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All Journal Berkala Ilmiah Kedokteran Duta Wacana Smart Medical Journal MEDICINUS
Probowati, Wiwiek
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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ASSOCIATION BETWEEN ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) INCIDENCE AND INCREASED D-DIMER IN COVID-19 PATIENTS AT BETHESDA HOSPITAL YOGYAKARTA Hutagaol, Frans Iqlessias; Probowati, Wiwiek; Manus, Widya Christine
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i1.930

Abstract

Background: Acute Respiratory Distress Syndrome (ARDS) is one of the most common complications of COVID-19 infection and is closely related with patient mortality. Increased D-dimer levels are considered one of the most consistent clinical indicators of coagulopathy. Theoretically, this event is based on the emergence of a cytokine storm triggering lung tissue damage, pulmonary microvascular endothelial damage and alveolar edema, leading to hypoxia in the body. Objective: To determine the association between ARDS incidence and the increase in D-dimer levels in COVID-19 patients at Bethesda Hospital Yogyakarta. Method: This research was conducted in retrospective cohort design. The data utilized in this study came from the medical records of male and female COVID-19 patients between 19 and 60 years old, who were diagnosed with ARDS by doctors at Bethesda Yogyakarta Hospital. The medical records were collected between June 1, 2021, and September 30, 2021. The data analysis included univariate (descriptive statistics) and bivariate (Chi-Square, Mann-Whitney, Spearman Rank) analyses. Result: There was a significant relationship between COVID-19 ARDS patients and the increased levels of D-dimer in patients undergoing hospitalization at Bethesda Hospital Yogyakarta (p<0,001, OR=4,589, 95%CI=2,104-10,007). Additionally, there was a significant difference in D-dimer levels between ARDS and non-ARDS patients. The severity of ARDS, duration of hospitalization, gender, and age did not have a significant association with the increase in D-dimer levels (p>0,05). Conclusion: There was a significant relationship between the incidence of ARDS and elevation of D-dimer levels in COVID-19 patients at Bethesda Hospital Yogyakarta.
THE CORRELATION OF ABO BLOOD TYPES AND COVID-19 SEVERITY IN BETHESDA HOSPITAL YOGYAKARTA Pranata, Korin Bagas; Probowati, Wiwiek; Wuryaningsih, Nining Sri
Berkala Ilmiah Kedokteran Duta Wacana Vol. 8 No. 2 (2023): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v8i2.588

Abstract

Background COVID-19 is caused by the SARS-CoV-2 virus. The most recent study showed that there was a possible correlation between ABO blood types and COVID-19 risk. However, some studies disproved the correlation. The contradiction indicated that the correlation between the two variables has not been established. Objective To find the correlation between ABO blood types and the severity of COVID-19.  Methods It applied an observational-analytic method with a retrospective cohort approach. It used secondary data from 2020-2021 in Bethesda Hospital Yogyakarta. Samples were taken using a consecutive sampling technique. The collected data were analyzed using SPSS 26. Univariate analysis was made using descriptive statistics. Sequentially, bivariate and multivariate analyses were made using chi-square, odds-ratio, relative-risk, and ordinal logistic regression analysis. Results There were 212 data. Blood type O got the biggest percentage (38.2%) with a sample of 81 individuals. There were 88 patients with severe symptoms (41.5%), 86 patients with moderate symptoms (40.6%), and 38 patients with mild symptoms (17.9%). The Chi-square analysis of ABO blood types and the severity of COVID-19 was 0.05 (?0.05). The blood type B had a 2.8 times higher probability of severe incidence (95% CI 0.618–12.16) than the non-B blood type. Meanwhile, blood type O had a 0.33 times lower probability of severe incidence (95% CI 0.618–12.16) than non-O blood type. Conclusion The ABO blood types correlated with COVID-19 severity. Blood type O became a protective factor, and blood type B is the risk factor for severe COVID-19. TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian     TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back
The Role of Systemic Immune-Inflammation Index on The Clinical Degree of Dengue Hemorrhagic Fever Patients at Bethesda Hospital Yogyakarta Amumpuni, Antonia Namelia Wahyu; Sooai, Christiane Marlene; Wicaksono, Hendi; Probowati, Wiwiek; Priskila, Loury
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/y6daha15

Abstract

Background: Dengue hemorrhagic fever (DHF) is a mosquito-borne infectious disease caused by the dengue virus and transmitted primarily by Aedes aegypti. According to the World Health Organization (WHO), DHF remains a major globalhealth concern, particularly in tropical and subtropical regions. The disease can result in severe complications, including hemorrhage and hypovolemic shock, which may lead to death. Despite ongoing vector control initiatives, DHF continues to pose a significant public health challenge, especially in areas with inadequate sanitation and limited healthcare infrastructure.Objectives: To evaluate the role of systemic immune-inflammation index (SII) in determining the clinical severity of denguehemorrhagic fever (DHF) among patients at Bethesda Hospital Yogyakarta.Methods: This was a cross-sectional study utilizing medical records from 333 DHF patients at Bethesda Hospital Yogyakarta. Records were screened based on predefined inclusion and exclusion criteria. A total of 172 eligible cases were selected using odds ratio-based sample size calculations. Consecutive sampling was employed as the samplingtechnique. Data analysis was performed using SPSS and Microsoft Excel to determine statistical significance.Results: The findings demonstrated that neutrophil, lymphocyte, and platelet counts significantly influenced the clinical severity of dengue hemorrhagic fever (DHF). Chi-square analysis revealed a statistically significant association between the systemic immune-inflammation index (SII) and disease classification (DF/DHF) (p<0.001). However, the relationshipbetween SII levels and clinical severity did not follow a linear pattern. Contrary to established theories—where elevated SII values are typically associated with increased disease severity—this study observed variations that may be attributed toconfounding factors such as patient age, comorbidities, and individual immune response.Conclusion: The systemic immune-inflammation index (SII) is significantly associated with the clinical severity of DHF in patients at Bethesda Hospital Yogyakarta, although its correlation may be influenced by additional patient-specificvariables such as patient age, comorbidities, and individual immune responses.Keywords: systemic immune-inflammation index (SII), dengue hemmorhagic fever (DHF), dengue severity, clinicalseverity.
The Association Between Age Groups with Clinicopathologic and Molecular Subtypes of Breast Cancer Patients Jayadi, Tejo; Rustam, Brenda Miriane; Kristi, Puji; Dewi, Ngesti Chintia; Probowati, Wiwiek; Hariatmoko, Hariatmoko; Siagian, Jonathan Willy
Smart Medical Journal Vol 5, No 2 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i2.59179

Abstract

 Introduction: The increase in incidence proportion of breast cancer disease among young patients < 40 years old is exceeding that of older patients. The purpose of the research is to know the differences between clinicopathologic and molecular subtypes between patients < 40 years old and ≥ 40 years old.Methods: The conducting research on Medical Records (MR) was an observational analytic method with a cross-sectional design. The independent variable was age. Dependent variables were histopathological type, stage of disease, grade of tumor, and molecular subtype of cancer. Univariate analyses to describe the samples. The differences between those variables according to age groups were analyzed by a bivariate statistic and the odds ratio with a confident interval (CI) of 95% of each variable would be displayed by binary logistic regression statistic. Results: The most prevalent age of breast cancer patients was in the range of 50-59 years (47%), the mean age of 53.66 ± 0.977 years, in the range of 29 years old to 86 years old, and patients aged < 40 years was 12%. Ductal carcinoma type (89.7%), stage III tumor (40.2%), poor differentiation grade III (60.7%), and luminal A subtype (42.7%) were the most prevalent clinicopathologic and molecular subtypes. There weren’t differences between histopathologic type, stage of disease, and molecular subtype with age. The histopathologic grade was different from the age variable (p=0.015). Old age had worse histopathologic differentiation than young age (OR 2.166; 95% CI 0.973-4.823).Conclusions: There weren’t significant differences between stage and molecular subtypes of breast cancer between age groups. There was poorer histopathologic differentiation in patients ≥ 40 years.  
Co-Authors Amumpuni, Antonia Namelia Wahyu Christiane Marlene Sooai, Christiane Marlene Dewi, Ngesti Chintia Hariatmoko, Hariatmoko Hendi Wicaksono Hutagaol, Frans Iqlessias Jonathan Willy Siagian, Jonathan Willy Kristi, Puji Manus, Widya Christine Neneng Ratnasari Nining Sri Wuryaningsih, Nining Sri Pranata, Korin Bagas Priskila, Loury Putut Bayupurnama Rustam, Brenda Miriane Tejo Jayadi, Tejo