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Gene expression and Levels of Plasma Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22)in Pulmonary Tuberculosis Patients and their Household Contacts in Makassar, Indonesia Ibrahim A1,3, Djaharuddin I2 , Hidayah N1 , Subair1 , Handayani I1 , Tenriola A1 , Massi MN4,5*
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10704

Background: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gen,has been involved in the immune response to tuberculosis infection by affecting the inflammatory response and subsequent anti microbial immunity. This study aims to determine the PTPN22 expression and differences in the levels of PTPN22 in pulmonary TB patients (PTB) with household contacts and healthy control. Methods: We analyzed PTPN22 expression and the level of plasma PTPN22 from pulmonary tuberculosis patients (PTB), household contacts and healthy control using real time PCR and ELISA method. Results: ThirtyPTB, 30 household contacts and 30 control were involved in this study. Analysis of the assocation of PTPN22 gene expression against TB showed that PTPN22 gene expression was 7.3 times upregulated compared to household contact and 12.1 times upregulated compared to healthy controls.Levels of plasma PTPN22 in PTB: 10.0620 ng/ml, in Household contact: 6.7923 ng/ml and in control: 4.4293 ng/ These values did not differ significantly between the patients, household contact and control. Conclusion: Our study results found that PTPN22 gene expression is significantly increased in PTB than household contact and control.Levels of plasma PTPN22 in PTB patientsdid not differ significantly than in household contact and control.

The Effect Of Blended Learning Implementation On Learning Motivation And Learning Outcomes Of Nursing Students During The Covid-19 Pandemic Nurlaela Amin A.; Amirullah; Tenriola Andi; Samsidar
Comprehensive Health Care Vol 7 No 2 (2023): Comprehensive Health Care
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jch.v7i2.1049

The Corona Virus Disease pandemic has had an impact on changes in the order of human life in various sectors throughout the world, including the education sector. One type of learning using internet technology (e-learning) that has been effectively used in higher education is blended learning. The application of Blended learning motivates students to better understand the material and be more active in participating in learning, so as to improve student learning outcomes. The research objective is to identify and explore the implementation of blended learning on learning motivation and learning outcomes of nursing students during a pandemic. The research design used was Mix Methods with a sequential explanatory approach, the sample in the quantitative study was 76 people and the qualitative research was 8 people with the sampling technique being simple random sampling. The results of the study with the Chi square test obtained a value of p = 0.019 (<0.05), which means that there is an influence between learning methods and learning outcomes, and qualitative research identified four themes, namely: 1) Internal motivation, 2) External motivation, 3) Supporting factors, and 4) inhibiting factors. There is an effect of the application of blended learning on student learning outcomes during the pandemic. Learning motivation is not only influenced by internal and external motivation, but comes from supporting factors and inhibiting factors. It is hoped that further research can dig deeper into other learning methods related to student motivation and learning outcomes. Keywords: Blended Learning, Learning Motivation, Learning Outcomes

Body Mass Index Status; Underweight In Active TB Patients at H. Andi Sulthan Daeng Radja's Hospital Andi Tenriola; Ewit Irianti; Muriyati
Comprehensive Health Care Vol 7 No 3 (2023): Comprehensive Health Care
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jch.v7i3.1188

Tuberculosis (TB) is a serious public health problem causing increasing morbidity and mortality rates and is of global concern. In tuberculosis (TB) sufferers experience poor nutrition which can reduce a person's immune system so that the disease can easily occur, a lack of protein as well as calories and iron can increase the risk of pulmonary tuberculosis. Objective: To determine the body mass index (BMI) of Tuberculosis (TB) sufferers at H. Andi Hospital. Sultan Daeng Radja Bulukumba Method: This research uses a quantitative type of research using a cross-sectional research design. The number of respondents was 99 people, with a sampling technique using total sampling. This research uses univariate analysis to analyze the data. Results: The body mass index of patients suffering from tuberculosis, found 57 (57.6%) respondents who had a low BMI, in the normal category there were 34 (34.3%) respondents, while in the overweight category, there were 8 respondents with a presentation of (8.1 %). Conclusions and Suggestions: The body mass index of patients suffering from tuberculosis is more likely to be underweight. Tuberculosis patients are expected to be more regular in taking medication so that therapy goals can be achieved as well as regulating diet and improving nutritional status which can influence recovery so that it can improve the patient's body mass index. Keywords: BMI; Tuberculosis; Body Mass Index; Underweight; TB

Edukasi Perawatan Diri Penderita Stroke Pada Keluarga Penderita Stroke Di Wilayah Kerja Puskesmas Bontonyeleng Tenriola, Andi; Aulia Khumaerah
Jurnal ABDIMAS Panrita Vol 5 No 1 (2024): Jurnal ABDIMAS Panrita
Publisher : Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jap.v5i1.1343

Stroke adalah kondisi yang terjadi ketika sebagaian sel – sel otak mengalami kematian akibat gangguan aliran darah karena sumbatan atau pecahnya pembuluh darah di otak. Aliran darah yang berhenti membuat suplai oksigen dan zat makanan ke otak juga berhenti, sehingga sebagaian otak tidak dapat berfungsi sebagaimana mestinya (Agromedia, 2009). Stroke sering muncul secara tiba – tiba, serta berlangsung cepat dan langsung menyebabkan penderita tidak sadar diri (coma). Gaya hidup tidak sehat seperti mengonsumsi makanan tinggi lemak dan tinggi kolesterol, kurang aktivitas fisik dan kurang olahraga, meningkatkan risiko terkena penyakit stroke. Hal ini disebabkan, gaya hidup yang tidak sehat rentan terkena obesitas, diabetes, arteriosclerosis, dan penyakit jantung. Penyakit tersebut sebagai salah satu pemicu terjadinya stroke. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi tentang apa itu penyakit Stroke dan bagaimana perawatan diri pada pasien Stroke. Edukasi dilakukan menggunakan pendekatan partisipatif. Materi yang diberikan berupa pengenalan tentang penyakit Stroke dan bagaimana perawatannya pada pasien Stroke. Dalam penyuluhan ini dengan menggunakan metode ceramah, diskusi, Tanya jawab, dan demonstrasi. Penyampaian materi juga dilakukan dengan menggunakan media pembelajaran berupa poster. Evaluasi dilakukan dengan bertanya kepada masyarakat dan keluarga tentang apa itu Stroke dan bagaimana cara perawatan anggota keluarga yang terkena Stroke sesuai dengan apa yang telah dijelaskan sebelumnya.

EDUKASI DOOR-TO-DOOR PADA IBU HAMIL TANTANG PENTINGNYA ASI EKSKLUSIF DI WILAYAH KERJA PUSKESMAS CENDRAWASIH KOTA MAKASSAR Hestiani K, Dewi; Tenriola, Andi; Riakurnaini, Riakurnaini; Risan, Rahmad
PEDAMAS (PENGABDIAN KEPADA MASYARAKAT) Vol. 3 No. 02 (2025): MARET 2025
Publisher : MEDIA INOVASI PENDIDIKAN DAN PUBLIKASI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pemberian ASI eksklusif selama enam bulan pertama kehidupan bayi merupakan faktor penting dalam mendukung tumbuh kembang yang optimal. Namun, cakupan ASI eksklusif di Sulawesi Selatan masih berada di bawah target nasional, yakni 58,6% dari target 70%. Salah satu faktor utama yang menyebabkan rendahnya cakupan ini adalah kurangnya pemahaman ibu hamil mengenai manfaat dan manajemen ASI eksklusif. Oleh karena itu, diperlukan metode edukasi yang lebih efektif untuk meningkatkan kesadaran ibu hamil mengenai pentingnya ASI eksklusif. Kegiatan ini dilakukan dengan pendekatan door-to-door kepada 15 ibu hamil di wilayah kerja Puskesmas Cendrawasih Kota Makassar. Tiga tahap utama dalam kegiatan ini meliputi pengambilan data awal untuk mengukur tingkat pengetahuan peserta, pemberian edukasi melalui metode bincang interaktif dan pembagian leaflet, serta evaluasi efektivitas edukasi melalui pengukuran ulang tingkat pengetahuan. Hasil evaluasi menunjukkan adanya peningkatan signifikan dalam tingkat pemahaman ibu hamil mengenai ASI eksklusif setelah dilakukan edukasi door-to-door. Sebagian besar peserta mengalami peningkatan skor pemahaman mereka terhadap ASI eksklusif sebesar 30-40% dibandingkan sebelum edukasi diberikan. Metode edukasi door-to-door terbukti efektif dalam meningkatkan pemahaman ibu hamil mengenai pentingnya ASI eksklusif. Pendekatan ini memungkinkan komunikasi yang lebih personal dan interaktif, sehingga pesan edukasi dapat lebih mudah dipahami dan diterapkan oleh peserta.

Culture Shock and Maternal Anxiety During Pregnancy: A Review of Health System Responses in Low-Income Countries Nuraisyah Bahar; Dewi Hestiani K; Andi Tenriola
Jurnal Life Birth Vol. 9 No. 2 (2025): Jurnal Life Birth
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jlb.v9i2.562

Pregnancy is a crucial and unique period in a woman's life marked by significant physiological and psychological changes. One of the main challenges is maternal anxiety, especially when women must adapt to new norms, values, or health practices that differ from their cultural background, known as culture shock. This phenomenon is often experienced by pregnant migrants, minority groups, and women in low-income countries who undergo shifts in roles and traditions during pregnancy. This study aims to systematically review how health systems in low-income countries respond to culture shock and maternal anxiety during pregnancy. This research employed a systematic review design with a PRISMA approach. The sample consisted of 48 selected scientific articles, identified through screening, eligibility, and exclusion processes from an initial total of 513 articles obtained from Google Scholar, Scopus, and PubMed databases. The results reveal that culture shock among pregnant women manifests as confusion about new practices and rituals, value and norm conflicts, social isolation, language barriers, as well as stigma and social pressure. Maternal anxiety is influenced by physiological changes, lack of knowledge, social pressures, and cultural differences. Health system responses in low-income countries still face major challenges, but several effective strategies have been identified, such as integrating psychological interventions (CBT, mindfulness), involving communities and families, culturally-based education, and health worker training on cultural competence. In conclusion, culture shock is a major trigger for maternal anxiety during pregnancy and requires adaptive, culturally sensitive, and community-oriented health system responses to optimize maternal and infant health outcomes.

The Effect of Respiratory Exercise Therapy on Improving Lung Function in Tuberculosis Patients: A Systematic Review Tenriola, Andi; Aulia Khumaerah; Dewi Hestiani K
Comprehensive Health Care Vol. 9 No. 2 (2025): Comprehensive Health Care
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/chc.v9i2.601

Tuberculosis (TB) remains a major global health concern with a high burden of disease, particularly in developing countries. Pulmonary TB infection often leads to permanent lung damage and impaired pulmonary function even after completion of standard treatment. Pulmonary rehabilitation, especially through breathing exercises, is considered a simple, low-cost, and promising intervention to improve lung function and quality of life in TB patients. However, existing evidence has reported inconsistent results. To evaluate the effects of breathing exercise therapy on pulmonary function in patients with tuberculosis through a systematic review based on PRISMA 2020 guidelines. A comprehensive literature search was conducted in PubMed, Scopus, ProQuest, ScienceDirect, and Google Scholar using the keywords “tuberculosis,” “breathing exercise,” “respiratory physiotherapy,” and “lung function.” The search was limited to articles published between 2010 and 2025. Eligible studies included primary research with randomized controlled trials, quasi-experimental, or cohort designs that investigated breathing exercises in TB patients with pulmonary function outcomes. Article selection followed the PRISMA flow diagram. Data extracted included authors, year, study design, sample size, intervention type, duration, frequency, and outcomes. Study quality was assessed using the JBI Critical Appraisal Tools and the Cochrane Risk of Bias Tool. Out of 1,235 articles identified, 7 studies met the inclusion criteria. Interventions examined included pursed-lip breathing, diaphragmatic breathing, incentive spirometry, and structured pulmonary rehabilitation programs. Most studies reported significant improvements in pulmonary function parameters (FEV1, FVC, FEV1/FVC), as well as enhanced exercise capacity and quality of life. Interventions lasting at least 6–12 weeks with a frequency of ≥3 sessions per week produced more consistent results compared to short-term interventions. Variations in findings were observed across study designs, sample sizes, and types of breathing exercise. Breathing exercise therapy is effective in improving lung function, exercise tolerance, and quality of life in patients with TB and post-TB lung disease. This intervention should be considered as part of pulmonary rehabilitation and long-term TB management strategies. Further large-scale randomized controlled trials with standardized protocols are needed to strengthen evidence-based physiotherapy recommendations.

Exploring The Health Education Potential Of The Maccerak Pea Tradition In The Massenrempulu Community Dewi Hestiani K; Andi Tenriola
Jurnal Kesehatan Panrita Husada Vol. 10 No. 1 (2025): Jurnal Kesehatan Panrita Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Stikes Panrita Husada Bulukumba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jkph.v10i1.620

Kesehatan ibu dan anak tidak dapat dilepaskan dari sistem nilai budaya lokal yang hidup dalam komunitas. Tradisi Maccerak Pea dari etnis Massenrempulu di Enrekang, Sulawesi Selatan, merupakan salah satu bentuk praktik kesehatan berbasis budaya yang mengiringi fase pascapersalinan. Namun, kajian ilmiah tentang potensi edukatif dalam tradisi ini masih terbatas. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan desain eksploratif. Data dikumpulkan melalui wawancara mendalam dan observasi partisipatif terhadap pelaksanaan tradisi Maccerak Pea di tiga desa, yaitu Tanete, Kadingeh, dan Bulo, yang dipilih secara purposif. Informan terdiri dari tokoh adat, tokoh agama, dan tabib perempuan yang terlibat langsung dalam pelaksanaan ritual. Analisis data menghasilkan empat tema utama: (1) proses pelaksanaan tradisi, (2) makna simbolik dan spiritual, (3) peran sosial budaya dalam perawatan ibu, dan (4) potensi Maccerak Pea sebagai media edukasi kesehatan komunitas. Tradisi ini terbukti mengandung nilai edukatif mengenai perawatan ibu, pemberian ASI, pemulihan fisik, serta pembentukan dukungan sosial dan spiritual melalui mekanisme budaya yang diwariskan lintas generasi. Maccerak Pea berfungsi sebagai saluran pendidikan kesehatan berbasis komunitas yang berakar kuat pada nilai-nilai spiritual, sosial, dan medis-tradisional. Praktik ini selaras dengan pendekatan antropologi kesehatan dan menunjukkan potensi untuk diintegrasikan ke dalam strategi promosi kesehatan ibu dan anak yang berbasis budaya lokal.

Pengaruh Backward Walking Exercise Terhadap Nyeri Dan Kemampuan Fungsional Pasien Osteoarhtritis Genu Khumaerah, Aulia; Yusfina, Yusfina; Tenriola, Andi
Jurnal Fisioterapi Terapan Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Osteoarthritis (OA) is a degenerative disease that mainly attacks the joints and surrounding tissues, causing progressive damage to cartilage, subchondral bone and synovial structures. Genu OA is the most common OA and can cause disabilities that interfere with daily activities, reduce quality of life and increase the risk of falls. Physiotherapy intervention for genu OA can be conducted using various methods, one of them is backward walking exercise. The study is a quasi experimental research using two group pre and post-test control group design. The aim of the research is to determine the effect of backward walking exercise on pain and functional ability in patients with genu OA. The pain scale was measured using the Visual Analog Scale (VAS) and the patient's functional ability was measured using the Physical Function using Western Ontario and McMaster Universities Arthritis Index (WOMAC). The samples were all patients who had been diagnosed with Genu OA and met the predetermined inclusion and exclusion criteria. The samples were divided into 2 groups, the intervention group and the control group. Each group will receive the same physiotherapy intervention, but the intervention group was given additional intervention in the form of backward walking exercises. Backward walking exercise was conducted 2 times a week for 4 weeks. Before administering the exercise, each patient measured their pain scale and functional capacity. The measurement was done again after 8 interventions. The results showed that patients in the intervention group experienced a significant increase in functional ability (p=0.003) and a significant reduction in pain (p=0.000). In the control group there was also a significant increase in functional ability (p=0.000) and pain reduction (p=0.000). However, there was no significant difference in results between the control group and the intervention group in terms of functional ability (p=0.135) and pain level (p=0.490)

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