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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian
Fauziyyah Al Hasanah
Study Program Of Pharmacy, Faculty Of Pharmacy, Universitas Darussalam Gontor, Indonesia
Medicine & Pharmacology

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OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN Fauziyyah Al Hasanah; Gunawan Pamudji Widodo; Endang Dyah Ikasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1071

Abstract

Loss becomes a problem in the hair that causes baldness. Biotin is a vitamin that nourishes hair and prevents hair loss. Biotin which is formulated in microemulsion tends to be transparent, has low viscosity and high solubility. Formula optimization was carried out to determine the concentration of span 80, tween 80, and PEG 400 in biotin microemulsion hair tonic. The research was conducted on an experimental basis using a factorial design method with 3 factors, namely span 80, tween 80, and PEG 400. The optimum microemulsion formula was determined using Design Expert 13 software using the Factorial Design method. Testing the physical quality of the preparation is carried out at the optimum formula. Optimization of biotin microemulsion hair tonic showed results of span 80 (20%), tween 80 (9.466%) and PEG 400 (5%) with a predicted viscosity of 46.75 cPs and globule size of 2.98 µm. Prediction testing and test results compared to the One Sample T-test showed results that were not significantly different with a significance value of >0.05. The optimum formula has a viscosity value of 47.67 cPs and a globule size of 2.4 µm. The results obtained concluded that the optimal composition composition of the biotin microemulsion formula from the combination of span 80, tween 80 and PEG 400 which produces hair tonic with good effects and physical quality is span 80 20%, tween 80 9.47% and PEG 400 5%.
FORMULATION AND EFFICACY TESTING OF SPF (Sun Protecting Factor) SUNSCREEN GEL EXTRACT OF RAMBUSA LEAVES (Passiflora Foetida L) Fauziyyah Al Hasanah; Muthi’ah Rabbaniyyah; Eni Kurniati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1236

Abstract

The rambusa plant contains flavonoid compounds found in rambusa leaves which are good antioxidants because they have hydroxyl groups attached to aromatic carbon rings. This makes rambusa leaves able to ward off free radicals. The choice of gel composition is based on practical considerations because gel not only provides effective protection against sunlight but also has non-sticky properties, provides a soft feel and forms a film that adheres well to the skin. This research aims to determine the flavonoid content in rambusa leaves, which are antioxidants that can be formulated into sunscreen gel preparations to help protect the skin from sunlight. Determination of antioxidant levels in sunscreen gel preparations made from rambusa leaf extract was carried out by measuring the SPF (Sun Protection Factor) value at three different concentrations, namely 2%, 4%, and 6% using UV-Vis spectroscopy. The research results showed that all formulas had good physical quality values of the gel preparations. All formulas have varying SPF values, where the 2% concentration has maximum protection with an SPF value of 11.7 and the 4% and 6% concentrations have ultra protection with SPF values of 18.8 and 33.9. The conclusion of this research is that rambusa leaf extract has the potential to be an effective natural ingredient in sunscreen preparations and shows the ability to protect the skin from sunlight, where formulation 3 only has the highest SPF number, namely 33.90 (super protection).  Keywords: Rambusa leaves, Protection, Sunscreen, SPF
Co-Authors Endang Dyah Ikasari Eni Kurniati Gunawan Pamudji Widodo Muthi'ah Rabbaniyyah Muthi’ah Rabbaniyyah Shobiyyah Hasna Fadhilah Siti Norli Aisyah Yulisa Raras Dewi