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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian
Riat El Khair
Department Of Clinical Pathology And Laboratory Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada, Yogyakarta; Clinical Laboratory Installation, Dr. Sardjito Central General Hospital, Yogyakarta 55281
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics

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KINETIKA FAKTOR VON WILLEBRAND DEMAM BERDARAH DENGUE ORANG DEWASA Riat El Khair; Usi Sukorini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.965

Abstract

Dengue haemorrhagic fever (DHF) is still a problem in Indonesia. It is a syndrome that in most severe form may threaten the patient’slife, primarily through increased vascular permeability due to endothelial dysfunction leading to shock. Von Willebrand factor (vWf) is ablood glycoprotein involved in haemostasis and present in the blood plasma. The vWf is reported as one of dysfunction endothelial marker.However, there is limited information about the kinetics and contribution of vWf in the pathogenesis of DHF in adult patients. In thisstudy, a serial level of vWf was measured as kinetic of plasma vWf. It is expected that, the evidence based medicine will give contributionin the management of DHF patients. Also, in the future a study will be conducted especially about the prediction of shock to know thekinetic of plasma von Willebrand factor in adult dengue haemorrhagic fever patients. A cross-sectional repeated–measurement study wasconducted from October 2007 up to January 2008 in the Department of Clinical Pathology at the Sardjito General Hospital Yogyakarta.Subjects who met the eligible criteria were selected i.e. adult patients hospitalized in the Department of Internal Medicine diagnosed asDHF based on WHO criteria and antibody anti-dengue detection. Serial measurement of plasma vWf was determined on days five (5),seven (7) and 15 using enzyme linked fluorescent assay (ELFA) principle. The resulting data was shown graphically and the differencein levels of vWf among the three groups of time was analyzed by Friedman’s test. The study results showed an increase of vWf on dayfive /5 (218.48 %), followed by 187.08 % on day seven (7). Interestingly, there was a sharp increase of vWf on day 15 (233.80 %). Inaddition, there were statistically significant different levels of vWf among those three groups (p = 0.00) in adult dengue haemorrhagicfever patients with the von Willebrand kinetic factor showing a fluctuation pattern. There is an increased level of vWf on the fifth (5)day but a decrease on the seventh (7) day. However, there is a sharp increase in the convalescence phase.
Identifikasi Variasi Gen dan Ekspresi Gen Yang Berhubungan Dengan Anemia Aplastik Menggunakan Pendekatan Genomik dan Bioinformatika Ayu Lifia Nur Kartikasari; Anisa Devi Kharisma Wibowo; Henry Budiawan Prasetya; La Malihi; Nanik Sulistyani; Lalu Muhammad Irham; Wirawan Adikusuma; Abdi Wira Septama; Riat El Khair; Rahmat Dani Satria
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 2 (2023): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i2.13335

Abstract

Anemia aplastik merupakan anemia yang disertai oleh pansitopenia pada tepi darah yang disebabkan oleh kelainan primer pada sumsum tulang dalam bentuk aplasia atau hipoplasia tanpa adanya infiltrasi, supresi atau pendesakan sumsum tulang. Pada anemia aplastik terjadi penurunan produksi sel darah dari sumsum tulang sehingga menyebabkan retikulositopenia, anemia, granulositopenia, monositopenia dan trombositopenia. Anemia aplastika termasuk dalam penyakit yang rentan disebabkan oleh faktor genetik. Salah satu faktor genetik yang banyak diidentifikasi adalah variasi gen atau single nucleotide polymorphism ( SNP). Hingga hari inimetodologi untuk bantuan variasi gen tersebut sudah tersedia dengan bentuk berbagai macam database dan bioinformatika. Tujuan penelitian ini untuk mengidentifikasi variasi gen yang berhubungan dengan Anemia aplastik dan memprioritaskan variasi gen tersebut berdasarkan tingkat kerentanannya melalui pemanfaatan katalog GWAS dan integrasi beberapa database bioinformatika. Hasil penelitian ini kami menemukan ada dua SNP rs1042151 dan rs28367832 yang rentan terhadap anemia aplastik berdasarkan ekpresi gen di jaringan darah . Variasi gen tesebut juga mengkode gen  HLA- DPB1 dan HLA-B dan menunjukkan ekspresi yang tinggi pada jaringan darah ( whole blood ) .Penelitian ini menunjukkan bahwa integrasi variasi gen dan bioinformatika potensial untuk memberikan informasi kepada si terkait kerentanan suatu variasi gen pada suatu penyakit termasuk pada anemia aplastik.
IDENTIFIKASI GEN YANG BERISIKO UNTUK PSORIASIS VULGARIS MELALUI PEMANFAATAN INFORMASI GENOMIC Lisza Niarisessa; Anisa Nova Puspitaningrum; Wirawan Adikusuma; Lalu Muhammad Irham; Maulida Mazaya; Abdi Wira Septama; Riat El Khair; Rahmat Dani Satria; Arief Rahman Afief
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.727

Abstract

Psoriasis vulgaris merupakan penyakit yang berkaitan dengan autoimun menyebabkan terjadinya inflamasi pada permukaan kulit. Psoriasis vulgaris ditandai dengan adanya plak berwarna merah atau merah muda diselimuti oleh sisik putih atau keabuan. Psoriasis vulgaris mempengaruhi sekitar 2% populasi di Amerika Utara dan Eropa. Kerentanan karena faktor genetik merupakan faktor yang berperan penting dalam terjadinya psoriasis vulgaris. Farmakogenomik berkaitan dengan ilmu yang mempelajari faktor genetik yang mempengaruhi variabilitas respon obat antar individu. Salah satu pemanfaatan farmakogenomik untuk pengembangan biomarker farmakogenomik yang digunakan dalam penemuan obat baru memalui penemuan kandidat gen. Identifikasi variasi gen Single Nucleotide Polimorfism (SNPs) sudah banyak dilakukan sekaligus dikembangkan. Database genomic yang menyimpan data SNPs antara lain Database Genomic Wide Association Study (GWAS) dan Phenom Wide Association Studies (PheWAS). Dalam penelitian ini kami mengidentifiasi 245 SNPs terkait psoriasis vulgaris dengan kriteria r2 < 0.8 untuk populasi asia. Untuk memprioritaskan kandidat gen terkait psoriasis vulgaris, kami menggunakan lima kriteria anotasi fungsional (missense, cis-eQTL, PPI, KEGG, Komice) dimana jika lebih dari dua skor kriteria penilaian, maka didefinisikan sebagai gen resiko biologis psoriasis vulgaris. Sebanyak 52 gen teridentifikasi sebagai gen resiko biologis psoriasis vulgaris. Diperoleh satu gen dengan skor tertinggi 4 yaitu Cluster of differentiation 247 (CD247). Pada penelitian ini dijelaskan potensi genetik sebagai biomarker terhadap kerentanan penyakit psoriasis vulgaris dan juga sebagai target obat. Kata Kunci : Psoriasis Vulgaris, Penyakit autoimun, Variasi Genomik.
PROFIL PENGGUNAAN CHOP DAN RCHOP PADA PASIEN LIMFOMA NON-HODGKIN DI RSUP DR. SARDJITO Gustinanda, Rizky; Irham, Lalu Muhammad; Supadmi, Woro; Khair, Riat El
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2529

Abstract

Non-Hodgkin lymphoma (LNH) is a heterogeneous malignancy of the lymphatic system with CHOP and RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) chemotherapy regimens as main options. Local data on patient characteristics undergoing these treatments are still limited, especially at Dr. Sardjito General Hospital. This study evaluates the characteristics of LNH patients receiving both regimens at Dr. Sardjito (2020–2023). It is a descriptive observational study with a cross-sectional design. Data from patient medical records were analyzed descriptively. Of 176 patients, 80 received CHOP and 96 R-CHOP. Most were male (CHOP: 70%; R-CHOP: 60.4%) and aged >50 years, with peak age of 51–60 in CHOP (40%) and >60 in R-CHOP (44.8%). Comorbidities were found in one-third of patients. Advanced stage predominated (CHOP: 31.3% stage 4; R-CHOP: 38.5% stage 2), and most completed 6 chemotherapy cycles. Rituximab ≥550 mg was widely used in R-CHOP; cyclophosphamide >1100 mg, doxorubicin 70–79 mg, and vincristine ≥2 mg were standard in both regimens. Prednisone 100 mg was common. Diffuse Large B-Cell Lymphoma (DLBCL) dominated R-CHOP (98.96%), while CHOP patients included DLBCL (38.75%), FL, PTCL-NOS, and others. Findings highlight the importance of individualized treatment based on histopathology and disease stage.
Co-Authors Abdi Wira Septama Abdi Wira Septama Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Arief Rahman Afief Ayu Lifia Nur Kartikasari Gustinanda, Rizky Henry Budiawan Prasetya La Malihi Lalu Muhammad Irham Lisza Niarisessa Maulida Mazaya Nanik Sulistyani Rahmat Dani Satria Usi Sukorini Wirawan Adikusuma Woro Supadmi