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All Journal Jurnal Sains dan Teknologi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Adinugraha Amarullah
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Potensi Interaksi Obat pada Pasien Layanan Apotek Adinugraha Amarullah; Rifdah Nuur Ronaa Puteri; Klau, Ivan Charles Seran; Farida Anwari; Bella Fevi Aristia; Hamidah
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 1 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i1.59

Abstract

Interaksi obat terjadi ketika dua atau lebih obat dikonsumsi bersamaan, dan risikonya meningkat seiring jumlah obat yang digunakan. Polifarmasi, yakni pemakaian lima obat atau lebih, berpotensi memperbesar kejadian interaksi. Penelitian ini bertujuan menganalisis potensi interaksi obat pada pasien dengan resep polifarmasi selama Oktober 2024. Metode deskriptif retrospektif diterapkan pada data resep yang memuat minimum lima obat, dengan analisis interaksi berdasarkan Stockley Drug Interactions edisi 2015. Hasil menunjukkan 17 kasus interaksi teridentifikasi dan 5 kasus interaksi tak terklasifikasi. Mekanisme interaksi terbanyak berupa farmakokinetik (45,4%), diikuti farmakodinamik (31,8%). Dari segi keparahan, mayoritas interaksi bersifat minor (40,9%), diikuti moderate (36,3%), dan tanpa temuan interaksi mayor. Temuan ini menegaskan pentingnya skrining interaksi obat pada pasien polifarmasi untuk meminimalkan efek merugikan.
Analisis Pemahaman Masyarakat Mengenai Dagusibu Obat di Desa Larangan Pamekasan Adinugraha Amarullah; Farida Anwari; Bella Fevi Aristia; Ivan Charles Seran; Hamidah, Hamidah
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 2 (2025): April 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i2.4945

Abstract

Medicine is an essential part of daily life, yet public knowledge regarding safe medication management often falls short of health standards. To address this issue, the Indonesian Pharmacists Association (Ikatan Apoteker Indonesia, IAI) launched the DAGUSIBU educational program (Obtain, Use, Store, Dispose) to enhance understanding of proper medication management. This study aims to assess the level of knowledge among the residents of Larangan Dalam Village, Larangan District, Pamekasan Regency regarding the DAGUSIBU principles and identify factors influencing their understanding. The study employs a quantitative descriptive approach using purposive sampling techniques, involving 98 respondents from a total population of 3,303 aged 17 to 60 years. Data were collected through a questionnaire covering demographic variables and questions about procedures for obtaining, using, storing, and disposing of medications according to IAI guidelines. Analysis was conducted using the Guttman scale to classify knowledge into three categories: good, moderate, and poor. The results reveal that 42.9% of respondents have good knowledge, 36.7% have moderate knowledge, and 20.4% have poor understanding of medication management. These findings highlight the importance of enhancing health education and strategic interventions to optimize medication management at the household level and prevent the risks of misuse and negative health impacts. The recommendations based on this study are expected to serve as a reference for healthcare institutions and related organizations in designing effective intervention programs.
Kualitas Morfologi Sel Asites Setelah Dilakukan Fiksasi Alkohol 96% dan NBF 10% pada Sediaan Sitologi Pewarnaan Hematoksilin-Eosin (HE)" Yohanes Ardian; Eviomitta Rizki; Adinugraha Amarullah; Marinta, Marinta
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 6 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i6.6397

Abstract

Ascitic fluid is an important specimen in diagnostic cytology for detecting malignancy and inflammation within the peritoneal cavity. The accuracy of cytological interpretation depends on cellular morphology, which is influenced by the type and effectiveness of fixation. Fixatives help preserve cellular integrity prior to Hematoxylin–Eosin (HE) staining. Alcohol 96% acts as a coagulative fixative that rapidly denatures proteins, whereas 10% Neutral Buffered Formalin (NBF) is a non-coagulative fixative that forms protein cross-links, providing greater structural stability but requiring longer fixation time. This study aimed to evaluate and compare the morphological quality of ascitic fluid cells fixed with 96% alcohol and 10% NBF on HE-stained cytological preparations to determine the most optimal fixative. A quantitative comparative design with a laboratory-based observational approach was used. Six ascitic fluid specimens were fixed with 96% alcohol for 15 minutes and 10% NBF for 24 hours. Thin smear preparations were stained with HE and assessed for nuclear clarity, cytoplasmic integrity, and staining artifacts using an ordinal score of 1–4. Data were analyzed using the Mann–Whitney U test at a 95% confidence level (α = 0.05). Results showed that 96% alcohol produced clearer nuclear details, sharper cytoplasmic borders, and fewer artifacts than 10% NBF. Although NBF provided stable cellular structures, nuclei appeared darker and cytoplasmic homogeneity decreased due to prolonged fixation. Statistical analysis showed a significant difference (p < 0.05). Thus, 96% alcohol offers superior ascitic cell morphology and serves as an efficient alternative fixative for body fluid cytology.
Co-Authors Anwari, Farida Bella Fevi Aristia Eviomitta Rizki HAMIDAH Hamidah . Ivan Charles Seran Klau, Ivan Charles Seran Marinta, Marinta Rifdah Nuur Ronaa Puteri Yohanes Ardian