<![CDATA[Fatigue is a multidimensional condition that can reduce students' energy, concentration, and academic performance. Students enrolled in the Health Department, Vocational Education Program, Universitas Indonesia are at risk of experiencing fatigue due to demanding academic and practical learning activities. This study aimed to analyze the relationship between internal and external factors associated with fatigue among students. A quantitative study with a cross-sectional design was conducted involving 382 students. Fatigue was assessed using the Fatigue Severity Scale (FSS), academic stress was measured using the Educational Stress Scale for Adolescents (ESSA), and social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Data were analyzed using the Chi-square test, Fisher's Exact Test, and Spearman correlation. The results showed that gender (p=0.030), body mass index (p=0.012), physical activity (p=0.001), smoking habits (p=0.017), and academic stress (p=0.001) were significantly associated with fatigue. In contrast, sleep duration, academic year, study program, organizational involvement, commuting time, and social support were not significantly associated with fatigue. These findings may inform the development of health promotion strategies and fatigue prevention programs for vocational health students.]]>
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