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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Ratih Aryani, Ratih
Program Studi S1 Farmasi STIkes Bakti Tunas Husada Tasikmalaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Formulation of Green Tea Spray Gel as Supportive Therapy for Diabetic Foot Infection Priani, Sani Ega; Efrida, Delfiana Aura; Aryani, Ratih; Mulkiya, Kiki; Syafnir, Livia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.54042

Abstract

Diabetic foot infection (DFI) is a common complication of diabetes, most frequently caused by Staphylococcus aureus. Green tea contains antibacterial compounds and may serve as a potential supportive therapy for DFI. This study aimed to develop a spray gel formulation containing green tea ethanol extract and evaluate its antibacterial activity against S. aureus. The extract was obtained using 96% ethanol through the reflux method and subsequently tested for antibacterial activity using the agar well diffusion method. The extract was incorporated into a spray gel formulation with Viscolam MAC 10 as the gelling agent. The resulting spray gels were evaluated for their physical properties and antibacterial activity. Green tea extract demonstrated antibacterial activity against S. aureus with a minimum inhibitory concentration (MIC) of 0.1%. Furthermore, the ethanol extract was successfully formulated into a spray gel using 5% Viscolam MAC 10, meeting quality requirements in terms of organoleptic properties, pH, viscosity, spray pattern, spray weight, drying time, and adhesion time. Formulations containing 0.75% and 1% GTE exhibited potent antibacterial activity against S. aureus. In conclusion, a green tea–based spray gel formulation with good physical characteristics and potent antibacterial activity has been successfully developed.
Co-Authors Bertha Rusdi Efrida, Delfiana Aura Fetri Lestari Fetri Lestari Hilda Aprilia, Hilda Kiki Mulkiya Yuliawati Mulkiya, Kiki Nabilla, Qori Sadiyah, Esti Rachmawati Sani Ega Priani Setianty, Tia Nur Somantri, Sri Yulianingsih Sri Peni Fitrianingsih Syafnir, Livia Umi Yuniarni Yani Lukmayani