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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry
Azmi, Wihda Aisarul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Materials Science & Nanotechnology

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Antimalarial Activity of Mangrove Plants and Possible Mechanisms of Action: A Scoping Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9236

Abstract

Malaria is one of life threatening-infectious diseases with high mortality rate in African regions. Malaria is also one of public health problem in most of Southeast Asia (SEA) regions. This disease is caused by a Apicomplexan parasite; Plasmodium sp., which can be transmitted from humans to humans via Anopheles sp. To date, the need of a new antimalarial drug is still high, due to the rapid increase of drug resistance. Natural-derived drug candidates are still being used by researchers to develop new antimalarials. One of the natural resources which could potentially be a source of antimalarial agents are mangrove plants. Traditionally, mangrove plants have been employed as antibacterial, antioxidant, anticancer, and antidiabetic. Therefore, we conducted a scoping review to identify, evaluate and summarize findings of newly found antimalarial drug activity from mangrove plants and elaborate the possible mechanism of actions in killing the parasites. From several databases, we found six mangrove species which have been suggested as potential antimalarial sources. Various phytochemical compounds in extracts made from those plants were revealed to exert antimalarial activity. These include alkaloids, flavonoids, tannins, phenols, terpenoids, saponins, coumarins, triterpenes, glycosides, and anthraquinones which were indicated to have antimalarial activity against Plasmodium. From eight studies investigating mangrove plant extracts, no toxic effects were shown. Therefore, considering the available evidences, we suggested that mangrove plants can be used as a source for the discovery of antimalarial compounds with promising activities against Plasmodium sp. However, deeper understanding on the exact mechanisms of their actions still requires further elucidation. Keywords: Antimalaria, Anthraquinone, Mangrove, Plasmodium sp., Protozoa
Pharmacological Activities of Sonneratia Alba Mangrove Plant : A Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Journal of The Indonesian Society of Integrated Chemistry Vol. 15 No. 2 (2023): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v15i2.29274

Abstract

Indonesia is a country with a high amount of diverse natural resources. Various plants have important roles in supporting human medicinal needs due to their availability in providing various medicinal resources. One of the natural resources is Sonneratia alba, a species of mangrove plant known with high adaptive ability and tolerance to extreme environmental conditions such as high saline stress, light intensity exposure, and free radicals. This review summarized the findings on pharmacological activities of S. alba.  Several studies reported the adaptive ability of S. alba with its various pharmacological activities such as antimalarial, antioxidant, antimicrobial, and anticancer. These activities are strongly correlated with its bioactive constituents such as terpenoid, alkaloid, tannin, quinone, phenolic, and flavonoid. The mechanism of each pharmacological activity has been suggested in several studies. These findings could be beneficial in drug discovery for several infectious and degenerative diseases and in the development of drugs at industrial stage. Keyword: Anticancer, antimalaria, antimicrobial, antioxidant, Sonneratia alba  
Genetic Diversity of Graptophyllum pictum (L.) Griff from Eastern Indonesia Ethnics Based on Sequence-Related Amplified Polymorphismr Azmi, Wihda Aisarul; Husnawati; Puspita, Puspa Julistia; Safira, Ukhradiya M; Subositi, Dyah; Maruzy, Anshary
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 50 No. 2 (2022): Jurnal Agronomi Indonesia
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (638.903 KB) | DOI: 10.24831/jai.v50i2.40644

Abstract

Indonesia berada diposisi kedua dengan jumlah tanaman obat asli tertinggi di dunia setelah Hutan Hujan Amazon. G. pictum (L) Griff merupakan salah satu etnomedisin yang telah dimanfaatkan secara luas oleh masyarakat Indonesia, tapi keragaman genetiknya belum dipetakan. Penelitian ini bertujuan menganalisis keragaman genetik G. pictum (L) Griff dari Indonesia Bagian Timur berdasarkan marka molekuler SRAP melalui pencarian keberadaan polimorfisme. G. pictum (L) Griff yang digunakan berasal dari 11 etnis Indonesia Timur yang sudah dikeringkan sebelumnya, kemudian dilakukan isolasi DNA kromosom, amplifikasi PCR dengan menggunakan 8 kombinasi primer SRAP terpilih, kemudian dianalisis kekerabatan dari 7 etnis menggunakan software NTSYS (Numerical Taxonomy and Multivariative Analysis System) 2.0 dan PopGene (Population Genetic Analysis) 1.3. Dari hasil penelitian diperoleh nilai Persen Lokus Polimorfik (PLP) sebesar 88.55% dengan total lokus ditemukan 49 (44 lokus poliformik dan 5 lokus monomorfik), dan variasi Indonesia menduduki peringkat kedua dengan jumlah tanaman obat asli tertinggi di dunia setelah Hutan Hujan Amazon. Handeuleum (G. pictum (L) Griff) merupakan salah satu tanaman obat yang telah dimanfaatkan secara luas oleh masyarakat Indonesia, namun informasi mengenai keragaman genetiknya masih terbatas. Penelitian ini bertujuan untuk memperoleh informasi mengenai keragaman genetik 52 aksesi G. pictum (L) Griff dari 11 etnis Indonesia Bagian Timur berdasarkan marka molekuler SRAP. Penelitian ini dilaksanakan pada bulan November 2018 hingga Januari 2019. Sebanyak 52 aksesi G. pictum (L) Griff dan 16 kombinasi primer SRAP digunakan dalam penelitian ini. Analisis kekerabatan dilakukan berdasarkan nilai indeks similaritas dan konstruksi dendogram dengan menggunakan program NTSYS 2.0 dan PopGene 1.3. Sebanyak 49 lokus (44 lokus polimorfik dan 5 lokus monomorfik) diperoleh dari delapan kombinasi primer terpilih dengan presentase polimorfik sebesar 88.55%. Keragaman genetik antar aksesi tergolong tinggi (86%) sedangkan antar etnis tergolong rendah (47.23%). Etnis dengan keragaman tertinggi adalah Demta (81.63%), sedangkan Auyu adalah Etnis dengan keragaman genetik yang paling rendah (2.04%). Berdasarkan nilai Indeks Dissimilarity (ID) atau nilai keragaman yang menunjukkan tingkat kekerabatan, Etnis Bajawa dan Auyu memiliki tingkat kekerabatan terjauh (ID = 1.0720). Informasi yang dihasilkan dalam penelitian ini bermanfaat untuk mendukung program pemuliaan dan konservasi daun wungu. Kata kunci: dendogram, handeuleum, SRAP, tanaman obat
Co-Authors Andita Fitri Mutiara Rizki, Andita Fitri Mutiara Dyah Subositi Husnawati I MADE ARTIKA Maruzy, Anshary Melva Louisa Muhaimin Muhaimin Puspa Julistia Puspita Safira, Ukhradiya M Siregar, Josephine Elizabeth