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All Journal Jurnal Biodjati Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry
Andita Fitri Mutiara Rizki, Andita Fitri Mutiara
Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran ¬University.
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Materials Science & Nanotechnology

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Antimalarial Activity of Mangrove Plants and Possible Mechanisms of Action: A Scoping Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9236

Abstract

Malaria is one of life threatening-infectious diseases with high mortality rate in African regions. Malaria is also one of public health problem in most of Southeast Asia (SEA) regions. This disease is caused by a Apicomplexan parasite; Plasmodium sp., which can be transmitted from humans to humans via Anopheles sp. To date, the need of a new antimalarial drug is still high, due to the rapid increase of drug resistance. Natural-derived drug candidates are still being used by researchers to develop new antimalarials. One of the natural resources which could potentially be a source of antimalarial agents are mangrove plants. Traditionally, mangrove plants have been employed as antibacterial, antioxidant, anticancer, and antidiabetic. Therefore, we conducted a scoping review to identify, evaluate and summarize findings of newly found antimalarial drug activity from mangrove plants and elaborate the possible mechanism of actions in killing the parasites. From several databases, we found six mangrove species which have been suggested as potential antimalarial sources. Various phytochemical compounds in extracts made from those plants were revealed to exert antimalarial activity. These include alkaloids, flavonoids, tannins, phenols, terpenoids, saponins, coumarins, triterpenes, glycosides, and anthraquinones which were indicated to have antimalarial activity against Plasmodium. From eight studies investigating mangrove plant extracts, no toxic effects were shown. Therefore, considering the available evidences, we suggested that mangrove plants can be used as a source for the discovery of antimalarial compounds with promising activities against Plasmodium sp. However, deeper understanding on the exact mechanisms of their actions still requires further elucidation. Keywords: Antimalaria, Anthraquinone, Mangrove, Plasmodium sp., Protozoa
Pharmacological Activities of Sonneratia Alba Mangrove Plant : A Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Journal of The Indonesian Society of Integrated Chemistry Vol. 15 No. 2 (2023): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v15i2.29274

Abstract

Indonesia is a country with a high amount of diverse natural resources. Various plants have important roles in supporting human medicinal needs due to their availability in providing various medicinal resources. One of the natural resources is Sonneratia alba, a species of mangrove plant known with high adaptive ability and tolerance to extreme environmental conditions such as high saline stress, light intensity exposure, and free radicals. This review summarized the findings on pharmacological activities of S. alba.  Several studies reported the adaptive ability of S. alba with its various pharmacological activities such as antimalarial, antioxidant, antimicrobial, and anticancer. These activities are strongly correlated with its bioactive constituents such as terpenoid, alkaloid, tannin, quinone, phenolic, and flavonoid. The mechanism of each pharmacological activity has been suggested in several studies. These findings could be beneficial in drug discovery for several infectious and degenerative diseases and in the development of drugs at industrial stage. Keyword: Anticancer, antimalaria, antimicrobial, antioxidant, Sonneratia alba  
Potensi Ekstrak Buah Buni (Antidesma bunius L) Sebagai Antibakteri dengan Bakteri Uji Salmonella thypimurium dan Bacillus cereus Indrawati, Ida; Rizki, Andita Fitri Mutiara
Jurnal Biodjati Vol 2 No 2 (2017): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v2i2.1309

Abstract

Terdapat senyawa bioaktif pada tumbuhan yang berkhasiat sebagai obat. Tumbuhan genus Antidesma menunjukkan adanya aktivitas antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas zat antibakteri yang terkandung di dalam buah buni (Antidesma bunius L) terhadap bakteri uji Salmonella thypimurium dan Bacillus cereus. Metode yang digunakan untuk penelitian ini adalah metode difusi Kirby Bauer dan data dianalisis secara deskriptif. Hasil yang diperoleh adalah diameter zona hambat yang dihasilkan dari uji antibakteri terhadap bakteri B. cereus terbesar yaitu 20 mm pada konsentrasi ekstrak 80%, dan terkecil sebesar 6 mm pada konsentrasi ekstrak 1,25%. Hasil uji antibakteri ekstrak buah buni terhadap bakteri S. thypimurium dengan zona hambat terbesar yaitu 28 mm pada konsentrasi 80% dan zona hambat terkecil yaitu 0 mm pada konsentrasi 1,25%. Simpulan yang diperoleh adalah terdapat aktivitas antibakteri dari ekstrak buah buni terhadap bakteri uji S. thypimurium dan B. cereus. Rata-rata diameter zona hambat yang terbentuk pada ekstrak Buah Buni (Antidesma bunius) terhadap bakteri B. cereus pada konsentrasi 80; 40; 20; 10; 5; 2,5; dan 1,25% masing-masing adalah sebesar 18,4; 12; 9,4; 8,4; 7,4; 7; dan 6,4 mm. Sedangkan terhadap bakteri S. thypimurium pada konsentrasi 80; 40; 20; 10; 5; 2,5; dan 1,25% masing-masing adalah sebesar 26,7; 21; 11; 10; 8; 7; dan 4,3 mm. 
Co-Authors Azmi, Wihda Aisarul I MADE ARTIKA Ida Indrawati Melva Louisa Muhaimin Muhaimin Siregar, Josephine Elizabeth