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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Sciences of Pharmacy
Nuri Ari Efiana
Fakultas Farmasi, Universitas Ahmad Dahlan
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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Development of detection method for carcinogenic compounds using radish seeds Raphanus sativus, L via measuring the alkaline phosphatase enzyme activity Nuri Ari Efiana; Mulyadi Mulyadi; Annas Binarjo
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27733

Abstract

Convincing data regarding carcinogenic substances is very useful for handling materials correctly to avoid exposure to cancer-triggering substances in the body. To collect as much carcinogen data as possible, low-requirement carcinogen detection setups need to be developed. In this study, the first steps in the development of carcinogen detection through functional protein expression assessment are reported. Hydrazine sulfate, one of the well-known carcinogens chosen as a model material, was tested on germinating seeds of Raphanus sativus, L, with various concentrations, namely 0 (control), 1 mM, 10 mM, and 100 mM. Within a predetermined germination time, seeds and/or sprouts were observed and germination rate, protein concentration, and alkaline phosphatase activity were measured. The results showed that hydrazine sulfate slowed seed germination, and increased 72-h protein concentration but decreased alkaline phosphatase activity in the control group. This suggests that changes in alkaline phosphatase activity in seeds during germination have the potential to be a marker for cancer. In this research, it can be concluded that the method used can be applied as a first step to prove the carcinogenicity of a compound.
Application of vegetable oils as pharmaceutical ingredient: the impact of liquid lipid type on the characteristics of nanostructured lipid carrier Binarjo, Annas; Ernidawati; Khotimah, Khusnul; Wahyuningsih, Iis; Efiana, Nuri Ari
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.30281

Abstract

Recently, drug encapsulation using a Nanostructured Lipid Carrier (NLC) has gained attention in formulation studies due to its high loading capacity and prevent drug expulsion during storage. Drug loading capacity is mainly affected by lipid type and composition, especially liquid lipids. Therefore, this research aims to evaluate the potential of avocado oil as a liquid lipid of NLC replacing pure oleic acid. All components including oil, glyceryl monostearate, Tween 20®, and Span 60® were processed to NLC by solvent injection method. The colloidal characteristics of NLC dispersion in water and 20 mM PBS pH 7 were determined, including transmittance, particle size, size distribution, zeta potential, loading capacity (LC), and loading efficiency (LE) of capsanthin in NLC. The results showed that NLC containing oleic acid (Fola) and avocado oil (Favo) dispersion in PBS exhibited a similar transmittance and zeta potential of 69-74% and -51 to -58 mV, respectively, whereas the particle size and size distribution of Favo were significantly higher than Fola. Moreover, the 1.3-fold higher LC and LE of Favo compared to Fola was insignificant (p>0.05).   Additionally, the Tween 20® and Span 60® ratio of Favo should be improved to obtain an ideal particle size and size distribution as in Fola.  In conclusion, avocado oil indicated the potential to be utilized as a liquid lipid of NLC formulation regarding zeta potential and drug loading. However, the surfactant composition should be adjusted to reduce the particle size of the NLC, leading to permeability enhancement in delivery, particularly oral administration.
Enhancement of Losartan Transdermal Transport Through Incorporation into Chitosan Nanoparticles Efiana, Nuri Ari; Nugroho, Akhmad Kharis; Martien, Ronny
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49978

Abstract

Losartan, an antihypertensive agent, has low oral bioavailability. Therefore, developing a design for transdermal delivery of losartan is interesting. This study aims to enhance losartan in vitro transport by incorporating it into chitosan nanoparticles. Transdermal transport studies were conducted using two experimental groups: the pretreatment group using oleic acid and propylene glycol, and the group without pretreatment. The results showed that losartan incorporated into chitosan nanoparticles resulted in a significantly higher amount of drug being transported than the losartan solution (control) in both experimental groups. In the experiment without pretreatment, the amount of losartan from the control could not be detected in the receptor compartment until 28 hours. In contrast, losartan was detected at 16 hours of transport from chitosan nanoparticles. In pretreatment, chitosan nanoparticles exhibited 6.6fold higher losartan transport than the control. In addition, losartan chitosan nanoparticles showed significant increases in steady-state flux and transport efficiency by 3.3 and 6.6 times higher than the control, respectively. It can be concluded that the incorporation of losartan into chitosan nanoparticles can increase its transdermal transport.
Pometia pinnata in Pharmaceutical Research: Bioactivity, Mechanisms, and Formulation Prospects Sulastri, Lela; Sugihartini, Nining; Efiana, Nuri Ari
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403331

Abstract

A literature review was conducted to gather information on the pharmacological properties and pharmaceutical dosage forms made from the Matoa plant (Pometia pinnata). The review aimed to provide a basis for further research and explore the potential of Matoa in the health sector. The method involved searching electronic media platforms, specifically Google Scholar, PubMed, and Open Knowledge Maps, using targeted keywords such as "Matoa,” "Pometia pinnata,” "Matoa preparation formulation,” "Pometia pinnata pharmaceutical preparation,” "Preparation of Pometia pinnata," and "Function of Pometia pinnata." The inclusion criteria included original research, full-text articles, and open-access journals, all published within the last 10 years, in both Indonesian and English. After screening, 64 articles were identified from the 185 search results. The review revealed that various parts of the Matoa plant, including leaves, fruit, stem bark, fruit peel, and roots, possess pharmacological properties such as antibacterial, analgesic, antioxidant, sunscreen, anticancer, antidiarrheal, anti-HIV, anti-obesity, diuretic, nephrotoxic, and antihypertensive activities. Additionally, various pharmaceutical dosage forms containing Matoa were studied, including topical preparations such as lotions, creams, liquid soap, and body scrubs, as well as oral preparations like effervescent powders, herbal drinks, and jelly candies. The review suggests that numerous research opportunities remain to further explore the potential of Matoa in the pharmaceutical and healthcare fields, as well as to develop innovative dosage forms for optimal results.
Co-Authors Akhmad Kharis Nugroho Annas Binarjo Ernidawati Iis Wahyuningsih khusnul khotimah Lela Sulastri, Lela Mulyadi Mulyadi Nining Sugihartini Ronny Martien