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Rahmawati, Siti Farah
Department Of Pharmacology-Clinical Pharmacy, School Of Pharmacy Institut Teknologi Bandung

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Pengaruh Pemberian Jus Daun Katuk, Jus Daun Ubi Jalar, dan Kefir Terhadap Profil Hematologi Mencit Anemia yang Diinduksi Alumunium Sulfat Adnyana, I Ketut; Rosmadi, Arief; Sigit, Joseph Iskendiarso; Rahmawati, Siti Farah
Acta Pharmaceutica Indonesia Vol 37, No 2 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Daun katuk, daun ubi jalar, dan kefir secara empiris digunakan dalam penanganan kondisi anemia. Penelitian ini bertujuan untuk menentukan pengaruh pemberian jus daun katuk, jus daun ubi jalar, serta kefir terhadap profil hematologi mencit anemia. Mencit diinduksi anemia menggunakan larutan alumunium sulfat selama 12 hari berturut-turut kemudian dilanjutkan dengan pemberian sediaan uji selama 14 hari berturut-turut. Profil hematologi mencit diamati pada hari ke-0, 12, 15, 19, 22, dan 26. Mencit yang diinduksi anemia mengalami anemia kronis, di mana 80% kelompok kontrol mengalami kematian setelah hari ke-19, sedangkan mencit dari ketiga sediaan uji tetap hidup tetap hidup sampai hari ke-26. Pada pengukuran rata-rata jumlah hemoglobin, jumlah eritrosit, dan persen hematokrit pada hari ke-19, kelompok mencit yang diberikan jus daun katuk memberikan hasil yang paling baik dibandingkan kelompok yang diberikan jus daun ubi jalar dan kefir. Pemberian jus daun katuk, jus daun ubi jalar, dan kefir dapat memperbaiki profil hematologi mencit anemia lebih baik dibandingkan kelompok kontrol. Ketiga sediaan juga mampumempertahankan hidup mencit yang menderita anemia. Jus daun katuk mempu memperbaiki profil hematologi paling baik dibandingkan jus daun ubi jalar dan kefir.Kata kunci: Daun katuk, daun ubi jalar, kefir, anemia. Star gooseberry leaves, sweet potato leaves, and kefir empirically used as treatment for anemia. This study aimed to examine the effect of star gooseberry leaves juice, sweet potato leaves juice, and kefir on hematology profiles of anemic mice. Mice was induced by alumunium sulfate solution for 12 consecutive days followed by the testing materials for 14 consecutive days. Hematology profile of mice was observed on day 0, 12, 15, 19, 22, and 26. The induced mice developed chronic anemia. 80% of the control group died after day 19, whereas the testing groups survived until day 26. On day 19, the gooseberry leaves juice group showed the best and significant result on the hemoglobin profile, erythrocytes profile, and hematocrite percentages. Star gooseberry leaves, sweet potato leaves, and kefir improved the hematology profile better than control group and was able to keep the anemic mice alive. Star gooseberry leaves had the best effect on improving the hematology profile of anemic mice.Keywords: Star gooseberry leaves, sweet potato leaves, kefir, anemia.
Pengaruh Pemberian Jus Daun Katuk, Jus Daun Ubi Jalar, dan Kefir Terhadap Profil Hematologi Mencit Anemia yang Diinduksi Alumunium Sulfat I Ketut Adnyana; Arief Rosmadi; Joseph Iskendiarso Sigit; Siti Farah Rahmawati
Acta Pharmaceutica Indonesia Vol. 37 No. 2 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Daun katuk, daun ubi jalar, dan kefir secara empiris digunakan dalam penanganan kondisi anemia. Penelitian ini bertujuan untuk menentukan pengaruh pemberian jus daun katuk, jus daun ubi jalar, serta kefir terhadap profil hematologi mencit anemia. Mencit diinduksi anemia menggunakan larutan alumunium sulfat selama 12 hari berturut-turut kemudian dilanjutkan dengan pemberian sediaan uji selama 14 hari berturut-turut. Profil hematologi mencit diamati pada hari ke-0, 12, 15, 19, 22, dan 26. Mencit yang diinduksi anemia mengalami anemia kronis, di mana 80% kelompok kontrol mengalami kematian setelah hari ke-19, sedangkan mencit dari ketiga sediaan uji tetap hidup tetap hidup sampai hari ke-26. Pada pengukuran rata-rata jumlah hemoglobin, jumlah eritrosit, dan persen hematokrit pada hari ke-19, kelompok mencit yang diberikan jus daun katuk memberikan hasil yang paling baik dibandingkan kelompok yang diberikan jus daun ubi jalar dan kefir. Pemberian jus daun katuk, jus daun ubi jalar, dan kefir dapat memperbaiki profil hematologi mencit anemia lebih baik dibandingkan kelompok kontrol. Ketiga sediaan juga mampumempertahankan hidup mencit yang menderita anemia. Jus daun katuk mempu memperbaiki profil hematologi paling baik dibandingkan jus daun ubi jalar dan kefir.Kata kunci: Daun katuk, daun ubi jalar, kefir, anemia. Star gooseberry leaves, sweet potato leaves, and kefir empirically used as treatment for anemia. This study aimed to examine the effect of star gooseberry leaves juice, sweet potato leaves juice, and kefir on hematology profiles of anemic mice. Mice was induced by alumunium sulfate solution for 12 consecutive days followed by the testing materials for 14 consecutive days. Hematology profile of mice was observed on day 0, 12, 15, 19, 22, and 26. The induced mice developed chronic anemia. 80% of the control group died after day 19, whereas the testing groups survived until day 26. On day 19, the gooseberry leaves juice group showed the best and significant result on the hemoglobin profile, erythrocytes profile, and hematocrite percentages. Star gooseberry leaves, sweet potato leaves, and kefir improved the hematology profile better than control group and was able to keep the anemic mice alive. Star gooseberry leaves had the best effect on improving the hematology profile of anemic mice.Keywords: Star gooseberry leaves, sweet potato leaves, kefir, anemia.
PENGKAJIAN ANTIHIPERURISEMIA EMULSI MINYAK HATI IKAN KOD PADA MENCIT SWISS WEBSTER JANTAN Stefiani Emasurya Indrajaya; Andreanus Andaja Soemardji; Siti Farah Rahmawati
Acta Pharmaceutica Indonesia Vol. 42 No. 2 (2017)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

ABSTRAKEmulsi minyak hati ikan kod dipercaya membantu mencegah pembentukan asam urat. Penelitian ini bertujuan mengkaji aktivitas antihiperurisemia secara in vivo dan mengembangkan metode antihiperurisemia secara in vitro emulsi minyak hati ikan kod. Metode in vivo dilakukan menggunakan mencit Swiss Webster jantan yang diinduksi makanan tinggi purin 100 mg/kg BB suspensi hati ayam, bersama pemberian sediaan pembanding atau sediaan uji selama 20 hari. Kelompok kontrol sakit menerima induksi. Kelompok pembanding alopurinol menerima induksi dan 26 mg/kg BB alopurinol. Kelompok pembanding vitamin A menerima induksi dan 650 IU/kg BB vitamin A. Kelompok uji dosis rendah, sedang, dan tinggi menerima induksi dan 150 mg/kg BB, 300 mg/kg BB, dan 450 mg/kg BB emulsi minyak hati ikan kod. Efek antihiperurisemia terbesar ditunjukkan dosis 150 mg/kg BB dengan penurunan kadar asam urat sebesar 57,04% dibanding kelompok kontrol sakit. Hasil percobaan in vivo menunjukkan emulsi minyak hati ikan kod yang diberikan bersamaan induksi makanan tinggi purin memiliki efek antihiperurisemia. Metode in vitro dilakukan menggunakan asam urat dan basa purin murni yang ditambahkan homogenat hati tikus sebagai sumber enzim xantin oksidase. Hasil percobaan in vitro menunjukkan emulsi minyak hati ikan kod menguraikan asam urat dalam 0,525 mL medium campuran 0,075 mg asam urat dan 0,011 mL emulsi minyak hati ikan kod; emulsi minyak hati ikan kod mencegah pembentukan asam urat dari purin dalam 0,725 mL medium campuran 0,200 mg purin, 0,066 gram homogenat hati, dan 0,016 mL emulsi minyak hati ikan kod.Kata kunci : antihiperurisemia, emulsi minyak hati ikan kod, asam urat, purin. ABSTRACTCod liver oil emulsion is believed of being able to prevent uric acid accumulation. This research was held to examine antihyperuricemic activity with in vivo and develop antihyperuricemic method with in vitro of cod liver oil emulsion. In vivo method was accomplished using Swiss Webster male mice inducted with high purine meal 100 mg/kg BW chicken liver suspense, together with drugs or cod liver oil emulsion through 20 days. Control group consumed high purine meal. Allopurinol group consumed high purin meal and 26 mg/kg BW of allopurinol. Vitamin A group consumed high purine meal and 650 IU/kg BW of vitamin A. Low dose, medium dose, and high dose group consumed high purine meal and 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW of cod liver oil emulsion. Strongest antihyperuricemic capability was shown by dose of 150 mg/kg BW with 57,04% degradation of uric acid compared to control group. In vivo showed that cod liver oil emulsion given together with high purine meal had antihyperuricemic effect. In vitro method was accomplished using pure uric acid and purine base with rat liver homogenate as xanthine oxidase enzyme source added. In vitro showed cod liver oil emulsion degraded uric acid in 0,525 mL medium mixture of 0,075 mg of uric acid and 0,011 mL cod liver oil emulsion; cod liver oil emulsion prevented uric acid establishment from purine in 0,725 mL medium mixture of 0,200 mg of purin, 0,066 gram of liver homogenate, and 0,016 mL of cod liver oil emulsion. Keywords : antihyperuricemic, cod liver oil emulsion, uric acid, purine.
IDENTIFICATION OF DRUG-RELATED PROBLEMS ON BETA LACTAM ANTIBIOTICS USED FOR PEDIATRIC AT A SECONDARY-CARE HOSPITAL IN CIMAHI Zulfan Zazuli; Tomi Hendrayana; Siti Farah Rahmawati; Shalvierra Polyta Fitriah
Acta Pharmaceutica Indonesia Vol. 42 No. 2 (2017)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

WHO estimated that >50% of medicines are used inappropriately. One that posess highest risk due to inappropriate use is beta-lactam antibiotic, espescially in pediatric patient since the organ function in pediatric patient has not fully developed as in adult yet. This cross-sectional study was performed to identify drug-related problems (DRPs) occurred during beta-lactam therapy in pediatric hospitalized in a secondary-care hospital in Cimahi. A predetermined medication-use criteria based on the current literatures was created as an assessment standard tools. Furthermore, identification of DRPs based on PCNE v6.2 classification was carried out concurrently (January-March 2015) to 351 patients. As many as 458 DRPs were found including 22 cases inappropriate drugs (category C1.1), 127 cases no indication for drug (C1.2), 42 cases inappropriate combination of drugs, or drugs and food (C1.4), 1 case of too many drugs prescibed for indication (C1.6), 137 cases drug dose too low (C3.1), 89 cases drug dose too high (C3.2), 39 cases duration of treatment too short (C4.1), and 1 case of duration of treatment too long (C4.2). The potential DRPs was estimated to be occured for approximately 1-2 DRPs per patient.Keywords: drug-related problems; beta-lactam antibiotic; pediatric; pharmaceutical care
Co-Authors Arief Rosmadi I Ketut Adnyana I Ketut Adnyana Joseph Iskendiarso Sigit Rosmadi, Arief Shalvierra Polyta Fitriah Sigit, Joseph Iskendiarso Soemardji, Andreanus Andaja Stefiani Emasurya Indrajaya Tomi Hendrayana Zazuli, Zulfan