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All Journal Biology, Medicine, & Natural Product Chemistry JURNAL PENELITIAN BIDANG PENDIDIKAN
Puji Astuti
Universitas Tanjungpura
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health Other

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EFEKTIVITAS PEMBELAJARAN SISTEM BLOK SELAMA MATRIKULASI TERHADAP TINGKAT PENGETAHUAN MAHASISWA KEDOKTERAN UNIVERSITAS TANJUNGPURA Sari Rahmayanti; Puji Astuti
JURNAL PENELITIAN BIDANG PENDIDIKAN Vol 30, No 1 (2024)
Publisher : LPPM Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpbp.v30i1.52290

Abstract

Sistem blok merupakan metode pembelajaran student-centered yang telah banyak diterapkan di institusi pendidikan Kesehatan di Indonesia. Banyak mahasiswa baru mengalami kesulitan dalam beradaptasi dengan situasi pembelajaran mereka, dimana sebelumnya metode pembelajaran mereka adalah teacher-centered dan kini berubah menjadi student-centered. Matrikulasi merupakan program penyesuaian yang diselenggarakan oleh perguruan tinggi dengan tujuan untuk mempercepat kemampuan adaptasi akademik maupun non-akademik mahasiswa baru di perguruan tinggi. Penelitian ini bertujuan untuk mengetahui efektivitas pembelajaran sistem blok selama matrikulasi terhadap tingkat pengetahuan mahasiswa Program Studi S1 Kedokteran Universitas Tanjungpura. Penelitian ini merupakan penelitian kuantitatif menggunakan metode eksperimen dengan jenis penelitian berupa quasi experimental. Rancangan yang digunakan pada penelitian ini merupakan one group pre-test post-test design. Teknik pengumpulan data dilakukan dengan menggunakan kuisioner. Sampel diambil dengan metode total sampling yaitu sebanyak 78 mahasiswa. Hasil penelitian menunjukkan persiapan belajar yang dilakukan oleh mahasiswa dalam menghadapi post-test tidak berdampak signifikan terhadap kelulusan mereka berdasarkan standar nilai yang digunakan di jurusan kedokteran (α = 0.233). Kegiatan matrikulasi terbukti secara signifikan meningkatkan pengetahuan peserta, namun tidak cukup baik untuk mendapatkan predikat lulus berdasarkan sistem penilaian.
Evaluating Acute Toxicity of Jamu Cekok in Rats: A Histopathological Approach Based on OECD 425 Michelle The; Puji Astuti; Siti Aisyah; Hadi Kurniawan
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1207-1217

Abstract

Jamu cekok, an Indonesian traditional medicine to increase children appetite, has not passed preclinical or clinical trials. The rhizomes that make up jamu cekok such as pakai bahasa latinnya contain ethyl p-methoxycinnamate which is toxic, thus potentially harmful to the children. Therefore in this study we aim to determine the Lethal Dose (LD50) value of jamu cekok using the OECD 425 method as well as to observed the histopathological change in the liver in female Rattus norvegicus L. This study used an analytical experimental design with the OECD 425 method to test the acute toxicity of jamu cekok. The test rats used were in accordance with the OECD 425 protocol with an additional 2 negative control rats. Jamu cekok in the form of decocta were given once on the first day of the acute toxicity test and observed for 14 days. On the 15th day, rats were euthanized, dissected, and hepatic organs were taken to make histopathological preparations with Hematoxylin-Eosin staining. Analysis of hepatic damage was assessed using Histopathology Scoring Manja Roenigk and tested by Kruskal Wallis method. The results showed the LD50 value of decocta extract of jamu cekok was >5000 mg/kgBB. Observations of body weight, behavioral tests, organ index, and macroscopic hepar of test rats showed no signs of toxicity. However, The statistical analysis for histopathology test showed that there was a significant difference (p<0.05) between the negative control group and the 5000 mg/kgBB treatment group. In conclusion, the administration of jamu cekok was categorized as practically non-toxic but it can caused reversible hepatic damage at a dose of 5000 mg/kgBB.
The Antioxidant Activity and Acute Toxicity of Jamu Cekok: Kidney Histopathology Analysis of Female Wistar Puji Astuti; Virhan Novianry
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.69-75

Abstract

Jamu cekok is a traditional Indonesian herbal remedy for toddlers to improve appetite. While previous studies have shown benefits such as weight gain, its antioxidant activity and safety profile remain underexplored. This study evaluated the antioxidant potential and acute toxicity of jamu cekok, composed of Curcuma xanthorrhiza, Curcuma longa, Zingiber officinale, and Kaempferia galanga. Extracts were extracted with Aquadest and n-hexane, and antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Results showed weak antioxidant activity in both extracts (IC50: 481.59 ppm for decoction, 127.12 ppm for n-hexane), lower than some individual herbs. Moreover, an acute toxicity tests followed OECD 425 guidelines using female Wistar rats. No mortality occurred at doses up to 5,000 mg/kgBW, categorizing it as practically non-toxic. However, elevated creatinine levels and histopathological kidney changes, including degeneration and Bowman’s capsule dilation, were observed at higher doses. These findings suggest jamu cekok is safe at high doses but may induce temporary renal effects. Further research is needed to optimize formulations and evaluate long-term safety.
Analysis of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) Levels in Rats Given Jamu Cekok Decoction Risya Alfhadillah; Puji Astuti; Sari Rahmayanti; Virhan Novianry
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.189-198

Abstract

Jamu cekok is a traditional medicine used by Indonesians, especially children to increase appetite. However, the safety test of jamu cekok on liver function using Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) as parameters has never been evaluated. This study aimed to determine the effect of jamu cekok on liver function by assessing SGOT and SGPT levels in rats subjected to acute toxicity. The study employed an analytical experimental design with the OECD 425 method. The test rats used were 12, divided into a control group, a 2000 mg/kg BW treatment group and a 5000 mg/kg BW treatment group. The treatment of jamu cekok decoction was given once on the first day of the acute toxicity test and was observed for 14 days. SGOT and SGPT levels were measured and analyzed using one-way ANOVA to assess differences between groups. Through this study, observations of behavior and body weight over the 14 days showed no signs of toxicity or mortality. The LD50 value was determined to be greater than 5000 mg/kg BW, which is categorized as practically non-toxic. One-way ANOVA followed by Tukey’s HSD post hoc tests revealed no significant differences in SGOT levels between the control and treatment groups (p>0,05). Similarly, SGPT levels also showed no significant difference (p>0,05) between groups. These findings indicate that he administration of jamu cekok at a dose of 2000 mg/kg BW and 5000 mg/kg BW does not induce toxic effects on liver function, as reflected by SGOT and SGPT measurements.
Co-Authors Hadi Kurniawan Michelle The Risya Alfhadillah Sari Rahmayanti Siti Aisyah Virhan Novianry