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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Pharmaceutical Science and Technology Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Asian Journal of Health and Applied Sciences Journal of Advances in Medicine and Pharmaceutical Sciences JUKEJ: Jurnal Kesehatan Jompa Jurnal Sains dan Kesehatan Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya
Kodariah, Liah
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Antibacterial effect of corarian seed (Coriandrum sativum L.) extract on Streptococcus mutans Kodariah, Liah; Ghasani, Firzanah; Murtafi'ah, Ni'matul
Asian Journal of Health and Applied Sciences Vol. 1 No. 1 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.645 KB) | DOI: 10.53402/ajhas.v1i1.7

Abstract

Dental plaque plays an important role in causing dental caries. In plaque formation, gram-positive coccus bacteria are found, one of which is Streptococcus mutans which can secrete toxins so that tooth cells are damaged. Dental plaque or dental caries can be controlled in number by controlling plaque with antimicrobial agents such as mouthwash. However, the continuous use of antimicrobials can cause side effects for users, including hypersensitivity reactions and resistance, so it is necessary to use natural ingredients as antibacterial alternatives. Therefore, this study used coriander seeds as an alternative to inhibit the growth of Streptococcus mutans bacteria. The purpose of this study was to determine the effectiveness of coriander seed extract (Coriandrum sativum L.) with varying concentrations on the growth of Streptococcus mutans bacteria. This study used the diffusion method as a bacterial test method for coriander seed extract. The concentrations tested in this study were 3%, 6% and 9%. Based on the results of the study showed that there was an inhibition zone in the test of coriander seed extract against Streptococcus mutans. At a concentration of 3% the average inhibition zone was 3.7 mm, the concentration of 6% was 4.7 mm and concentration of 9% by 6.06 mm. The results of this study concluded that coriander seed extract (Coriandrum sativum L.) was effective in inhibiting the growth of Streptococcus mutans bacteria.
Identification of Trichomonas vaginalis Parasites In Commercial Sex Workers Conducting Examinations At The Mawar Clinic PKBI Bandung, Indonesia Kodariah, Liah; Nisa, Putri Khoerun; Pakpahan, Suyarta E.; Aulia, Syifa
Asian Journal of Health and Applied Sciences Vol. 1 No. 3 (2022): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v1i3.82

Abstract

Trichomoniasis is a sexually transmitted infection (STI) caused by the pathogenic Trichomonas vaginalis protozoa parasite found in the female genitourinary tract and can cause vaginal discharge, in severe conditions, vaginal inflammation will occur. Trichomoniasis has a high risk of infecting groups that often have multiple partners, such as Commercial Sex Workers (CSWs). This study aims to determine the presence or absence of Trichomonas vaginalis parasites in the urine sample of Commercial Sex Workers who conduct examinations at the Mawar Clinic PKBI Bandung. The research method used is observation. The sample is the urine of a prostitute who performs an examination at the Mawar Clinic PKBI Bandung, Indonesia. The examination was carried out in two ways, namely the wet method and the Giemsa staining method, which was carried out in the Rajawali Bandung Institute of Health laboratory. The results showed that out of 30 samples, 11 urine samples of CSW were infected with Trichomonas vaginalis,. The conclusion of this study is that Trichomonas vaginalis parasites were found in urine samples of prostitutes who were examined at the Mawar Clinic PKBI Bandung.
Histopathological of Mice (Mus musculus) Liver Induced by Lead (Pb) Orally Kodariah, Liah; Efrida, Pakpahan Suyarta; Aditya, Nugraha; Nurzal, Zalzabila Rena
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 5 No 2 (2023): Combatting Bacterial and Fungal Infections: The Critical Role of Advanced Researc
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v5i2.4295

Abstract

Lead (Pb) is a prominent heavy metal emitted by motor vehicle exhausts, factory and mining fumes. Its presence in the atmoshpere can endure for up to seven days, posing a considerable risk of contaminating surrounding food and beverages. Lead enters the body through inhalation and the skin. Lead can also enter the human body via the oral route and accumulate in the body. It causes health problems such as oxidative stress and damage human organs such as the kidneys and liver. This research aims to examine the effect of oral lead exposure on the liver histopathology of Swiss Webster strain mice (Mus musculus). Employing a non-probability sampling technique, 25 male mice were divided into 5 groups: negative control, K2, K3, K4 and K5. These mice were administered a daily oral dose of 0.5 mL and subsequently euthanized in CO2 chamber the following week for liver dissection. The findings reveal signs of hydropic degeneration characterized by cellular swelling, irregular shapes, and disrupted organelles in groups K2, K3, K4, and K5. In addition, the mean degree of liver damage was observed as 0 for the negative control, 1 for group K2, 1 for group K3, 2 for group K4, and 3 for group K5. In conclsuin, this study confirms that lead exposure can result in dentrimenal liver histopathology changes in mice.
The Effectiveness of Garlic Extract against Triglyceride Levels of Wistar Rats Induced by 50% Ethanol Kodariah, Liah; Mendrofa, Desmawaty
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 1 No 1: May 2022
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0101.425

Abstract

Alcohol affects the metabolism of triglycerides. Excessive intake of fat, carbohydrates, and protein can increase triglyceride levels. In addition to fat and carbohydrates, factors that can affect triglyceride levels are age, lifestyle, smoking, alcohol intake, hypertension, and liver disease. Triglyceride levels (> 200 mg/dL) raise the risk of atherosclerosis. The purpose of this study was to determine the levels of triglycerides of Wistar rats before and after induction of ethanol 50% and garlic extract therapy. The method was experimental, with a sample of 25 Wistar rats which were divided into 5 groups. G1, rats were given 50% ethanol from day 9-14, G2, rats were only given distilled water, G3, G4, and G5 treatment groups at doses I, II, and III, after ethanol administration 50% on the 9th – 14th day followed by the administration of garlic extract at a dose of 200 mg/gr BW, 400mg/gr BW and 600 mg/ gr BW, respectively. Rat blood was taken on the 8th day before administration of ethanol and garlic extract and taken again on the 15th day after administration of ethanol and garlic extract, then triglycerides were measured using a photometer. The results showed that there were significant differences in triglyceride levels in G1 with G2, G3, G4, and G5. Triglyceride levels in rats before treatment and after administration of 50% ethanol and garlic extract 200 mg/gramBW increased but were still within normal limits.
Efektivitas Rebusan Jahe Putih Kecil (Zingiber officinale var. Amarum) Terhadap Gambaran Histologi Pankreas Mencit (Mus Musculus) Diabetes Melitus: Effectivity of Small White Jahe (Zingiber officinale Var. Amarum) Decocolation on Histological Discussion of Heart of Mencites (Mus Musculus) Diabetes Mellitus Kodariah, Liah; Aulia, Syifa; Fadillah, Wasiyah Khusna; Rahayu, Amalia
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2336

Abstract

Diabetes is a chronic form of metabolic disorder characterized by an increase in blood sugar levels above the normal limit or called hyperglycemia. This hyperglycemia condition causes pancreatic beta cells to produce Reactive Oxygen Species (ROS). Ginger contains a variety of secondary metabolites and active phenolic compounds, such as flavonoids, gingerol and shogaol as a treatment for diabetes that has the potential to reduce blood sugar levels and improve the histology of the pancreas of mice. The purpose of this study was to determine the picture of pancreatic histology of mice (Mus musculus) induced by alloxan after being given small white ginger (Zingiber officinale var. Amarum). This study used experimental research using a complete randomized design method in mice consisting of 5 groups. The groups in this study consisted of negative control group, positive control group, comparison control group, dose I treatment group, and dose II. Pancreatic histology of mice (Mus musculus) was made with Hematoxylin Eosin (HE) staining. The results showed that dose I was more effective than dose II to reduce glucose and histology improvement in alloxan-induced pancreas. Keywords:          Diabetes, Small White Ginger, Pancreas   Abstrak Diabetes adalah bentuk gangguan metabolisme kronis yang ditandai dengan peningkatan kadar gula dalam darah di atas batas normal atau disebut hiperglikemia. Kondisi hiperglikemia ini menyebabkan sel beta pankreas memproduksi Reactive Oxygen Species (ROS). Jahe mengandung berbagai macam senyawa metabolit sekunder dan fenolik aktif, seperti flavonoid, gingerol dan shogaol sebagai pengobatan penyakit diabetes yang berpotensi menurunkan kadar gula darah dan memperbaiki gambaran histologi pankreas mencit. Tujuan penelitian untuk mengetahui gambaran histologi pankreas mencit (Mus musculus) yang diinduksi aloksan setelah diberi air rebusan jahe putih kecil (Zingiber officinale var. Amarum). Penelitian ini menggunakan penelitian eksperimental metode rancangan acak lengkap pada mencit yang terdiri dari 5 kelompok. Kelompok dalam penelitian ini terdiri dari kelompok kontrol negatif, kelompok kontrol positif, kelompok kontrol pembanding, kelompok perlakuan dosis I, dan dosis II. Histologi pankreas mencit (Mus musculus) dibuat dengan pewarnaan Hematoxylin Eosin (HE). Hasil penelitian menunjukkan bahwa dosis I lebih efektif daripada dosis II untuk menurunkan glukosa darah dan perbaikan histologi pada pankreas yang diinduksi aloksan. Kata Kunci:         Diabetes, Jahe Putih Kecil, Pankreas
Combination of Gmelina arborea and Falcataria moluccana Extracts in Reducing Glucose and Improving Histology in Hyperglycemic Mice Model Rumidatul, Alfi; Fadilah, Tyas I.; Rahayu, Amalia; Mawangi, Neng W. L.; Sandy, Pracilia S.; Kodariah, Liah; Mayuri, Nindya S.
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.61846

Abstract

The White Teak plant (G. arborea) and Sengon (F. moluccana) contain flavonoids that act as antioxidants and have the potential to lower blood sugar levels. This study aims to examine the effects of G. arborea and F. moluccana extracts with polar and non-polar (methanol and n-hexane) solvents on blood glucose levels as well as the histological condition of the pancreas and liver in mice. The extract was obtained through maceration, and its effectiveness was tested by measuring blood glucose levels and conducting histological analysis of the organs. Data were analyzed using SPSS. The research results show that extracts of G. arborea and F. moluccana lower blood glucose levels and improve the histology of the pancreas and liver in mice. Polar solvents (methanol) are more effective in lowering blood glucose levels, while non-polar solvents (n-hexane) have a greater impact on improving organ histology. In conclusion, the extracts of these two plants have a positive effect on the liver condition of hyperglycemic mice.
Pemeriksaan dan peningkatan pengetahuan masyarakat tentang penularan penyakit tuberculosis dalam rangka menurunkan angka penularan Kodariah, Liah; Murtafi’ah, Ni’matul; Baehaki, Farhan
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 1 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i1.17971

Abstract

Tuberkulosis (TB) adalah suatu penyakit menular yang disebabkan oleh kuman Mycobacterium tuberculosis. pemeriksaan mikroskopik dahak adalah komponen kunci dalam program penanggulangan TB untuk menegakkan diagnosis, evaluasi dan tindak lanjut pengobatan. Berdasarkan data dari Puskesmas Parongpong, bahwa penelusuran kasus TB di Desa Cihanjuang Rahayu harus tetap dilakukan meskipun di tengah kondisi pandemi COVID-19. Tujuan pengabdian pada masyarakat ini adalah untuk mengurangi penularan penyakit tuberculosis pada masyarakat Desa Cihanjuang, Kabupaten Bandung Barat. Pelaksanaan dilakukan melalui metode service learning dengan kegiatan penyuluhan teknik ceramah pada masyarakat, dengan menerapkan social distancing mengingat masih dalam kondisi pandemi. Pemeriksaan TB dilakukan dengan mendatangi rumah masyarakat berdasarkan data yang diperoleh dari Puskesmas setempat. Setelah dilakukan pelaksanaan kegiatan pengabdian masyarakat ini, simpulan yang dapat diambil bagi masyarakat Desa Cihanjuang DESA CIHANJUANG RAHAYU yaitu masyarakat memiliki kesadaran untuk berpartisipasi aktif dalam mencari informasi mengenai tuberkulosis.
Pengembangan Bahan Ajar Berbasis RADEC untuk Meningkatkan Keterampilan Literasi Sains Baehaki, Farhan; Murtafi’ah, Ni’matul; Kodariah, Liah
Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya Vol. 29 No. 4 (2023): Paradigma: Jurnal Filsafat, Sains, Teknologi, dan Sosial Budaya
Publisher : Universitas Insan Budi Utomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/paradigma.v29i4.550

Abstract

21st-century skills have become standard in graduate profiles designed by the government, including for prospective Medical Laboratory Technologists (ATLM). One of the skills that the government focuses on is developing literacy skills. Therefore, this research aims to develop RADEC-based teaching materials that can facilitate the development of literacy skills for prospective ATLM students. The research method used is Development & Validation whose steps consist of 1) literature review; 2) construction; and 3) Improvement. The development was carried out by involving 20 students from the Medical Laboratory Technology Study Program. The instruments used in the data collection process were expert validation sheets and readability test sheets. The research results show that teaching materials have very good validity (>80% suitability) in facilitating the development of scientific literacy skills. Therefore, the teaching materials developed can be implemented in lectures.
Perubahan Histologi Otak Mencit (Mus musculus) Akibat Efek Neurotoksik Paparan Subletal Insektisida Organofosfat Klorpirifos Rojab, Irfan Abdullah; Kodariah, Liah; Nurjanah, Siti; Situmorang, Rachel Roma Uliana; Vina Salmanda Junaedi; Indri; Rochmana, Fachriza Ali
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 11, No 1 (2026): February 2026
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v11i1.13073

Abstract

karena efektivitasnya tinggi terhadap hama, namun bersifat neurotoksik yang bekerja dengan menghambat enzim asetilkolinesterase (AChE) menyebabkan penumpukan asetilkolin, peningkatan Reactive Oxygen Species (ROS), dan stres oksidatif, akibatnya kematian sel dan berujung pada kerusakan neuron dan sel glial di otak. Penelitian ini bertujuan untuk mengamati perubahan histologis otak mencit (Mus musculus) akibat paparan subletal insektisida organofosfat klorpirifos. Penelitian ini menggunakan desain true experimental laboratories post-test only control group dengan 27 ekor mencit jantan yang dibagi menjadi kelompok kontrol, paparan 7 hari, dan 14 hari. Klorpirifos dosis 12 mg/kgBB/hari diberikan secara oral. Setelah perlakuan, dilakukan nekropsi dan pengambilan otak mencit. Pengamatan histologi cerebrum, cerebellum, dan batang otak dilakukan dengan pewarnaan hematoksilin-eosin lalu dianalisis secara deskriptif dan uji One-Way Anova serta uji lanjutan Tukey HSD. Hasil menunjukkan peningkatan signifikan jumlah neuron dan neuroglia nekrosis (p=0.000; p<0,05) disertai gambaran inti piknotik, vakuolisasi sitoplasma, kromatolisis dan hipereosinofik. Gejala tremor dan ataksia tampak nyata dan terdapat penurunan berat badan antar kelompok (p=0,046) terutama pada paparan minggu pertama. Simpulannya paparan subletal klorpirifos menimbulkan kerusakan histologis otak yang berdampak terhadap sistem motorik dan status metabolik mencit (Mus musculus).
Toksisitas Akut dan Efek Protektif Ekstrak Etanol Schima wallichii terhadap Histopatologi Hati dan Ginjal Mencit yang Diinduksi Aloksan Risa, Tiara Nova; Rahmawati, Mutia; G R, Lutfi Khoiriyah; Kodariah, Liah; Mayuri, Nindya Sekar; Rumidatul, Alfi
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 1 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss1.2491

Abstract

Diabetes melitus (DM) merupakan penyakit metabolik kronis yang memicu komplikasi pada hati dan ginjal melalui mekanisme stres oksidatif. Tanaman Puspa (Schima wallichii (D.C) Korth) mengandung senyawa bioaktif antioksidan seperti flavonoid dan tanin yang berpotensi sebagai agen antidiabetes. Penelitian ini bertujuan mengevaluasi toksisitas akut serta efek protektif ekstrak etanol ranting S. wallichii terhadap gambaran histopalogi hati dan ginjal mencit (Mus musculus) yang diinduksi aloksan. Mencit jantan diinduksi aloksan 150 mg/kgBB secara intraperitoneal, kemudian diberikan ekstrak secara oral dengan dosis 98 mg/kgBB (P1) dan 196 mg/kgBB (P2). Parameter yang diamati meliputi berat badan, kadar glukosa darah, gejala toksisitas klinis, serta perubahan mikroskopis jaringan hati dan ginjal. Hasil menunjukkan tidak terdapat mortalitas maupun gejala toksik berat selama 14 hari pengamatan, sehingga nilai LD₅₀ semu dikategorikan praktis tidak toksik (>196 mg/kgBB). Secara histopatologis, kelompok P2 menunjukkan perbaikan signifikan pada jaringan hati (p < 0,05) yang ditandai dengan penurunan derajat degenerasi dan nekrosis. Pada ginjal terdapat tren penurunan skor kerusakan secara deskriptif, namun belum menunjukkan perbedaan bermakna secara statistik (p > 0,05). Dapat disimpulkan bahwa ekstrak ranting S. wallichii aman pada dosis uji, efektif memperbaiki kerusakan hati (hepatoprotektif), serta memiliki potensi nefroprotektif terbatas pada model mencit diabetes.
Co-Authors Aditya, Nugraha Aulia, Syifa Fadilah, Tyas I. Fadillah, Wasiyah Khusna Farhan Baehaki G R, Lutfi Khoiriyah Ghasani, Firzanah Indri Mawangi, Neng W. L. Mayuri, Nindya S. Mayuri, Nindya Sekar Mendrofa, Desmawaty Murtafi’ah, Ni’matul NI'MATUL MURTAFI'AH Nisa, Putri Khoerun Nurzal, Zalzabila Rena Pakpahan, Suyarta E. Rahayu, Amalia Rahmawati, Mutia Risa, Tiara Nova Rochmana, Fachriza Ali Rojab, Irfan Abdullah Rumidatul, Alfi Sandy, Pracilia S. Siti Nurjanah Situmorang, Rachel Roma Uliana Suyarta Efrida Pakpahan Vina Salmanda Junaedi