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All Journal Jurnal Epidemiologi Kesehatan Komunitas Jurnal Sehat Indonesia (JUSINDO)
Ayleen Alicia Kosasih
Universitas Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Recent Findings in Malaria Emergence of Piperaquine-Resistant Plasmodium falciparum Genes in Malaria Endemic Areas of Indonesia: a Literature Review Ayu Nurdiantika Sari; Tri Yunis Miko Wahyono; Ayleen Alicia Kosasih; Yoshida Aussiana Samosir; Rania Rifdah Taufiq; Inge Sutanto
Jurnal Epidemiologi Kesehatan Komunitas Vol 8, No 2 : Agustus 2023
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v8i2.11803

Abstract

Background: In recent years, artemisinin and piperaquine (PPQ) resistance in the Greater Mekong Sub-region alarmed Southeast Asian countries, especially those relying on artemisinin- based combinations as antimalarial drugs. This study aims to review the current status of malaria research and examine the frequencies of piperaquine resistance in Plasmodium falciparum isolates originating from malaria-endemic areas in Indonesia.Methods: We undertook a review to identify empirical data on antimalarial piperaquine-inclusive artemisinin combination therapies (ACT) in Indonesia using studies conducted since 2015. Journal articles were searched using the keywords combination of malaria, piperaquine, Pfcrt, Pfmdr, Pfpm2, and Indonesia. The search was conducted in four databases. Trends in empirical data were summarised in a table and compared with emerging malaria prevalence and conditions in Indonesia.Results: Our study found that dihydroartemisinin-piperaquine (DHA-PPQ) is still effective in most area. Survey of PPQ resistance in regions using DHA-PPQ as the first-line treatment heavily depends on phenotypic tests of the given drug resistance. Molecular surveys exploring polymorphisms of Pfcrt, Pfmdr1, and Pfpm2 were not found.Conclusion: This study supports the use of dihydroartemisinin-piperaquine as the first-line antimalarial drug in malaria endemic areas of Indonesia. Further research examining efficacy is required to monitor piperaquine resistance in Indonesia.
The Relationship Between Independence in Daily Activities and Quality of Life Among The Elderly at Budi Mulia 1 Senior Living Facility Sari Putri Yanti; Purnama Betty Rosalyna Sitorus; Ayleen Alicia Kosasih
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.554

Abstract

Older adults experience various physical, psychological, and social changes associated with the aging process, which may reduce their ability to perform daily activities and subsequently affect their quality of life. Independence in Activities of Daily Living (ADL) is an important indicator of functional ability, particularly among older adults living in residential care facilities. This study aimed to examine the relationship between independence in daily activities and quality of life among older adults at PSTW Budi Mulia 1. This research employed a quantitative analytical design with a cross-sectional approach. The instruments used were the Barthel Index to assess independence in ADL and the Short Form-36 (SF-36) Health Survey to measure quality of life across eight domains. The sample consisted of 61 older adults who met the predetermined inclusion and exclusion criteria at PSTW Budi Mulia 1. Data were analyzed using Pearson’s correlation test. The results showed a strong, positive, and significant relationship between independence in daily activities and quality of life among older adults at PSTW Budi Mulia 1, with a correlation coefficient of r = 0.639 and a significance value of p = 0.000. Higher levels of independence in performing daily activities were associated with better quality of life among older adults. These findings may serve as a basis for developing occupational therapy interventions aimed at improving functional ability, participation, and well-being among older adults in residential care settings.
Co-Authors Ayu Nurdiantika Sari Inge Sutanto Purnama Betty Rosalyna Sitorus Rania Rifdah Taufiq Sari Putri Yanti Tri Yunis Miko Wahyono Yoshida Aussiana Samosir