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p-Index From 2020 - 2025
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This Author published in this journals
All Journal IJOEP : International Journal of Ecophysiology Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Jelita Siregar
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PLASMA β-SECRETASE1 (BACE1) LEVELS AS MARKER OF COGNITIVE FUNCTION DECLINE IN ELDERLY Syahfira A Syahna; Muhammad Ichwan; Nuraiza Meutia; Jelita Siregar; Zulham Yamamoto
International Journal of Ecophysiology Vol. 5 No. 2 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i2.14129

Abstract

BACE1 which forms amyloid plaques consisting of amyloid β peptides is a typical neuropathological lesion in the brain of Alzheimer's disease. Many studies have shown that β-amyloid is central to the pathophysiology of Alzheimer's disease and may play an early role in neurodegenerative disorders. The BACE1 enzyme forms amyloid β plaques. The BACE1 protein is detectable in plasma and its levels are significantly increased in patients with mild cognitive impairment and future Alzheimer's. This Aβ peptide accumulates into senile plaques causing the characteristics of Alzheimer's disease, can cause neuronal death and cognitive decline
Comparison of Rapid Typhidot Test Based on Sanitation Environment in Healthy Individuals in Medan Robby Awaluddin Perangin-Angin; Rina Amelia; Jelita Siregar
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.15365

Abstract

Typhoid fever is a gastrointestinal tract infectious disease frequently found endemic in Indonesia, which can be transmitted by oro-fecal from food or water contaminated directly or vector carries these bacteria. Medan Belawan subdistrict has a high rate of diarrhea cases and a low percentage of a health-house model. Otherwise, the Medan Petisah subdistrict has fewer diarrhea cases and a high percentage of the health-house model. This study was aimed to compare the presence of antibodies from the Typhidot Test in people living in poor and healthy sanitation conditions. This study is an observational study with a cross-sectional design. The population is all people around Medan Petisah and Medan Belawan health center. All data were calculated using SPSS and analyzed with Chi-Square and Regression Logistics tests. The result indicates no significant association between the presence of IgM and IgG from the results of the Typhidot test on environmental sanitation in Medan (p>0.05). Thus, it can be concluded that Sanitation conditions did not affect the formation of IgM and IgG against Salmonella Typhi bacteria.
Co-Authors Muhammad Ichwan Nuraiza Meutia Rina Amelia Robby Awaluddin Perangin-Angin Syahfira A Syahna Yamamoto, Zulham