRP antibody and its relationship with disease activity in SLE patients at Cipto Mangunkusumo General Hospital,Jakarta.Methods: This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from December 2009 until May 2010. Subjects were SLE patients whowere diagnosed based on the 1982 American College of Rheumatology criteria. Disease activity was measured using the Mexican SLE Disease Activity Index scoringsystem. Anti-CRP antibody assay was performed using the Western blot analysis. Correlation between the presence of anti-CRP antibody and disease activitywas evaluated using the T-test and multivariate logistic regression analysis.Result: Forty SLE patients with a mean age of 31.65 (SD 8.84) were enrolled in the study, 33 of which (82.5%) had positive autoantibody to CRP pentamer. The anti-CRP antibody was signifi cantly correlated (p = 0.024) with disease activity. Conclusions: There was a relatively large proportion of patients with positive anti-CRP antibody among SLE patients in Cipto Mangunkusumo General Hospital. Therewas also a signifi cant correlation between anti-CRP antibody and the disease activity.]]>
<![CDATA[Current Role of Anti-Integrin Therapy in Inflammatory Bowel Disease ]]>
<![CDATA[Kevin Winston]]>;
<![CDATA[Hasan Maulahela]]>;
<![CDATA[Lusiani Lusiani]]>;
<![CDATA[Raditya Dewangga]]>;
<![CDATA[Lazuardi G Ilhami]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 2 (2020): VOLUME 21, NUMBER 2, August 2020 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
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DOI: 10.24871/2122020137-145
<![CDATA[Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder with multifactorial etiology. Management of IBD is divided into conventional treatment and new treatment with biologic agents. The first biologic agents used for IBD was tumor necrosis factor (TNF)-inhibitor. However, TNF-inhibitor as a biologic agent has several limitations such as low rate of clinical response and systemic immunosuppressive side effects. Anti-integrin is a recently developed biologic agent which selectively inhibits leukocyte trafficking towards site of inflammation. The inhibition is caused by blocking the actions of integrin, a cell adhesion molecules (CAMs) that is necessary for leukocyte trafficking and leukocytes express specific integrin receptors for specific organs. Therefore, use of gut-specific anti-integrin agents in IBD can selectively prevent influx of leukocytes into the intestine to reduce inflammation without reducing immune function in other locations. As a result, gut-specific anti-integrin is hypothesized to have lower risk of infections and lower risk of malignancy than TNF-inhibitor while maintaining high therapeutic benefits, making anti-integrin a promising therapy for IBD in the future.]]>
<![CDATA[Modifikasi Skor TIMI sebagai Model Prediksi Mortalitas 30 Hari Pasien STEMI Muda ]]>
<![CDATA[Mansur, M. Tasrif]]>;
<![CDATA[Yamin, Muhammad]]>;
<![CDATA[Rusdi, Lusiani]]>;
<![CDATA[Abdullah, Murdani]]>;
<![CDATA[Karim, Birry]]>;
<![CDATA[Rumende, Cleopas Martin]]>;
<![CDATA[Marbun, Maruhum Bonar H.]]>;
<![CDATA[Shatri, Hamzah]]>
<![CDATA[ Jurnal Penyakit Dalam Indonesia Vol. 10, No. 4 ]]>
Publisher : <![CDATA[UI Scholars Hub ]]>
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<![CDATA[Introduction. Cardiovascular disease is a leading cause of death worldwide. Three-quarters of these deaths occur in lowand middle-income countries among individuals in their productive years. ST-segment elevation myocardial infarction (STEMI) is a dangerous manifestation of coronary artery disease (CAD) and can lead to sudden death. Smoking and a family history of early CAD are major risk factors for STEMI cases. However, their role in any risk stratification system for patients has not been clearly established. The most widely used score in assessing the prognosis of STEMI patients is the TIMI score, but its accuracy in the young patient population is still unknown. The objectives of this study were to determine the proportion of mortality in young STEMI patients at RSCM, validate the TIMI score in young patients, and develop a risk stratification system for young STEMI patients. Methods. This research is a retrospective cohort study using medical record data from the Dr. Cipto Mangunkusumo National General Hospital (RSCM) on patients aged ≤50 years who were treated for ST-elevation myocardial infarction (STEMI) from 2018 to 2022. Univariate analysis was conducted to obtain subject characteristics and the 30-day mortality proportion of young STEMI patients. Bivariate Cox regression analysis was performed to examine the relationship between smoking and a family history of early coronary artery disease (CAD) with 30-day mortality. The TIMI score was validated in the study subjects of young patients. Multivariate analysis was conducted to obtain a new prediction model, and the model’s discriminatory performance was assessed using the area under the ROC curve (AUC), and model calibration was modified using the Hosmer-Lemeshow test. Results. A total of 164 study subjects were included. There were 107 patients (65.2%) with a smoking risk factor, while 39 patients (23.9%) had a family history of early CAD. The proportion of 30-day mortality among young patients was 7.9% (13 individuals). Statistical analysis showed that there was no correlation between 30-day mortality in young STEMI patients and a history of smoking (HR 0.0441 (95% CI 0.148-1.312)) or a family history of early CAD (HR 0.567 (95% CI 0.126- 2.559)). The TIMI score showed good predictive ability for 30-day mortality in young STEMI patients, with an AUC value of 0.836 (95% CI 0.717- 0.956). The combination of the TIMI score with the smoking history variable demonstrated good discriminatory performance in predicting 30-day mortality among young STEMI patients, with an AUC value of 0.875. However, when comparing the AUC values between the TIMI score and the TIMI score with the addition of the smoking history factor, no significant increase in accuracy was observed (p-value=0.215). Conclusions. The TIMI score demonstrates good discrimination and calibration in predicting 30-day mortality among young STEMI patients. The TIMI score, when combined with the smoking history factor, shows improved discriminatory performance and calibration in predicting 30-day mortality among young STEMI patients compared to the pure TIMI score but does not significantly enhance the accuracy.]]>
<![CDATA[Efektivitas Sacubitril/Valsartan dalam Mencegah Gagal Jantung pada STEMI Pasca Percutaneous Coronary Intervention ]]>
<![CDATA[Andre, Nobian]]>;
<![CDATA[Adila, Lana]]>;
<![CDATA[Rizka, Aulia]]>;
<![CDATA[Rusdi, Lusiani]]>
<![CDATA[ Jurnal Penyakit Dalam Indonesia Vol. 10, No. 4 ]]>
Publisher : <![CDATA[UI Scholars Hub ]]>
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<![CDATA[Heart failure is a possible complication following ST-elevation myocardial infarction (STEMI) even after revascularization. Neuroendocrine activation in the process of ventricular remodeling can be regulated by angiotensin receptor-neprilysin inhibitor (ARNI) as well as angiotensin-converting enzyme (ACE) inhibitor. The use of ARNI in heart failure with reduced ejection fraction has been found to be superior to ACE inhibitor. The role of ARNI on cardiac function in STEMI has not been established. A clinician treating a patient with STEMI considered giving sacubitril/valsartan to reduce the risk of developing heart failure. Literature search was performed in three electronic databases: PubMed, Embase, and Cochrane. Keywords in the form of text words and MeSH terms were arranged using Boolean operator technique. Critical appraisal of selected articles was carried out according to the guideline from Oxford Centre for Evidence-Based Medicine. Four relevant randomized clinical trials were obtained. There was a reduced risk of heart failure events at 6 months following STEMI who underwent percutaneous coronary intervention (PCI) in the sacubitril/valsartan group compared to ACE inhibitor group, with a relative risk (RR) of 0.35 (95%CI 0.15 – 0.84; p=0.037); RR 0.5 (95%CI 0.31 – 0.82; p=0.004); and number needed to treat (NNT) of 6. Similar results were also found in STEMI patients complicated by cardiogenic shock: RR 0.47 (95%CI 0.24 – 0.94; p=0.044). Sacubitril/valsartan is more effective than ACE inhibitor in reducing the risk of heart failure at 6 months following STEMI post-PCI.]]>
<![CDATA[Program Multidisiplin Pasien Gagal Jantung Kronik untuk Menurunkan Angka Perawatan Ulang Rumah Sakit ]]>
<![CDATA[Lusiani, Lusiani]]>;
<![CDATA[Adnan, Nurhayati]]>
<![CDATA[ Jurnal Penyakit Dalam Indonesia Vol. 11, No. 1 ]]>
Publisher : <![CDATA[UI Scholars Hub ]]>
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<![CDATA[Heart failure is a complex disease caused by abnormalities in the structure or function of the heart resulting in decreased cardiac output. The complexity of heart failure causes an increasing burden of mortality and morbidity. This has further exacerbated the burden of treatment costs as well as the high rate of hospital readmissions. Readmission rate in patients with heart failure within 30 days post-hospitalization can reach 17.5%. In order to reduce re-hospitalization rates, multidisciplinary programs were introduced. The program involves collaboration of cardiologists, specialty nurses, pharmacists, nutritionists, and social workers using home or clinic-based models. Studies show that special management programs with a multidisciplinary approach can reduce re-hospitalization, mortality, and morbidity in heart failure patients. Multidisciplinary programs can also increase the level of medication adherence in heart failure patients. Therefore, multidisciplinary programs can be considered as one of the main lines in the management of heart failure.]]>
<![CDATA[Penggunaan Aplikasi Mentimeter sebagai upaya motivasi belajar Taruna Teknika pada Materi Mekanika Terapan ]]>
<![CDATA[Lusiani, Lusiani]]>
<![CDATA[ Jurnal Penelitian Pembelajaran Fisika Vol 12, No 2 (2021): SEPTEMBER 2021 ]]>
Publisher : <![CDATA[Universitas PGRI Semarang ]]>
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DOI: 10.26877/jp2f.v12i2.8338
<![CDATA[Tujuan dalam penelitian ini menganalisis penggunaan aplikasi mentimeter sebagai upaya motivasi belajar taruna teknika pada materi mekanika terapan. Metode penelitian yakni survei serta kajian literature. Tempat penelitian di Program Studi Teknika Akademi Maritim Nusantara Cilacap. Waktu pelaksanaan penelitian pada bulan April 2020 dengan subjek sejumlah 40 taruna Teknika pada mata kuliah Mekanika Terapan. Pengambilan sampel di lingkup Akademi dikarenakan materi Termodinamika dan Mekanika terdapat pada kurikulum Akademi Kemaritiman. Pada kajian berikut, dianalisis data hasil belajar ranah kognitif dan afktif peserta. Hasil belajar kognitif dan afektif didapatkan melalui instrumen berupa media mentimeter serta mekanika terapan. Prosedur pengambilan data yaitu dengan 2 cara dengan sampel yang sama. Hasil belajar kognitif diperoleh menggunakan media mentimeter sedangkan hasil afektif melalu media angket. Data yang diperoleh kemudian dianalisis masing-masing, dengan deskripsi gambar dan grafik kedua media. Analisis perbandingan media mentimeter dan angket dijabarkan secara kualitatif dan kuantitatif. Simpulan pada penelitian ini yakni penggunaan aplikasi mentimeter sebagai upaya motivasi belajar taruna teknika pada materi mekanika terapan dalam ranah kognitif penguasaan awal taruna teknik pada materi mekanika terapan sudah cukup baik, sedangkan dalam ranah afektif dalam menambah motivasi belajar taruna, aplikasi mentimeter memiliki nilai 77,5% ini mengandung makna bahwa penggunaan aplikasi mentimeter dapat menjadi salah satu faktor menumbuhkan motivasi belajar peserta didik dengan nilai diatas 75%. Sedangkan dalam menambah minat belajar, aplikasi mentimeter dapat juga menjadi salah satu faktor menumbuhkan motivasi belajar peserta dididk dengan nilai 75%. Penggunaan aplikasi mentimeter sebagai upaya motivasi belajar taruna teknika pada materi mekanika terapan tercapai dengan baik. Kata kunci: Mekanika terapan, Mentimeter, Motivasi belajar]]>
