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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Pharmaceutical Reports Journal of Multimedia Trend and Technology JURNAL PENGABDIAN MASYARAKAT YAMASI MPSJ
Irma Santi, Irma
Unknown Affiliation
Arts Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji Nefroterapi Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile) Dengan Parameter Ureum Tikus Putih Jantan yang Diinduksi Gentamisin Azizah, Rizqi Nur; Santi, Irma; Marlian, Ayu
Window of Health : Jurnal Kesehatan Vol. 2 No. 2 (April, 2019)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.191 KB) | DOI: 10.33368/woh.v0i0.166

Abstract

African leaves (Vernonia amygdalina Delile.) contain flavonoids having an antioxidant activities. The research aimed to determine the nephrotherapy effect of the ethanolic extract of African leaves with the parameter of male rat urea (Rattus norvegicus) induced by gentamicin. The research used 18 rats divided into 6 groups consisting of group I as the normal group, group Il the Negative Control (gentamicin 80 mg I kgBW), group Ill the Positive Contfol (amino acid supplement), group IV, V, and VI given the ethanol extract of African leaves, each dose of 100 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW. The induction of gentamicin 80 mg/kg BW was administered for eight days and the therapy for the ethanol extract of African leaves for fourteen days. The research data were statistically analyzed using the ANOVA test followed by the Post Hoc LSD test. The results showed that the ethanol extract of African leaves had the nephrotherapy effects in reducing the urea in male rat induced by gentamicin.
STUDI PENGGUNAAN OBAT DIARE PADA ANAK PASIEN RAWAT INAP DI RSUD ANDI DJEMMA MASAMBA KABUPATEN LUWU UTARA PERIODE JANUARI-DESEMBER 2014 Santi, Irma; Herman, Hendra; Aninditia, Dian Dwi
Jurnal Ilmiah As-Syifaa Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.108 KB) | DOI: 10.33096/jifa.v9i2.277

Abstract

Diarrhea is generally caused by the bacteria contamined in food and drink. If the bacteria are not the right treatment, it can be fatal and cause death. This research aimed to present the drug use on the diarrhea patient of hospitalized children ar RSUD Andi Djemma Masamba North Luwu district. This research used descriptive method  by collecting data retrospectively. The data were collected by searching the treatment  records given by doctors to diarrhea patient of hospitalized children. The data obtained included patient medical record number, sex, age, body temperature, therapy (drug name, dose, frequency, route of administration) and length of stay.  The result showed that the diarrhea drug use on children included antibiotic drugs(cotrimoxazole 4,3%, amoxicillin 2,9%, gentamicin 4,3%, cefotaxime 1.4%) antimicrobial (metronidazole 14,5%) zinc supplements 30,4%,probiotics 2,9%, antipyretics (paracetamol 34,8%) antiemetic (methoclopramide 1,5%) and antidispepsia (omeprazole 2,9%).
EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR Santi, Irma; Herman, Hendra; Al Ishak, Andi Afifatun Nisa
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.879 KB)

Abstract

Infective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases.
UJI EFEK ANTIDIARE EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R Forst & G. Forst) PADA TIKUS PUTIH JANTAN (Rattus novergicus) Santi, Irma; Putra, Bayu; Kosman, Rachmat; Ramadhani, Fitrah Anggun; Hativa, Hativa
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.991

Abstract

Diarrhea is a condition where defecation with a frequency of more than 3 times a day and the consistency of liquid or semi-liquid feces with water content that exceeds normal limits. One plant that is thought to have antidiarrheal effects with tannin content in it is matoa leaves (Pometia pinnata J.R Forst &; G. Forst). This study was conducted experimentally using 25 male white rats induced castor oil (Oleum ricini) as a laxative. After being induced, experimental animals were divided into 5 groups, namely the negative control group (NaCMC), the positive control group (Loperamid), the the ethanol extract of matoa leaves group with doses of 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB. All treatments were carried out orally. Then observed the frequency of diarrhea and the consistency of feces every 30 minutes for 5 hours. Furthermore, the results of the study were analyzed statistically using the Kruskal Wallis test then continued with the Post Hoc LSD test. From the results of the study it can be concluded that the ethanol extract of matoa leaves has an antidiarrheal effect on male white rats induced castor oil with an effective dose of 800 mg/KgBB
UJI EFEK ANTIINFLAMASI DARI EKSTRAK ETANOL DAUN AWAR AWAR (Ficus septica Burm L. ) TERHADAP TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KARAGEN Rahmadani, Andi Syafirah; Asmaliani, Ira; Santi, Irma; Sukmawati, Sukmawati; Kosman, Rachmat; Herman, Hendra
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1148

Abstract

Inflammation occurs as a normal protective response to tissue damage caused by physical trauma, harmful chemicals, or microbiological substances. Awar-awar leaves contain flavonoid compounds with anti-inflammatory properties, as they can inhibit cyclooxygenase or lipoxygenase enzymes and prevent the accumulation of leukocytes, thereby reducing the inflammatory response. This study aims to determine the effect and effective dose of ethanol extract from awar-awar leaves (Ficus septica Burm L.) as an anti-inflammatory agent in white rats (Rattus norvegicus). The research involved 25 male white rats divided into five treatment groups: Group I received Na-CMC, Group II received 50 mg Diclofenac Sodium, and Groups III, IV, and V received ethanol extract of awar-awar leaves (Ficus septica Burm L.) at doses of 100, 200, and 400 mg/kgBW, respectively. The results showed that the ethanol extract of awar-awar leaves at a dose of 200 mg/kgBW had the most effective anti-inflammatory effect in reducing the volume and diameter of edema in male rats
Dose Optimization of Antihyperuricemia Effects of Matoa Leaf (Pometia pinnata J.R.Forst & G.Forst) in Rats Afiah, Nurul; Santi, Irma; Putra, Bayu
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.271

Abstract

Hyperuricemia is a condition of increased uric acid levels in the blood above normal limits that can cause pain or soreness, which if not treated immediately will cause chronic gout, the formation of tofus, and severe kidney function disorders. One plant that is thought to have anti-hyperuricemia effects is matoa leaves (Pometia pinnata J.R.Forst ; G.Forst) because they contain secondary metabolite compounds, namely flavonoids. This study is an experimental study using 25 male white rats divided into 5 treatment groups, namely group I (Na-CMC, negative control), group II (Allopurinol, positive control 100 mg), group III, IV, and V were given matoa leaf ethanol extract (EEDM) with successive doses of 200 mg/kg body weight (BW), 400 mg/kg BW, and 800 mg/kg BW for 4 days. Test animals were induced with fresh chicken liver juice orally for 7 consecutive days and potassium oxonate 250 mg/kg BW intraperitoneally on day 8. On the 9th to 12th day, EEDM therapy was carried out. Measurement of uric acid levels was carried out on days 0 (before treatment), 7, 8, and 12. The data were then processed statistically using Kruskal-Wallis and the Mann-Whitney follow-up test. From the results of the study, it can be concluded that ethanol extract of matoa leaves has an effect as anti-hyperuricemia with the most effective dose being 200 mg/kg BW.
Effects of Pamelo Orange Peel (Citrus maxima) Ethanol Extract on Macroscopic Kidney and Heart of Hypertensive Rats: Efek Ekstrak Etanol Kulit Jeruk Pamelo (Citrus maxima) pada Makroskopik Ginjal dan Jantung Tikus Hipertensi Arifin, Sukmawati; Emelda, Andi; Santi, Irma; Putrisari, Nur Awaliah; Intan, Tri Rahmaputri Nur; Husain, Nurul Fadillah; Adawiyah, Rabiyah Al
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16946

Abstract

Background: Hypertension, characterized by elevated blood pressure (≥140/90 mmHg), leads to kidney and heart damage. Hypertension causes increased heart rate, heart enlargement, risk of heart failure, and damage to kidney blood vessels. One way to treat hypertension is by administering drugs such as herbal medicines. Pamelo oranges (Citrus maxima) are starting to be developed in the treatment of diseases. The ethanol extract of pomelo orange peel (EEKJP) contains flavonoid compounds which have antihypertensive activity as a natural Angiotensin Converting Enzyme (ACE) inhibitor, diuretic, increases Nitric Oxide Synthase (NOS) activity and activates Endothelium Derived Relaxing Factor (EDRF). Objectives: This study aims to examine the effect of ethanol extract of pomelo orange peel on the macroscopic features of the heart and kidneys of hypertensive rats (Rattus norvegicus). Methods: This research uses The Posttest-Only Control Group Design. Thirty rats were divided into six groups, namely naive control, negative control (NaCMC 1%), positive control (Captopril 0,45 mg/200 gramBB), EEKJP 100 mg/KgBW group, EEKJP 150 mg/KgBW group, and EEKJP 200 mg/KgBW group. Hypertension condition through induction with prednisone 1.5 mg/KgBW and NaCl 2% for 21th days. The test preparation was administered orally for 14th days. Next, all rats were dissected to remove the heart and kidney organs for macroscopic observations. Results: The results of the study showed that ethanol extract of pomelo (Citrus maxima) orange peel had a varied effect on the macroscopic appearance of the heart and kidneys of rats with hypertension. The heart organ shows structural improvements, while the kidneys have not shown any improvement. Conclusions: Extract with a dose of 100 mg/KgBW has no changes in the macroscopic appearance of the heart so it is thought to be able to repair damage to the heart organ.
Konsep Game “Treasure in Borobudur” Menggunakan Unity 3D Sebagai Media Belajar Pesona Indonesia Wahyuningsih, Eka; Santi, Irma; Dwi Lutfiyah, Evi
Journal of Multimedia Trend and Technology Vol. 1 No. 2 (2022): Journal of Multimedia Trend and Technology
Publisher : Universitas Amikom Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1263.595 KB) | DOI: 10.35671/jmtt.v1i2.6

Abstract

Indonesia memiliki beragam kebudayaan. Banyak peninggalan sejarah yang ada di Indonesia. Salah satunya yang diakui dunia yaitu Candi Borobudur. Para wisatawan cukup banyak menaruh perhatian terhadap warisan candi Borobudur termasuk anak – anak. Budaya hendaknya mulai dikenalkan pada anak – anak sejak dini. Namun para anak – anak saat ini dalam belajar memerlukan banyak sumber informasi melalui teknologi informasi. Salah satu media teknologi informasi ini adalah dalam bentuk permainan. Anak – anak sangat menyukai permainan. Oleh karena itu pada kasus mengenalkan budaya seperti candi Borobudur ini diperlukan strategi yang baik sebagai media belajar untuk anak – anak. Makalah ini akan mencoba membahas bagaimana konsep merancang permainan dengan tema kultur budaya yang menyenangkan. Target yang dibahas dalam makalah ini adalah anak – anak sekolah dasar dimana mereka masih senang dengan model belajar dan bermain. Hasil dari pembahasan makalah adalah berupa rancangan game yang dinilai layak digunakan untuk industri. Tujuan dibangunnya game ini merupakan kontribusi sebagai pendukung pesona Indonesia.
Antiobesity Effect of NADES (Natural Deep Eutectic Solvent) Extract of Purslane Herb (Portulaca oleracea L.) on Male Rats (Rattus norvegicus) Azizah, Rizqi Nur; Santi, Irma; Awali, Muhammad Noer; Putra, Bayu; , Faradiba
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.56230

Abstract

Introduction: Obesity is a metabolic disorder characterized by excessive fat accumulation, leading to various health complications. One potential approach to managing obesity is through natural products, such as medicinal plants. Aims: This study evaluates the anti-obesity activity of purslane (Portulaca oleracea L.) extract obtained using the green extraction method in male rats (Rattus norvegicus). Method: A total of 18 male rats were divided into six groups: normal control, negative control (Na-CMC + NADES), positive control (orlistat), and three treatment groups receiving NADES Purslane Herb Extract (NPHE) at doses of 50, 100, and 200 mg/kg BW. The treatment groups were induced with a high-fat diet for 30 days, followed by 14 days of therapy. Result: Statistical analysis using One-Way ANOVA and Bonferroni post-hoc test showed that NADES purslane herb extract exhibited significant anti-obesity effects, with the most effective dose being 200 mg/kg BW, which reduced body weight by 13.004% and BMI by 17.935% in male rats. Conclusion: These findings suggest that purslane extract has potential as a natural anti-obesity agent. Further research is needed to explore its bioactive compounds and mechanisms of action, supporting its potential development in pharmaceutical and nutraceutical applications.
PENYULUHAN NARKOTIKA DI PESANTREN AN-NAHDHLAH MAKASSAR St. Maryam; Rahmawati; Razak, Rais; Emelda, Andi; Maryam, St; Santi, Irma; Amriati Syarif, Rezky
JURNAL PENGABDIAN MASYARAKAT YAMASI Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat Yamasi
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jpmy.v4i1.379

Abstract

In recent decades, drug abuse has had a very high prevalence. Drug abuse has become a global issue. Its distribution is increasing and supported by the use of advanced technology. The deviation in drug use in Indonesia is already at a very urgent position that needs to be addressed immediately. The ease of drug distribution and use among young people is closely related to the neglect of values, norms, rules, and laws that apply in their social environment. This Community Service aims to provide counseling to third-year students of Madrasah Aliyah Pesantren An-Nahdhlah Makassar about the types, benefits, and dangers of drug abuse in society. The transfer of material was conducted using the method of direct counseling to the PkM partners at the school. The results of the activity included an increase in the partners' knowledge and understanding of the types, benefits, and dangers of drug abuse. Based on the results of the pre and post-test evaluations conducted with the partners, an increase in understanding of the material by 30% was achieved.
Co-Authors , Faradiba Adawiyah, Rabiyah Al Al Ishak, Andi Afifatun Nisa Amriati Syarif, Rezky Andi Emelda Arifin, Sukmawati Ashar, Muhammad Affan Aulia Wati, Aulia Aulya, Riska Awali, Muhammad Noer Bayu Putra, Bayu Dian Dwi Aninditia, Dian Dwi Dwi Lutfiyah, Evi Eka Wahyuningsih Hativa, Hativa Husain, Nurul Fadillah Intan, Tri Rahmaputri Nur Marlian, Ayu Mochammad Imron Awalludin Muarsih, Ahmad Juniardhy Multazania, Multazania Nurul Afiah Putrisari, Nur Awaliah Rachmat Kosman, Rachmat Rahmadani, Andi Syafirah Rahmawati Rais Razak, Rais Ramadhani, Fitrah Anggun Rizqi Nur Azizah sahab, Fitria St Maryam, St sukmawati Sukmawati Sukmawati