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All Journal Smart Medical Journal Jurnal Kedokteran Meditek
Jonathan Willy Siagian, Jonathan Willy
Fakultas Kedokteran Universitas Kristen Duta Wacana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Profil dan Kesintasan Penderita Kanker Kolorektal RS Bethesda Yogyakarta Ang Supono, Effie; Jayadi, Tejo; Hariatmoko; Siagian, Jonathan Willy
Jurnal Kedokteran Meditek Vol 29 No 3 (2023): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i3.2547

Abstract

Kanker kolorektal pada tahun 2020 merupakan penyebab kematian paling banyak kedua dari seluruh kasus kanker. Di Indonesia, jumlah kasus baru kanker kolorektal sebesar 8,6% (34.189) dari seluruh kasus baru kanker. Data terkait kenaikan jumlah kasus, jumlah kematian, jenis kanker tersering sudah sering dilaporkan di Indonesia namun terkait dengan kesintasan masih jarang dilaporkan. Penelitian ini bertujuan untuk memberikan informasi terkait profil dan kesintasan kanker kolorektal di Rumah Sakit Bethesda Yogyakarta. Penelitian ini menggunakan metode deskriptif observasional dengan desain potong lintang. Data diambil dari rekam medis RS Bethesda Yogyakarta periode tahun 2013-2021 dan dianalisis secara univariat. Hasil penelitian menunjukkan jenis kelamin terbanyak adalah laki-laki 63,6%, kelompok usia tua (>40 tahun) 93,5%, keluhan terbanyak berupa perubahan pola BAB 72,53%, jenis histopatologi epitel (adenokarsinoma) 92,2%, lokasi kiri 90,9%, didiagnosis pada stadium IV 39%, tata laksana pembedahan 84,42%, dan kesintasan 2 tahun 20,8%. Kesimpulan penelitian ini adalah profil kanker kolorektal lebih banyak pada jenis kelamin laki-laki, usia tua, keluhan berupa perubahan pola BAB, histopatologi tipe sel epitel (adenokarsinoma), lokasi kiri, stadium IV, tata laksana paling banyak pembedahan, serta kesintasan 2 tahun adalah 20,8%.
The Association Between Age Groups with Clinicopathologic and Molecular Subtypes of Breast Cancer Patients Jayadi, Tejo; Rustam, Brenda Miriane; Kristi, Puji; Dewi, Ngesti Chintia; Probowati, Wiwiek; Hariatmoko, Hariatmoko; Siagian, Jonathan Willy
Smart Medical Journal Vol 5, No 2 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i2.59179

Abstract

 Introduction: The increase in incidence proportion of breast cancer disease among young patients < 40 years old is exceeding that of older patients. The purpose of the research is to know the differences between clinicopathologic and molecular subtypes between patients < 40 years old and ≥ 40 years old.Methods: The conducting research on Medical Records (MR) was an observational analytic method with a cross-sectional design. The independent variable was age. Dependent variables were histopathological type, stage of disease, grade of tumor, and molecular subtype of cancer. Univariate analyses to describe the samples. The differences between those variables according to age groups were analyzed by a bivariate statistic and the odds ratio with a confident interval (CI) of 95% of each variable would be displayed by binary logistic regression statistic. Results: The most prevalent age of breast cancer patients was in the range of 50-59 years (47%), the mean age of 53.66 ± 0.977 years, in the range of 29 years old to 86 years old, and patients aged < 40 years was 12%. Ductal carcinoma type (89.7%), stage III tumor (40.2%), poor differentiation grade III (60.7%), and luminal A subtype (42.7%) were the most prevalent clinicopathologic and molecular subtypes. There weren’t differences between histopathologic type, stage of disease, and molecular subtype with age. The histopathologic grade was different from the age variable (p=0.015). Old age had worse histopathologic differentiation than young age (OR 2.166; 95% CI 0.973-4.823).Conclusions: There weren’t significant differences between stage and molecular subtypes of breast cancer between age groups. There was poorer histopathologic differentiation in patients ≥ 40 years.  
Co-Authors Ang Supono, Effie Dewi, Ngesti Chintia Hariatmoko Hariatmoko, Hariatmoko Kristi, Puji Probowati, Wiwiek Rustam, Brenda Miriane Tejo Jayadi, Tejo