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EFEKTIVITAS KUERSETIN DARI EKSTRAK APEL LOKAL TERHADAP BERAT BADAN DAN GLUKOSA DARAH PUASA TIKUS MODEL DIABETES Nila Authoria Authoria; Lilik Wijayanti Wijayanti; Ratih Puspita Febrinasari
GIZI INDONESIA Vol 46 No 2 (2023): September 2023
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v46i2.847

Diabetes mellitus is a metabolic disease characterized by an increase in blood glucose levels due to insulin resistance by pancreatic β cells. Local apple plants can be used as a therapy for diabetes mellitus due to their content of quercetin which can control the increase in blood glucose levels. This study aims to determine the effectiveness of local apple extract of Romebeauty and Manalagi types to changes in body weight and fasting blood glucose levels in type 2 diabetes mellitus rats. This experimental study used pre and post-tests with a control group design involving 25 Wistar rats with diabetes mellitus model by injection STZ-NA. They were divided into 5 groups: negative control (KN), positive control with glibenclamide 0.09 mg/kg BW (KP), and the treatment group with local apple extract of Romebeauty and Manalagi at a dose of 90 mg/kg BW with 32,5 mg/g quercetin (P1), 180 mg/kg BW with 65 mg/g quercetin (P2), and 270 mg/kg BW with 97,5 mg/g quercetin (P3). The rats were weighed 4 times and fasting blood glucose levels were measured before and after the intervention. The results showed that there was a significant difference in body weight in all treatment groups after 14 days of intervention (p=0.003). Besides, there were significant differences in fasting blood glucose levels before and after the intervention in the KP (p=0.043), P1 (p=0.001), and P3 (p=0.005). Thus, it can be concluded that local apple extract affects changes in blood glucose levels and body weight of the diabetes mellitus rat model.ABSTRAK Diabetes melitus adalah penyakit metabolik ditandai dengan peningkatan kadar glukosa darah akibat resistensi insulin oleh sel β pankreas. Tumbuhan apel lokal sebagai tanaman komoditi holtikultura mampu dijadikan sebagai terapi untuk diabetes melitus karena mempunyai kandungan kuersetin yang mampu mengontrol kenaikan kadar glukosa darah. Tujuan penelitian ini untuk mempelajari efektivitas pemberian ekstrak apel lokal jenis romebeauty dan manalagi terhadap perubahan berat badan dan kadar glukosa darah puasa tikus model diabetes melitus tipe 2. Penelitian ini adalah eksperimental pre and post test with control group design menggunakan 25 tikus wistar model diabetes mellitus dengan injeksi STZ-NA dibagi menjadi 5 kelompok yaitu kontrol negative (KN), kontrol positif dengan glibenklamide 0,09 mg/kgBB (KP), dan kelompok perlakuan diberikan ekstrak apel lokal jenis romebeauty dan manalagi dosis 90 mg/ kgBB mengandung 32,5 mg/g kuersetin (P1), 180 mg/ kgBB mengandung 65 mg/g kuersetin (P2) dan 270 mg/ kgBB mengandung 97,5 mg/g kuersetin (P3). Selama penelitian berlangsung, tikus dilakukan penimbangan sebanyak 4 kali serta dilakukan pengukuran kadar glukosa darah puasa sebelum dan sesudah intervensi . Hasil menunjukkan bahwa terjadi perbedaan berat badan tikus yang signifikan pada semua kelompok perlakuan setelah 14 hari diberikan intervensi (p=0,003). Terdapat perbedaan signifikan kadar glukosa darah puasa sebelum dan sesudah intervensi pada kelompok KP (p=0,043), P1 p=(0,001), dan P3 (p=0,005). Kesimpulan penelitian ini adalah terdapat pengaruh pemberian ekstrak apel lokal terhadap perubahan kadar glukosa darah dan berat badan tikus model diabetes melitus.Keywords: ekstrak apel lokal, kadar glukosa darah, berat badan, diabetes melitus

GAMBARAN KUALITAS SARAPAN DAN STATUS GIZI SISWA SDN IBU JENAB 3 CIANJUR authoria, Nila; Pratiwi1, Riska Y. Pratiwi1 Y; Permana, Dany; Pratiwi, Tiara F; Yunitaningrum, Utari
Jurnal GIZIDO Vol 16 No 2 (2024): JURNAL GIZIDO EDISI NOVEMBER 2024
Publisher : POLTEKKES KEMENKES MANADO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47718/gizi.v16i2.2385

Introduction: Breakfast for elementary school students is very important in supporting physical growth and improving learning achievement. Objective: This research is to determine the description of breakfast and nutritional status of grade 5 students at SDN Ibu Jenab 3 Cianjur. Method: This research is a descriptive study with a cross sectional design. This research was conducted in June 2024 with a sample size of 32 students from class 5 of SDN Ibu Jenab 3 Cianjur. Description of breakfast was obtained through interviews from questionnaires and nutritional status was obtained from anthropometric measurements. Results: This research showed that the behavior of students who did not miss breakfast was 84.4% and their nutritional status was in the good category, 62.5%. The quality of breakfast related to nutrition is in the poor category at 59.3%. Conclusion: In this study, the majority of students had good nutritional status, but the nutritional quality of students' breakfast was in the poor category. Key words: Breakfast quality, Nutritional status, Elementary school students.

The Effectiveness of Nutritional Therapy in Patient with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials Hasanudin, Hasanudin; Arif, Taufan; Authoria, Nila; Salma Yunia Rachmah, Ade; Tirmidzi, Achmad
Critical Medical and Surgical Nursing Journal Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cmsnj.v14i2.75739

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is often complicated by malnutrition and muscle wasting, which adversely affect prognosis. Although nutritional therapy has been recommended as part of comprehensive COPD care, the effectiveness of recent interventions has not been systematically evaluated. This systematic review aimed to evaluate the impact of nutritional therapy on clinical, functional, and patient-centered outcomes in individuals with COPD. Methods: Following the PRISMA guidelines, we searched Scopus, PubMed, EBSCO, and Nature for randomized controlled trials (RCTs) published between January 2020 and June 2025. Eligible studies included adult patients with COPD who received nutritional interventions. The risk of bias was assessed using the Cochrane RoB 2 tool. From 252 screened records, 13 RCTs involving 2,962 participants were included. Given the heterogeneity across interventions and outcomes, the findings were synthesized narratively. Results: The interventions included oral nutritional supplements, high-energy formulas, individualized dietary counseling, vitamin D, ω-3 fatty acids, and multi-nutrient combinations. Seven studies reported significant improvements in quality of life, six demonstrated gains in weight and nutritional status, and three showed increased muscle strength. Two trials observed enhanced physical activity, whereas both vitamin D studies found no overall protective effect against exacerbations, except in patients with severe deficiencies. The risk of bias was low in eight studies and raised concerns in five. Overall, the strength of evidence was moderate, limited by heterogeneity, and inconsistent outcome reporting. Conclusion: Nutritional therapy improves nutritional status and selected clinical outcomes in patients with COPD. Standardized, adequately powered RCTs are warranted to establish optimal protocols and to confirm long-term benefits.

Profil Status Gizi dan Parameter Asam Urat pada Pengunjung Stand Kegiatan Pekan Kesehatan Kabupaten Cianjur Authoria, Nila; Permana, Dany; Yunitaningrum, Utari; Yulia Pratiwi, Riska; Handayani, Tri
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 2: Februari 2026
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i2.13368

Kegiatan pengabdian kepada masyarakat pada Pekan Kesehatan Kabupaten Cianjur dilaksanakan untuk memperoleh gambaran status gizi, kadar asam urat, dan tekanan darah pengunjung sebagai bagian dari upaya promotif dan preventif terhadap Penyakit Tidak Menular (PTM). Sebanyak 45 peserta mengikuti skrining yang mencakup pemeriksaan antropometri, tekanan darah, dan kadar asam urat, disertai pengisian kuesioner serta edukasi gizi. Hasil menunjukkan bahwa mayoritas responden berada pada kelompok usia pra-lansia (51,1%) dan didominasi perempuan (64,4%). Status gizi memperlihatkan tingginya proporsi gizi lebih, dengan 24,4% berada pada kategori overweight dan 42,2% tergolong obesitas kelas 1. Pemeriksaan kadar asam urat mengungkapkan bahwa 35,6% peserta mengalami hiperurisemia, terdiri atas 15,6% laki-laki dan 20% perempuan. Selain itu, 24,4% responden tercatat memiliki tekanan darah di atas normal, menunjukkan adanya potensi risiko metabolik yang perlu mendapatkan perhatian. Temuan ini menegaskan pentingnya edukasi gizi, pembatasan konsumsi makanan tinggi purin, peningkatan aktivitas fisik, serta pemeriksaan kesehatan rutin sebagai langkah pencegahan. Kegiatan ini diharapkan dapat mendukung pemerintah daerah dalam merancang program kesehatan yang lebih tepat sasaran.

Profil Status Gizi dan Parameter Asam Urat pada Pengunjung Stand Kegiatan Pekan Kesehatan Kabupaten Cianjur Authoria, Nila; Permana, Dany; Yunitaningrum, Utari; Yulia Pratiwi, Riska; Handayani, Tri
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 2: Februari 2026
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i2.13368

Kegiatan pengabdian kepada masyarakat pada Pekan Kesehatan Kabupaten Cianjur dilaksanakan untuk memperoleh gambaran status gizi, kadar asam urat, dan tekanan darah pengunjung sebagai bagian dari upaya promotif dan preventif terhadap Penyakit Tidak Menular (PTM). Sebanyak 45 peserta mengikuti skrining yang mencakup pemeriksaan antropometri, tekanan darah, dan kadar asam urat, disertai pengisian kuesioner serta edukasi gizi. Hasil menunjukkan bahwa mayoritas responden berada pada kelompok usia pra-lansia (51,1%) dan didominasi perempuan (64,4%). Status gizi memperlihatkan tingginya proporsi gizi lebih, dengan 24,4% berada pada kategori overweight dan 42,2% tergolong obesitas kelas 1. Pemeriksaan kadar asam urat mengungkapkan bahwa 35,6% peserta mengalami hiperurisemia, terdiri atas 15,6% laki-laki dan 20% perempuan. Selain itu, 24,4% responden tercatat memiliki tekanan darah di atas normal, menunjukkan adanya potensi risiko metabolik yang perlu mendapatkan perhatian. Temuan ini menegaskan pentingnya edukasi gizi, pembatasan konsumsi makanan tinggi purin, peningkatan aktivitas fisik, serta pemeriksaan kesehatan rutin sebagai langkah pencegahan. Kegiatan ini diharapkan dapat mendukung pemerintah daerah dalam merancang program kesehatan yang lebih tepat sasaran.

Differences of Quercetin Content in Fresh and Extracts Local Apples using High Performance Liquid Chromatography Method Nila Authoria; Lilik Wijayanti; Ratih Puspita Febrinasari
Journal of Healthcare and Biomedical Science Vol. 1 No. 1 (2022): Journal of Healthcare and Biomedical Science (JHBS)
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v1i1.1369

Background : Oxidative stress is an imbalance between pro-oxidants and endogenous antioxidants resulting in cell damage and degenerative diseases. As horticultural commodities, apples have superior varieties of Manalagi and Romebeauty. Apples contain exogenous antioxidants, namely quercetin that effectively contributes to the management of oxidative stress. Purpose : The study used laboratory experimental methods to determine differences in quercetin content in fresh apples and apple extracts of Manalagi and Romebeauty. Research methodology : Determination of quercetin content of fresh apples and apple extract used the High Performance Liquid Chromatograph (HPLC) method. The samples used were fresh apples and apple viscous extract of Manalagi and Romebeauty obtained respectively from UPT Medika Material Laboratory of Batu City and Food Engineering Laboratory of Soegijapranata Catholic University Semarang using maceration process with ethanol solvent.Findings : The results showed that the average levels of quercetin in fresh apples of Manalagi and Romebeauty varieties were 13,685 ppm and 15,544 ppm respectively. Extraction of 70% ethanol from 100 grams of Manalagi and Romebeaty varieties resulted in 38.123 grams and 52.699 grams of thick extract. The average levels of quercetin in Manalagi and Romebeauty extracts were 422.235 ppm and 243.454 ppm. It can be concluded that the extract can optimize the quercetin content. Research limitations : The quercetin content in local apple extracts of Manalagi and Romebeauty can be used as an alternative to antioxidant therapy due to oxidative stress. Originality/value : Analyzing differences in quercetin content in fresh apples and apple extracts.

The Use of Instagram and TikTok in the GEN SMART Program for Academic Writing Ethics Education: A Study of First Year Students Nila Authoria; Darmawan, Mochammad Arief
Jurnal Teknologi Pendidikan : Jurnal Penelitian dan Pengembangan Pembelajaran Vol. 11 No. 2 (2026): April
Publisher : UNDIKMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jtp.v11i2.19409

Abstract: Ethical academic writing is a fundamental competency that should be developed early in higher education, particularly in health-related vocational education, where academic integrity is closely linked to professional ethics. This study aims to examine the use of Instagram and TikTok in the GEN SMART (Generasi Sadar Menulis Akademik Beretika) Program as social media–based educational platforms for promoting ethical academic writing among students of the Nutrition Department at Poltekkes Kemenkes Malang. A descriptive quantitative design with an evaluative approach was employed using non-participant digital observation to analyze interaction metrics on the Instagram and TikTok accounts @tulisituetis. Data included likes, saves, and views of educational content posted between 25–26 October 2025, with recapitulation conducted up to 27 October 2025. These quantitative data were supported by participant testimonials to strengthen the interpretation of engagement and program impact. The findings show that Instagram helps maintain consistent exposure to educational messages with stable engagement, while TikTok achieves higher audience reach and interaction due to its dynamic short-video format. Testimonials further indicate positive perceptions of the program, including increased awareness of academic ethics and integrity, as well as improved understanding of technical aspects of ethical academic writing.

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