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INDONESIAN PEOPLE RISK FACTORS OF NOCTURIA (TWO OR MORE VOIDS PER NIGHT) OLDER THAN 40 YEARS-OLD Besut Daryanto; Athaya Febriantyo Purnomo; Taufiq Nur Budaya; Seskoati Prayitnaningsih; Nadia Artha Dewi
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.6

Background: Nocturia is a common urinary system disease. Objective: This study aimed to investigate the causes of nocturia in women Indonesian inhabitants aged≥ 40 years. Methods: A stratified sample strategy was used to conduct a randomized cross-sectional study on 562 residents under the age of 40 in Malang City, East Java, Indonesia. A questionnaire was completed, which included socioeconomic demographics, lifestyle characteristics, and clinical history. Each night, nocturia was defined as at least two voids. The chi-squared test was used to determine proportional differences between age and gender groups. Multivariate logistic regression analysis was used to assess gender-related factors. This was determined that P0.05 was statistically significant. Results: Data on 562 people aged 61.60 + 9.81 years eligible for statistical analysis at the end, comprising 185 (32.92%) men and 377 (67.08%) women. Overall nocturia prevalence was 31.8% (179/562). It rose significantly with age (P<0.001) and reached >48% in those above the age of 70. In both men and women, nocturia was linked with diabetes, hypertension, cardiovascular disease, and the overactive bladder symptom score (OABSS) (P0.05). There was no link discovered between nocturia and education, profession, civil status, BMI, female birth history, or the International Prostate Symptom Score. Conclusion: Nocturia is linked to aging, cardiovascular disease, hypertension, OABSS, and diabetes in Indonesians over the age of 40.

FACTORS INFLUENCING POST-CIRCUMCISION WOUND HEALING Daryanto, Besut; Satyagraha, Paksi; Kustono, Andri; Dhani, Fauzan Kurniawan; Negara, Edvin Prawira; Purnomo, Athaya Febriantyo; Sholihah, Nikmatus; Hanggara, Dian Sukma
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.960

Objective: This study aims to determine the effect of the penile gland and smegma smear, the expression of collagen and fibroblasts in the preputium, on post-circumcision wound healing. Material & Methods: A cross-sectional study conducted in Malang with samples obtained by purposive sampling on September 17, 2022. Inclusive criteria were uncircumcised males who agreed to be circumcised and had no contraindications to the procedure. Furthermore, the preputium obtained from the circumcision procedure was stained with Hematoxylin-Eosin (HE) and counted under an optical microscope. Post-circumcision evaluation was carried out seven days after the procedure. The data were analyzed using the regression method; p denotes the probability value or significance level, while the b score denotes the degree of influence. Results: There were total of 31 research samples that had a significant difference in the average age between the samples with post-circumcision complaints (11.25 ± 2.75) and those without complaints (8.5 ± 2.73) (p=0.05). The regression test found that bacterial culture, fibroblasts, and collagen had significant effects of 24%, 25%, and 24%, respectively. Conclusions: Skin elasticity decreases with age, as marked by increased fibroblasts and decreased collagen density. Fibroblast factors, collagen, and bacterial culture are significant in wound healing. Keywords: Circumcision, collagen, fibroblast, wound healing.

Efficacy and safety of rituximab in children with steroid- and calcineurin inhibitor-dependent nephrotic syndrome: a systematic review of randomized controlled trials Sharon, Sharon; Nadhifah, Nadhifah; Heriawan, Timotius Ivan; Rahmatika, Nadya; Zahara, Nadia Eva; Purnomo, Athaya Febriantyo; Lazarus, Gilbert
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.490-500

Background Efficacy of rituximab in the management of idiopathic nephrotic syndrome in children is well-established, however there is limited evidence of its efficacy in children with steroid- and calcineurin inhibitor-dependent nephrotic syndrome (CNI-SDNS). Objective To investigate the efficacy and safety of rituximab in children with CNI-SDNS. Methods We conducted a comprehensive search for relevant RCTs in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. Eligible RCTs were included, assessed for risk of bias using the Revised Cochrane risk-of-bias tool for randomized trials, and summarized narratively. Results A total of five RCTs (299 children) were included in the review. Rituximab was effective in maintaining remission and preventing relapse in pediatric CNI-SDNS patients, in a manner potentially superior to conventional therapy. Furthermore, rituximab successfully resulted in a higher rate of steroid and CNI withdrawal, along with prolonged drug-free period. However, the benefits of rituximab in children with focal segmental glomerulosclerosis (FSGS) remains equivocal. The drug was generally well-tolerated, both in the short-term and long-term, with a low incidence of adverse events and infusion reactions, typically of mild and reversible nature. Conclusion Rituximab appears to be effective and safe in treating children with CNI-SDNS, offering potential benefits in reducing dependence on steroids and CNIs. Larger trials comparing the effectiveness of rituximab specifically between children with minimal change disease (MCD) and FSGS are warranted to further validate and strengthen our findings.

Polymorphic CAG and GGN repeats in Cryptorchidism patient risk: A meta-analytical study Nurul Cholifah Lutfiana; Athaya Febriantyo Purnomo; Nur Aisah Ibrahimiyah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.22603

Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000). In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.

Coenzyme Q10 as adjuvant therapy could reduce oxidative stress and enhance sperm quality in cryptorchidism animal models Nurhadi, Pradana; Daryanto, Besut; Dhani, Fauzan K.; Purnomo, Athaya F.; Kusworini, Kusworini; Alfandy, Tommy N.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2474

The role of coenzyme Q10 (CoQ10) as an antioxidant in the context of cryptorchidism is increasingly recognized due to its potential protective effects against oxidative stress, a key contributor to testicular dysfunction in this condition. The aim of this study was to evaluate the antioxidant activity of CoQ10 and its impact on sperm parameters as an adjuvant therapy in a cryptorchidism mouse model. A total of 36 male Sprague Dawley mice were divided into six groups: control (negative control), cryptorchidism (positive control), orchidopexy only, and orchidopexy treated with CoQ10 at 5, 10 and 20 mg/kg body weight (BW). After seven days of induction into the cryptorchidism model, the mice underwent orchidopexy, and CoQ10 was administered orally from day 1 to day 7 post-orchidopexy. At the end of the treatment period, all mice were euthanized, and the left testes were collected for immunohistochemical analysis of malondialdehyde (MDA) and superoxide dismutase (SOD), as well as histological examination and sperm parameter assessment. Testicular tissue damage was assessed using the Cosentino grade, while spermatogenesis was evaluated using the Johnsen scoring system. Additionally, sperm parameters were analyzed from the left testis. MDA expression in the cryptorchidism group was significantly lower than in all CoQ10-treated groups (p<0.001). In contrast, SOD expression was significantly higher in the cryptorchidism group compared to the 10 mg/kg BW and 20 mg/kg BW CoQ10 groups (both had p<0.001). Cosentino grade and Johnsen score showed no significant differences between the control group and the group treated with 20 mg/kg BW CoQ10 (p=0.891 and p=0.123, respectively). Furthermore, the 20 mg/kg BW CoQ10 group had significantly greater sperm concentration and motility compared to the cryptorchidism group (p<0.001 for both). These findings demonstrated that CoQ10 had significant antioxidant activity as an adjuvant therapy in a cryptorchidism mouse model. CoQ10 supplementation could reduce oxidative stress markers, enhance antioxidant enzyme expression, and improve sperm parameters, supporting its potential to mitigate testicular damage associated with cryptorchidism.

Polymorphic CAG and GGN repeats in Cryptorchidism patient risk: A meta-analytical study Lutfiana, Nurul Cholifah; Purnomo, Athaya Febriantyo; Ibrahimiyah, Nur Aisah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.22603

Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000). In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.

Effectiveness of Deep Brain Stimulation (DBS) in the Anterior Thalamic Nucleus (ATN) for Drug-Resistant Epilepsy: A Comprehensive Literature Review Hidayat, Yoga Arif; Monika, Caroline; Rusli, Bryant Agustino; Ramadhan, Irfan Fadillah; Purnomo, Athaya Febriantyo
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3274

Epilepsy, a chronic neurological disorder characterized by recurrent seizures, significantly impacts the lives of millions worldwide. While antiepileptic drugs have become the standard of care for seizure control, a substantial portion of epilepsy patients, estimated at approximately one-third, continues to experience seizures despite trying multiple medications. Consequently, there is a pressing need to explore alternative and more effective treatment options. This study was conducted to review more deeply Deep Brain Stimulation (DBS) has emerged as a promising intervention for individuals with drug-resistant epilepsy. DBS entails the implantation of small electrodes into specific brain regions to provide controlled electrical stimulation, aiming to modulate abnormal neural activity associated with seizures. Among the targeted brain regions, the Anterior Thalamic Nucleus (ATN) has garnered substantial attention due to its potential to reduce seizure frequency in individuals for whom conventional therapies have proven inadequate. A literature search was conducted from journal articles using databases in the form of Pubmed, Medline, Google Scholar, Proquest, Embase, SAGE, and Web of Science. The search strategy involved using a set of keywords and their synonyms without any publication date restrictions. In this comprehensive review, the effectiveness of DBS in the ATN for drug-resistant epilepsy is critically examined. Notably, recent clinical trials have shown significant promise. For instance, the SANTE (Stimulation of Anterior Nucleus of Thalamus for Epilepsy) study demonstrated that, after three months, 110 drug-resistant epilepsy patients receiving DBS in the ATN experienced a remarkable 40% reduction in seizure frequency. Long-term follow-up revealed progressive improvements, with a subsequent 69% decrease in seizure frequency over five years. There is potential adverse events associated with DBS, including bledding, infections, paresthesia, moving disorder and psychiatric disorder. DBS is highly effective in reducing seizure frequency, controlling seizures, and improving the patient’s quality of life. DBS can also serve as a treatment option for various other neurological disorders. In the future it is expected to become more effective with advances in neuroscience, particularly neurointerventions, which allow more precise anatomical targeting. Monitoring possible side effects caused by DBS is critical to optimizing patient outcomes. In conclusion, this review underscores the potential of DBS in the ATN as an effective therapy for drug-resistant epilepsy. While significant progress has been made, further research is needed to refine treatment parameters, enhance patient selection, and evaluate long-term outcomes. DBS represents a beacon of hope for individuals whose lives are profoundly affected by drug-resistant epilepsy, offering the prospect of improved seizure control and enhanced quality of life.

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