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All Journal Journal of Pharmaceutical and Sciences. JPMP
Nani Wijayanti Dyah Nurrahman
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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PENYULUHAN PENGGUNAAN ANTIBIOTIK YANG TEPAT DALAM UPAYA PENCEGAHAN RESISTENSI DI KELURAHAN WONOREJO SURABAYA Rina Andayani; Ana Khusnul Faizah; Nani Wijayanti Dyah Nurrahman; Liza Yudistira Yusan; Astrid Kusuma Putri; Ersanda Nurma Praditapuspa; Hardiyono Hardiyono; Yanu Andhiarto
Jurnal Pengabdian Masyarakat Pesisir VOLUME 1 NO 2
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v1i2.75

Abstract

Antibiotik merupakan zat-zat kimia yang dapat menghambat dan membunuh bakteri yang digunakan masyarakat untuk menangani penyakit infeksi. Namun, penggunaan antibiotik yang tidak rasional dan tepat dapat menyebabkan resistensi bakteri terhadap antibiotik, dibuktikan dari data di Rumah Sakit Dr Kariadi yang menunjukkan bahwa semua isolat dari darah memiliki tingkat multiresisteni tinggi terhadap antibiotik yaitu 45-65%. Oleh karena itu dibutuhkan edukasi kepada masyarakat terkait bagaimana penggunaan antibiotik yang benar dan tepat kepada masyarakat. Penyuluhan diselenggarakan di kantor kelurahan Wonorejo dan dihadiri oleh 57 ibu-ibu PKK. Kegiatan ini bertujuan meningkatkan tingkat pengetahuan masyarakat Wonorejo terjadap penggunaan antibiotik yang benar. Evaluasi dilakukan dengan pengisian kuisioner sebelum dan sesudah penyuluhan dilakukan kepada masyarakat. Berdasarkan hasil kuisioner yang dianalisis diperoleh adanya peningkatan pengetahuan peserta dari kategori rendah (4,5) menjadi baik (6,8). Kegiatan penyuluhan dapat dilakukan secara rutin untuk meningkatkan kesadaran masyarakat dalam penggunaan antibiotik secara tepat.
Analisis dan Faktor Interaksi Obat Pada Pasien Hipertensi di Daerah Pesisir Surabaya Ana Khusnul Faizah; Nani Wijayanti Dyah Nurrahman; Amitasari Damayanti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.602

Abstract

Hypertension is a severe health problem that generally requires combination therapy. Using a combination of antihypertensive therapy and long-term therapy requires monitoring the effects of potential drug-drug interactions (PDDIs) experienced by patients. This study aims to determine the drug interaction profile related to severity and mechanism. The method was descriptive and observational by recapitulating the prescription in several pharmacies in the coastal area of Surabaya. The samples are prescriptions consist of antihypertensives with other drugs. This research was conducted for three months. This study showed that 43% potential drug-drug interactions. The pharmacodynamic interactions are slightly more dominant (49%) than pharmacokinetics (45%). Meanwhile, the highest severity of drug interactions, namely minor (49%), followed by moderate (39%) and severe (12%), was in the last position. The modest drug interaction at a moderate level is amlodipine, which can decrease the pharmacological effect of metformin. Therefore, pharmacists need to monitor blood sugar levels regularly. Serious interactions are indeed the lowest incidence; otherwise, the effects can be dangerous, so pharmacists need to monitor patients who receive drugs with severe drug interactions. One of them is amlodipine and simvastatin, which can increase the risk of rhabdomyolysis from statins. Pharmacists have an important role in monitoring the effects of drug interactions in hypertensive patients. Patients get the maximum therapeutic effect with minimal drug interactions or prevent drug interactions.
Co-Authors Amitasari Damayanti Ana Khusnul Faizah Andayani, Rina Astrid Kusuma Putri Hardiyono Hardiyono Liza Yudistira Yusan Praditapuspa, Ersanda Nurma Yanu Andhiarto