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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Halal Science and Research Jurnal Kesehatan Amanah Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat
Anisa Devi Kharisma Wibowo
STIKES Telogorejo Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Identifikasi Variasi Gen dan Ekspresi Gen Yang Berhubungan Dengan Anemia Aplastik Menggunakan Pendekatan Genomik dan Bioinformatika Ayu Lifia Nur Kartikasari; Anisa Devi Kharisma Wibowo; Henry Budiawan Prasetya; La Malihi; Nanik Sulistyani; Lalu Muhammad Irham; Wirawan Adikusuma; Abdi Wira Septama; Riat El Khair; Rahmat Dani Satria
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 2 (2023): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i2.13335

Abstract

Anemia aplastik merupakan anemia yang disertai oleh pansitopenia pada tepi darah yang disebabkan oleh kelainan primer pada sumsum tulang dalam bentuk aplasia atau hipoplasia tanpa adanya infiltrasi, supresi atau pendesakan sumsum tulang. Pada anemia aplastik terjadi penurunan produksi sel darah dari sumsum tulang sehingga menyebabkan retikulositopenia, anemia, granulositopenia, monositopenia dan trombositopenia. Anemia aplastika termasuk dalam penyakit yang rentan disebabkan oleh faktor genetik. Salah satu faktor genetik yang banyak diidentifikasi adalah variasi gen atau single nucleotide polymorphism ( SNP). Hingga hari inimetodologi untuk bantuan variasi gen tersebut sudah tersedia dengan bentuk berbagai macam database dan bioinformatika. Tujuan penelitian ini untuk mengidentifikasi variasi gen yang berhubungan dengan Anemia aplastik dan memprioritaskan variasi gen tersebut berdasarkan tingkat kerentanannya melalui pemanfaatan katalog GWAS dan integrasi beberapa database bioinformatika. Hasil penelitian ini kami menemukan ada dua SNP rs1042151 dan rs28367832 yang rentan terhadap anemia aplastik berdasarkan ekpresi gen di jaringan darah . Variasi gen tesebut juga mengkode gen  HLA- DPB1 dan HLA-B dan menunjukkan ekspresi yang tinggi pada jaringan darah ( whole blood ) .Penelitian ini menunjukkan bahwa integrasi variasi gen dan bioinformatika potensial untuk memberikan informasi kepada si terkait kerentanan suatu variasi gen pada suatu penyakit termasuk pada anemia aplastik.
Pengaruh Variasi Konsentrasi Bahan Pengikat Terhadap Formulasi dan Stabilitas Fisik Tablet Detergen Effervescent Ekstrak Daun Serai Dapur (Cymbopogon citratus) Girsang, Valentina; Kusuma Dewi, Liestyani; Rustaman, Heri; Sa’adah, Anifatus; Wibowo, Anisa Devi Kharisma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p10-19

Abstract

Lemongrass leaves (Cymbopogon citratus) contain saponins that can form foam in water so that they are used as natural compounds that produce foam used in industry. The purpose of this study was to provide the effect of variations in PVP concentrations of 2%, 3% and 4% on the physical characteristics, physical stability and detergenation ability of effervescent detergent tablets of lemongrass leaf extract (Cymbopogon citratus). This study used the maceration extraction method with 96% ethanol and the manufacture of effervescent tablets by the wet granulation method. The results of the characterization and stability study of effervescent tablets of lemongrass leaf extract with variations in PVP concentration showed that the tablets met the requirements for characterization testing of effervescent tablets before and after stability. Based on the results of the foam height test on effervescent tablets before and after stability did not affect the high foam with the results of F1, F2, F3 after stability of 86.56 ± 0.34; 86.56 ± 0.34; 88.20 ± 2.28. This study shows that PVP affects the characteristics and stability of tablets but does not affect the detergent ability of effervescent detergent tablets.
Evaluasi Peresepan Antibiotik pada Pasien ISPA Pediatri Metode ATC/DDD Anak Agung Pradnya Paramitha Vidiani; Livania Indri Aswara; Madyo Adrianto; Anisa Devi Kharisma Wibowo
Jurnal Kesehatan Amanah Vol. 7 No. 2 (2023): Oktober: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v7i2.735

Abstract

Acute Respiratory Infections (ARI) are infectious diseases that cause the highest mortality rate in children. Antibiotics are administered to ARI patients if the infection is caused by bacteria. Excessive use of antibiotics increases the risk of resistance and irrational antibiotic use. Efforts to prevent antibiotic resistance and irrational use include evaluating antibiotic utilization based on WHO recommendations, specifically using ATC/DDD classification system and the DU90% method. This study aims to determine the antibiotic utilization profile, DDD/1000 patient-days, and DU90% among pediatric ARI from January 2022 to December 2023. This study employs a quantitative research method with retrospective data collection. The results indicate that the highest antibiotic class used was penicillin (98%), with Amoxicillin 500 mg being the most commonly prescribed antibiotic (98%). The most prevalent ARI diagnosis was Acute Pharyngitis (J.02) (66.1%). The most frequently used dosage form was syrup (54.7%), and the average duration of therapy was 3–5 days. The total antibiotic consumption was 137.4 DDD/1000 patient-days, with antibiotics included in the DU90% segment being Amoxicillin 500 mg (102.3 DDD/1000 patient-days) and Amoxicillin 250 mg (21.6 DDD/1000 patient-days). This study highlights that the most widely used antibiotic in terms of quantity was Amoxicillin 500 mg (102.3 DDD/1000 patient-days).
Efektivitas Antibakteri Ekstrak Daun Glodokan Tiang (Polyalthia longifolia) Terhadap Cutibacterium acnes dan Staphylococcus epidermidis Girsang, Valentina; Nufus , Nunky; Saptawati , Tunik; Sa’adah , Anifatus; Wibowo, Anisa Devi Kharisma; Vidiani , Anak Agung Pradnya Paramitha
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.815

Abstract

Introduction: Polyalthia longifolia, commonly known as Glodokan tiang, is a plant typically found along roadsides, serving as shade and an ornamental feature in gardens. In addition to its aesthetic function, the leaves of this plant have been found to contain compounds with effective antibacterial activity. Natural ingredients with antibacterial properties, such as Polyalthia longifolia leaf extract, can be an alternative acne treatment due to their lower side effects than chemical drugs. Research Objective: This study aims to test the antibacterial activity of Polyalthia longifolia leaf extract in inhibiting the growth of Staphylococcus epidermidis and Cutibacterium acnes, which are significant causes of acne. Research Method: Polyalthia longifolia leaves were extracted using a maceration method with 70% ethanol as the solvent. The resulting extract was then tested for antibacterial activity using the disc diffusion method at 30%, 35%, 40%, 45%, and 50%. The bacteria used in the tests were Staphylococcus epidermidis and Cutibacterium acnes. Clindamycin was used as a positive control, and sterile water was used as a negative control. The data obtained from the tests were analyzed using the Kruskal-Wallis and post-hoc Games-Howell tests. Results: The study showed that Polyalthia longifolia leaf extract at various concentrations (30%, 35%, 40%, 45%, 50%) exhibited significant antibacterial activity against both bacteria tested. At a concentration of 50%, the extract demonstrated the most potent inhibitory effect on Cutibacterium acnes and Staphylococcus epidermidis, with inhibition zones reaching 15.82 mm and 15.74 mm, respectively. Conclusion: Polyalthia longifolia leaf extract shows significant antibacterial potential against Staphylococcus epidermidis and Cutibacterium acnes. The 50% extract concentration exhibited the most potent inhibitory effect, making it a promising candidate for natural acne treatment with minimal side effects.
PENYULUHAN KESEHATAN DAN PEMERIKSAAN GIGI MULUT ANAK-ANAK BEKERJASAMA DENGAN PAFI DAN PTGMI DI PURWODADI KABUPATEN GROBOGAN Suwarni, Sri; Ariani, Yovita Dwi; Dahliyanti, Novita Dwi; Sulistyoningsih, Danik; Kalsum, Ummi; Wibowo, Anisa Devi Kharisma; Purwanjani, Wahyu; Saraswati, Maulita
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 7 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juli 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i7.1673

Abstract

Pembangun kesehatan masyarakat diperlukan upaya dalam bidang Kesehatan secara partisipatif, maka dilakukan kegiatan Pengabdian Masyarakat secara kolaboratif berupa penyuluhan kesehatan dan pemeriksaan gigi-mulut untuk anak-anak telah dilaksanakan di Purwodadi, Kabupaten Grobogan, bekerja sama dengan Persatuan Ahli Farmasi Indonesia (PAFI) dan Persatuan Terapis Gigi dan Mulut Indonesia (PTGMI). Tujuan kegiatan ini adalah meningkatkan pengetahuan dan kesadaran anak-anak serta orang tua mengenai pentingnya menjaga kesehatan gigi dan mulut sejak usia dini, sekaligus memberikan layanan pemeriksaan gigi gratis dan edukasi preventif, teknik menyikat gigi yang benar, serta pentingnya pemeriksaan gigi rutin. Metode yang digunakan Adalah penyuluhan secara edukatif ke anak-anak secara menyenangkan. Kegiatan ini diikuti oleh 107 peserta dari berbagai profesi kesehatan dan masyarakat umum, berlangsung lancar, tertib, serta mendapat respon positif. Melalui kolaborasi lintas profesi, kegiatan ini diharapkan dapat berkelanjutan sebagai upaya promotif dan preventif untuk meningkatkan kesehatan gigi dan mulut masyarakat Purwodadi
Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants Wibowo, Anisa Devi Kharisma; Puspitaningrum, Anisa Nova; Ma’ruf, Muhammad; Irham, Lalu Muhammad; Supadmi, Woro; Kartikasari, Ayu Lifia Nur; Adikusuma, Wirawan; Chong, Rockie; Firman, Firman; Nugraha, Media Fitri Isma Isma; Siswanto, Lalu Muhammad Harmain; Khairi, Sabiah; Pranata, Satria
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.28297

Abstract

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections. The risk factor for stunting is dominated by disease during 1000 days of life. The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results. This study aimed to identify stunting biomarkers based on the priority scoring of gene variants. Identification of stunting risk genes used the Genome-Wide Association Studies (GWAS) approach and Haploreg v4.1. We found 33 genes that identifies as stunting risk gene. And then, we prioritize based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL). Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17. This research demonstrates the integration of genomic variants and bioinformatics approaches to reveal biological insights for stunting.
Optimization of naringenin sunscreen cream formula using the simplex lattice design method Kartikasari, Ayu Lifia Nur; Wibowo, Anisa Devi Kharisma; Kuncahyo, Ilham
Journal of Halal Science and Research Vol. 4 No. 2 (2023): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v4i2.7172

Abstract

Naringenin is a pure isolate belonging to a group of flavonoid compounds with pharmacological effects such as anti-inflammatory, anticancer, antiatherogenic, antifibrogenic, and antioxidant properties. The purpose of this study was to determine the effect of variations in the combination of emulator tween 80 and span 80 on physical quality and stability in naringenin sunscreen preparations, obtain the optimum formula composition from emulsifying agents, and activity of naringenin sunscreen cream preparations in terms of their SPF values. The study used Design Expert 7.1.5 software to design the simplex lattice design method. Each formula was tested for the physical properties of the cream to determine dispersal adhesion for 4 weeks. Naringenin sunscreen cream with a combination of emulsifier tween 80 and span 80 in various concentrations gives a significant difference in the physical quality consisting of the parameters of spreadability, adhesion, and viscosity. The optimum formula for naringenin sunscreen cream obtained the proportion of 9% Tween 80 and 5% span 80. Keywords: Naringenin, Simplex Lattice Design, SPF, Sunscreen.
Co-Authors Abdi Wira Septama Anak Agung Pradnya Paramitha Vidiani Ariani, Yovita Dwi Ayu Lifia Nur Kartikasari Chong, Rockie Dahliyanti, Novita Dwi Firman Firman Girsang, Valentina Henry Budiawan Prasetya Ilham Kuncahyo, Ilham Kartikasari, Ayu Lifia Nur Khairi, Sabiah Kusuma Dewi, Liestyani La Malihi Lalu Muhammad Irham Livania Indri Aswara Madyo Adrianto Maulita Saraswati Ma’ruf, Muhammad Nanik Sulistyani Nufus , Nunky Nugraha, Media Fitri Isma Isma Pranata, Satria Purwanjani, Wahyu Puspitaningrum, Anisa Nova Rahmat Dani Satria Riat El Khair Rustaman, Heri Sa’adah , Anifatus Sa’adah, Anifatus Siswanto, Lalu Muhammad Harmain Sri Suwarni Sulistyoningsih, Danik Tunik Saptawati Ummi Kalsum Wirawan Adikusuma Woro Supadmi