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All Journal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical Care Anwar Medika Jurnal Farmasi Sains dan Praktis Journal of Pharmacy Science and Technology Journal of Pharmaceutical and Sciences.
Ana Khusnul Faizah
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisis dan Faktor Interaksi Obat Pada Pasien Hipertensi di Daerah Pesisir Surabaya Ana Khusnul Faizah; Nani Wijayanti Dyah Nurrahman; Amitasari Damayanti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.602

Abstract

Hypertension is a severe health problem that generally requires combination therapy. Using a combination of antihypertensive therapy and long-term therapy requires monitoring the effects of potential drug-drug interactions (PDDIs) experienced by patients. This study aims to determine the drug interaction profile related to severity and mechanism. The method was descriptive and observational by recapitulating the prescription in several pharmacies in the coastal area of Surabaya. The samples are prescriptions consist of antihypertensives with other drugs. This research was conducted for three months. This study showed that 43% potential drug-drug interactions. The pharmacodynamic interactions are slightly more dominant (49%) than pharmacokinetics (45%). Meanwhile, the highest severity of drug interactions, namely minor (49%), followed by moderate (39%) and severe (12%), was in the last position. The modest drug interaction at a moderate level is amlodipine, which can decrease the pharmacological effect of metformin. Therefore, pharmacists need to monitor blood sugar levels regularly. Serious interactions are indeed the lowest incidence; otherwise, the effects can be dangerous, so pharmacists need to monitor patients who receive drugs with severe drug interactions. One of them is amlodipine and simvastatin, which can increase the risk of rhabdomyolysis from statins. Pharmacists have an important role in monitoring the effects of drug interactions in hypertensive patients. Patients get the maximum therapeutic effect with minimal drug interactions or prevent drug interactions.
Uji Aktivitas Analgesik Minyak Ikan pada Mencit Putih (Mus musculus) Jantan Galur BALB/c dengan Metode Writhing Test Risca Amilia; Angelica Kresnamurti; Ana Khusnul Faizah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 17 No. 01 Juli 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5049

Abstract

Minyak ikan merupakan sumber EPA dan DHA yang berasal dari sumber daya laut. Kapsul minyak ikan merupakan salah satu nutraseutikal untuk memenuhi kebutuhan omega-3 dan omega-6. Penelitian telah dilakukan menggunakan minyak ikan salmon yang mengandung EPA dan DHA. Tujuan dari penelitian ini adalah untuk menentukan aktivitas analgesik pada tikus putih jantan (Mus musculus) strain BALB/c. Sejumlah 25 ekor tikus putih jantan dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor tikus putih jantan. Kelompok kontrol negatif diberi kombinasi emulsi Tween 80 dan Span 80, kelompok kontrol positif diberi aspirin, dan kelompok perlakuan diberi emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB. Metode yang digunakan pada penelitian ini adalah writhing test dengan menginduksi tikus putih jantan dengan asam asetat 0,6%. Hasil penelitian menunjukkan bahwa emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB memiliki persentase hambatan nyeri masing-masing sebesar 29,44; 42,64; dan 52,59%. Dapat disimpulkan bahwa emulsi minyak ikan salmon memiliki aktivitas analgesik.  
Co-Authors Adinda Kumala Sari Amitasari Damayanti Amitasari Damayanti Andayani, Rina Effendi Rachmat Eri Destin Anggraini Ersanda Praditapuspa Giftani Wardani Sudjwaro Hardiyono Hardiyono Jala Kesit Dewayani Kresnamurti, Angelica Lestiono Lestiono Nani Khusnul Wijayanti DN Nani W.D Nurrahman Nani Wijayanti Dyah Nurrahman Oki Nugraha Putra Oki Nugraha Putra Oki Nugraha Putra Risca Amilia Widyananda Kartikasari Yagi Dimas Nuryanto