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All Journal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical Care Anwar Medika Jurnal Farmasi Sains dan Praktis Journal of Pharmacy Science and Technology Journal of Pharmaceutical and Sciences.
Ana Khusnul Faizah
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisis dan Faktor Interaksi Obat Pada Pasien Hipertensi di Daerah Pesisir Surabaya Ana Khusnul Faizah; Nani Wijayanti Dyah Nurrahman; Amitasari Damayanti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.602

Abstract

Hypertension is a severe health problem that generally requires combination therapy. Using a combination of antihypertensive therapy and long-term therapy requires monitoring the effects of potential drug-drug interactions (PDDIs) experienced by patients. This study aims to determine the drug interaction profile related to severity and mechanism. The method was descriptive and observational by recapitulating the prescription in several pharmacies in the coastal area of Surabaya. The samples are prescriptions consist of antihypertensives with other drugs. This research was conducted for three months. This study showed that 43% potential drug-drug interactions. The pharmacodynamic interactions are slightly more dominant (49%) than pharmacokinetics (45%). Meanwhile, the highest severity of drug interactions, namely minor (49%), followed by moderate (39%) and severe (12%), was in the last position. The modest drug interaction at a moderate level is amlodipine, which can decrease the pharmacological effect of metformin. Therefore, pharmacists need to monitor blood sugar levels regularly. Serious interactions are indeed the lowest incidence; otherwise, the effects can be dangerous, so pharmacists need to monitor patients who receive drugs with severe drug interactions. One of them is amlodipine and simvastatin, which can increase the risk of rhabdomyolysis from statins. Pharmacists have an important role in monitoring the effects of drug interactions in hypertensive patients. Patients get the maximum therapeutic effect with minimal drug interactions or prevent drug interactions.
Co-Authors Adinda Kumala Sari Amitasari Damayanti Amitasari Damayanti Andayani, Rina Effendi Rachmat Eri Destin Anggraini Ersanda Praditapuspa Giftani Wardani Sudjwaro Hardiyono Hardiyono Jala Kesit Dewayani Kresnamurti, Angelica Lestiono Lestiono Nani Khusnul Wijayanti DN Nani W.D Nurrahman Nani Wijayanti Dyah Nurrahman Oki Nugraha Putra Oki Nugraha Putra Oki Nugraha Putra Risca Amilia Widyananda Kartikasari Yagi Dimas Nuryanto