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All Journal Indonesian Journal of Biotechnology Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry
Siregar, Josephine Elizabeth
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Materials Science & Nanotechnology

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Antimalarial Activity of Mangrove Plants and Possible Mechanisms of Action: A Scoping Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9236

Abstract

Malaria is one of life threatening-infectious diseases with high mortality rate in African regions. Malaria is also one of public health problem in most of Southeast Asia (SEA) regions. This disease is caused by a Apicomplexan parasite; Plasmodium sp., which can be transmitted from humans to humans via Anopheles sp. To date, the need of a new antimalarial drug is still high, due to the rapid increase of drug resistance. Natural-derived drug candidates are still being used by researchers to develop new antimalarials. One of the natural resources which could potentially be a source of antimalarial agents are mangrove plants. Traditionally, mangrove plants have been employed as antibacterial, antioxidant, anticancer, and antidiabetic. Therefore, we conducted a scoping review to identify, evaluate and summarize findings of newly found antimalarial drug activity from mangrove plants and elaborate the possible mechanism of actions in killing the parasites. From several databases, we found six mangrove species which have been suggested as potential antimalarial sources. Various phytochemical compounds in extracts made from those plants were revealed to exert antimalarial activity. These include alkaloids, flavonoids, tannins, phenols, terpenoids, saponins, coumarins, triterpenes, glycosides, and anthraquinones which were indicated to have antimalarial activity against Plasmodium. From eight studies investigating mangrove plant extracts, no toxic effects were shown. Therefore, considering the available evidences, we suggested that mangrove plants can be used as a source for the discovery of antimalarial compounds with promising activities against Plasmodium sp. However, deeper understanding on the exact mechanisms of their actions still requires further elucidation. Keywords: Antimalaria, Anthraquinone, Mangrove, Plasmodium sp., Protozoa
Pharmacological Activities of Sonneratia Alba Mangrove Plant : A Review Rizki, Andita Fitri Mutiara; Azmi, Wihda Aisarul; Muhaimin, Muhaimin; Louisa, Melva; Artika, I Made; Siregar, Josephine Elizabeth
Journal of The Indonesian Society of Integrated Chemistry Vol. 15 No. 2 (2023): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v15i2.29274

Abstract

Indonesia is a country with a high amount of diverse natural resources. Various plants have important roles in supporting human medicinal needs due to their availability in providing various medicinal resources. One of the natural resources is Sonneratia alba, a species of mangrove plant known with high adaptive ability and tolerance to extreme environmental conditions such as high saline stress, light intensity exposure, and free radicals. This review summarized the findings on pharmacological activities of S. alba.  Several studies reported the adaptive ability of S. alba with its various pharmacological activities such as antimalarial, antioxidant, antimicrobial, and anticancer. These activities are strongly correlated with its bioactive constituents such as terpenoid, alkaloid, tannin, quinone, phenolic, and flavonoid. The mechanism of each pharmacological activity has been suggested in several studies. These findings could be beneficial in drug discovery for several infectious and degenerative diseases and in the development of drugs at industrial stage. Keyword: Anticancer, antimalaria, antimicrobial, antioxidant, Sonneratia alba  
The role of astaxanthin‐Cu2+ in stabilizing glycated human serum albumin for type 2 diabetes mellitus management: a computational approach Abiyyu, Naufal; Fitrianita, Alfia; Artika, I Made; Siregar, Josephine Elizabeth; Wibowo, Syahputra; Wardhani, Bantari Wisynu Kusuma; Budi, Canggih Setya; Nuringtyas, Tri Rini
Indonesian Journal of Biotechnology Vol 31, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.109830

Abstract

Type 2 diabetes mellitus (T2DM) leads to the non‐enzymatic glycation of proteins, resulting in the formation of advanced glycation end products (AGEs), which contribute to diabetic complications. Human serum albumin (HSA), a major plasma protein, undergoes structural alterations upon glycation (gHSA), reducing its stability and biological functions. Astaxanthin (ASX), a potent antioxidant, is limited by its instability and moderate binding affinity. In this study, we explore the use of copper (Cu2+) to form a stable ASX‐Cu2+ complex, enhancing the antioxidant properties of ASX and improving its interaction with HSA and gHSA. Utilizing computational approaches such as molecular docking, molecular dynamics (MD) simulations, and free energy landscape (FEL) mapping, we analyze the stability and conformational changes of HSA and gHSA upon binding with ASX and ASX‐Cu2+. The residue interaction network (RIN) analysis reveals that ASX‐Cu2+ complexes create a more robust and interconnected network of non‐covalent interactions, particularly enhancing hydrogen bonding, π‐stacking, and ionic interactions. The ASX‐Cu2+ complex at a 1:2 molar ratio significantly improved the binding affinity and structural stability of both native and glycated HSA, reducing protein fluctuations and promoting a more compact conformation. These findings suggest that ASX‐Cu2+ complexes offer therapeutic potential for stabilizing albumin under glycation‐induced stress, with implications for managing oxidative stress and diabetes‐related complications.
Co-Authors ABIYYU, NAUFAL Andita Fitri Mutiara Rizki, Andita Fitri Mutiara Azmi, Wihda Aisarul Canggih Setya Budi Fitrianita, Alfia I MADE ARTIKA Melva Louisa Muhaimin Muhaimin Tri Rini Nuringtyas Wardhani, Bantari Wisynu Kusuma Wibowo, Syahputra