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Efektivitas Kombinasi Ekstrak Bunga Kecombrang (Etlingera elatior) Dan Ekstrak Jahe (Zingiber officinale) Terhadap Penurunan Glukosa Darah Pada Mencit Jantan Yang Diinduksi Aloksan Yasinta Aritonang; Meka Faizal Farabi; Dini Puspodewi
Jurnal Kesehatan Vol 16, No 3 (2023): Jurnal Kesehatan
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jk.v16i3.2322

Pendahuluan: Bunga kecombrang dapat menurunkan glukosa darah dengan mekanisme menghambat enzim pencernaan karbohidrat pada usus halus. Jahe memiliki kandungan gingerol dan shogaol yang mampu menaikkan produksi insulin. Metode: Penelitian ini bersifat eksperimental, hewan uji diinduksi aloksan dosis 150 mg/kg BB secara intraperitoneal. Kombinasi ekstrak bunga kecombrang dan ekstrak jahe diberikan dalam besaran dosis 50 mg/kg BB, 75 mg/kg BB, dan 100 mg/kg BB. Data yang diperoleh diolah secara statistik menggunakan uji Kruskal-Wallis dan Mann-Whitney. Hasil: Hasil uji statistik menunjukkan kelompok dosis berbeda signifikan dengan kelompok kontrol negatif (p<0,05) dan tidak berbeda signifikan dengan kelompok kontrol positif (p>0,05). Penurunan glukosa darah tertinggi terjadi pada kelompok dosis 100 mg/kg BB (59,52%). Simpulan: Kombinasi ekstrak bunga kecombrang dan ekstrak jahe mampu menurunkan glukosa darah pada mencit jantan yang diinduksi aloksan.

Pemanfaatan Tanaman Rambutan (Nephelium lappaceum L.) sebagai Bahan Eco-Print untuk Peningkatan Pengetahuan dan Ketrampilan Masyarakat Endang Tri Wahyuni Maharani; Stalis Norma Ethica; Ana Hidayati Mukaromah; Asiva Khoirunisa; Sa’if Revallindo Mirza; Dinah Fauziyyah; Iqbal Tamimi; Pepi Febrianti; Meka Faizal Farabi
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 4 No 4 (2025): Oktober
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v4i4.729

Latar Belakang: Desa Sidorejo kelurahan Tambangan kecamatan Mijen merupakan suatu desa yang banyak warganya menanam tanaman buah rambutan (Nephelium lappaceum L.), namun banyak masyarakat yang belum memiliki pengetahuan tentang manfaat tanaman tersebut sebagaibahan Eco-print. Kegiatan pengabdian kepada Masyarakat (PKM) ini merupakan implementasi hasil penelitian tentang pemanfaatan tumbuhan sebagai motif pada eco-print. Tujuan: Untuk mengedukasi masyarakat tentang manfaat daun rambutan sebagai bahan eco-print, sehingga dapat meningkatkan pendapatan Masyarakat. Metode: Kegiatan dilaksanakan di Sidorejo, Kelurahan Tambangan, Mijen Semarang dalam bentuk ceramah dan pelatihan ketrampilan Eco-print. Partisipan pengabdian masyarakat sebanyak 20 orang. Hasil: Partisipan lebih memahami tentang manfaat daun tanaman rambutan sebagai bahan eco-print. Nilai rata-rata pengetahuan partisipan mengalami peningkatan dari 56,5 poin saat pre-test menjadi 90,25 post-test, mengalami peningkatan rerata skor pengetahuan sebesar 59,74%. Kesimpulan: Edukasi dalam bentuk ceramah dan pelatihan dapat meningkatkan pengetahuan masyarakat tentang manfaat daun tanaman rambutan dalam pembuatan Eco-print. Kata kunci: daun rambutan, eco-print, nephelium lappaceum l _________________________________________________________________________ Abstract Background: Sidorejo Village, Tambangan Subdistrict, Mijen District, is a village where many residents grow rambutan (Nephelium lappaceum L.), but no one has knowledge of the benefits as an Eco-print material. In the previous research, results on the use of plants as motifs in eco-print were presented. This community service activity is an implementation of it. Objective: To educate the community about the benefits of rambutan leaves as an eco-print material, so that it can increase community income. Method: The activity was carried out in Sidorejo, Tambangan Subdistrict, Mijen, Semarang, in the form of lectures and Eco-print skills training. Among the 20 community service participants are present. Result: Participants better understand the benefits of rambutan leaves as an eco-print material. The average knowledge score of participants increased from 56.5 points in the pre-test to 90.25 in the post-test. The average knowledge score has increased by 59.74%. Conclusion: Education by lectures and training can increase community knowledge about the benefits of rambutan leaves in making Eco-print. Keywords: rambutan leaves, eco-print, nephelium lappaceum l

DIFFERENCES IN NON FASTING TRIGLICERIDE LEVELS BETWEEN 8 HOURS FASTING AND 12 HOURS FASTING Desika Dewi; Dini Puspodewi; Meka Faizal Farabi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 2 (2025): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v13i2.6604

Triglycerides are a type of blood fat that plays an important role in energy metabolism, but excessive levels can increase the risk of cardiovascular disease. The examination of triglyceride levels generally requires fasting, but the optimal duration of fasting is still debatable. This study aims to analyze the differences in triglyceride levels in non-fasting conditions, 8-hour fasting, and 12-hour fasting. This study is an analytical study with a cross sectional design involving 39 students of the Bachelor of Applied Medical Laboratory Technology Study Program at Al-Irsyad University Cilacap as samples. Blood was taken in three conditions: non-fasting, 8-hour fasting, and 12-hour fasting, then examined using the GPO-PAP colorimetric enzymatic method. The analysis showed that the average triglyceride level in the non-fasting condition was 104.59 mg/dL, 8-hour fasting was 91.90 mg/dL, and 12-hour fasting was 87.08 mg/dL. The results of the Paired Sample T-Test test showed that there was a significant difference between non-fasting conditions and 8-hour fasting (p = 0.009), as well as between non-fasting and 12-hour fasting (p < 0.001). However, there was no significant difference between 8-hour fasting and 12-hour fasting (p = 0.172). Based on these findings, it can be concluded that fasting for 8 hours is enough to significantly reduce triglyceride levels, so it can be considered as the minimum feasible duration for triglyceride. Keywords: Triglycerides, Non Fasting, 8 Hours Fasting, 12 Hours Fasting

PERBEDAAN PROFIL PROTEIN PADA TAHU SUTERA, TAHU KUNING DAN TAHU PONG METODE SDS-PAGE Raden Bagus Muhamad Tsabitul Fikriyansyah; Meka Faizal Farabi; Dini Puspodewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 2 (2025): Desember
Publisher : LPPM Universitas Abdurrab

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A food made from soybeans has a nutritional content in the form of protein, namely tofu. The principle of making tofu is made from white soybeans and the process is soaked in water, ground until smooth, boiled, filtered then separate the tofu dregs and filtrate (water) and added coagulants and food additives (BTP) then molded, but there are differences in the process of making tofu. Silken tofu has a soft texture and the process of making the curd is not pressed and not separated from the liquid so it resembles jelly. Yellow tofu has a yellow color from the addition of turmeric juice solution in the manufacturing process and its dense texture. Pong tofu has a distinctive feature after the manufacturing process is fried first before being packaged. To determine the differences in protein profiles, protein profile analysis was carried out using the SDS-PAGE method, for samples of silken tofu, yellow tofu and raw pong tofu. This type of research is descriptive analytical. The first analysis of total protein content with a standard curve and using a UV-Vis spectrophotometer, then continued with protein profile analysis using an SDS-PAGE electrophoresis tool. Results of total protein content and protein profile Silken tofu has a total protein content of 0.63 µg/µL and 1 protein band. Yellow tofu has a total protein content of 0.79 µg/µL and 2 protein bands. Pong tofu has a total protein content of 1.10 µg/µL and 4 protein bands. The difference in the process of the three tofus can affect the protein content of tofu, which can increase or decrease

PENGARUH PERBANDINGAN ANTIKOAGULAN EDTA DAN VOLUME DARAH YANG TIDAK SESUAI PADA PEMERIKSAAN HEMOGLOBIN, ERITROSIT, DAN TROMBOSIT PADA PASIEN MEDICAL CHECK UP DI RS PERTAMINA CILACAP Kartika Palupi; Meka Faizal Farabi; Dini Puspodewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 2 (2025): Desember
Publisher : LPPM Universitas Abdurrab

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Medical Check Up (MCU) is a procedure intended to determine the overall health condition. The results of this examination can be a reference for companies to measure the physical ability of employees to perform tasks. The purpose of this study was to determine the effect of the use of EDTA anticoagulant that was not in accordance with blood volume on the examination of hemoglobin, erythrocytes, and platelets in Medical Check Up patients at RSPC. The research sample was taken using purposive sampling technique consisting of 33 Medical Check Up patients.This study is an observational analytic study with cross sectional method. The results showed that the average hemoglobin level of 2 ml blood volume in EDTA vacutainer tubes was 15.488 g/dL while the average hemoglobin level of 3 mL blood volume in EDTA vacutainer tubes was 15.515 g/dL and the Paired Sample T-Test test showed no significant difference (p>0.05). The average erythrocyte level of 2 ml blood volume in EDTA vacutainer tubes is 5.518 million /µL, while the average erythrocyte level of 3 mL blood volume in EDTA vacutainer tubes is 5.117 million /µL and the Paired Sample T-Test test shows no significant difference (p>0.05). The average platelet level of 2 ml blood volume in EDTA vacutainer tubes is 274.576 thousand/µL while the average platelet level of 3 mL blood volume in EDTA vacutainer tubes is 267.970 thousand/µL and from the Wilcoxon Signed Rank Test which shows that there is a significant difference in platelet levels (p<0.05).

GAMBARAN STATUS RESISTENSI RIFAMPISIN PASIEN TUBERKULOSIS EKSTRA PARU (TBEP) PEMERIKSAAN TES CEPAT MOLEKULER (TCM) DI RSUD CILACAP PERIODE JANUARI – OKTOBER 2025 Legiana Elza Syariah; Fitri Galih Ramadhani; Junior Dwi Cahyo; Meka Faizal Farabi; Dwi Sulistyowati; Fery Nugroho
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7618

Extrapulmonary tuberculosis (EPTB) is tuberculosis that occurs outside the respiratory system and often experiences delays in diagnosis due to the characteristics of low-concentration specimens. The Xpert MTB/RIF-based Molecular Rapid Test (TCM) is recommended as an initial diagnostic method because it can detect Mycobacterium tuberculosis and rifampicin resistance quickly. This study aims to describe the results of TCM examination and rifampicin resistance status in EPTB cases at Cilacap Regional Hospital during January–October 2025. This study used a non-experimental observational design with a retrospective descriptive approach. Data were obtained from TCM examination results on extrapulmonary specimens of EPTB patients. The results showed that of all EPTB samples examined, a small proportion were detected positive for Mycobacterium tuberculosis. The majority of positive samples showed sensitivity to rifampicin, although cases with resistance and intermediate categories were still found. Variations in positive EPTB specimens included biopsy tissue, pleural fluid, feces, gastric lavage, abscess pus, and ultraascites fluid, reflecting the spectrum of extrapulmonary TB infection. The conclusion of this study shows that rifampicin sensitivity in EPTB cases in Cilacap Regency is still dominant, indicating that the effectiveness of the first-line anti-TB regimen is still maintained, but vigilance against the potential for drug-resistant TB is still needed through continuous TCM examination.

Perbandingan Maserasi Daun Pala, Daging Pala dan Biji Pala sebagai Agen Antibakteri Terhadap bakteri Staphylococcus aureus Meka Faizal Farabi; yusuf eko Nugroho
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7761

Staphylococcus aureus is a pathogenic bacterium that can cause various infections in humans and has the potential to develop antibiotic resistance. The utilization of medicinal plants as natural antibacterial agents has gained increasing attention, including nutmeg (Myristica fragrans Houtt.), which is known to contain various bioactive compounds. This study aimed to compare the antibacterial activity of nutmeg leaf, seed, and mace infusions against Staphylococcus aureus. The study was conducted using an experimental laboratory design with the agar well diffusion method. Infusions were prepared using a 1:10 (w/v) ratio of simplicia to distilled water and heated at 90°C for 15 minutes. A suspension of S. aureus was inoculated onto Mueller Hinton Agar (MHA), followed by antibacterial activity testing using leaf, seed, and mace infusions. The inhibition zone diameters were measured after incubation at 37°C for 24 hours. The results showed that nutmeg leaf infusion produced an average inhibition zone diameter of 13.67 ± 1.53 mm, whereas seed and mace infusions did not produce any inhibition zones. These findings indicate that only nutmeg leaf infusion exhibited antibacterial activity against S. aureus under the conditions of this study. Therefore, nutmeg leaves have the potential to be developed as a natural antibacterial agent that can be easily applied through a simple infusion method. Further studies are recommended to evaluate the phytochemical profile, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) to support its development as an antibacterial agent.

PERBANDINGAN KADAR HEMOGLOBIN DAN MCV SEBAGAI INDIKATOR ANEMIA DEFISIENSI BESI PADA IBU HAMIL TRIMESTER I DAN TRIMESTER III DI PUSKESMAS MAJENANG I Damara Desiyanti; Yusuf Eko Nugroho; Meka Faizal Farabi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7766

Pregnancy is a condition in which the ovum and sperm meet. Changes during pregnancy include changes in erythrocyte mass, plasma volume, and blood volume, resulting in low hemoglobin (Hb) levels due to a decrease in erythrocyte in the blood. Anemia is a global health problem, especially in developing countries, with an estimated 30% of the world’s population suffering from anemia. Anemia is common in the community, especially among pregnant women. Anemia in pregnant women that is not treated properly can increase the risk of dangerous complications, such as premature labor. In addition, anemia can also increase the risk of low birth weight in babies. On the mother’s side, anemia can increase the risk of postpartum depression and postpartum maternal mortality. The purpose of this study was to determine the comparison of hemoglobin and MCV levels as indicators of iron deficiency anemia in pregnant women in the first and third trimesters at the Majenang I Community Health Center. This was an observational analytical study with a cross-sectional approach, with samples taken at the Majenang I Community Health Center from September 2024 to April 2025 according to the inclusion and exclusion cricetria, totalling 33 samples. The results showed a significant difference in hemoglobin levels between at first trimester (average 11.97 g/dL) and the third trimester (11.00 g/dL). Additionally, there was a significant difference in MCV values between the two groups. The average MCV value increased from 82.75 in the first trimester to 84.12 in the third trimester. The increase in MCV values was still within the normocytic range and reflected the adaptation of erythropoiesis during pregnancy. The conclusion of this study is that there are differences in hemoglobin and MCV levels in pregnant women in the first and third trimesters at the Majenang I Community Health Center. Both hemoglobin and MCV levels undergo significant changes and can be used as early indicators in detecting iron deficiency anemia in pregnant women.

HUBUNGAN KADAR MIKROALBUMIN TERHADAP KADAR UREUM DAN KREATININ PADA PASIEN DIABETES MELLITUS TIPE 2 DI PUSKESMAS CILACAP TENGAH 1 Hastuti Budi Rahayu; Meka Faizal Farabi; Dini Puspodewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7882

Diabetes Mellitus is a serious, long-term condition that occurs when a person's blood glucose levels rise because the body cannot produce enough insulin. According to the International Diabetes Federation (IDF), there were approximately 20.4 million adults aged 20-79 years old with diabetes in Indonesia in 2024, and this number is expected to increase to 28.6 million by 2050. Diabetic nephropathy is a complication of diabetes mellitus that begins with microalbuminuria, which can be detected before kidney function declines, indicated by increased blood urea and creatinine levels. This study aims to determine the relationship between microalbuminuria and serum urea and creatinine levels in patients with type 2 diabetes mellitus Method: This research is descriptive with a cross-sectional research design using medical record data from patients participating in the Chronic Disease Management Program (Prolanis) at the Central Cilacap 1 Puskesmas in the period of April 2025. Data were analyzed using the Kolmogorov-Smirnov normality test and continued using the Spearman non-parametric correlation test. Result: The results of the study showed that the average microalbumin level was 122.9491 mg/g creatinine, the average urea level was 28.60 mg/dL and the average creatinine level was 0.91 mg/dL. The results of the Spearman correlation test showed a significant value (ρ-value) between microalbumin and urea levels of 0.003 and between microalbumin and creatinine levels of 0.003. he ρ-value of each is <0.05 Conclusion: can be concluded that there is a relationship between microalbumin levels and urea and creatinine levels in type 2 Diabetes Mellitus patients at the Central Cilacap 1 Puskesmas

PERBANDINGAN KADAR UREUM DARAH SEBELUM DAN SESUDAH HEMODIALISA PADA PENDERITA GAGAL GINJAL DI RSUD MAJENANG Sri Lestari; Dini Puspodewi; Meka Faizal Farabi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.8028

Chronic kidney disease (CKD) is a progressive and irreversible decline in kidney function that leads to the accumulation of metabolic waste products, including urea. Hemodialysis is a renal replacement therapy that functions to remove metabolic waste and maintain fluid balance in the body. Measurement of blood urea levels before and after hemodialysis is important to evaluate the effectiveness of the therapy. This study aimed to determine the comparison of blood urea levels before and after hemodialysis in patients with chronic kidney disease at Majenang Regional General Hospital. This study was a quantitative study with an observational analytic design using secondary data obtained from medical records of chronic kidney disease patients undergoing hemodialysis at Majenang Regional General Hospital during June–November 2025. A total of 103 patients who met the inclusion and exclusion criteria were included in the study. Data were analyzed using the Kolmogorov-Smirnov normality test and Paired Sample t-Test with a 95% confidence level. The results showed that the mean blood urea level before hemodialysis was 133.54 ± 38.13 mg/dL, with a minimum value of 29 mg/dL and a maximum value of 244 mg/dL. After hemodialysis, the mean blood urea level decreased to 46.51 ± 21.61 mg/dL, with a minimum value of 6 mg/dL and a maximum value of 102 mg/dL. The Kolmogorov-Smirnov test indicated that the data were normally distributed (p>0.05). The Paired Sample t-Test revealed a statistically significant difference between blood urea levels before and after hemodialysis (p=0.000). In conclusion, hemodialysis is effective in reducing blood urea levels in patients with chronic kidney disease. Measurement of blood urea levels before and after hemodialysis can be utilized as a laboratory parameter to evaluate treatment effectiveness and assist in monitoring the clinical condition of patients with chronic kidney disease..

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