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All Journal Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Journal of Pharmaceuticals and Natural Sciences MPSJ
Aulia Wati, Aulia
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI EFEKTIVITAS EKSTRAK ETANOL KULIT PISANG MAS (Musa acuminata Colla) TERHADAP PENURUNAN KADAR KOLESTEROL TIKUS (Rattus norvegicus) HIPERLIPIDEMIA Sukmawati, Sukmawati; Wati, Aulia; Asmaliani, Ira; Meilinda, Mega
Jurnal Ilmiah As-Syifaa Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.645

Abstract

Hyperlipidemia is the escalation level of cholesterol and triglyceride in blood. Lady finger banana peel had chemical flavonoid, tanin, and saponin contents having the activity to reduce cholesterol level. The research aimed to determine the effect of cholesterol level reduction of ethanol exctract of lady finger peel on hyperlipidemia rat. The research used twenty rats divided into five groups. Group I (negative control) was given Na. CMC of 1% b/v, group II (positive control) was given simvastatin of 1,023 mg/kgBW, group III, IV, V groups were given the extract of 500 mg/kgBW 1000 mg/kgBW, and 1500 mg/kgBW. The rats were fed a high dietary fat during treatment and induces with pristine cholesterol for twenty one days. The measurement of rat cholesterol level was conducted on day 0, 22 and 36. The result were statistically processed using One Way Anova proceeded to Post Hoc Bonferroni. The result of the research showed that the positive control group had no different tangible effect to ethanol extract of lady finger banana groups (p>0,5). In conclusion, the ethanol extract of lady finger banana had the activity in reducing cholesterol level with effective doses of 500 mg/kgBW, 1000 mg/kgBW, and 1500 mg/kgBW.
UJI EFEK KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill.) DAN DAUN SRIKAYA (Annona squamosa L.) SEBAGAI ANTIOBESITAS PADA TIKUS JANTAN Wati, Aulia; Asmaliani, Ira; Herman, Hendra; Fira, Alfiah
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.975

Abstract

Obesity is a condition where there is a buildup of excess body fat so that a person's weight is far above normal.  This study aims to determine the effectiveness  of the combination of avocado leaf extract (Persea americana Mill. ) and srikaya leaves (Annona squamosa L.) as antiobesity in male rats. This study used 18 mice. Rats were given high-fat carbohydrate feed as much as 25 grams a day for 28 days to get obese conditions, followed by oral trial preparation therapy for 14 days with dose variations, namely group I (negative control), group II (positive control), group III avocado leaf extract 60 mg / kg BB, group IV srikaya leaf extract 125 mg / kg BB,  group V extract combination small dose avocado leaf extract 60 mg/kgBB and srikaya leaf 125 mg/kgBB, and group VI extract combination large dose avocado leaf extract 120 mg/kgBB and srikaya leaf extract 250 mg/kgBB. Measurement  of the  Lee index of  test animals was carried out before induction, after induction and after therapy then continued with surgery to determine the weight of perianal, perirenal, and peritonial fat. The results showed that a combination extract of small doses of avocado leaves 60 mg/kgBB and srikaya leaves 125 mg/kgBB had the most effective effect compared to other treatment groups
PENGARUH PEMBERIAN EKSTRAK DAUN BIDARA (Zizipus mauritiana Lam.) TERHADAP FUNGSI HATI TIKUS DENGAN PARAMETER SGPT Amirah, Sitti; Rahman, Safriani; Fitriana, Fitriana; Wati, Aulia; Putra, Bayu; Rakhmat, Syahgita; Mustakim, Putri Dwiyanti Adha; Resvani, Syahyu; Hasbullah, Nurhijjah; Arini, Arini
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1127

Abstract

Repeated administration of traditional medicines can be potentially poisonous and damage vital organs such as the heart, lungs, liver and kidneys. Tests of safety need to be carried out. Bidara leaves are used traditionally used as antimicrobial, analgesic, antipyretic, anti-inflammatory, anti-diabetic. This study aims to determine safety of ethanol extract of bidara leaves on liver function. This research used wistar rats as test animals which were divided into 4 groups. Test animals were given ethanol extract of bidara leaves at a dose of 50 mg/kgBW, 500 mg/kgBW and 2000 mg/kgBW given orally for 14 days. SGPT rate checks are carried out before and after administering the extract. The results showed that giving ethanol extract of bidara leaves for 14 days did not have a significant effect on rat SGPT levels (p<0.05).
Studi Penggunaan Antibiotik pada Pasien Rawat Inap dengan Diagnosis Infeksi Saluran Pernapasan Akut Herman, Hendra; Wati, Aulia; Ninsih, Ulfah Ayu
Jurnal Pharmascience Vol 11, No 1 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.18390

Abstract

Penggunaan antibiotik menjadi pilihan utama untuk mengobati ISPA yang disebabkan oleh bakteri. Namun, penggunaan antibiotik yang tidak tepat dan berlebihan dapat menyebabkan efek samping dan resistensi antibiotik, yang menjadi masalah kesehatan global. Penelitian ini bertujuan untuk menganalisis penggunaan antibiotik pada pasien rawat inap dengan ISPA di rumah sakit swasta. Metode penelitian menggunakan Single Cohort dengan menggunakan data rekam medik sebagai sumber utama. Sebanyak 94 dari 134 pasien mendapatkan antibiotik. Pemeriksaan WBC masih menjadi parameter pemberian antibiotik (p<0,05). Pemberian antibiotik kategori Watch masih mendominasi pilihan antibiotik empiris (82,03%). Penggunaan ceftriaxone pada ISPA sangat besar dibandingkan antibiotik lain (DDD/100 patient days = 42,37). Hasil penelitian menyimpulkan bahwa antibiotik yang diberikan kepada pasien dengan Infeksi Saluran Pernapasan Akut (ISPA) di rumah sakit ini sesuai untuk melawan bakteri penyebab ISPA. Meskipun penggunaan antibiotik golongan Access memerlukan pertimbangan lebih lanjut, Ceftriaxone menonjol sebagai antibiotik yang paling sering diresepkan untuk pasien ISPA, dengan total DDD/100 hari pasien sebesar 42,37. Kata Kunci: Antibiotik, DDD, Infeksi Saluran Napas, Antibiotik Aware, Seftriakson The utilization of antibiotics represents the primary therapeutic approach for managing bacterial-induced Acute Respiratory Infections (ISPA). Nevertheless, indiscriminate and excessive antibiotic usage can give rise to adverse effects and antibiotic resistance, constituting a pervasive global health concern. This study endeavors to scrutinize antibiotic utilization among inpatients diagnosed with ISPA within a private hospital. Employing a Single Cohort design, medical records serve as the principal data source. Among 134 patients, 94 were administered antibiotics. Notably, White Blood Cell (WBC) examination emerges as a pivotal parameter influencing antibiotic administration (p<0.05). The Watch category continues to predominate as the preferred choice for empirical antibiotics (82.03%). Ceftriaxone emerges as the predominant antibiotic in ISPA treatment, surpassing other counterparts (DDD/100 patient days = 42.37). Findings underscore the absence of established protocols governing antibiotic usage in ISPA patients within the hospital, accentuating the imperative role of the Antimicrobial Stewardship Team in guiding and overseeing antibiotic practices. The study's findings suggest that the antibiotics administered to patients with Acute Respiratory Tract Infections (ISPA) in this hospital are fitting for combating the bacteria responsible for ISPA. While the utilization of Access group antibiotics warrants further consideration, Ceftriaxone stands out as the most frequently prescribed antibiotic for ISPA patients, with a total DDD/100 patient days of 42.37.
UJI EFEK EPITELISASI EKSTRAK DAUN PALA (Myristica fragrans Houtt.) PADA TIKUS JANTAN Azhary, Nursyahidah; Wati, Aulia; Herman, Hendra; Kosman, Rachmat
As-Syifaa Jurnal Farmasi Vol 16, No 2 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i2.1143

Abstract

Burns are damage or loss of tissue that occurs due to exposure to a heat source such as fire, hot liquids or fats, steam, radiation, electric current, or chemicals. Purpose of the research This is to determine the effect and effective dose of the ethanol extract of nutmeg leaves (Myristica fragrans Houtt.) in accelerating the epithelialization process in burn wounds. This study used 15 animals mice were divided into five treatment groups, namely negative control group (Na-CMC), positive control group (lanaeloid), and three test groups that received the dosed extract different: 200 mg/kgBB, 400 mg/kgBB, and 600 mg/kgBB. Burns are induced using a plate heat at 100ºC for 2 seconds on the rat's back. Therapy given topically twice a day for 21 days. Wound area measurements were carried out on days 1, 3, 5, 7, 14, and 21. The research results were statistically tested using the One Way Anova test with the Bonferroni post hoc test. Results The research showed that the positive control group was not significantly different from the test extract group. Based on the research results, it can be concluded that the ethanol extract of nutmeg leaves (Myristica fragrans Houtt.) has an epithelialization effect on mice with an effective dose of 600 mg/kgBB
Aktivitas Ekstrak Daun Salam (Syzygium polyanthum) sebagai Antirheumatoid Artritis pada Tikus yang Diinduksi Complete Freund’s Adjuvants (CFA): Antirheumatoid Arthritis Activity of Salam (Syzygium polyanthum) Leaf Extract to Mice Induced by Complete Freund’s Adjuvants (CFA) Amirah, Sitti; Wati, Aulia; Putra, Bayu; Alani, Fitri Wasto
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.259 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14581

Abstract

Rheumatoid arthritis is an chronic autoimmune disease, which is characterized by inflammation and degradation of the joints and cartilages. Rheumatoid therapy is currently using immunosuppressant drugs, nonsteroidal anti-inflammatory drugs and corticosteroids. Treatment of chronic rheumatoid can trigger side effects. Syzygium polyanthum leaves contain alkaloid compounds, flavonoids, saponins, tannins and essential oils consist of citral and eugenol which are thought to be potential as antirheumatoid. This study aims to determine the effect antirheumatoid arthritis and effective dose of ethanol extracts of Syzygium polyanthum leaf. This study used 15 male rats. Treatment started by measuring foot volume using a pletismometer and then inducting CFA intraplantary as much as 0,1 mL on day 1 and left until day 16th. On the day 17th a foot volume and arthritis index was measured and then treated until the day 30th. The animals were divided into 5 groups: negative control (Na. CMC 1%), positive control (methylprednisolone dose 1.646 mg / kg BW), ethanol extractof Syzygium polyanthum leaf at a dose of 75 mg / kg, 150 mg / kg and 300 mg / kg. On the day 31st, foot volume and arthritis index measurements were taken again. The results showed a decrease in foot volume and arthritis index after given of the extract. Foot volume difference data were analyzed using the One Way Anova test followed by the Post Hoc LSD test. The difference between the arthritis index data was analyzed using Kruskal-Wallis followed by the Mann-Whitney test. Statistical results show that positive control has the same effect as extract (P> 0.05). Based on the results of statistical analysis of inflammation of the foot volume and the arthritis index shows that the ethanol extract of Syzygium polyanthum leaf had an effect as an antirheumatoid arthritis
Ethanol Extract of Miana Leaf (Coleus atropurpureus Benth) As Analgetic Antiinflamation in Rats (Rattus novergicus): Ekstrak Etanol Daun Miana (Coleus atropurpureus Benth) sebagai Analgetik Antiinflamasi pada Tikus (Rattus novergicus) Sukmawati; Santi, Irma; Wati, Aulia; Aulya, Riska
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15678

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation is pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage and inhibit cyclooxygenase, which is the first pathway for the synthesis of pain mediators such as prostaglandins. Objectives: This study aims to determine the effectiveness of ethanol extract of Miana leaves (Coleus atropurpureus Benth) (EEML) as analgesic and anti-inflammatory in rats (Rattus novergicus). Material and Methods: This study used The Pre-Posttest-Only Control Group Design, twenty male rats were divided into 5 groups namely negative control, positive control was given diclofenac sodium, treatment with EEML dose of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Test of Antiinflammatory uses the Rat Hind Paw Edema method where the condition of inflammation in rats is induced with 5% egg white by subplantar. The measurement of edema in rat feet used a caliper every 30 minutes for 5 hours. While The measurement of analgesic testing used the method of nociception test which evaluates pain responses such as Staggering Gait, Vocalization, and Writhing. Results: The results of the measurement of the inflammatory parameters were analyzed with the One Way Anova test for the width of edema foot and Kruskal Walis for the thickness of edema foot. While the results of observing the pain response were analyzed with the Kruskal Walis test. Conclusions: This study concluded that the ethanol extract of Miana leaves has anti-inflammatory analgesic especially at a dose of 600 mg/kg BW which results are non-significant (p> 0.05) with a positive control group (sodium diclofenac).
Potential of Extract of Tamarindus Indica L Leaves an Anti-Inflammatory on Carrageenan Induced Wistar Rats Wati, Aulia; Sukmawati, Sukmawati; Putra, Bayu
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1107

Abstract

Tamarind leaves are used in traditional medicine for inflammation, stomach pain, rheumatism, and sore throats. The aims of this study was to determined the potential of extract tamarind leaf as an anti-inflammatory in Wistar rats. This study was used experimental rats divided into 5 groups, namely group I was given Na. CMC, group II was given diclofenac sodium dose of 5.136 mg/kgBW, groups III, IV, and V were given ethanol extract of tamarind leaves at a doses of 250, 500 and 1000 mg/kgBW. The test animals induced with 1% lambda carrageenan by intraplantar after one hour given test preparation orally. Measurements of edema volume and thickness of the rats were carried out before and after induction for 7 hours at 1 hour intervals using a pletysnometer and calipers. The research data was calculated statistically using the one way anova test and Post Hoc LSD. The results of the study showed that the extract group at a dose of 1000 mg/kgBW had an anti-inflammatory effect not significantly different compared to  the diclofenac sodium group at a dose of 5.136 mg/kgBW. Therefore, obtained results showed that the extract of tamarind leaf  has an anti-inflammatory effect with an effective dose of 1000 mg/kgBW.
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) SECARA IN VITRO DENGAN MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Zulhijja .S, Faradiba; Abidin, Zainal; Wati, Aulia
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.75

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which is caused by insulin resistance and dysfunction of insulin secretion. Avocado is used as a traditional medicine to treat various diseases, one of which is the seed of the avocado which contains alkaloids, polyphenols, tannins, flavonoids, triterpenoids, quinones, saponins, monoterpenes and sesquiterpenes and can lower blood glucose levels. The aim of this study was to determine the antidiabetic potential of ethanol extract of avocado seeds (Persea americana Mill.) in vitro using the Nelson Somogyi method. The test began with preparing a series of sample ethanol extract concentrations with concentrations of 40, 50 and 60 ppm using a UV-Vis spectrophotometer measured at a wavelength of 745 nm. The results of testing the anti-diabetic activity by the test samples were able to show the effectiveness of reducing glucose levels in vitro by showing the EC50 value in the ethanol extract sample was 59.1018 μg/mL. From the results of the study it can be concluded that the ethanol extract of avocado seeds (Persea americana Mill) has activity in reducing glucose levels.
Uji Aktivitas Sitotoksik Ekstrak Daun Matoa (Pometia pinnata) dengan Metode BSLT (Brine Shrimp Lethality Test) Rahmawati, Junita Eka; Wati, Aulia; Handayani, Selpida
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 1 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i1.159

Abstract

Matoa plant (Pometia pinnata) is a typical Papuan plant included in the Sapindaceae family which can relieve hypertension and has diuretic, antidiabetic and antioxidant activities. Matoa leaves contain chemical alkaloids, flavonoids, saponins, and steroids. The purpose of this study was to determine the toxic effect and LC50 value of n-hexan extract of matoa leaves against Artemia Salina Leach larvae. Extraction is carried out by maceration method with n-hexane solvent. The n-hexan extract of matoa leaves is prepared in a test solution with concentration variations of 500 ppm, 750 ppm, 1000 ppm, and 1500 ppm. Toxicity testing was carried out using Artemia Salina Leach larvae then the toxic effect of the extract was identified with the percentage of death of Artemia Salina Leach larvae using probit analysis (LC50). The results of this study showed the highest mortality at a concentration of 1500 ppm with the death of 30 larvae. Based on the results of the research conducted, it can be concluded that matoa leaf extract (Pometia pinnata) has a toxic effect on Artemia Salina Leach larvae with a Lethal Concentration value of 50 (LC50) of 509.577 ppm and is included in the toxic category.
Co-Authors Alani, Fitri Wasto Arini Arini Aulya, Riska Azhary, Nursyahidah Bayu Putra, Bayu Fira, Alfiah Fitriana Fitriana Hardiyanti, Purnamasari Hasbullah, Nurhijjah Hendra Herman Irma Santi, Irma Meilinda, Mega Mustakim, Putri Dwiyanti Adha Ninsih, Ulfah Ayu Nur Azizah, Rizqi Rachmat Kosman, Rachmat Rahmawati, Junita Eka Rahmawati, Rahmawati Rakhmat, Syahgita Resvani, Syahyu Rian Iryansyah, Rian Iryansyah Safriani Rahman, Safriani Selpida Handayani, Selpida Sitti Amirah sukmawati Sukmawati Sukmawati Zainal Abidin Zulhijja .S, Faradiba