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All Journal Jurnal Riset Kimia Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Molekul: Jurnal Ilmiah Kimia Jurnal Kimia Unand
Norman Ferdinal
Universitas Andalas
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Energy Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Journal : Jurnal Kimia Unand

 1 
Isolasi dan Karakterisasi Senyawa Metabolit Sekunder dari Ekstrak Etil Asetat Daun Salam (Syzygium polyanthum (Wight) Walp) Norman Ferdinal; Afrizal; Reynol Devryonda
Jurnal Kimia Unand Vol. 11 No. 1 (2022): May 2022
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.11.1.19-24.2022

Abstract

Salam plant (Syzygium polyanthum) is a plant from the Myrtaceae family and the Syzygium genus, which is widely used as a traditional medicine to treat hypertension, ulcers, diarrhea, skin diseases, lower cholesterol, control uric acid levels, and diabetes. This study aims to isolate and characterize secondary metabolites from the ethyl acetate extract of bay leaves. Isolation of secondary metabolites was carried out by column chromatography and characterization with Ultravolet-Visible (UV-Vis) and Fourier Transform Infrared (FTIR) spectrophotometers. The isolated compound is a white solid of 0.0082 g with a melting point of 190-192°C. The results of the identification of the phytochemical profile on the TLC plate with the Liebermen-Burchard (LB) reagent showed that the compound was a triterpenoid group. The results of the UV-Vis spectrum analysis showed maximum absorption at a wavelength of 221 nm indicating the presence of π-π* electron transitions from the unconjugated C=C bond and the results of the FTIR spectrum analysis showed the presence of OH, C-O (alcohol), C=C groups. (alkenes), C-H is aliphatic and geminal dimethyl.
Isolasi dan Karakterisasi Senyawa Triterpenoid dari Ekstrak Etil Asetat Daun Salam (Syzygium polyanthum (Wight) Walp.) serta Uji Sitotoksik Menggunakan Metode BSLT (Brine Shrimp Lethality Test) Ferdinal, Norman; Muhamad Fadli; Rizki Septiardi; Adlis Santoni
Jurnal Kimia Unand Vol. 12 No. 1 (2023): May 2023
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.12.1.7-13.2023

Abstract

   The bay plant (Syzygium polyanthum (Wight) Walp.) is a member of the myrtaceae family. The most widely used part of the bay plant is the bay leaf. The leaves of this plant are often used as traditional medicine to treat gout, diarrhea, diabetes, and high blood pressure. This study aims to isolate and determine the characteristics of triterpenoid compounds from ethyl acetate extract of bay leaves. Isolation was carried out by column chromatography method with SGP (Step Gradient Polarity) elution system, then the isolated compound was purified by recrystallization method and obtained in the form of white crystals weighing 0.0188 g. TLC results showed a single purple spot after being treated with Liebermann Buschard reagent with a melting point range of 137-139 oC. The results of the UV spectrum data showed no conjugated double bonds and the results of the FTIR spectrum data showed the presence of hydroxyl groups, C-O alcohols, C-H alkanes, C=C alkenes, geminal dimethyl which are characteristic of triterpenoid compounds. Cytotoxic activity testing was carried out using the Brine Shrimp Lethality Test (BSLT) method.  Ethyl acetate extract and methanol extract had strong cytotoxic activity with LC50 values 316.23 mg/L and 234.42 mg/L respectively, while the hexane extract was weak with an LC50 value of 1148.15 mg/L.
IDENTIFIKASI METABOLIT SEKUNDER DAN UJI AKTIVITAS ANTIOKSIDAN DARI EKSTRAK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr). Ferdinal, Norman; Seprianti, Lusi; Afrizal, A.
Jurnal Kimia Unand Vol. 12 No. 2 (2023): November 2023
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.12.2.8-12.2023

Abstract

Sambung nyawa (Gynura procumbens (Lour.) Merr) is one of the plants used in traditional medicine. This has life-saving properties such as preventing polyps, dysentery, hypertension, diabetes, and cancer. In this study, the secondary metabolite content and antioxidant activity of sambung nyawa leaf extract were tested and its antioxidant activity. The extraction process was carried out by multilevel maceration using three different solvents, starting with hexane, ethyl acetate, and methanol. Secondary metabolite content test results showed that ironwood leaves contain flavonoids, phenolics, steroids, terpenoids, and alkaloids. The result of the antioxidant activity test using the DPPH method (1,1-Difenil-2- pikrilhidrazil) showed that the methanol extract showed very strong activity with an IC50 value of 15,01 mg/L, while the ethyl acetate showed moderate antioxidant activity with an IC50 value of 147,04 mg/L, and the hexane extract showed antioxidant activity with an IC50 value of 361,66 mg/L.
Co-Authors A. Afrizal Adlis Santoni Afrizal Afrizal Afrizal Afrizal, A. Asri Amelia Bustanul Arifin BUSTANUL ARIFIN Fivi Mona Bareno Hermansyah Aziz Hermansyah Aziz Imelda Imelda Indah Putri Lestari Leidina Zein Lusi Seprianti Matlal Fajri Alif Muhamad Fadli Muhamad Fadli Novesar Jamarun Novesar Jamarun Novizar Nazir Olly Norita Tetra Rahmiana Zein Refilda Refilda Refinel - Reynol Devryonda Rizki Septiardi Rizki Septiardi Safni Safni Salim, Emil Seprianti, Lusi Silfani Mairanti Sumaryati Syukur Suryati Suryati Suryati Suryati Syukri Syukri Tommi Hermansyah Yanisa Fitria Ningsih Yefrida Yefrida Yetria Rilda Yulizar Yusuf Zilfa Zilfa Zulkarnain Chaidir